Microchip Technology

ATMEGA645-16MI - 8-Bit AVR MCU 16MHz 64KB Flash | Microchip

MPN: ATMEGA645-16MI ✓ Active
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64-QFN (9x9 mm) Package 16 MHz Speed 64 KB (32K x 16) Flash Memory
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Price updated: 2026-09-18
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Qty Unit Price Extended
1 $6.2 $6.20
10 $5.58 $55.80
100 $4.96 $496.00
500 $4.4 $2,200.00
1,000 $3.92 $3,920.00
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ATMEGA645-16MI Overview

The Microchip Technology ATMEGA645-16MI is an 8-bit AVR RISC microcontroller with 64KB of In-System Programmable Flash (32K x 16 organization), 4KB SRAM, and 2KB EEPROM, executing at up to 16MHz in a 64-pin QFN (9x9 mm) package.

An 8-bit AVR microcontroller is a Harvard-architecture RISC processor that executes most of its 130 powerful instructions in a single clock cycle. In the system hierarchy, the ATmega645 sits in the ATmega family of flash-based MCUs, positioned above the ATmega325 and below the ATmega1281, and is a core building block of embedded power management and control systems.

Key features include a 16MHz maximum core clock (16 MIPS throughput at 16MHz Dhrystone), 53 programmable I/O lines, an 8-channel 10-bit ADC, and an on-chip JTAG interface for boundary-scan and on-chip debugging. The device also integrates a segment LCD controller, making it distinct from the ATmega644 and other same-pin-count AVR parts. Boot-code self-programming enables in-system reprogramming over SPI, UART, or JTAG.

Architecturally, the ATmega645 uses the advanced AVR RISC core with 32 general-purpose working registers directly connected to the ALU, allowing two independent registers to be accessed in one instruction executed in one clock cycle. Read-While-Write Flash capability allows code updates while the program is running. Low-power modes including Idle, Power-down, Power-save, and Standby reduce consumption for battery-powered designs.

Typical applications include industrial control panels with LCD user interfaces, battery-powered metering, HVAC controllers, and consumer appliances that benefit from the integrated LCD driver and 10-bit ADC.

Design consideration: the -16MI speed grade is rated for 16MHz across the full industrial temperature range, but analog ADC accuracy and Flash endurance figures degrade near the extremes, so verify operating margins at maximum ambient.

This page synthesizes distributor stock data, drop-in alternative analysis, and practical design guidance not found in the manufacturer datasheet.

Drop-in alternatives for ATMEGA645-16MI — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with ATMEGA645-16MI (same form factor and footprint) — differing in Package, ADC Channels, Debug Interface, Number of I/O, Program Memory Size.

Microchip Technology
Package: 64-QFN / MLF (9x9 mm) with exposed pad
Number of I/O: 54 programmable I/O lines
Compare with ATMEGA645-16MI →
Microchip Technology
ADC Channels: 8 channels
Debug Interface: JTAG (on-chip debugging and boundary scan)
Program Memory Size: 64 KB (32K x 16) Flash, ISP
Compare with ATMEGA645-16MI →

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

ATMEGA645-16MU

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9)
8-bit AVR RISC · 64 KB (32K x 16) Flash, ISP · 4 KB · 2 KB · 16 MHz · 16 MIPS at 16 MHz · 2.7 V to 5.5 V · 68

✓ In Stock

$4.65 / Unit

View Datasheet →

ATMEGA325-16MI

✅ Drop-In ⚠️ 参数待验证
Microchip Technology
📦 64-QFN (9x9)
8-bit AVR RISC · 16 MHz · 32 KB (16K x 16) · 1 KB · 2 KB · 2.7 V to 5.5 V · 54 programmable I/O lines · 130 powerful instructions, most single-cycle

