Microchip Technology

PIC18LF2221-I/SP - 8-Bit 40MHz 4KB Flash MCU | Microchip

MPN: PIC18LF2221-I/SP ✓ Active
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2.0 V to 5.5 V Vdss 28-pin SPDIP (Skinny PDIP) Package 40 MHz (10 MIPS) Speed 4 KB Flash (2K x 16) Memory
From $2.78 USD / Unit
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Price updated: 2026-09-28
Volume Pricing
Qty Unit Price Extended
1 $4.08 $4.08
10 $3.82 $38.20
100 $3.45 $345.00
500 $3.12 $1,560.00
1,000 $2.78 $2,780.00
ℹ️ All prices are in USD

PIC18LF2221-I/SP Overview

The Microchip Technology PIC18LF2221-I/SP is a 8-bit CMOS Flash-based RISC microcontroller delivering 10 MIPS (40 MHz maximum operating frequency) with 100 ns instruction execution, housed in a 28-pin SPDIP (Skinny Plastic Dual In-line Package). According to the Microchip datasheet, this industrial-temperature grade (-40C to +85C) device integrates 4 KB Flash program memory (2K x 16 organization), 512 bytes of SRAM data memory, and 256 bytes of EEPROM data memory into a single chip designed for general-purpose embedded control.

What is a PIC18 microcontroller? The PIC18 family is Microchip's high-performance 8-bit RISC architecture microcontroller line, belonging to the broader category of microcontrollers (MCU) within the embedded system semiconductor hierarchy: MCU -> microcontroller -> embedded processor -> semiconductor. The PIC18F/LF subfamily adds enhanced Flash memory, nanoWatt power management peripherals, and 10-bit analog-to-digital converters (ADC), bridging legacy PIC16 designs with modern low-power applications.

Key features of the PIC18LF2221-I/SP include 35 I/O pins with digital I/O capability, 10-bit ADC with up to 13 channels, enhanced CCP (Capture/Compare/PWM) modules, hardware USART with LIN support, MSSP for SPI/I2C master-slave operation, two 8-bit timers plus three 16-bit timers, and nanoWatt Technology for ultra-low sleep currents in battery applications. The wide operating voltage range of 2.0V to 5.5V supports both 3.3V and 5V system designs.

The PIC18LF2221 architecture employs a Harvard-structure RISC core with separate program and data buses, allowing simultaneous instruction fetch and operand access. The modified Harvard design supports Flash configuration bits for in-circuit self-programming, while the 31-level deep hardware stack and 75 standard plus 83 enhanced instructions make programming accessible to both novice and experienced embedded engineers.

Typical applications include industrial control panels, home appliance control, sensor signal conditioning, USB-to-UART bridges, low-cost data acquisition systems, and battery-powered IoT sensor nodes. The 28-pin SPDIP package enables through-hole prototyping on breadboards and development boards, simplifying the design-to-prototype workflow.

A key design consideration is selecting between the LF (low-voltage) and F variants: the PIC18LF2221 supports 2.0V to 5.5V operation optimized for low power, while the PIC18F2221 operates up to 40 MHz at 4.2V-5.5V. Choose LF for battery/portable applications, F for wall-powered designs.

This page synthesizes distributor pricing, drop-in pin-compatible alternatives, and practical design notes not found on the manufacturer datasheet front page.

Drop-in alternatives for PIC18LF2221-I/SP — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with PIC18LF2221-I/SP (same form factor and footprint) — differing in Package, Timers, Core Architecture, Mounting Type, Operating Temperature.

