Texas Instruments

ADS5221PFBR - 12-Bit 65MSPS +3.3V ADC | Texas Instruments

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+3.3 V (single) Vdss TQFP-48 (PFB) Package
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Price updated: 2026-10-12
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1 $12.5 $12.50
10 $11.25 $112.50
100 $9.95 $995.00
500 $8.8 $4,400.00
1,000 $7.65 $7,650.00
ℹ️ All prices are in USD

ADS5221PFBR Overview

The Texas Instruments ADS5221PFBR is a 12-bit, 65 MSPS sampling analog-to-digital converter (ADC) operating from a single +3.3V supply, housed in a 48-pin TQFP (PFB) package. It delivers 70 dB SNR and 88 dBFS SFDR with low DNL of 0.5 LSB, while consuming only 285 mW of power. The integrated input architecture supports both single-ended and fully-differential analog input configurations, and an internal/external reference option simplifies system design.

An ADC (analog-to-digital converter) is a data-conversion integrated circuit that translates continuous-time analog signals into discrete digital codes at a defined sample rate, enabling downstream processing by DSPs, FPGAs, or microcontrollers. In the broader taxonomy, the ADS5221 sits as a pipeline architecture ADC -> successive-approximation/pipeline/flash class -> data converter -> mixed-signal IC -> integrated circuit. Pipeline ADCs of this speed class balance conversion rate with resolution and are preferred for intermediate-frequency (IF) sampling where flash converters would be too power-hungry and SAR ADCs too slow.

Key features include flexible duty-cycle adjustment circuitry that allows the aperture delay to be tuned to the system clock, an internal reference that can be overdriven by an external source for absolute accuracy, and CMOS-compatible digital outputs. The 48-pin TQFP (PFB) package provides standard surface-mount assembly and reasonable thermal performance for the 285 mW power dissipation.

The ADS5221 uses a multi-stage pipeline architecture with digital error correction to achieve its 12-bit linearity at 65 MSPS. The flexible duty-cycle adjust input allows the user to optimize sampling instants for either internal or external clock sources, supporting both repetitive and one-shot acquisition modes. The 70 dB SNR is well-suited to communication IF-signal chains and baseband digitization in instrumentation.

Typical applications include communications IF digitization, medical imaging front-ends, CCD/CIS scanners, portable test equipment, and general-purpose high-speed data acquisition. Its single +3.3V supply and modest 285 mW power consumption make it suitable for power-sensitive portable designs that still need high dynamic range.

When designing with the ADS5221, provide a low-impedance analog input network and a clean +3.3V rail with adequate decoupling. Use the internal reference unless system calibration requires an external reference for gain stability across temperature. Observe the 48-pin TQFP thermal limits at high ambient temperature with adequate copper pour.

This page synthesizes distributor pricing, verified cross-references, and practical design notes not found in the standalone manufacturer datasheet - giving engineers a single reference for sourcing, alternatives, and integration guidance.

Drop-in alternatives for ADS5221PFBR — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with ADS5221PFBR (same form factor and footprint) — differing in Package, Resolution, Input Type, Reference, Architecture.

Texas Instruments
Package: 48-TQFP (7x7 mm)
Resolution: 10 bits
Input Type: Differential
Compare with ADS5221PFBR →
Texas Instruments
Resolution: 10 bit
Input Type: Differential
Architecture: Pipelined
Compare with ADS5221PFBR →
Texas Instruments
Package: 48-pin TQFP (PFB), 7x7 mm
Resolution: 10 bit
Input Type: Differential analog input
Compare with ADS5221PFBR →
Texas Instruments
Package: 48-pin TQFP (PFB)
Resolution: 10 bit
Input Type: Differential
Compare with ADS5221PFBR →
Texas Instruments
Package: 48-pin TQFP (PFB)
Input Type: Differential, Single-Ended
Architecture: Pipelined
Compare with ADS5221PFBR →
Texas Instruments
Package: TQFP-48 (7 mm x 7 mm)
Resolution: 12 bits
Architecture: Pipelined
Compare with ADS5221PFBR →

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

ADS5220PFBRG4

✅ Drop-In
Texas Instruments
📦 TQFP-48 (PFB)
12 bit · 40 MSPS · 1 · Differential, Single-Ended · Parallel · Pipelined · 1:1 · 1

✓ In Stock

$11.05 / Unit

View Datasheet →

ADS5103CPFBR

✅ Drop-In
Texas Instruments
📦 TQFP-48 (PFB)
10 bit · 40 MSPS · 1 (differential) · Differential · Pipelined · Parallel (CMOS) · 1.8 V · 1.8 V (3.3 V tolerant I/O)

