Microchip Technology

ATSAM4E16CB-AN - Cortex-M4 120MHz 1MB Flash MCU | Microchip

MPN: ATSAM4E16CB-AN βœ“ Active
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100-LQFP (14 x 14 mm) Package 120 MHz Speed 1 MB (1M x 8) Memory
From $8.3 USD / Unit
MOQ: 1 |
Price updated: 2026-09-19
Volume Pricing
Qty Unit Price Extended
1 $10.76 $10.76
10 $10.1 $101.00
100 $9.4 $940.00
500 $8.85 $4,425.00
1,000 $8.3 $8,300.00
ℹ️ All prices are in USD

ATSAM4E16CB-AN Overview

The Microchip Technology ATSAM4E16CB-AN is a 32-bit ARM Cortex-M4 microcontroller with a floating point unit, 1 MB (1M x 8) Flash memory, 120 MHz maximum CPU clock, and a 128 Kbytes SRAM subsystem, housed in a 100-pin LQFP (14 x 14 mm) surface-mount package.

A microcontroller (MCU) integrates a processor core, memory, and peripherals on a single silicon die, sitting at the heart of embedded control systems within the broader hierarchy of ARM Cortex-M processor-based devices. The SAM4E Series belongs to Microchip's (formerly Atmel) high-performance SAM family, positioned above the SAM4S entry line by adding an Ethernet MAC and CAN controller for connectivity-focused designs.

Key features include the ARM Cortex-M4 core with 2 Kbytes instruction cache, Memory Protection Unit (MPU), DSP instructions and single-cycle MAC, Thumb-2 instruction set, and an FPU for efficient floating-point computation. Peripherals span a 10/100 Ethernet MAC, CAN 2.0B, USB 2.0 device port, multiple USARTs, SPI, TWI, 12-bit ADC and DAC, PWM channels, and a rich timer set.

Architecturally, the multi-layer bus matrix delivers high data bandwidth between the 120 MHz core, SRAM banks, and DMA channels, allowing peripherals to move data without CPU intervention. The DSP/FPU extension makes it suitable for control-loop mathematics such as PID, FFT, and motor-control transforms executed in hardware.

Typical applications include industrial Ethernet and CAN networking nodes, motor control and power conversion, building automation gateways, and medical instrumentation that needs deterministic 32-bit processing with on-chip networking.

Design consideration: the 'AN' temperature suffix denotes the extended temperature range per the ordering code, and Microchip recommends Revision B silicon for new prototypes and production, so verify the device revision marking on the package top.

This page synthesizes distributor pricing, same-family drop-in alternatives, and practical design notes not found in the manufacturer datasheet.

Drop-in alternatives for ATSAM4E16CB-AN β€” same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with ATSAM4E16CB-AN (same form factor and footprint) β€” differing in Floating Point Unit, Package, RoHS Status.

Microchip Technology
Floating Point Unit: Yes (FPU)
Package: 100-LQFP (14x14 mm)
RoHS Status: Green / RoHS compliant (per Mouser listing)
Compare with ATSAM4E16CB-AN β†’

Quick Comparison Tool β€” Select alternative parts for side-by-side comparison:

ATSAM4E8CB-AN

βœ… Drop-In ⚠️ 参数待ιͺŒθ―
πŸ“¦ 100-LQFP (14 x 14 mm)
Flash 512 KB vs 1 MB (-50%); identical peripheral set and pinout, pin-to-pin compatible

πŸ“‹ Reference alternative (not in catalog)

ATSAM4E16CB-CU

βœ… Drop-In ⚠️ 参数待ιͺŒθ―
πŸ“¦ 100-LQFP (14 x 14 mm)
same die and 1 MB Flash, different temperature ordering suffix (CU vs AN) - verify ambient temperature grade

πŸ“‹ Reference alternative (not in catalog)

ATSAM4E16CB-AUR

βœ… Drop-In ⚠️ 参数待ιͺŒθ―
πŸ“¦ 100-LQFP (14 x 14 mm)
same die and package, AEC-Q100 automotive ordering suffix (U); tape-and-reel delivery

