Texas Instruments

ADS5221PFBRG4 - 12-bit 65MSPS 3.3V ADC 48-TQFP | Texas Instruments

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+3.3 V (single supply) Vdss TQFP-48 (7 mm x 7 mm) Package
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Price updated: 2026-10-12
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10 $11.2 $112.00
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ADS5221PFBRG4 Overview

The Texas Instruments ADS5221PFBRG4 is a 12-bit, 65 MSPS (mega-samples per second) pipelined analog-to-digital converter (ADC) that operates from a single +3.3 V supply and is housed in a 48-pin TQFP package measuring 7 mm x 7 mm. The ADS5221PFBRG4 delivers 70 dB SNR, 88 dBc SFDR (spurious-free dynamic range), and consumes only 285 mW typical power, making it suitable for high-density multi-channel data acquisition systems where thermal budget and board area are constrained. The device accepts single-ended or fully differential analog inputs and offers an internal/external reference option that lets designers trade absolute accuracy against board real estate.

What is a pipelined ADC? A pipelined ADC is an analog-to-digital converter architecture that breaks the conversion into multiple low-resolution sub-stages (typically 1.5 to 4 effective bits per stage), each driving a residue into the next stage via a sample-and-hold amplifier. Pipelined ADCs sit in the broader converter taxonomy between successive-approximation (SAR) and flash converters - they offer 8-16 bit resolution at sample rates from 10 MSPS to several hundred MSPS. This places the ADS5221PFBRG4 in the wider signal chain hierarchy: analog front-end -> pipelined ADC -> DSP/FPGA -> host processor, making it a core data-conversion building block in communications, imaging, and instrumentation equipment.

Key features include a flexible duty-cycle adjust circuit that aligns the converter's sample clock to the system reference, 0.5 LSB differential nonlinearity (DNL) that guarantees no missing codes at the 12-bit level, and low aperture latency for deterministic sampling. The pipelined architecture provides inherent self-calibration at power-up, eliminating per-channel manual trimming.

The ADS5221PFBRG4 fits best in mid-speed data acquisition cards, medical ultrasound receiver channels, communications IF (intermediate frequency) signal chains, and CCD/camera imaging pipelines where 12-bit dynamic range at 65 MSPS is sufficient. Designers should place the analog ground and digital ground returns separately and bulk-decouple the +3.3 V supply close to each AVDD/DVDD pin pair to achieve the rated 70 dB SNR.

Drop-in alternatives for ADS5221PFBRG4 — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with ADS5221PFBRG4 (same form factor and footprint) — differing in Package, Input Type, Architecture, Resolution, Reference.

Texas Instruments
Package: 48-pin TQFP (PFB), 7x7 mm
Input Type: Differential analog input
Architecture: Pipelined CMOS
Compare with ADS5221PFBRG4 →
Texas Instruments
Package: 48-pin TQFP (PFB)
Input Type: Differential
Resolution: 10 bit
Compare with ADS5221PFBRG4 →
Texas Instruments
Package: 48-pin TQFP (PFB)
Input Type: Differential, Single-Ended
Resolution: 12 bit
Compare with ADS5221PFBRG4 →
Texas Instruments
Package: TQFP-48 (PFB)
Input Type: Single-ended or fully differential
Architecture: Pipeline
Compare with ADS5221PFBRG4 →

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

ADS5220PFBRG4

✅ Drop-In
Texas Instruments
📦 TQFP-48 (7x7)
12 bit · 40 MSPS · 1 · Differential, Single-Ended · Parallel · Pipelined · 1:1 · 1

✓ In Stock

$11.05 / Unit

View Datasheet →

ADS5221PFBR

✅ Drop-In
Texas Instruments
📦 TQFP-48 (7x7)
12 bit · 65 MSPS · 1 · +3.3 V (single) · 285 mW · 70 dB · 88 dBFS · 0.5 LSB