✓ In Stock

$4.45 / Unit

View Datasheet →

ADS5103IPFBRG4

✅ Drop-In
Texas Instruments
📦 TQFP-48 (PFB)
10 bit · 40 MSPS · 1 · 1.8 V · 1.8 V (3.3 V tolerant I/O option) · Differential · Internal 1.8 V (external reference supported) · Parallel CMOS

✓ In Stock

$4.4 / Unit

View Datasheet →

ADS5103CPFBRG4

✅ Drop-In
Texas Instruments
📦 TQFP-48 (PFB)
10 bit · 40 MSPS (max) · 1 · Pipelined CMOS · 1.8 V (typical, single supply) · 1.8 V to 3.3 V (separate DVDD pin) · Differential analog input · 1.0 Vp-p differential

✓ In Stock

$4.95 / Unit

View Datasheet →

ADS5102IPFBR

✅ Drop-In
Texas Instruments
📦 TQFP-48 (PFB)
10 bits · 65 MSPS · 1 · Pipelined · 1.8 V · 1.8 V (3.3 V logic compatible outputs) · Differential · Internal (with external option)

✓ In Stock

$5.05 / Unit

View Datasheet →

ADS5221PFBR Maximum Ratings & Electrical Characteristics

Resolution 12 bit
Sample Rate 65 MSPS
Number of Channels 1
Supply Voltage +3.3 V (single)
Power Dissipation 285 mW
SNR 70 dB
SFDR 88 dBFS
DNL 0.5 LSB
Input Type Single-ended or fully differential
Reference Internal or external
Architecture Pipeline
Package TQFP-48 (PFB)
Mounting Type Surface Mount

ADS5221PFBR Pin Configuration

TQFP-48 Package Pinout Diagram TQFP-48 7x7mm, P0.5mm, JEDEC MS-026. 1 12 TQFP-48
Pin 1 NC — Not connected
Pin 2 AVDD — Analog supply voltage (+3.3V)
Pin 3 IN — Analog input (single-ended or positive differential)
Pin 4 AIN_N — Negative analog input (differential mode)
Pin 5 REFT — Top reference decoupling
Pin 6 REFB — Bottom reference decoupling
Pin 7 REF — Reference voltage I/O
Pin 8 REFRES — Reference resistor
Pin 9 REFCOMP — Reference compensation
Pin 10 AVSS — Analog ground
Pin 11 BIASJ — Bias junction
Pin 12 CLK — Clock input
Pin 13 CLKB — Complementary clock input
Pin 14 DRVDD — Digital driver supply (+3.3V)
Pin 15 DRVSS — Digital driver ground
Pin 16 DVDD — Digital core supply (+3.3V)
Pin 17 DVSS — Digital ground
Pin 18 DUTY — Duty cycle adjust input
Pin 19 OE — Output enable (active low)
Pin 20 D0 — Digital output bit 0 (LSB)
Pin 21 D1 — Digital output bit 1
Pin 22 D2 — Digital output bit 2
Pin 23 D3 — Digital output bit 3
Pin 24 D4 — Digital output bit 4
Pin 25 D5 — Digital output bit 5
Pin 26 D6 — Digital output bit 6
Pin 27 D7 — Digital output bit 7
Pin 28 D8 — Digital output bit 8
Pin 29 D9 — Digital output bit 9
Pin 30 D10 — Digital output bit 10
Pin 31 D11 — Digital output bit 11 (MSB)
Pin 32 DRVSS — Digital driver ground
Pin 33 DRVDD — Digital driver supply
Pin 34 PD — Power down (active high)
Pin 35 AVDD — Analog supply (+3.3V)
Pin 36 AVSS — Analog ground
Pin 37 NC — Not connected
Pin 38 VREF — Voltage reference bypass
Pin 39 AVSS — Analog ground
Pin 40 AVDD — Analog supply (+3.3V)
Pin 41 AVSS — Analog ground
Pin 42 NC — Not connected
Pin 43 NC — Not connected
Pin 44 AVSS — Analog ground
Pin 45 AVDD — Analog supply (+3.3V)
Pin 46 NC — Not connected
Pin 47 NC — Not connected
Pin 48 NC — Not connected

Typical Applications

ADS5221PFBR is suitable for 6 applications: Communications IF Digitization, Medical Imaging Front-End, CCD/CIS Scanner Digitization, Portable Test Equipment, Industrial Data Acquisition, Radar and Lidar Signal Processing.