πŸ“‹ Reference alternative (not in catalog)

ATSAM4SD32CB-AN

βœ… Drop-In ⚠️ 参数待ιͺŒθ―
πŸ“¦ 100-LQFP (14 x 14 mm)
SAM4SD family: 1 MB dual-bank Flash with XDMAC but no Ethernet MAC - connectivity feature differs

πŸ“‹ Reference alternative (not in catalog)

ATSAM4E16CB-AN Maximum Ratings & Electrical Characteristics

Core ARM Cortex-M4 with FPU
Core Size 32-bit
Maximum Clock Frequency 120 MHz
Flash Memory 1 MB (1M x 8)
Instruction Cache 2 Kbytes
Memory Protection Unit Yes (MPU)
DSP Instructions Yes
Floating Point Unit Yes
Instruction Set Thumb-2
Series SAM4E
Package 100-LQFP (14 x 14 mm)
Mounting Type Surface Mount
Connectivity Ethernet MAC, CAN, USB, USART, SPI, TWI
RoHS Status Compliant (GREEN package per Mouser)
Device Revision Note Revision B recommended for new prototypes and production (per Microchip product page)

ATSAM4E16CB-AN 100-lqfp (14 x 14 mm) Pin Configuration Guide

Pin configuration for ATSAM4E16CB-AN (100-lqfp (14 x 14 mm) package). This digital IC includes GPIO, communication interfaces (UART, SPI, I2C), and power pins. Refer to the manufacturer datasheet for alternate pin functions and configuration options. Essential for embedded system design and PCB layout.

100-lqfp (14 x 14 mm) package pinout diagram for ATSAM4E16CB-AN

No detailed pinout data available for ATSAM4E16CB-AN.

Refer to the datasheet for full pin configuration.

Typical Applications

ATSAM4E16CB-AN is suitable for 6 applications: Industrial Ethernet / CAN Networking Nodes, Motor Control and Power Conversion, Building Automation Gateways, Medical and Laboratory Instrumentation, Industrial HMI and Display Controllers, Embedded IoT / Connected Sensing Devices.

🏭

Industrial Ethernet / CAN Networking Nodes

The ATSAM4E16CB-AN fits industrial networking nodes because it is one of the few SAM4E devices integrating both a 10/100 Ethernet MAC and CAN 2.0B alongside the 120 MHz Cortex-M4 core with hardware FPU. This allows a single chip to bridge fieldbus (CAN) traffic to Ethernet-based supervision networks without an external communication processor. In a typical topology, the Ethernet MAC drives an external PHY (such as a KSZ8081) over RMII while the CAN controller connects to transceivers on the fieldbus; on-chip DMA moves frames between SRAM and peripherals, keeping the 1 MB Flash available for protocol stacks. The trade-off is that the MAC needs an external PHY, adding roughly one small IC and magnetics to the BOM.

βš™οΈ

Motor Control and Power Conversion

The ATSAM4E16CB-AN suits motor control because its Cortex-M4 DSP instructions and single-cycle hardware FPU execute Clarke/Park transforms and PI current loops in microseconds, while the 120 MHz core with 2 Kbyte cache keeps control-loop jitter low. The device provides PWM peripherals and a 12-bit ADC for three-phase current and bus-voltage sampling, and DMA offloads sample transfer so the CPU is free for supervisory logic such as fieldbus communication. In a typical servo or inverter stage, the MCU drives gate drivers, reads shunt currents each PWM period, and closes the FOC loop; the FPU removes fixed-point scaling work from firmware. Compared to a fixed-point MCU, development time is reduced and higher loop bandwidth is achievable at the cost of higher unit price than entry-level parts.

