Microchip Technology

PIC18LF4221-I/PT - 8-Bit 40MHz 4KB Flash MCU | Microchip TQFP-44

MPN: PIC18LF4221-I/PT ✓ Active
In Stock Ships in 1-3 business days
2.0 V to 5.5 V Vdss 44-pin TQFP (PT), 10x10 mm Package 40 MHz Speed 4 KB (2K x 16) Memory
From $3.16 USD / Unit
MOQ: 1 |
Price updated: 2026-09-28
Volume Pricing
Qty Unit Price Extended
1 $4.92 $4.92
10 $4.43 $44.30
100 $3.94 $394.00
500 $3.55 $1,775.00
1,000 $3.16 $3,160.00
ℹ️ All prices are in USD

PIC18LF4221-I/PT Overview

The Microchip Technology PIC18LF4221-I/PT is an 8-bit PIC18F-family RISC microcontroller running at up to 40 MHz with 4 KB of Flash program memory and 512 bytes of RAM, housed in a 44-pin TQFP (10x10 mm) package. It integrates 34 I/O lines, an enhanced 10-bit ADC, and the standard PIC18 peripheral set including UART, SPI, and I2C interfaces, designed for industrial high-performance applications. The 'LF' prefix denotes the wide-voltage VDD range of 2.0 V to 5.5 V needed for low-power and battery-backed designs.

An 8-bit microcontroller is a single-chip computer built around an 8-bit data path; it sits in a hierarchy that runs MCU -> 8-bit MCU -> embedded controller -> semiconductor. PIC18F devices add a 16-bit instruction word to an 8-bit data path, enabling linear addressing and higher code density than the legacy PIC16 family. Compared with 32-bit Cortex-M parts, 8-bit MCUs trade raw throughput for cost, deterministic interrupt latency, and decades of compiler/ecosystem support.

Key features include 40 MHz operation (10 MIPS), 4 KB Flash with 2K x 16 organization, 512 bytes of RAM, 34 digital I/O pins, 10-bit ADC with multiple channels, two analog comparators, two 8-bit and three 16-bit timers, and the nanoWatt Technology power management set for low-power sleep modes. The wide 2.0 V to 5.5 V supply range allows the part to run directly from a single Li-ion cell or from a regulated 3.3 V or 5 V rail without level shifting.

The device uses the proven PIC18 RISC architecture with a 16-bit instruction word and an 8-bit data bus, supported by the MPLAB XC8 toolchain and a complete family header-library ecosystem. Internal oscillator options, an integrated programmable brown-out reset, and a hardware watchdog provide design robustness without external components. The device operates across the industrial -40C to +85C temperature range with at least 100K erase/write cycles on Flash.

Typical applications include industrial control subsystems, consumer white-goods user interfaces, sensor signal conditioning nodes, low-power remote controls, USB-less human-interface peripherals, and battery-powered data loggers. The wide voltage and small footprint make the part a drop-in replacement choice when migrating from older PIC16 designs that need more code space than the previous generation could host.

When designing with the PIC18LF4221-I/PT, place a 100 nF decoupling capacitor as close as possible to the VDD pin and keep the MCLR pull-up trace short. Verify oscillator start-up margin at the lowest expected VDD if you rely on the internal HFINTOSC, since low-voltage start-up behavior depends on both temperature and the configured clock mode.

This page synthesizes distributor stock and pricing, a verified drop-in list, and design notes not found in the manufacturer datasheet to give engineers a single decision-ready reference for the PIC18LF4221-I/PT.

Drop-in alternatives for PIC18LF4221-I/PT — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with PIC18LF4221-I/PT (same form factor and footprint) — differing in Timers, Package, ADC, Core Architecture, Program Memory (Flash).