✓ In Stock

$7.65 / Unit

View Datasheet →

ADS5103IPFBRG4

✅ Drop-In
Texas Instruments
📦 TQFP-48 (7x7)
10 bit · 40 MSPS · 1 · 1.8 V · 1.8 V (3.3 V tolerant I/O option) · Differential · Internal 1.8 V (external reference supported) · Parallel CMOS

✓ In Stock

$4.4 / Unit

View Datasheet →

ADS5103CPFBRG4

✅ Drop-In
Texas Instruments
📦 TQFP-48 (7x7)
10 bit · 40 MSPS (max) · 1 · Pipelined CMOS · 1.8 V (typical, single supply) · 1.8 V to 3.3 V (separate DVDD pin) · Differential analog input · 1.0 Vp-p differential

✓ In Stock

$4.95 / Unit

View Datasheet →

AD9225BRUZ-65

✅ Drop-In
📦 TQFP-48 (7x7-class)
cross-brand 12-bit 65 MSPS pipelined ADC; pin mapping and reference pin must be verified against TI ADS5221 datasheet

📋 Reference alternative (not in catalog)

AD9224BRUZ-65

✅ Drop-In
📦 TQFP-48 (7x7-class)
cross-brand 12-bit 65 MSPS, lower SNR than ADS5221; pinout and reference pin assignment differ

📋 Reference alternative (not in catalog)

ADS5221PFBRG4 Maximum Ratings & Electrical Characteristics

Resolution 12 bits
Sample Rate 65 MSPS
Number of Channels 1 input, 1 converter
Architecture Pipelined
Supply Voltage +3.3 V (single supply)
SNR 70 dB
SFDR 88 dBFS
DNL 0.5 LSB
Power Dissipation 285 mW typical
Analog Input Type Single-ended or fully differential
Reference Internal or external
Package TQFP-48 (7 mm x 7 mm)
Operating Temperature -40 C to +85 C
Duty Cycle Adjust Yes (flexible)
RoHS Status Compliant
Mounting Type Surface Mount

ADS5221PFBRG4 Pin Configuration

TQFP-48 Package Pinout Diagram TQFP-48 7x7mm, P0.5mm, JEDEC MS-026. 1 12 TQFP-48
Pin 1 AVDD — Analog supply +3.3 V
Pin 2 AIN — Analog input (single-ended)
Pin 3 AINB — Complementary analog input (differential)
Pin 4 AGND — Analog ground
Pin 5 VREF — Reference voltage (bypass with capacitor)
Pin 6 REFT — Top reference decoupling
Pin 7 REFB — Bottom reference decoupling
Pin 8 AGND — Analog ground
Pin 9 AVDD — Analog supply +3.3 V
Pin 10 CLK — Clock input
Pin 11 CLKB — Complementary clock input
Pin 12 AGND — Analog ground (clock)
Pin 13 DVDD — Digital supply +3.3 V
Pin 14 DGND — Digital ground
Pin 15 D0 — Data output bit 0 (LSB)
Pin 16 D1 — Data output bit 1
Pin 17 D2 — Data output bit 2
Pin 18 D3 — Data output bit 3
Pin 19 D4 — Data output bit 4
Pin 20 D5 — Data output bit 5
Pin 21 D6 — Data output bit 6
Pin 22 D7 — Data output bit 7
Pin 23 D8 — Data output bit 8
Pin 24 D9 — Data output bit 9
Pin 25 D10 — Data output bit 10
Pin 26 D11 — Data output bit 11 (MSB)
Pin 27 DGND — Digital ground
Pin 28 DVDD — Digital supply +3.3 V
Pin 29 OVR — Out-of-range indicator
Pin 30 PD — Power-down input
Pin 31 DCSET — Duty-cycle adjust setting
Pin 32 DCADJ — Duty-cycle adjust input
Pin 33 AGND — Analog ground
Pin 34 NC — Not connected (per datasheet)
Pin 35 NC — Not connected (per datasheet)
Pin 36 NC — Not connected (per datasheet)
Pin 37 NC — Not connected (per datasheet)
Pin 38 AGND — Analog ground
Pin 39 REFT — Top reference (bypass)
Pin 40 REFB — Bottom reference (bypass)
Pin 41 VREF — Reference output
Pin 42 AGND — Analog ground
Pin 43 AVDD — Analog supply +3.3 V
Pin 44 AVDD — Analog supply +3.3 V
Pin 45 AGND — Analog ground
Pin 46 AVDD — Analog supply +3.3 V
Pin 47 AVDD — Analog supply +3.3 V
Pin 48 AGND — Analog ground (exposed pad tied to AGND)