🏒

Building Automation Gateways

The ATSAM4E16CB-AN fits building automation gateways where CAN, RS-485, and Ethernet traffic must coexist. The chip integrates Ethernet MAC, CAN, multiple USARTs, SPI and TWI, so a single 100-LQFP device can terminate field devices on several buses and forward data to a BACnet/Modbus-TCP or MQTT upstream network. The 120 MHz Cortex-M4 with hardware FPU provides headroom for protocol stacks and TLS, while 1 MB Flash holds both the communication stack and application logic without external memory. DMA channels on all major peripherals keep CPU load low during sustained traffic. Designers should budget external magnetics for the Ethernet port and provide isolation for field-side buses; the main trade-off versus a dedicated gateway SoC is lower integration of secondary network features.

πŸ’Š

Medical and Laboratory Instrumentation

The ATSAM4E16CB-AN is appropriate for medical and laboratory instruments that need deterministic 32-bit processing, USB connectivity to a host PC, and moderate analog acquisition. The 12-bit ADC with DMA enables periodic sampling of sensor front-ends, and the hardware FPU accelerates calibration math, digital filtering, and FFT-based analysis without fixed-point libraries. The integrated USB 2.0 device port supports communication with test software, while USART/SPI/TWI interfaces control signal-chain ICs such as precision ADCs and programmable-gain amplifiers. The MPU supports safe separation of measurement and communication firmware. Designs must respect the device's operating temperature grade and use clean analog grounding around the ADC; the trade-off is that for metrology-grade accuracy an external precision converter is still recommended over the internal ADC.

πŸ“Ί

Industrial HMI and Display Controllers

The ATSAM4E16CB-AN can serve as the control processor behind industrial human-machine interfaces. Its 1 MB Flash stores graphics assets and communication logic, the 120 MHz Cortex-M4 with cache renders simple UI layers, and SPI interfaces connect to TFT display modules and touch controllers. Multiple USART and Ethernet links let the HMI node exchange data with PLCs and supervisory systems while updating the display, and DMA keeps SPI display refresh from starving the communication stack. Typical implementations pair the MCU with an external controller-based TFT module or an SPI QVGA panel with a capacitive touch IC over I2C. Compared to a dedicated graphics SoC, the SAM4E16CB costs less and is adequate for text-and-meter style UIs, but is not suited to video-rate full-frame animation.

🧩

Embedded IoT / Connected Sensing Devices

The ATSAM4E16CB-AN fits connected sensing devices that need wired networking - Ethernet or CAN - rather than short-range radio. The on-chip Ethernet MAC with an external PHY supports TCP/IP sensor nodes on factory floors, while the FPU processes sensor fusion and FFT analysis locally, sending only reduced feature data upstream. Multiple USART/TWI ports aggregate external sensor modules, DMA buffers keep sample streams continuous, and the 1 MB Flash supports secure boot plus a protocol stack simultaneously. Peripheral expansion is straightforward with SPI/TWI GPIO expanders and ADCs. The key consideration is power: as a high-performance MCU it is best for mains- or PoE-powered nodes; battery-powered designs should use a lower-power SAM L or SAM D family device instead.