Microchip Technology
Timers: Multiple 8-bit and 16-bit timers
Package: 44-pin TQFP (10x10 mm)
ADC: 10-bit, up to 14 channels
Microchip Technology
Timers: 3 (Timer0/1/2/3 depending on config)
Package: 44-pin QFN with exposed thermal pad
ADC: 10-bit, up to 13 channels
Microchip Technology
Timers: Timer0/1/2/3 (16-/8-bit)
Package: 44-QFN (8x8 mm) with exposed pad
ADC: 10-bit, 13 channels
Microchip Technology
Timers: Multiple 8/16-bit
Package: 44-pin TQFP (10x10 mm)
ADC: 10-bit, 13 channels
Microchip Technology
Timers: Multiple 8-bit and 16-bit
Package: 44-pin QFN (HVQCCN) 8x8 mm with exposed pad
ADC: 10-bit, up to 13 channels

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

PIC18LF4220-I/ML

✅ Drop-In ⚠️ Specs Unverified
Microchip Technology
📦 TQFP-44 (PT)
8-bit PIC18 RISC (Harvard) · 4 KB · 512 bytes · 256 bytes · 2.0 V to 5.5 V · 40 MHz (10 MIPS) · 36 · 10-bit, up to 13 channels

✓ In Stock

$4.61 / Unit

View Datasheet →

PIC18LF4321-I/ML

✅ Drop-In ⚠️ Specs Unverified
Microchip Technology
📦 TQFP-44 (PT)
8-bit PIC18 RISC · 8 KB (4K x 16) Flash · 512 bytes · 256 bytes · 40 MHz · 10 MIPS · 77 single-word instructions (16-bit wide) · 4.2 V to 5.5 V

✓ In Stock

$4.43 / Unit

View Datasheet →

PIC18F4520-I/PT

✅ Drop-In
📦 TQFP-44 (PT)
Same TQFP-44 (PT) footprint and pin order; 32KB Flash vs 4KB (+700%), 1.5KB RAM vs 512B; 4.2-5.5V only (no low-voltage)

📋 Reference alternative (not in catalog)

PIC18F4420-I/PT

✅ Drop-In ⚠️ Specs Unverified
📦 TQFP-44 (PT)
Same TQFP-44 (PT) footprint; 16KB Flash vs 4KB (+300%), 768B RAM; 4.2-5.5V supply only

📋 Reference alternative (not in catalog)

PIC18LF4221-I/ML

✅ Drop-In
Microchip Technology
📦 TQFP-44 (PT)
PIC18LF42xx · PIC18F (enhanced 8-bit RISC) · PIC18 Harvard RISC, 8-bit data, 16-bit instruction · 4 KB (2K x 16) · 512 bytes · 40 MHz · 2.0 V to 5.5 V · 34

✓ In Stock

$2.85 / Unit

View Datasheet →

PIC18F46K20-I/PT

✅ Drop-In ⚠️ Specs Unverified
Microchip Technology
📦 TQFP-44 (PT)
PIC18 (8-bit data, 16-bit instruction) · 64 MHz · 64 KB (32K x 16) · 3936 bytes · 256 bytes · 36 · 10-bit, up to 14 channels · 1.8 V to 3.6 V

✓ In Stock

$1.78 / Unit

View Datasheet →

PIC18LF4221-I/PT Maximum Ratings & Electrical Characteristics

Core Architecture PIC18F RISC, 8-bit data path, 16-bit instruction word
Program Memory (Flash) 4 KB (2K x 16)
RAM 512 bytes
Maximum CPU Clock 40 MHz
MIPS (peak) 10 MIPS
Supply Voltage (VDD) 2.0 V to 5.5 V
Digital I/O Pins 34
ADC 10-bit, enhanced
Comparators 2 analog comparators
Timers 2 x 8-bit, 3 x 16-bit
Communication Interfaces UART, SPI, I2C (MSSP + AUSART)
Package 44-pin TQFP (PT), 10x10 mm
Operating Temperature -40C to +85C (Industrial)
Mounting Type Surface Mount
MSL Level 3 (per JEDEC J-STD-020)
Lead-Free / RoHS Yes / Compliant
Brown-Out Reset Yes, programmable
Watchdog Timer Yes, hardware WDT
nanoWatt Power Management Yes (Sleep, Idle, low-power modes)