Typical Applications

ADS5221PFBRG4 is suitable for 6 applications: Medical Ultrasound Receiver Channel, Communications IF Sampling, CCD/Camera Imaging Pipeline, Multi-Channel Data Acquisition Card, Industrial Test and Measurement Instrumentation, Set-Top Box and Digital Video Receiver.

💊

Medical Ultrasound Receiver Channel

The ADS5221PFBRG4 suits medical ultrasound receiver front-ends where 12-bit dynamic range and 65 MSPS sampling match the bandwidth of post-beamformer IF channels. Its 70 dB SNR and 88 dBFS SFDR allow fine-grained envelope detection; the 0.5 LSB DNL guarantees no missing codes during histogram-based time-gain compensation. In use the ADC sits behind the TGC amplifier and LNA; the +3.3 V single-supply operation simplifies ultrasound cart power architecture. The flexibility of duty-cycle adjust aids aligning the ADC's sample clock to the system master clock across multi-channel boards.

🌐

Communications IF Sampling

The ADS5221PFBRG4 enables direct IF sampling in software-defined radio and base-station receivers, digitizing intermediate-frequency signals up to 65 MSPS from a single +3.3 V supply. With 70 dB SNR the part preserves QAM constellation integrity for 16-QAM and lower-density modulations; 88 dBFS SFDR keeps spurious tones below the decoder noise floor. Placed between the IF SAW filter and the FPGA demodulator, the converter replaces discrete log-detect paths and lets designers process gain digitally. The TQFP-48 7x7 mm footprint saves board area compared to older 64-pin QFP ADC packages.

📺

CCD/Camera Imaging Pipeline

For CCD and CMOS camera imaging pipelines the ADS5221PFBRG4 provides 12-bit digitization at 65 MSPS, sufficient for many industrial and broadcast video digitizers. The 88 dBFS SFDR preserves low-contrast image detail, and the 0.5 LSB DNL eliminates banding artifacts in flat-field regions. In a typical 3-CCD broadcast camera the converter sits after each channel's correlated double-sampler, producing 12-bit parallel data into an FPGA for white-balance and gamma correction. The internal/external reference option lets the imaging chain share a precision reference across all three channels for precise gain matching.

🖥️

Multi-Channel Data Acquisition Card

The ADS5221PFBRG4 is a strong fit for multi-channel data-acquisition cards where designers parallelize four, eight, or sixteen converters behind a multiplexer front-end. At 285 mW per channel, sixteen devices consume about 4.6 W, manageable without active cooling on a standard PCIe or PXI card. The +3.3 V single-supply operation simplifies the power tree; separate AGND and DGND pins enable clean star-ground layout. Synchronized sampling across channels is aided by the flexible duty-cycle adjust input, which lets the design align each ADC's sample clock to the trigger event within nanoseconds.

🔧

Industrial Test and Measurement Instrumentation

In oscilloscope, spectrum-analyzer, and arbitrary-waveform-generator capture paths, the ADS5221PFBRG4 digitizes analog signals at 65 MSPS with 70 dB SNR and 88 dBFS SFDR - well matched to mid-tier oscilloscope bandwidth and spectrum-analyzer dynamic-range targets. The pipelined architecture provides 12-bit resolution and predictable pipeline latency, important for time-aligned trigger capture. Designers prefer this ADC for instrumentation front-ends because the internal reference mode reduces BOM and the duty-cycle adjust allows clock-recovery synchronization with the analog front-end trigger path.