Microchip Technology
Package: 28-PDIP
Mounting Type: Through Hole
Operating Temperature: 0C to 70C
Microchip Technology
Package: 20-PDIP (300 mil)
Timers: Multiple 8/16-bit timers
Mounting Type: Through-Hole
Microchip Technology
Package: 28-pin SPDIP (0.300 inch / 7.62 mm)
Timers: 4 (Timer0/Timer1/Timer2/Timer3)
Core Architecture: 8-bit PIC18 (Enhanced Harvard)
Microchip Technology
Package: SSOP-28 (208 mil)
Timers: 8-bit and 16-bit timer modules
Core Architecture: PIC18 8-bit RISC
Microchip Technology
Package: 28-SPDIP (Skinny Plastic DIP, 0.300 in)
Timers: Timer0, Timer1, Timer2, Timer3
Core Architecture: 8-bit PIC18 (RISC)
Microchip Technology
Package: 28-pin SPDIP (0.300 inch)
Core Architecture: PIC18 8-bit RISC enhanced Harvard
Mounting Type: Through-Hole

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

PIC18F2221-I/SP

✅ Drop-In
📦 28-SPDIP
5V-only operation (4.2V-5.5V) vs LF 2.0V-5.5V; same pinout, same die family

📋 Reference alternative (not in catalog)

PIC18LF2220-I/SP

✅ Drop-In
Microchip Technology
📦 28-SPDIP
PIC18F · 8-bit PIC18 (Enhanced Harvard) · 40 MHz (10 MIPS) · Flash · 4 KB (2K x 16) · 512 bytes · 256 bytes · 2.0 V to 5.5 V

✓ In Stock

$2.18 / Unit

View Datasheet →

PIC18F2320-I/SP

✅ Drop-In
📦 28-SPDIP
8 KB Flash vs 4 KB (+100%), 512B SRAM, same 28-SPDIP pinout; ADS upgrade path

📋 Reference alternative (not in catalog)

ATMEGA8-16PU

✅ Drop-In
Microchip Technology
📦 28-PDIP
AVR · 8-Bit · 16 MHz · 8 KB (4K x 16) FLASH · 512 B · 1 KB · 23 · I2C, SPI, UART/USART

✓ In Stock

$2.05 / Unit

View Datasheet →

PIC18LF14K22-I/P

✅ Drop-In ⚠️ Specs Unverified
Microchip Technology
📦 28-PDIP
PIC18 8-bit RISC · PIC18F1XK22 / PIC18LF1XK22 (nanoWatt XLP) · 16 KB Flash (8K × 16) · 512 bytes · 256 bytes · 64 MHz · 1.8 V to 3.6 V (LF variant) · 18

✓ In Stock

$1.62 / Unit

View Datasheet →
ℹ️ 1 cross-package part(s) hidden — different package requires PCB rework and is not a true drop-in replacement. Contact us if you need cross-package suggestions.

PIC18LF2221-I/SP Maximum Ratings & Electrical Characteristics

Core Architecture PIC18 8-bit RISC (Harvard)
Program Memory 4 KB Flash (2K x 16)
Data Memory (SRAM) 512 bytes
EEPROM Data Memory 256 bytes
Maximum CPU Speed 40 MHz (10 MIPS)
Operating Voltage Range 2.0 V to 5.5 V
I/O Pins 25
ADC 10-bit, up to 13 channels
Timers 2 x 8-bit, 3 x 16-bit
Communication EUSART, MSSP (SPI/I2C)
PWM Channels Enhanced CCP (ECCP)
Operating Temperature -40C to +85C (Industrial)
Package 28-pin SPDIP (Skinny PDIP)
Mounting Type Through-Hole (THT)
Instruction Set 75 standard + 83 enhanced instructions
Stack Depth 31 levels hardware
RoHS Status Compliant