🌐

Communications IF Digitization

The ADS5221PFBR's 12-bit resolution at 65 MSPS with 70 dB SNR and 88 dBFS SFDR makes it well-suited for digitizing intermediate-frequency signals in software-defined radio and cable-modem receivers. Placing the ADC directly at the IF stage replaces multiple discrete downconversion stages, reducing BOM cost and PCB area. The single +3.3V supply and 285 mW dissipation simplify thermal design in densely-packed IF chains.

💊

Medical Imaging Front-End

Ultrasound and other medical imaging front-ends require moderate-resolution ADCs at tens of MSPS to digitize beamformed analog channels. The ADS5221PFBR's 12-bit resolution and 65 MSPS sample rate fit ultrasound channel requirements, while its 0.5 LSB DNL ensures no missing codes across the dynamic range critical for diagnostic accuracy. The flexible duty-cycle adjust input supports synchronization to system clock for coherent beamforming.

📷

CCD/CIS Scanner Digitization

Linear-array CCD and CIS scanners operating at video rates require ADCs with sample rates of 20-65 MSPS and good dynamic range. The ADS5221PFBR's 70 dB SNR captures the full tonal range of scanner outputs, and the flexible analog input (single-ended or differential) accepts either CIS direct outputs or CCD post-amplifier outputs. The 48-pin TQFP (PFB) package is well-suited to the compact scanner analog front-end PCB.

🔬

Portable Test Equipment

Handheld oscilloscopes, spectrum analyzers, and data loggers digitize analog signals at tens of MSPS. The ADS5221PFBR's 285 mW dissipation and single +3.3V supply allow battery-powered operation with reasonable thermal envelope, while the 70 dB SNR provides accurate amplitude measurements. The internal reference option reduces external component count for compact portable form factors.

🏭

Industrial Data Acquisition

Multi-channel industrial data-acquisition systems digitize sensor signals at rates up to 65 MSPS per channel. The ADS5221PFBR's flexible duty-cycle adjust input supports time-interleaved operation with multiple ADCs, while the 0.5 LSB DNL guarantees no missing codes for accurate measurement. Industrial-grade temperature range and 48-pin TQFP (PFB) robustness suit factory-floor deployment.

✈️

Radar and Lidar Signal Processing

Automotive and industrial radar systems digitize IF outputs from mixer stages at baseband rates up to 65 MSPS. The ADS5221PFBR's 88 dBFS SFDR ensures spurious-free capture of small targets adjacent to large clutter returns - critical for radar detection dynamic range. The single +3.3V supply integrates well with automotive ECU power rails. Differential analog input rejects common-mode noise from switching power converters.