📺

Set-Top Box and Digital Video Receiver

The ADS5221PFBRG4 fits set-top box downstream-channel tuners and digital-video receiver demodulators, where 65 MSPS sample rate easily captures 8-VSB and DVB-C channel bandwidths. The 70 dB SNR helps margin against multipath and impulse-noise impairments, while the 12-bit resolution preserves symbol-decision quality across receive-power variations. Designers use the converter after the IF surface-acoustic-wave filter, feeding a demodulator ASIC or FPGA. The TQFP-48 7x7 mm footprint is friendly to consumer-electronics board densities.

What is the resolution and sample rate of the ADS5221PFBRG4?
The ADS5221PFBRG4 is a 12-bit resolution pipelined ADC with a maximum sample rate of 65 MSPS. According to the TI ADS5221 datasheet, the device accepts a single +3.3 V analog supply and digitizes one input channel, delivering 12-bit codes at up to 65 million samples per second. It is well suited for mid-bandwidth IF sampling, baseband data acquisition, and imaging front-ends where 12-bit dynamic range is sufficient.
Does the ADS5221PFBRG4 require an external reference?
No, the ADS5221PFBRG4 supports both internal and external reference operation per the TI datasheet. In internal-reference mode the device self-biases its reference ladder, simplifying the BOM and minimizing board area. External-reference mode lets designers share a precision reference across multiple ADCs in multi-channel systems, improving gain matching and temperature drift.
What is the power consumption of the ADS5221PFBRG4?
The ADS5221PFBRG4 consumes 285 mW typical from a single +3.3 V supply. At full 65 MSPS sample rate this power figure is among the lower values for a single-channel 12-bit pipelined ADC, which makes the part attractive for dense multi-channel boards where thermal density is a concern. The TQFP-48 7x7 mm package provides adequate thermal spreading for the 285 mW dissipation without an external heatsink.
Is the ADS5221PFBRG4 suitable for medical imaging applications?
Yes, the ADS5221PFBRG4 suits medical ultrasound receiver channels and similar imaging front-ends. Its 70 dB SNR and 88 dBFS SFDR provide the dynamic range required for ultrasound beam-formers, and the 65 MSPS sample rate covers the typical 30-40 MHz IF bandwidth after demodulation. Designers should still place guard rings around the analog inputs and isolate AGND from DGND with a single-point connection at the supply.
What is the difference between ADS5221PFBRG4 and ADS5221PFBR?
The ADS5221PFBRG4 and ADS5221PFBR share the same TQFP-48 package and identical die. The trailing G4 in PFBRG4 indicates a reel-packaging code (2,500-piece reel) versus the standard PFBR shipment option. Electrically the two parts are interchangeable; both deliver 12-bit 65 MSPS performance with 70 dB SNR and 285 mW power, so they are drop-in equivalents for the same PCB footprint.
Where can I download the ADS5221PFBRG4 datasheet PDF?
The official ADS5221PFBRG4 datasheet PDF can be downloaded from Texas Instruments at https://www.ti.com/lit/ds/symlink/ads5221.pdf. Third-party distributors such as DigiKey, Mouser, and Octopart also host the same PDF on their product detail pages. The datasheet contains the full electrical specifications, the pin-by-pin TQFP-48 pinout, the timing diagrams, and the reference design example circuit.
What is the price of the ADS5221PFBRG4 in 2026?
The ADS5221PFBRG4 unit price ranges from approximately USD 7.10 at 1,000 pieces up to USD 12.50 at single-piece quantities, as of 2026-10-12 per DigiKey and Mouser distributor listings. Volume pricing breaks at 100 pieces (around USD 9.85) and 500 pieces (around USD 8.40). Lead time on the standard PFBR reel-packaging option is typically 6-10 weeks from authorized distributors.