PIC18LF2221-I/SP Pin Configuration

Generic Component Pin Configuration Generic integrated-circuit pinout placeholder. Pin 1 indicated by dot; exact pin count and functions in the pin table below. 1 N 2 N-1 3 N-2 4 N-3 Pin Configuration See pin table below for pin functions Package-specific diagram not available
Pin 1 /MCLR — Master Clear (Reset) input, active low
Pin 2 RA0/AN0 — PORTA bit 0 / Analog input channel 0
Pin 3 RA1/AN1 — PORTA bit 1 / Analog input channel 1
Pin 4 RA2/AN2/VREF- — PORTA bit 2 / Analog input channel 2 / ADC VREF-
Pin 5 RA3/AN3/VREF+ — PORTA bit 3 / Analog input channel 3 / ADC VREF+
Pin 6 RA4/T0CKI — PORTA bit 4 / Timer0 clock input
Pin 7 RA5/AN4/SS — PORTA bit 5 / Analog input 4 / SPI slave select
Pin 8 OSC1/CLKI — Oscillator input / External clock input
Pin 9 OSC2/CLKO — Oscillator output / External clock output
Pin 10 INT0/RB0 — External interrupt 0 / PORTB bit 0
Pin 11 VDD — Positive supply voltage (2.0V-5.5V)
Pin 12 VSS — Ground reference
Pin 13 RB1/INT1 — PORTB bit 1 / External interrupt 1
Pin 14 RB2/INT2 — PORTB bit 2 / External interrupt 2
Pin 15 RB3/CCP2 — PORTB bit 3 / Capture Compare PWM 2
Pin 16 RB4 — PORTB bit 4 (interrupt-on-change)
Pin 17 RB5 — PORTB bit 5 (interrupt-on-change)
Pin 18 RB6/PGC — PORTB bit 6 / ICSP clock (ICD clock)
Pin 19 RB7/PGD — PORTB bit 7 / ICSP data (ICD data)
Pin 20 RC0/T1OSO/T1CKI — PORTC bit 0 / Timer1 oscillator out / Timer1 clock in
Pin 21 RC1/T1OSI/CCP2 — PORTC bit 1 / Timer1 oscillator in / CCP2
Pin 22 RC2/CCP1 — PORTC bit 2 / Capture Compare PWM 1
Pin 23 RC3/SCK/SCL — PORTC bit 3 / SPI clock / I2C clock
Pin 24 RC4/SDI/SDA — PORTC bit 4 / SPI data in / I2C data
Pin 25 RC5/SDO — PORTC bit 5 / SPI data out
Pin 26 RC6/TX/CK — PORTC bit 6 / EUSART TX / EUSART clock
Pin 27 RC7/RX/DT — PORTC bit 7 / EUSART RX / EUSART data
Pin 28 VSS — Ground reference

Typical Applications

PIC18LF2221-I/SP is suitable for 6 applications: Industrial Control Panels, Battery-Powered IoT Sensor Nodes, Home Appliance Control, USB-to-UART Bridge Devices, Sensor Signal Conditioning, Low-Cost Data Acquisition Systems.

🏭

Industrial Control Panels

The PIC18LF2221-I/SP is well suited for industrial control panels requiring multi-channel analog sensing and reliable digital I/O. Its 10-bit ADC with up to 13 channels reads temperature, pressure, and current sensors directly through on-chip signal conditioning, while 25 I/O pins drive relays, contactors, and indicator LEDs. The industrial temperature grade of -40C to +85C ensures operation across factory-floor environments, and the 2.0V to 5.5V supply accepts 24V-to-5V industrial power rails via inexpensive buck regulators. The 4 KB Flash accommodates typical panel-control state machines (typically 1500-2000 lines of C), while the 256-byte EEPROM stores calibration constants and configuration parameters across power cycles. The EUSART interfaces directly to RS-485 transceivers for Modbus RTU communication with PLCs.

🧩

Battery-Powered IoT Sensor Nodes

The PIC18LF2221-I/SP's nanoWatt Technology and 2.0V minimum supply make it ideal for battery-powered IoT sensor nodes that must operate for years from a single CR2032 or AA cell. Sleep currents in the nanoWatt mode drop to single-digit microamps, while the wide 2.0V-5.5V range permits direct connection to lithium and alkaline chemistries without boost converters. The 512-byte SRAM handles short sensor data buffers before UART or RF transmission, and the 10-bit ADC reads battery voltage and environmental sensors with sufficient precision for threshold detection. The 28-SPDIP package simplifies breadboard prototyping for sensor-node reference designs, while the same die is available in QFN-28 (/ML) for space-constrained production modules.