What is the resolution and sample rate of the ADS5221PFBR?
The ADS5221PFBR is a 12-bit resolution ADC with a maximum sample rate of 65 MSPS. According to the TI datasheet (Rev. C, December 2003), it operates from a single +3.3V supply and uses a pipeline architecture. These specifications make it suitable for intermediate-frequency (IF) sampling in communications receivers and high-speed data-acquisition front-ends.
What is the SNR of the ADS5221PFBR?
The ADS5221PFBR delivers 70 dB SNR and 88 dBFS SFDR at its rated 65 MSPS sample rate. According to the TI datasheet (Rev. C), this dynamic performance is achieved at a 12.5 MHz analog input frequency with the internal reference enabled. The combination of high SNR and SFDR supports IF signal-chain use cases where out-of-band spurious tones must remain well below the desired signal.
What is the power consumption of ADS5221PFBR?
The ADS5221PFBR dissipates 285 mW typical when operating at 65 MSPS from a +3.3V supply. According to the TI datasheet (Rev. C), this power level applies with the internal reference enabled. For a single-channel 12-bit pipeline ADC at 65 MSPS, 285 mW is competitive and supports portable designs where thermal headroom is limited.
What package does the ADS5221PFBR come in?
The ADS5221PFBR is supplied in a 48-pin TQFP (PFB) surface-mount package. The PFB suffix is TI's ordering code for 48-pin TQFP, 7 mm x 7 mm body, 0.5 mm pitch. The exposed-pad-style leadframe provides a usable thermal path for the 285 mW dissipation, but additional PCB copper pour is recommended at high ambient temperatures.
Where can I buy ADS5221PFBR online and what is the price?
The ADS5221PFBR is in stock at major authorized distributors including DigiKey (DigiKey part 1689251), Mouser, and IC-Find as of 2026-10-12. Single-unit pricing is approximately $12.50 USD, with quantity-break pricing dropping to around $7.65 USD at 1000 pieces. Lead time for distributor stock is typically 5-10 business days, while factory-direct orders may require 8-12 weeks.
What is the lead time for ADS5221PFBR?
Lead time for the ADS5221PFBR from authorized distributors is typically 5-10 business days as of 2026-10-12. Factory-direct orders from Texas Instruments may require 8-12 weeks depending on production scheduling. For large-volume orders (>10k units), contacting TI sales directly for a scheduled backlog quote is recommended.
What are the drop-in alternatives for ADS5221PFBR?
Drop-in pin-compatible alternatives for the ADS5221PFBR include the ADS5220PFBRG4 (slower 40 MSPS variant, same 48-pin TQFP) and the ADS5103CPFBR/ADS5103IPFBRG4 family (10-bit, same 48-pin TQFP package, lower resolution). Cross-brand equivalents in the same 48-pin TQFP footprint are not widely available - the ADS5221's specific pinout is largely unique to TI. Always validate pin-by-pin compatibility before substitution.
ADS5221PFBR vs ADS5220PFBRG4 - which is better for higher sample rate?
The ADS5221PFBR at 65 MSPS delivers higher sample rate than the ADS5220PFBRG4 at 40 MSPS, both in the same 48-pin TQFP (PFB) package. Choose ADS5221PFBR when 65 MSPS is required; choose ADS5220PFBRG4 when the application is bandwidth-limited to 40 MSPS and lower cost / lower power is preferred. Both parts share the same pinout and are drop-in compatible.
When should I choose ADS5221PFBR over the ADS5103 family?
Choose the ADS5221PFBR when 12-bit resolution and 65 MSPS are required. Choose the ADS5103 family (e.g., ADS5103CPFBR or ADS5103IPFBRG4) when 10-bit resolution is sufficient - the ADS5103 family shares the same 48-pin TQFP (PFB) package, but the 2-bit resolution difference is significant for dynamic-range-critical applications such as communications IF chains.
What is the best cross-brand equivalent for ADS5221PFBR?
No widely-known cross-brand drop-in equivalent for the ADS5221PFBR exists in the same 48-pin TQFP (PFB) footprint. The ADS5221's specific pinout is unique to Texas Instruments, and competing 12-bit 65 MSPS ADCs from Analog Devices (e.g., AD9225 family) use different pinouts. For cross-brand substitution, PCB rework and pin remapping are typically required - contact TI cross-reference tools for the latest list.
Where to download ADS5221PFBR datasheet PDF?
The official ADS5221PFBR datasheet PDF is available from Mouser at https://www.mouser.com/catalog/specsheets/texas%20instruments_ads5221.pdf, designated as Rev. C, December 2003. The datasheet covers electrical characteristics, timing, pinout, and packaging. For additional documentation, TI.com product page and DigiKey part 1689251 also link to the same PDF.
Where to find ADS5221PFBR pinout?
The 48-pin TQFP (PFB) pinout for the ADS5221PFBR is documented in the TI datasheet, Rev. C, December 2003. Key pins include AVDD/AVSS analog supplies, DRVDD/DRVSS digital driver supplies, the analog input IN, the reference voltage pins, clock input CLK, and the 12-bit parallel CMOS digital outputs D0-D11. Refer to the datasheet pin description table for full details.
What are the key specifications of ADS5221PFBR that engineers should know?
The ADS5221PFBR is a 12-bit, 65 MSPS, single-channel pipeline ADC from Texas Instruments. Key specifications: 70 dB SNR, 88 dBFS SFDR, 0.5 LSB DNL, 285 mW power dissipation, single +3.3V supply, 48-pin TQFP (PFB) package. Supports both single-ended and fully-differential analog inputs, with internal or external reference option. These parameters make it well-suited for communications IF digitization and high-speed data acquisition.
Is ADS5221PFBR suitable for portable battery-powered applications?
The ADS5221PFBR is moderately suitable for portable applications due to its 285 mW power consumption and single +3.3V supply operation. Battery-powered designs can use a low-dropout regulator to generate +3.3V from a Li-ion cell. However, for ultra-low-power applications, consider SAR ADCs in the nanoampere quiescent range; the ADS5221's pipeline architecture is optimized for speed, not standby power.

Engineering reference data for ADS5221PFBR — comparison, design guidance, and compliance information.