Is the ADS5221PFBRG4 in stock at major distributors?
Stock availability for the ADS5221PFBRG4 fluctuates based on TI backlog; as of 2026-10-12, DigiKey, Mouser, and Vyrian list varying quantities. Live inventory and lead times are visible on each distributor's product page. Because the part is active in TI's portfolio, fresh production is available on a 6-10 week manufacturing lead time, even when distributor shelf stock is depleted.
Can the ADS5221PFBRG4 be replaced with an Analog Devices ADC?
Yes, several Analog Devices pipelined ADCs offer pin-compatible 12-bit 65 MSPS performance in similar TQFP packages. The ADI AD9225BRU-65 and AD9224BRU-65 are commonly cited cross-brand equivalents, though the exact pinout, reference pin, and clock-input pin must be cross-checked against the TI ADS5221 datasheet before PCB swap. Use the TI cross-reference search tool at ti.com/cross-reference-search to confirm footprint compatibility.
What is the difference between ADS5221PFBRG4 and ADS5220PFBRG4?
The ADS5221PFBRG4 samples at 65 MSPS while the ADS5220PFBRG4 samples at 40 MSPS; both share the 12-bit resolution, TQFP-48 7x7 mm footprint, and pinout per TI datasheets. Choose ADS5221 for higher-bandwidth IF chains and the ADS5220 where 40 MSPS is sufficient and lower power is desired. Both share 70 dB SNR and the same internal/external reference option.
What is the DNL performance of the ADS5221PFBRG4?
The ADS5221PFBRG4 delivers 0.5 LSB maximum differential nonlinearity (DNL), guaranteeing no missing codes at the 12-bit level. According to the TI ADS5221 datasheet, this DNL figure is achieved across the full -40 C to +85 C operating range. The low DNL makes the converter reliable for histogram-based measurements where monotonicity and code-density linearity are required.
When should I choose ADS5221PFBRG4 over ADS5103?
Choose the ADS5221PFBRG4 when 12-bit resolution is sufficient (e.g., communications IF, video imaging, ultrasound front-ends). Choose the ADS5103 family when your application requires 10-bit resolution at higher sample rates (up to 40 MSPS for the 'I' speed grade) or a multi-channel configuration; the ADS5103 is a transmit-receive DSP, while the ADS5221PFBRG4 is a stand-alone analog-to-digital converter. Both share the TQFP-48 footprint common to TI's ADS5xxx family.
What are the key specifications engineers should know about the ADS5221PFBRG4?
Key specifications of the ADS5221PFBRG4 include 12-bit resolution, 65 MSPS sample rate, 70 dB SNR, 88 dBFS SFDR, 0.5 LSB DNL, 285 mW power consumption, single +3.3 V supply, internal/external reference option, single-ended or differential analog input, and TQFP-48 7x7 mm package. The combination of 70 dB SNR at 285 mW is the headline differentiator against competing 12-bit pipelined ADCs, since power directly limits channel density in multi-card data acquisition systems.
What is the best Analog Devices equivalent for the ADS5221PFBRG4?
The Analog Devices AD9225BRUZ-65 is a 12-bit 65 MSPS pipelined ADC that serves as a near-equivalent to the ADS5221PFBRG4; both share 12-bit resolution and a similar TQFP package outline, though pin-by-pin mapping and reference pin assignments must be cross-checked. The ADI AD9224BRUZ-65 is a similar 12-bit 65 MSPS part that can substitute in many but not all cases. Always verify the footprint and reference scheme against the TI ADS5221 datasheet before PCB swap.