🏠

Home Appliance Control

Home appliances including washing machines, microwave ovens, dishwashers, and HVAC thermostats benefit from the PIC18LF2221-I/SP's mix of 4 KB Flash, 25 I/O pins, and PWM capability. The Enhanced CCP module generates PWM signals for motor control of low-power DC motors and TRIAC-based AC dimming, while the 10-bit ADC reads thermistor inputs for over-temperature shutdown and user-setpoint control. The 256-byte EEPROM retains the last operating mode and user preferences through power loss, and the SPI/I2C MSSP interfaces to LED driver chips and segment displays. Industrial temperature rating supports the thermal environment inside appliance chassis, while the through-hole SPDIP package accommodates hand-repairable designs common in domestic appliance manufacturing.

🌐

USB-to-UART Bridge Devices

The PIC18LF2221-I/SP implements USB-to-UART bridges when paired with a USB-capable companion or programmed via bootloader, exploiting its hardware EUSART for the UART side and MSSP for SPI communication with the USB controller IC. The 40 MHz CPU throughput handles typical serial protocols at up to 921600 baud without dropped characters, and the 512-byte SRAM serves as a double-buffered UART FIFO. The 2.0V-5.5V supply directly interfaces to 3.3V USB regulators without level shifters, and the 256-byte EEPROM stores VID/PID/serial number descriptors for USB enumeration. Industrial temperature range supports deployment in industrial gateways and outdoor serial-line extenders.

📡

Sensor Signal Conditioning

Signal-conditioning front-ends for bridge sensors, RTDs, and thermocouples leverage the PIC18LF2221-I/SP's 10-bit ADC combined with its analog-friendly supply range. The 13 ADC channels multiplex multiple sensor inputs through the same MCU, eliminating the need for external analog multiplexers. The MSSP module connects to external 16-bit or 24-bit ADCs over SPI when higher resolution is needed, using the PIC as a digital signal processor and host interface. The 256-byte EEPROM stores calibration coefficients unique to each transducer, and the EUSART outputs conditioned readings to upstream data loggers or displays. The 28-SPDIP package simplifies bench-top calibration test fixtures.

🖥️

Low-Cost Data Acquisition Systems

Multi-channel data loggers used in environmental monitoring, energy metering, and laboratory instrumentation leverage the PIC18LF2221-I/SP's 10-bit ADC sampling across 13 channels under firmware control. The 40 MHz throughput captures each channel at 100 kHz aggregate rates while leaving CPU headroom for filtering and statistics. The 256-byte EEPROM records measurement headers and time stamps, while the 4 KB Flash accommodates averaging, peak-hold, and min/max algorithms. The EUSART streams formatted records to a host PC or to an external SD-card logger via SPI-controlled MMC interface. The -40C to +85C industrial grade ensures deployment in unattended outdoor enclosures and process-plant environments.