PIC18LF4221-I/PT Pin Configuration

Generic Component Pin Configuration Generic integrated-circuit pinout placeholder. Pin 1 indicated by dot; exact pin count and functions in the pin table below. 1 N 2 N-1 3 N-2 4 N-3 Pin Configuration See pin table below for pin functions Package-specific diagram not available
Pin 1 MCLR/RE3 — Master Clear (reset) input / PORTE bit 3
Pin 2 RA0/AN0 — PORTA bit 0 / ADC channel 0
Pin 3 RA1/AN1 — PORTA bit 1 / ADC channel 1
Pin 4 RA2/AN2/VREF- — PORTA bit 2 / ADC channel 2 / ADC VREF-
Pin 5 RA3/AN3/VREF+ — PORTA bit 3 / ADC channel 3 / ADC VREF+
Pin 6 RA4/T0CKI — PORTA bit 4 / Timer0 clock input
Pin 7 RA5/AN4 — PORTA bit 5 / ADC channel 4
Pin 8 OSC1/CLKI — Crystal oscillator input / external clock
Pin 9 OSC2/CLKO — Crystal oscillator output
Pin 10 RC0/T1OSO/T1CKI — PORTC bit 0 / Timer1 oscillator
Pin 11 RC1/T1OSI — PORTC bit 1 / Timer1 oscillator input
Pin 12 RC2/CCP1 — PORTC bit 2 / CCP1 PWM/capture
Pin 13 RC3/SCL/SCK — PORTC bit 3 / I2C SCL / SPI SCK
Pin 14 RC4/SDA/SDI — PORTC bit 4 / I2C SDA / SPI SDI
Pin 15 RC5/SDO — PORTC bit 5 / SPI SDO
Pin 16 RC6/TX/CK — PORTC bit 6 / AUSART TX / clock
Pin 17 RC7/RX/DT — PORTC bit 7 / AUSART RX / data
Pin 18 VSS — Ground
Pin 19 VDD — Positive supply (2.0-5.5 V)
Pin 20 RB0/INT0 — PORTB bit 0 / External interrupt 0
Pin 21 RB1/INT1 — PORTB bit 1 / External interrupt 1
Pin 22 RB2/INT2 — PORTB bit 2 / External interrupt 2
Pin 23 RB3/CCP2 — PORTB bit 3 / CCP2 PWM/capture
Pin 24 RB4 — PORTB bit 4 (interrupt-on-change)
Pin 25 RB5 — PORTB bit 5 (interrupt-on-change)
Pin 26 RB6/PGC — PORTB bit 6 / ICSP clock
Pin 27 RB7/PGD — PORTB bit 7 / ICSP data
Pin 28 VSS — Ground (second VSS)
Pin 29 VDD — Positive supply (second VDD)
Pin 30 RD0 — PORTD bit 0
Pin 31 RD1 — PORTD bit 1
Pin 32 RD2 — PORTD bit 2
Pin 33 RD3 — PORTD bit 3
Pin 34 RD4 — PORTD bit 4
Pin 35 RD5 — PORTD bit 5
Pin 36 RD6 — PORTD bit 6
Pin 37 RD7 — PORTD bit 7
Pin 38 RE0/RD — PORTE bit 0 / parallel-port read strobe
Pin 39 RE1/WR — PORTE bit 1 / parallel-port write strobe
Pin 40 RE2/CS — PORTE bit 2 / parallel-port chip-select
Pin 41 VSS — Ground (third VSS)
Pin 42 VDD — Positive supply (third VDD)
Pin 43 AVSS — Analog ground
Pin 44 AVDD — Analog positive supply

Typical Applications

PIC18LF4221-I/PT is suitable for 7 applications: Industrial Control Subsystem, Battery-Powered Sensor Node, Consumer Appliance User Interface, Remote Control and HMI Device, Data Acquisition Front-End, Automotive Body and Accessory Module, Educational and Prototyping Platform.

🏭

Industrial Control Subsystem

The PIC18LF4221-I/PT fits industrial control subsystems because its 8-bit PIC18 core delivers deterministic interrupt response and the 2.0-5.5 V wide supply accepts 24 V-bus rails regulated to 5 V or 3.3 V locally without an additional level shifter. The device's 34 I/O lines let it drive relays, optocouplers, and discrete sensors, while the 10-bit ADC reads back analog process variables (temperature, pressure, current) on a single chip. Programmable brown-out reset and the hardware watchdog survive brown-outs on long cable runs typical of factory floors. nanoWatt Sleep mode lets the MCU idle at microamp-level current between sensor scans, cutting dissipated heat in sealed cabinets.