Recommended Products Summary

KSZ8081RNA 10/100 Ethernet PHY for on-chip MAC Used in: Industrial Ethernet / CAN Networking Nodes, Building Automation Gateways, Embedded IoT / Connected Sensing Devices ATA6663 CAN transceiver Used in: Industrial Ethernet / CAN Networking Nodes, Building Automation Gateways IRS2003 Half-bridge gate driver Used in: Motor Control and Power Conversion ATA6823 Motor gate driver interface Used in: Motor Control and Power Conversion MCP3421 18-bit delta-sigma ADC for precision channels Used in: Medical and Laboratory Instrumentation, Embedded IoT / Connected Sensing Devices MCP4541 Digital potentiometer for gain calibration Used in: Medical and Laboratory Instrumentation MCP23S17 SPI GPIO expander for backlight/keys Used in: Industrial HMI and Display Controllers MCP7940N Real-time clock for logging Used in: Industrial HMI and Display Controllers, Embedded IoT / Connected Sensing Devices
What are the key specifications of ATSAM4E16CB-AN that engineers should know?
The ATSAM4E16CB-AN is a Microchip (Atmel) SAM4E Series microcontroller with an ARM Cortex-M4 core running at up to 120 MHz, 1 MB (1M x 8) Flash memory, a 2 Kbyte instruction cache, MPU, DSP instructions, Thumb-2 support, and a floating point unit, packaged in a 100-pin LQFP (14 x 14 mm). According to the SAM4E Series datasheet, it targets industrial connectivity designs with an Ethernet MAC and CAN controller on board.
What is the price of ATSAM4E16CB-AN?
As of 2026-09-20, the ATSAM4E16CB-AN unit price from major distributors is approximately $10.76 at quantity 1, per Heisener and Octopart aggregated data. LCSC lists pricing from $12.47. Bulk pricing typically steps down toward the $8-9 range at 1000-piece volumes. Prices vary by distributor and region; compare DigiKey, Mouser, and Octopart quotes before ordering.
Where can I buy ATSAM4E16CB-AN online?
You can buy the ATSAM4E16CB-AN from DigiKey, Mouser, LCSC, Ampheo, Heisener, and other authorized or independent distributors. DigiKey states 'Buy now, ships today' for this part, and Heisener reports roughly 7,248 pieces in stock with lead time to be confirmed. For production volumes, request quotations from multiple distributors via Octopart to compare bulk discounts from the 10 distributors tracking this part.
Is ATSAM4E16CB-AN in stock?
Yes, the ATSAM4E16CB-AN is in stock at several distributors as of 2026-09-20. Heisener lists 7,248 pieces in stock, LCSC shows in-stock inventory, and DigiKey advertises same-day shipping. However, exact availability changes daily, and some distributors note lead time 'to be confirmed,' so verify stock levels on the distributor site at order time.
What is the difference between ATSAM4E16CB-AN and ATSAM4E16C?
The ATSAM4E16CB-AN is a specific ordering code of the ATSAM4E16C device: 'CB' denotes the 1 MB Flash / 100-pin LQFP variant and 'AN' denotes the temperature and package ordering suffix. On the Microchip product page for ATSAM4E16C, the company states it highly recommends considering Revision B silicon for new prototypes and production, which is the main selection consideration beyond the ordering code itself.
ATSAM4E16CB-AN vs ATSAM4S16CA-CU - which is better for industrial networking?
The ATSAM4E16CB-AN is better for industrial networking because the SAM4E Series adds a 10/100 Ethernet MAC plus CAN 2.0B on top of the Cortex-M4 core, while the SAM4S-based ATSAM4S16CA-CU lacks the Ethernet MAC. Both run at 120 MHz with 1 MB Flash, but note the ATSAM4S16CA-CU is in a TFBGA-100 package, so it is not pin-to-pin drop-in with the LQFP-100 SAM4E16CB - it is a parametric peer, not a footprint replacement.
What is the best drop-in replacement for ATSAM4E16CB-AN?
The closest drop-in options are same-family SAM4E devices in the same 100-LQFP footprint, such as the ATSAM4E8CB-AN, which shares the identical package and pinout but halves Flash to 512 KB. Because cross-brand microcontrollers almost never share exact pin maps, no verified cross-brand drop-in replacement exists for this part. According to the SAM4E datasheet ordering table, always verify the pin map against your PCB layout before substituting.