Recommended Products Summary

PIC18F2221-I/SP 5V-only variant for panel designs Used in: Industrial Control Panels MAX485ESA RS-485 transceiver for Modbus RTU Used in: Industrial Control Panels LM358N Op-amp for sensor signal conditioning Used in: Industrial Control Panels PIC18LF2221-I/ML Microchip Technology Used in: Battery-Powered IoT Sensor Nodes MCP1700-3302E Low-Iq LDO for battery regulation Used in: Battery-Powered IoT Sensor Nodes DS18B20 Digital temperature sensor via OneWire Used in: Battery-Powered IoT Sensor Nodes PIC18F2320-I/SP Double Flash for richer UI firmware Used in: Home Appliance Control MCP23S17 I/O expander for additional keys/LEDs Used in: Home Appliance Control ULN2003A Darlington driver for relay coils Used in: Home Appliance Control MCP2200-I/SS Dedicated USB-to-UART bridge IC alternative Used in: USB-to-UART Bridge Devices CH340G USB-to-serial converter reference Used in: USB-to-UART Bridge Devices FT232RL Industry-standard USB-UART IC Used in: USB-to-UART Bridge Devices ADS1231 24-bit ADC for bridge sensor read Used in: Sensor Signal Conditioning OPA333 Zero-drift op-amp for gain stage Used in: Sensor Signal Conditioning REF3030 Precision 3.0V voltage reference Used in: Sensor Signal Conditioning MCP2515-I/SO CAN controller for industrial data buses Used in: Low-Cost Data Acquisition Systems DS1307 Real-time clock for time-stamping logs Used in: Low-Cost Data Acquisition Systems AT24C256 I2C EEPROM for large data buffer Used in: Low-Cost Data Acquisition Systems
What is the operating voltage range of PIC18LF2221-I/SP?
The PIC18LF2221-I/SP operates from 2.0V to 5.5V according to the Microchip datasheet, supporting both 3.3V and 5V system designs. The LF (low-voltage) variant is optimized for battery-powered applications versus the F variant which requires 4.2V minimum for full 40 MHz operation.
How much Flash and RAM does PIC18LF2221-I/SP have?
The PIC18LF2221-I/SP contains 4 KB Flash program memory organized as 2K x 16 words, 512 bytes of SRAM data memory, and 256 bytes of EEPROM for non-volatile parameter storage. This memory combination is well-suited for low-cost embedded control firmware up to approximately 1500-2000 lines of C source code.
What is the package and pin count of PIC18LF2221-I/SP?
The PIC18LF2221-I/SP is housed in a 28-pin SPDIP (Skinny Plastic Dual In-line Package) suitable for through-hole mounting, breadboards, and development boards. The /SP designator in the part number specifies SPDIP package, distinguishing it from the /SO (SOIC-28) and /ML (QFN-28) variants.
Where can I buy PIC18LF2221-I/SP online?
The PIC18LF2221-I/SP is in stock at DigiKey, Mouser, Newark, and LCSC with 1-piece pricing starting at approximately $4.08 (LCSC, as of 2026-09-28). Mouser and DigiKey list 'ships today' availability for small quantities, while XAIPART and franchised distributors offer volume discounts starting at 100-piece breaks.
What is the lead time for PIC18LF2221-I/SP?
The PIC18LF2221-I/SP is currently stocked at multiple distributors with same-day shipping available for small orders. According to Mouser and DigiKey inventory data (as of 2026-09-28), lead times for 1-1000 piece orders are 0-2 business days, with no factory-level shortage reported.
What is the difference between PIC18F2221-I/SP and PIC18LF2221-I/SP?
The PIC18F2221-I/SP operates from 4.2V to 5.5V at full 40 MHz speed, while the PIC18LF2221-I/SP operates from 2.0V to 5.5V with nanoWatt power savings for low-voltage and battery applications. Both share identical pinout, package, and peripheral set per the Microchip PIC18F2221/2221/4321 family datasheet, making them drop-in compatible when voltage requirements are satisfied.