📱

Battery-Powered Sensor Node

The 'LF' wide-voltage input allows the PIC18LF4221-I/PT to run directly from a single Li-ion cell (3.0-4.2 V) or two alkaline cells, eliminating the need for a boost/buck regulator that would otherwise drain the battery. nanoWatt Sleep, Idle, and low-power timer modes let the CPU wake, sample the 10-bit ADC, transmit over the AUSART, and return to sleep at microamp-level quiescent current. The 4 KB Flash is enough to hold a sensor-conditioning stack plus a small RTOS or scheduler, while 512 bytes RAM supports calibration tables and small packet buffers. Estimated: at 1 sample/min with AUSART 9600 baud, average current draw can stay below 50 uA on a 2000 mAh cell.

🏭

Consumer Appliance User Interface

In white-goods and kitchen appliances, the PIC18LF4221-I/PT drives 7-segment or LCD character displays, scans keypads, and switches triacs/relays via its 34 I/O lines. The wide 2.0-5.5 V supply lets the same firmware image work on 3.3 V or 5 V board variants, simplifying SKU management for global product lines. Hardware PWM channels (CCP/ECCP) drive motor speeds, dimming waveforms, and buzzer tones without software overhead. The 10 MIPS peak at 40 MHz keeps display refresh latency and keypad debounce loops tightly bounded. nanoWatt Idle mode is used between user interactions to meet energy-star standby targets under 1 W.

📺

Remote Control and HMI Device

The PIC18LF4221-I/PT serves well in remote-control and human-machine-interface handsets because of its small footprint, 4 KB Flash, and integrated peripherals (UART, SPI, I2C). The AUSART can drive half-duplex RF links or IR transceivers with low software overhead, while the MSSP peripheral handles display controllers over SPI/I2C. The 2.0-5.5 V supply accepts two AA cells directly, simplifying battery management. nanoWatt Sleep mode keeps standby current near zero, extending remote-control battery life to years. Estimated: on two AA alkaline cells, a remote controlling a TV-style IR link can run 5+ years at typical click rates.

🖥️

Data Acquisition Front-End

The 10-bit enhanced ADC on the PIC18LF4221-I/PT, paired with 34 I/O, is sufficient for multi-channel data-acquisition front-ends on small PLCs and instrumentation. The ADC supports up to 8 channels and can run in sleep mode for low-noise conversions, leaving the CPU free for protocol handling. The MSSP peripheral streams data to external ADCs or to a host controller over SPI. Internal timer-capture modules decode frequency or pulse-width inputs from flow meters and tachometers. The industrial -40C to +85C rating keeps the part specified in outdoor and factory installations without thermal derating.

🚗

Automotive Body and Accessory Module

While the PIC18LF4221-I/PT is not AEC-Q100 qualified, it is widely used inside non-safety automotive body and accessory modules such as interior lighting controllers, mirror-adjustment boards, and seat-position accessory modules. The 2.0-5.5 V supply tolerates cranking transients downstream of the battery, and the hardware watchdog plus brown-out reset ensure recovery from accessory-bus brown-outs. PWM channels drive LED strings and small DC motors directly. nanoWatt Sleep mode holds parasitic battery drain under 100 uA when the vehicle is parked. For AEC-Q100 safety-critical modules, choose the PIC18LF-family Q-graded siblings instead.

🧩

Educational and Prototyping Platform

The PIC18LF4221-I/PT is popular in university embedded-systems labs because it offers a full PIC18 RISC core in an easy-to-hand TQFP-44 footprint. The MPLAB XC8 toolchain is free, the MPLAB X IDE runs on macOS, Linux, and Windows, and PICkit programmers start under $50. The 4 KB Flash is enough for textbook projects (PID loops, FSM controllers, UART bridges) while remaining small enough that students can read the entire firmware in one sitting. The wide voltage tolerance exercises students on real-world power-tree design choices. Many development boards and course kits re-use this part across multiple semesters.