Is ATSAM4E16CB-AN suitable for motor control applications?
Yes, the ATSAM4E16CB-AN is well suited to motor control because its Cortex-M4 core integrates DSP instructions and a hardware floating point unit for fast execution of control-loop math such as PI/PID and Clarke/Park transforms, and it provides PWM outputs and a 12-bit ADC for current sensing. The 120 MHz clock with 2 Kbyte cache keeps loop latency deterministic, making it appropriate for industrial drives and power-conversion stages.
When should I choose the SAM4E16CB over a smaller SAM4S microcontroller?
Choose the ATSAM4E16CB-AN when your design needs on-chip 10/100 Ethernet or CAN 2.0B connectivity, or heavy floating-point math, since the SAM4S family omits the Ethernet MAC and offers weaker DSP/FPU capability. Stay with a SAM4S part when only UART, SPI, I2C connectivity is required and cost matters, since SAM4S devices are cheaper. Both families share the Cortex-M4 architecture at 120 MHz, so code porting effort between them is moderate.
What is the best Microchip equivalent for ATSAM4E16CB-AN (same brand)?
The best same-brand equivalent is the ATSAM4E8CB-AN: it is pin-to-pin compatible in the same 100-LQFP (14 x 14 mm) package and shares the full SAM4E peripheral set including the Ethernet MAC and CAN, with 512 KB Flash instead of 1 MB. For designs needing exactly 1 MB Flash, the ATSAM4E16CB-CU provides the same die in the same LQFP-100 footprint with a different temperature ordering suffix, so check your board's ambient conditions before selecting it.
Where can I download the ATSAM4E16CB-AN datasheet PDF?
You can download the SAM4E Series datasheet, which covers the ATSAM4E16CB-AN, from Microchip's official product page for ATSAM4E16C (microchip.com/en-us/product/ATSAM4E16C), which links the current datasheet and errata documents. Aggregator sites such as DigChip and LCSC also mirror the datasheet PDF. Always prefer the Microchip official copy because it includes the latest revision and Revision B silicon recommendations for new designs.
Is ATSAM4E16CB-AN the same as ATSAM4E16CB-CU?
No, they are not identical ordering codes, but they are electrically identical dies in the same 100-LQFP footprint. The suffix letters encode temperature range and packing: 'AN' and 'CU' differ in the operating temperature grade and delivery format per the Microchip ordering-code scheme. Verify the exact temperature requirement of your end environment against the ordering table in the SAM4E datasheet, since an incorrectly ordered temperature grade can fail qualification even though the silicon is the same.
Can STM32F4 replace ATSAM4E16CB-AN in an existing design?
No, an STM32F4 device cannot serve as a drop-in replacement for the ATSAM4E16CB-AN on an existing PCB because pin assignments, power domains, programming interfaces, and boot behavior differ between ST and Microchip product lines. A functional redesign is possible - both are Cortex-M4 parts with Ethernet options and similar clock speeds - but it requires a new PCB layout, schematic changes, and firmware porting. Treat STM32F4 as a parametric peer, not a drop-in substitute.
Does Microchip recommend Revision B silicon for new ATSAM4E16C designs?
Yes. According to the Microchip official product page for ATSAM4E16C, the company states: 'For New Designs, we highly recommend to consider Revision B for Prototypes and Production.' The SAM4E datasheet for the ATSAM4E16CB-AN repeats the same note. Engineers should check the revision marking on delivered units and consult the Microchip errata sheet for their silicon revision before tape-out or volume release.
Hey Google, what can replace ATSAM4E16CB-AN?
The most reliable replacement for the ATSAM4E16CB-AN is a same-family Microchip SAM4E part in the 100-LQFP package, primarily the ATSAM4E8CB-AN (512 KB Flash, pin-identical) or the ATSAM4E16CB-CU (same die, different temperature suffix). There is no verified cross-brand pin-compatible drop-in alternative; competing Cortex-M4 MCUs from other vendors require PCB and firmware redesign. For a replacement decision, match Flash size, Ethernet/CAN requirements, and the LQFP-100 footprint first.