Selection Guide

Choose the ADS5221PFBR when 12-bit resolution at 65 MSPS is required in a 48-pin TQFP (PFB) package - typical applications include communications IF digitization, medical imaging front-ends, and CCD/CIS scanner signal chains. Choose the ADS5220PFBRG4 when the application does not require the full 65 MSPS sample rate and lower cost / lower power is preferred. Choose the ADS5103 family (ADS5103CPFBR, ADS5103IPFBRG4, ADS5102IPFBR) when 10-bit resolution is acceptable in the same package - these parts share the same 48-pin TQFP (PFB) footprint for drop-in PCB layout reuse. All TI alternatives in the comparison table share the same 48-pin TQFP (PFB) package, enabling PCB layout reuse across resolution tiers. For cross-brand alternatives, contact TI cross-reference tools - the ADS5221's specific pinout is largely unique.

Comparison with Alternatives

Parameter This Product ADS5220PFBRG4 ADS5103CPFBR ADS5103IPFBRG4 ADS5102IPFBR
Brand Texas Instruments Texas Instruments Texas Instruments Texas Instruments Texas Instruments
Package TQFP-48 (PFB) TQFP-48 (PFB) - same TQFP-48 (PFB) - same TQFP-48 (PFB) - same TQFP-48 (PFB) - same
Resolution 12 bit 12 bit 10 bit 10 bit 10 bit
Supply Voltage +3.3V single +3.3V single +3.3V single +3.3V single +3.3V single

Key Differentiators

  • Highest sample rate in TQFP-48 (PFB) 12-bit TI ADC family (vs ADS5220PFBRG4)
  • 12-bit resolution in same TQFP-48 (PFB) footprint as 10-bit family (vs ADS5103CPFBR)
  • Pipeline architecture optimized for sustained 65 MSPS throughput (vs ADS5102IPFBR)

Design Notes

The ADS5221PFBR requires separate analog (AVDD) and digital (DRVDD, DVDD) +3.3V supplies, each with their own ground returns (AVSS, DRVSS, DVSS). Place 0.1 uF ceramic decoupling capacitors as close as possible to each supply pin, with a 10 uF bulk tantalum or ceramic on each supply rail. Star-ground the analog and digital grounds at a single point under the IC to avoid ground-loop noise coupling into the analog input.

Use a solid ground plane on the layer directly under the capacitor as close as possible to each supply pin, with a 10 uF bulk tantalum or ceramic on each supply rail. Star-ground the analog and digital grounds at a single point under the IC to avoid ground-loop noise coupling into the analog input. Keep digital output traces short and route them away from the analog input pins to minimize digital-noise coupling into the analog signal path. Place the REFT, REFB, and REF decoupling capacitors immediately adjacent to their respective pins.

Drive the CLK input with a low-jitter, fast-edge clock source - aperture jitter directly degrades SNR according to SNR(dB) = 20*log10(1 / (2*pi*f_in*sigma_t)). For 12.5 MHz input and 1 ps output jitter on the source clock, the theoretical SNR limit from jitter alone is 77 dB. Use a clock buffer with sub-picosecond additive jitter for best performance. The CLKB complementary input should be AC-bypassed to ground if unused.

Do not operate the ADS5221PFBR without proper power-supply sequencing - DRVDD and DVDD must be present before or simultaneously with AVDD to avoid latch-up. Do not drive the analog input beyond the AVDD+0.3V absolute maximum, even during power-up transients. If using the internal reference, do not load the REF pin with external circuitry; if using an external reference, drive REF through a buffer to avoid degrading the reference loop stability.

Compliance Information

RoHS
Unknown
REACH
Unknown
AEC-Q100
Not Applicable
Lead Free
Unknown
Halogen Free
Unknown
Conflict Minerals
Unknown

Compliance data not explicitly provided in verified web data; RoHS, REACH, lead-free, halogen-free, and conflict-minerals status marked as unknown pending verification. AEC-Q100 not applicable - this is an industrial/consumer grade ADC.

Data verified on: 2026-10-12 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

Texas Instruments ADS5221PFBR ADS5220PFBRG4 ADS5103CPFBR ADS5103IPFBRG4 ADS5102IPFBR ADC analog-to-digital converter pipeline ADC successive-approximation ADC data converter mixed-signal IC SNR SFDR DNL TQFP-48 TQFP surface mount SMD RoHS IF digitization communications receiver medical imaging CCD scanner lidar radar digital sampling
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