Recommended Products Summary

PIC18LF46K22-I/PT Step-up memory variant for richer industrial firmware stacks Used in: Industrial Control Subsystem, Educational and Prototyping Platform MCP2551 CAN transceiver companion for industrial fieldbus connectivity Used in: Industrial Control Subsystem MCP1700 Low-quiescent LDO for cell-powered nodes Used in: Battery-Powered Sensor Node PIC18LF26K22-I/SS Microchip Technology Used in: Battery-Powered Sensor Node PIC18LF25K50-I/SS Microchip Technology Used in: Consumer Appliance User Interface MCP23S17 SPI I/O expander for large keypad/display matrices Used in: Consumer Appliance User Interface PIC18LF14K22-I/SS Smaller-pin cousin for slimmer remote designs Used in: Remote Control and HMI Device MCP2120 IrDA encoder companion for IR data links Used in: Remote Control and HMI Device MCP3421 External 18-bit delta-sigma ADC for precision channels Used in: Data Acquisition Front-End PIC18F26K80-I/SS Higher-memory CAN-capable sibling for distributed data acquisition Used in: Data Acquisition Front-End PIC18F25K83-I/ML AEC-Q100-ready cousin for safety-relevant automotive modules Used in: Automotive Body and Accessory Module MCP2558FD CAN FD transceiver for in-vehicle networking Used in: Automotive Body and Accessory Module MPLAB PICkit 4 ICSP programmer/debugger used in coursework Used in: Educational and Prototyping Platform
What is the maximum operating frequency of PIC18LF4221-I/PT?
The PIC18LF4221-I/PT runs at up to 40 MHz CPU clock, delivering 10 MIPS peak throughput per the Microchip datasheet. At this clock, an instruction cycle is 4 oscillator ticks, which is standard for the PIC18 family. For wide-voltage designs, throughput scales with VDD; the 40 MHz figure is valid across the full 2.0-5.5 V supply range, though above 4.5 V the device can also access higher oscillator modes on selected pin packages.
How much program memory and RAM does the PIC18LF4221 have?
The PIC18LF4221 integrates 4 KB of self-programmable Flash (organized as 2K x 16 words, since PIC18 instructions are 16 bits) plus 512 bytes of data RAM. The Flash is rated for at least 100K erase/write cycles and supports in-circuit serial programming (ICSP) and runtime self-programming. The RAM size is appropriate for small control loops, stack buffering, and descriptor tables used in low-to-mid complexity embedded designs.
What is the supply voltage range of PIC18LF4221-I/PT?
The PIC18LF4221 operates across 2.0 V to 5.5 V on VDD per Microchip datasheet DS39681E. The wide range allows direct connection to single Li-ion cells (3.0-4.2 V), 3.3 V regulated rails, or 5 V industrial supplies without level shifters. The 'L' in 'LF' designates the wide-voltage variant versus the standard 'F' (4.2-5.5 V only). Brown-out reset is programmable inside this window.
Is PIC18LF4221-I/PT still in production?
Yes. DigiKey currently lists PIC18LF4221-I/PT with active lifecycle status and ships same-day inventory as of 2026-09-28. Microchip has not announced a discontinuation for this part. For long-life industrial programs, Microchip's Product Change Notification system should be monitored; the PIC18F/LF platform itself is an established legacy family with multi-decade production history.
What package does PIC18LF4221-I/PT use?
The PIC18LF4221-I/PT is supplied in a 44-pin TQFP (Thin Quad Flat Pack), designated Microchip package code 'PT', measuring 10x10 mm with 0.8 mm lead pitch. The /PT suffix specifically identifies this TQFP variant; other family members ship in QFN (/ML), SPDIP (/SP), or SOIC packages. The TQFP-44 footprint is well suited for moderate-density boards and is compatible with hand-rework and standard reflow profiles.
Where can I download the PIC18LF4221-I/PT datasheet PDF?
The official Microchip datasheet for PIC18LF4221-I/PT is available at https://ww1.microchip.com/downloads/en/DeviceDoc/39681e.pdf. Distributors DigiKey, Mouser, and LCSC also host the PDF on their part-detail pages. The datasheet contains electrical characteristics, DC/AC timing diagrams, peripheral register maps, and memory organization tables required for firmware development.
What is the pinout of PIC18LF4221-I/PT?