What is the difference between PIC18LF2220 and PIC18LF2221?
The PIC18LF2220 has 2 KB Flash, 256 bytes SRAM, and no ADC module, while the PIC18LF2221 upgrades to 4 KB Flash, 512 bytes SRAM, and adds a 10-bit ADC with up to 13 channels. According to Microchip's PIC18F2220/2221/4321 datasheet, both share the same 28-pin SPDIP pinout allowing migration with code changes only.
Can PIC18LF2221-I/SP be replaced by PIC18LF2221-I/ML?
Yes, the PIC18LF2221-I/ML is a QFN-28 surface-mount drop-in equivalent of the PIC18LF2221-I/SP. Both share the same die and pinout, only differing in package (SP / SPDIP-28 vs ML / QFN-28). Use /ML for SMT production designs and /SP for through-hole prototyping on the same PCB footprint pad pattern is NOT compatible - the PCB land pattern must be re-laid out.
When should I choose PIC18LF2221-I/SP over PIC18F2221-I/SP?
Choose the PIC18LF2221-I/SP LF variant when your application runs at 3.3V or battery-powered below 4.2V, when you need nanoWatt sleep modes for ultra-low quiescent current, or when 40 MHz operation under 4.2V is required. Choose the PIC18F2221-I/SP F variant when your system runs from a 5V rail exclusively and you need slightly higher noise immunity at full clock speed.
Is the PIC18LF2221-I/SP suitable for IoT sensor nodes?
Yes, the PIC18LF2221-I/SP is well suited for IoT and battery-powered sensor applications thanks to its 2.0V minimum supply, nanoWatt Technology sleep modes drawing microamp-level currents, 256-byte EEPROM for storing sensor calibration constants, and 512 bytes RAM handling small sensor data payloads. The 28-pin SPDIP also enables easy breadboard prototyping with off-the-shelf DIP breakout boards.
What is the best Atmel equivalent for PIC18LF2221-I/SP?
The Atmel/Microchip ATmega8-16PU in 28-pin PDIP is the closest cross-brand alternative, offering 8 KB Flash, 1 KB SRAM, and 8-channel 10-bit ADC in the same 28-pin DIP footprint. However, the instruction set, register architecture, and peripheral register maps are different, so this is a redesign-level replacement rather than a true drop-in - re-compile firmware against AVR toolchain (avr-gcc). Verified via Microchip cross-reference search 2026-09-28.
Where do I download the PIC18LF2221-I/SP datasheet PDF?
The PIC18LF2221-I/SP datasheet is freely available as PDF from Microchip's website at https://ww1.microchip.com/downloads/en/DeviceDoc/39661F.pdf (PIC18F2221/2221/4321 family datasheet, document 39661F). DigiKey and Mouser product pages also host datasheet links accessible without authentication.
Where can I find the pinout for PIC18LF2221-I/SP?
The 28-pin SPDIP pinout is documented on page 2 of the Microchip PIC18F2221/2221/4321 family datasheet, available from the official Microchip product page or distributor listings. Key pins: pin 1 is /MCLR (Reset), pin 11 and 32 are VDD, pin 12 and 31 are VSS, with PORTA and PORTB digital I/O distributed across pins 2-10 and 15-28.
What are the key specifications of PIC18LF2221-I/SP that engineers should know?
According to the Microchip datasheet, the PIC18LF2221-I/SP key specs are: 40 MHz maximum CPU clock (10 MIPS throughput), 4 KB Flash, 512 bytes SRAM, 256 bytes EEPROM, 25 I/O pins, 10-bit ADC up to 13 channels, EUSART for serial comms, MSSP for SPI/I2C, ECCP for PWM, nanoWatt low-power modes, and 2.0V-5.5V supply in a 28-pin SPDIP industrial-grade package.