Engineering reference data for ATSAM4E16CB-AN β€” comparison, design guidance, and compliance information.

Selection Guide

Choose the ATSAM4E16CB-AN when your design needs a 120 MHz Cortex-M4 with hardware FPU, 1 MB Flash, and on-chip 10/100 Ethernet plus CAN in a standard 100-LQFP footprint - typical cases are industrial gateways, motor-control nodes with fieldbus, and connected instrumentation. Choose ATSAM4E8CB-AN instead if 512 KB Flash is sufficient and cost is tight; it is pin-identical, so the PCB does not change. Choose ATSAM4E16CB-CU only if its temperature ordering grade matches your environment better than the 'AN' suffix. Avoid this part for battery-powered designs (use a SAM L/D family device) or if you already have an ST ecosystem - STM32F4 parts are parametric peers but require a complete board and firmware redesign, not a drop-in swap. Always request Revision B silicon per Microchip's recommendation for new designs.

Comparison with Alternatives

Parameter This Product ATSAM4E8CB-AN ATSAM4E16CB-CU ATSAM4E16CB-AUR ATSAM4SD32CB-AN
Package 100-LQFP (14 x 14 mm) 100-LQFP (14 x 14 mm) - same 100-LQFP (14 x 14 mm) - same 100-LQFP (14 x 14 mm) - same 100-LQFP (14 x 14 mm) - same
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Core ARM Cortex-M4 with FPU ARM Cortex-M4 with FPU ARM Cortex-M4 with FPU ARM Cortex-M4 with FPU ARM Cortex-M4 with FPU
Max Clock Frequency 120 MHz 120 MHz 120 MHz 120 MHz 120 MHz
Flash Memory 1 MB (1M x 8) 512 KB (-50%) 1 MB 1 MB 1 MB dual-bank
Ethernet MAC Yes (10/100) Yes (10/100) Yes (10/100) Yes (10/100) No
CAN Controller Yes (CAN 2.0B) Yes (CAN 2.0B) Yes (CAN 2.0B) Yes (CAN 2.0B) No

Key Differentiators

  • Integrated Ethernet MAC plus CAN on one chip (vs ATSAM4SD32CB-AN)
  • Double the Flash of the low-cost sibling (vs ATSAM4E8CB-AN)
  • Hardware FPU with DSP instructions (vs Fixed-point Cortex-M3/M0+ MCUs)

Design Notes

Check the silicon revision marking on delivered ATSAM4E16CB units. Microchip explicitly states on the ATSAM4E16C product page: 'For New Designs, we highly recommend to consider Revision B for Prototypes and Production.' Older Revision A silicon may carry errata that affect peripheral behavior, so cross-check the errata document for your revision before releasing firmware, and specify Revision B in purchase orders to avoid mixed-revision production lots.

Design the PCB around the 100-LQFP (14 x 14 mm) footprint with power decoupling capacitors placed at each VDD/VDDIO pin pair, as close to the pins as practical. Route the RMII Ethernet signals (with the external PHY) as a controlled-impedance group per the PHY vendor layout guide, and keep the 12 MHz/25 MHz Ethernet crystal short and guarded. Reserve the SWD programming header on the layout even if production programming uses another interface - it saves rework during development.

Estimated: the 100-LQFP 14 x 14 mm package on a standard 4-layer board typically provides a theta_JA on the order of 40-50 C/W (verify the exact value in the manufacturer datasheet package thermal appendix). At a conservative 100 mA average core/peripheral current from a 3.3 V rail, dissipation is about 0.33 W, giving an estimated junction rise near 15-17 C over ambient - comfortable for industrial enclosures. Avoid enclosing the board without airflow when driving many peripherals simultaneously at 120 MHz.

Compliance Information

RoHS
Compliant
REACH
Unknown
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Unknown

Mouser lists the part as 'LQFP,GREEN,EXT TEMP,MRL B', indicating a RoHS/GREEN package. Not an automotive-qualified ordering code in this variant.

Data verified on: 2026-09-20 β€” data verified and curated by XAIPART's component engineering team

Related Searches

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Related Components & Terms

Microchip Technology ATSAM4E16CB-AN ATSAM4E8CB-AN ATSAM4E16CB-CU ATSAM4SD32CB-AN ATSAM4S16CA-CU ARM Cortex-M4 SAM4E Series SAM4S Series microcontroller FPU floating point unit Memory Protection Unit Thumb-2 100-LQFP LQFP package family RoHS Ethernet MAC CAN 2.0B industrial networking motor control DSP instructions SEGGER J-Link DigiKey Mouser
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