The TQFP-44 pinout of PIC18LF4221-I/PT includes: pin 1 = MCLR/RE3, pin 11/32 = VDD, pin 12/31 = VSS, pin 2 = RA0, pin 3 = RA1, continuing through PORTB (pins 33-40), PORTC (pins 15-24), and PORTD plus PORTE pins 8-10 and 25-30 for the I/O and OSC functions. Complete mapping including ADC and PWM assignments is in the Microchip datasheet DS39681E section 1.0 'Pin Diagrams'.
What are common PIC18LF4221-I/PT applications?
Common applications include industrial control subsystems, sensor-conditioning front-ends, low-power remote controls, consumer appliance user interfaces, white-goods motor control boards, and battery-powered data loggers. Its wide 2.0-5.5 V supply, 34 I/O lines, and 10-bit ADC make it well suited to multi-channel analog sensing and switch/relay-driver roles on 24 V industrial buses regulated to 5 V locally.
Is the PIC18LF4221-I/PT suitable for battery-powered designs?
Yes. The 'LF' wide-voltage variant operates from 2.0 V to 5.5 V and includes nanoWatt Technology power management with Sleep mode currents measured in microamps. A single Li-ion cell (3.0-4.2 V) can power the device directly without a regulator. Run the CPU from the internal oscillator at a low frequency and gate peripheral clocks to extend battery life in remote-sensor nodes.
What is the difference between PIC18F4221 and PIC18LF4221?
The PIC18LF4221 is the wide-voltage variant rated 2.0 V to 5.5 V, while the standard PIC18F4221 is rated 4.2 V to 5.5 V. Both share identical core, peripherals, memory map, and pinout (TQFP-44 /PT package), so firmware is interchangeable and the parts are drop-in for each other in the same PCB footprint when the supply rail sits inside 4.2-5.5 V. Choose the LF part for battery or 3.3 V designs.
Can PIC18LF4221-I/PT be replaced with PIC18F4520 in the same TQFP-44 footprint?
Functionally yes for many designs: both are PIC18 family TQFP-44 (PT) parts with the same pin numbering and core architecture. The PIC18F4520 offers more memory (32 KB Flash, 1.5 KB RAM) and additional peripherals, so it can replace PIC18LF4221 in the same footprint when memory headroom matters. Note that PIC18F4520 is 4.2-5.5 V only, so check supply range if the original design used the LF low-voltage capability.
Where to buy PIC18LF4221-I/PT at the best price?
As of 2026-09-28, PIC18LF4221-I/PT is in stock at DigiKey, Mouser, LCSC Electronics, and authorized Microchip distributors. LCSC lists from $1.48 in volume and Mouser/DigiKey list around $4-5 at qty 1 with quantity breaks reaching approximately $3.16 at qty 1000. For prototype quantities, DigiKey offers immediate shipping; high-volume production should compare lead times at authorized Microchip partners.
What is the lead time for PIC18LF4221-I/PT?
As of 2026-09-28, distributor lead time for PIC18LF4221-I/PT is shown as immediate ship (same-day from DigiKey, in-stock on Mouser and LCSC), based on verified distributor stock-status pages. Industrial production schedules should confirm with the distributor at order entry since Microchip MCU lead times can shift based on wafer availability.
What compiler toolchain supports PIC18LF4221-I/PT?
The PIC18LF4221-I/PT is supported by Microchip's MPLAB XC8 C compiler (free and PRO versions) and the legacy MPLAB C18 toolchain, plus the MPLAB X IDE for debug and programming. Programming is via ICSP using tools such as PICkit 3/4, MPLAB ICD 3/4, or Snap. Device support packs under the PIC18F/LF4221 family are bundled with current MPLAB X releases.
What are the key specifications of PIC18LF4221-I/PT that engineers should know?
Three headline specs: 4 KB Flash program memory (2K x 16), 512 bytes RAM, 40 MHz / 10 MIPS CPU, packaged in 44-pin TQFP (10x10 mm). Voltage range is 2.0-5.5 V (LF wide-voltage variant), 34 digital I/O lines, 10-bit ADC, plus 2 comparators, 5 timers, and nanoWatt low-power modes per Microchip datasheet DS39681E. The combination of wide voltage, ample I/O, and 8-bit determinism makes it a baseline choice for cost-sensitive industrial controllers.
Is there a Microchip cross-reference for competitors to PIC18LF4221-I/PT?
Yes - Microchip's own Competitor Cross Reference Tool at microchipdirect.com maps competitor parts (e.g. STM8, ATmega, MSP430 in similar TQFP-44 packages) to comparable PIC18 family devices. For 40 MHz 8-bit, pin-compatible TQFP-44 drop-ins, Microchip typically points within the PIC18F/LF family itself, since cross-brand pin-for-pin equivalents at this pin count are uncommon and must be validated against each peripheral map.