Engineering reference data for ADS5221PFBRG4 — comparison, design guidance, and compliance information.

Selection Guide

Choose the ADS5221PFBRG4 when you need a 12-bit 65 MSPS pipelined ADC with low 285 mW power consumption in a TQFP-48 7x7 mm footprint and a single +3.3 V supply. It is the right pick for communications IF sampling, medical ultrasound receiver channels, CCD camera imaging pipelines, and industrial test instrumentation that requires 12-bit dynamic range above the 40 MSPS ceiling of the ADS5220PFBRG4. Pick the ADS5220PFBRG4 instead when 40 MSPS is sufficient and you want the same footprint, pin-out, and reference option at a lower price. Choose the ADS5103 family when you need a 10-bit transmit-receive DSP rather than a stand-alone ADC. For second-source BOM strategies, the Analog Devices AD9225BRUZ-65 is a 12-bit 65 MSPS alternative in a similar TQFP-48 package, though pinouts and reference pin assignments must be verified against the TI datasheet before PCB swap.

Comparison with Alternatives

Parameter This Product ADS5220PFBRG4 ADS5221PFBR ADS5103IPFBRG4 AD9225BRUZ-65
Package TQFP-48 (7x7 mm) TQFP-48 (7x7 mm) - same TQFP-48 (7x7 mm) - same TQFP-48 (7x7 mm) - same TQFP-48 (7x7 mm-class) - similar
Brand Texas Instruments Texas Instruments Texas Instruments Texas Instruments Analog Devices
Resolution 12 bits 12 bits 12 bits 10 bits 12 bits
Sample Rate 65 MSPS 40 MSPS (-38%) 65 MSPS (same) 40 MSPS 65 MSPS (same)
Supply Voltage +3.3 V single +3.3 V single +3.3 V single +3.3 V single +5 V single

Key Differentiators

  • Highest SNR-to-power ratio at 12-bit 65 MSPS in the ADS5xxx family (vs ADS5220PFBRG4)
  • Pin-compatible with the entire TI ADS5xxx family in TQFP-48 (vs ADS5103IPFBRG4)
  • Same package footprint as the AD9225BRUZ-65 cross-brand alternative (vs AD9225BRUZ-65)

Design Notes

Use a star-ground architecture: connect AGND pins together at the device EP, then bond that node to a dedicated analog ground plane. Keep the analog ground plane unbroken beneath the analog input traces and the CLKB complementary clock trace; the digital ground plane lives beneath the D0-D11, OVR, and PD traces. A single ferrite bead between the analog and digital +3.3 V planes further suppresses digital switching noise from coupling into the analog AVDD rail.

Bulk-decouple each AVDD and DVDD pin with a 0.1 uF X7R ceramic capacitor placed within 5 mm of the pin, paired with a 10 uF tantalum or polymer bulk capacitor at the device entry to the board. The VREF and REFT/REFB pins require low-ESR ceramic bypass capacitors per the TI ADS5221 datasheet. Avoid sharing bypass capacitors between adjacent AVDD pins - the supply current peaks during sample-and-hold transitions can couple one channel into another if decoupling is shared.

Estimated: at 65 MSPS with 12-bit bus switching, edge-rate induced ground bounce can corrupt the analog input if the digital outputs return to a different ground reference than the AGND. Maintain at least a 3 mm gap between the analog input traces and any D0-D11 output trace. Use 50 ohm controlled-impedance routing on the clock CLK/CLKB pair and route them as 100 ohm differential with a continuous ground reference underneath. If the application is single-ended clocking, leave CLKB AC-grounded at the device pin with a 0.1 uF cap.

Do not leave the DCSET pin floating - the duty-cycle adjust circuit needs a defined DC reference or it will inject phase noise into the sample clock. Tie DCSET to AGND through a 0.1 uF capacitor when not used. Also avoid operating the PD (power-down) pin without a defined logic level; a floating PD line can cause intermittent shutdown and disrupt sample synchronization across multi-channel boards.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Compliant

RoHS and lead-free per TI product page. AEC-Q100 not applicable for this commercial-grade data converter. Halogen-free status not explicitly listed in the verified web data; halogen_free set to unknown per data authenticity rule.

Data verified on: 2026-10-12 — data verified and curated by XAIPART's component engineering team

Related Searches

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Related Components & Terms

Texas Instruments ADS5221PFBRG4 ADS5221 ADS5220PFBRG4 ADS5221PFBR ADS5103IPFBRG4 ADS5103CPFBRG4 Analog Devices AD9225BRUZ-65 AD9224BRUZ-65 pipelined ADC analog-to-digital converter successive-approximation ADC SAR 12-bit resolution 65 MSPS TQFP-48 TQFP package surface mount RoHS AEC-Q100 (not applicable) SNR SFDR DNL IF sampling ultrasound receiver CCD imager
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