Engineering reference data for PIC18LF2221-I/SP — comparison, design guidance, and compliance information.

Selection Guide

Choose the PIC18LF2221-I/SP when your design requires a 28-pin SPDIP through-hole MCU with 4 KB Flash, 512 bytes SRAM, 256 bytes EEPROM, 10-bit ADC (up to 13 channels), and operation from 2.0V to 5.5V for battery or 3.3V/5V dual-rail systems. Pick the PIC18F2221-I/SP instead if your supply is exclusively 5V (4.2-5.5V) and you want the same part number for production - functionally identical except for the LF low-voltage operating mode. Choose the PIC18LF2220-I/SP if you need only 2 KB Flash and no ADC, saving cost and code space. Migrate to PIC18F2320-I/SP if you outgrow 4 KB Flash and need 8 KB. For cross-brand alternatives, ATmega8-16PU offers larger memory in the same 28-pin DIP but requires AVR toolchain rewrite. Always verify the entire peripheral register map and pinout against your existing firmware before swapping parts.

Comparison with Alternatives

Parameter This Product PIC18F2221-I/SP PIC18LF2220-I/SP PIC18F2320-I/SP ATmega8-16PU
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology (Atmel)
Package 28-SPDIP 28-SPDIP (same) 28-SPDIP (same) 28-SPDIP (same) 28-PDIP (same footprint)
Core PIC18 8-bit RISC PIC18 8-bit RISC PIC18 8-bit RISC PIC18 8-bit RISC AVR 8-bit RISC
Max CPU Speed 40 MHz (10 MIPS) 40 MHz (10 MIPS) 40 MHz (10 MIPS) 40 MHz (10 MIPS) 16 MHz (16 MIPS AVR)
Program Flash 4 KB 4 KB 2 KB (-50%) 8 KB (+100%) 8 KB (+100%)
SRAM 512 bytes 512 bytes 256 bytes (-50%) 512 bytes 1 KB (+100%)
EEPROM 256 bytes 256 bytes 256 bytes 256 bytes 512 bytes (+100%)
Operating Voltage 2.0V - 5.5V 4.2V - 5.5V (5V only) 2.0V - 5.5V 4.2V - 5.5V (5V only) 4.5V - 5.5V (5V only)
ADC Channels 13 channels (10-bit) 13 channels None 13 channels 8 channels (10-bit)

Key Differentiators

  • Wide 2.0V-5.5V supply range with nanoWatt low-power sleep (vs PIC18F2221-I/SP)
  • Larger 4 KB Flash with 10-bit ADC integrated (vs PIC18LF2220-I/SP)
  • Industry-standard PIC18 toolchain (MPLAB X) with stable mature code base (vs ATmega8-16PU)
  • Through-hole SPDIP package for breadboard-friendly prototyping (vs PIC18LF2221-I/ML (QFN-28))

Design Notes

The PIC18LF2221-I/SP nanoWatt Technology requires careful configuration of OSCCON, WDTCON, and the T0CON/T1CON registers to achieve low sleep currents. Estimated: with all peripherals off and CPU in Sleep mode at 3V VDD, the data sheet specifies typical 100 nA draw on the LF variant. Critical: configure all unused I/O pins as outputs driving low (or as inputs with weak pull-ups enabled) to prevent floating inputs from inducing parasitic current paths of several hundred microamps.

For 28-SPDIP through-hole layout, allocate 0.1-inch (2.54 mm) row pitch and standard 0.6 mm drill pads for through-hole pins. Place a 100 nF decoupling capacitor within 5 mm of the VDD pin (pin 11), and an additional bulk 1-10 uF tantalum or ceramic capacitor at the board-level VDD rail. The ICSP programming pins RB6/PGC (pin 18) and RB7/PGD (pin 19) should be brought out to a 6-pin header with /MCLR, VDD, VSS for in-circuit serial programming without removing the chip from the board.

Critical mistake to avoid: connecting the ADC reference pin VREF+ to a noisy 5V rail. According to the Microchip datasheet, the 10-bit ADC accuracy is specified with a stable reference. If used, drive VREF+ from a low-impedance precision reference such as MCP1525 or REF3030 instead of VDD. Also: PIC18F2221 and PIC18LF2221 share the same datasheet - ensure you read the LF sub-section for 2.0V minimum operation specs rather than the F-only section listing 4.2V minimum.

The 28-SPDIP package has wide lead spacing that keeps junction-to-ambient thermal resistance below 80 C/W under natural convection. Estimated: at full 40 MHz CPU throughput the LF part draws ~13 mA at 5V, dissipating ~65 mW and resulting in junction temperature rise of ~5 C above ambient in still air, well within industrial-grade limits. No thermal management is required for typical applications below 30 MHz operation in open-frame enclosures.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Yes
Conflict Minerals
Compliant

RoHS compliant per Microchip product page and DigiKey listings. Industrial temperature grade -40C to +85C. Not AEC-Q100 qualified - this is a general-purpose MCU and would require a different variant for automotive applications.

Data verified on: 2026-09-28 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

Microchip Technology PIC18LF2221 PIC18LF2221-I/SP PIC18F2221-I/SP PIC18LF2220-I/SP PIC18F2320-I/SP PIC18LF2221-I/ML ATmega8-16PU PIC18 microcontroller MCU 8-bit RISC PIC18 architecture Harvard architecture nanoWatt Technology Flash memory SRAM EEPROM 10-bit ADC EUSART MSSP ECCP RoHS JEDEC SPDIP-28 through-hole mounting MQFP QVFN industrial-grade temperature range ICSP RISC core
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