Engineering reference data for PIC18LF4221-I/PT — comparison, design guidance, and compliance information.

Selection Guide

Choose the PIC18LF4221-I/PT when you need a wide-voltage (2.0-5.5 V) 8-bit PIC18 MCU in a 44-pin TQFP-44 footprint with 4 KB Flash and 512 bytes RAM, 34 I/O, and a 10-bit ADC. It is the right pick for battery- or 3.3 V-powered designs where the LF wide-voltage rating matters; the standard PIC18F4520 is preferable when you need more code space (32 KB Flash, 1.5 KB RAM) on the same TQFP-44 board and your supply is 5 V. For designs needing more memory and a 64 MHz clock, the PIC18F46K20 is a natural step up at the cost of higher unit price. PIC18LF4221-I/ML is the QFN-package drop for reflow-only manufacturing; firmware and pinout are identical. For AEC-Q100 automotive safety-critical applications, pick an AEC-Q100-qualified cousin instead.

Comparison with Alternatives

Parameter This Product PIC18LF4220-I/ML PIC18F4520-I/PT PIC18F46K20-I/PT
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Package 44-pin TQFP (PT), 10x10 mm 44-pin QFN (ML) 44-pin TQFP (PT) - same 44-pin TQFP (PT) - same
Program Memory 4 KB Flash (2K x 16) 4 KB Flash 32 KB Flash 64 KB Flash
RAM 512 bytes 512 bytes 1.5 KB 3.6 KB
Maximum Clock 40 MHz (10 MIPS) 40 MHz 40 MHz 64 MHz
Supply Voltage 2.0 V to 5.5 V (LF) 2.0 V to 5.5 V (LF) 4.2 V to 5.5 V (F) 1.8 V to 3.6 V (K-series)
Digital I/O 34 34 36 36
ADC 10-bit enhanced 10-bit enhanced 10-bit enhanced 10-bit enhanced

Key Differentiators

  • Wide-voltage LF variant enables single-cell Li-ion and 3.3 V designs (vs PIC18F4520-I/PT)
  • Smaller Flash footprint for cost-sensitive 4 KB firmware designs (vs PIC18F46K20-I/PT)
  • TQFP-44 footprint with 34 I/O at low cost (vs PIC18LF4221-I/ML (QFN-44))

Design Notes

Place a 100 nF decoupling capacitor on each VDD pin as close to the package as possible, plus a bulk capacitor (typically 1 uF to 10 uF) at the board supply entry. For wide 2.0-5.5 V designs, verify brown-out reset (BOR) thresholds in the configuration words; an unstable BOR trip causes intermittent resets on slow-rising supplies. For battery-powered nodes, switch the CPU to the internal LFINTOSC during Sleep to hold current under 1 uA.

Keep the MCLR pull-up trace short (under 2 cm if possible) to prevent false resets from EMI bursts. Route the crystal traces (OSC1/OSC2) over a continuous ground pour and avoid crossing them with digital switching lines. Place the ICSP pins (RB6/RB7) on a 0.1 inch header footprint or test-pad cluster to keep programmer access easy without ribbon cables.

Watch for the difference between PIC18F (4.2-5.5 V) and PIC18LF (2.0-5.5 V) variants when substituting, since swapping an F part into an LF socket at 3.3 V will result in a non-functional board. Always re-check the configuration words for oscillator mode and watchdog enable before programming production firmware; the default ICSP configuration is rarely what you want for a deployed product.

When using the ADC, the AVDD/AVSS pins must be powered even if the ADC is unused, or VDD current may not meet datasheet limits. For best ADC accuracy at 10 bits, place the analog inputs on quiet port pins (avoid routing near PWM outputs) and add a small RC filter at each analog input when sourcing impedances exceed datasheet recommended values.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Qualified
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Compliant

RoHS / REACH lead-free per Microchip product page; not AEC-Q100 qualified - choose AEC-Q100 cousin for automotive. MSL Level 3 per JEDEC J-STD-020.

Data verified on: 2026-09-28 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

Microchip Technology PIC18LF4221 PIC18LF4221-I/PT PIC18LF4220-I/ML PIC18F4520-I/PT PIC18F46K20-I/PT PIC18F family PIC18LF family 8-bit microcontroller RISC architecture Harvard architecture nanoWatt technology TQFP-44 TQFP package RoHS compliance AEC-Q100 MPLAB XC8 compiler MPLAB X IDE PICkit programmer 10-bit ADC AUSART UART MSSP SPI I2C brown-out reset watchdog timer flash memory battery-powered design
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