✓ In Stock

$3.05 / Unit

View Datasheet →

ATMEGA645-16MI Maximum Ratings & Electrical Characteristics

Core Architecture 8-bit AVR RISC
Core Clock Speed 16 MHz
Program Memory Size 64 KB (32K x 16) Flash
Program Memory Type In-System Programmable FLASH
SRAM Size 4 KB
EEPROM Size 2 KB
Number of I/O 53 programmable I/O lines
ADC Resolution 10-bit
ADC Channels 8
LCD Controller Yes (segment LCD driver)
Debug Interface JTAG (on-chip debug, boundary scan)
Package 64-QFN (9x9 mm)
Mounting Type Surface Mount
Temperature Grade Industrial (-I suffix)
Instructions 130 powerful instructions, most single-cycle

ATMEGA645-16MI 64-qfn (9x9 mm) Pin Configuration Guide

Pin configuration for ATMEGA645-16MI (64-qfn (9x9 mm) package). This digital IC includes GPIO, communication interfaces (UART, SPI, I2C), and power pins. Refer to the manufacturer datasheet for alternate pin functions and configuration options. Essential for embedded system design and PCB layout.

64-qfn (9x9 mm) package pinout diagram for ATMEGA645-16MI

No detailed pinout data available for ATMEGA645-16MI.

Refer to the datasheet for full pin configuration.

Typical Applications

ATMEGA645-16MI is suitable for 6 applications: Industrial Control Panels with LCD, Battery-Powered Metering, HVAC and Building Automation Controllers, Consumer Appliance Displays, Portable Test and Measurement Instruments, Automotive-Adjacent and Security Panel Electronics.

🏭

Industrial Control Panels with LCD

The ATMEGA645-16MI is a natural fit for industrial HMI panels because it integrates a segment LCD controller directly on-chip, eliminating an external LCD driver IC and its SPI/I2C bus overhead. With 53 programmable I/O lines, one device can drive the LCD, scan a key matrix, and control relays or LEDs simultaneously. The 64KB ISP Flash accommodates multi-language menu structures and firmware field updates via boot-loader self-programming, while the 8-channel 10-bit ADC reads potentiometers, sensors, and supply-monitoring dividers. The 16MHz core executes most of its 130 instructions in a single cycle, keeping menu response times well under human-perception thresholds. Industrial temperature grading (-I suffix) supports panel environments up to the datasheet industrial limit.

Battery-Powered Metering

For electricity, water, and heat meters, the ATMEGA645-16MI combines the segment LCD driver, a low-power AVR core, and multiple sleep modes (Idle, Power-down, Power-save, Standby) in one die, minimizing bill-of-materials and quiescent drain. The 8-channel 10-bit ADC samples current and voltage sensing channels, while 2KB EEPROM stores calibration coefficients and accumulated consumption records through power cycles. The 16MHz single-cycle RISC core lets the meter complete accumulation math rapidly and return to Power-save, extending battery life in the field. Boot-loader-based Flash reprogramming over UART or SPI allows metrology firmware updates without opening the meter enclosure, an important field-service cost saver for utilities deploying large installed bases.

🧩

HVAC and Building Automation Controllers

The ATMEGA645-16MI suits thermostat and zone-controller boards where a display, sensors, and actuation converge. The integrated LCD controller drives temperature and setpoint digits directly, the 10-bit ADC reads NTC thermistors and humidity dividers across its 8 channels, and the 53 I/O lines operate valve and damper drives. The 64KB Flash is large enough to hold PID control loops, scheduling tables, and communication stacks, and the JTAG interface supports boundary-scan test on production boards as well as on-chip debugging during development. Industrial temperature grading tolerates control-cabinet ambient conditions, and Read-While-Write Flash allows the boot section to update application firmware over a building-management UART link without interrupting control output during the update cycle.

📺

Consumer Appliance Displays

Appliances such as ovens, washing machines, and coffee machines need a segmented display, a key-scanner, and relay or triac control - exactly the combination the ATMEGA645-16MI integrates. The on-chip LCD controller drives digits and icons without external drivers, cutting BOM cost and board area in cost-sensitive products. The 16MHz throughput handles UI event processing and safety-logic polling with margin, and the 64KB Flash stores multiple wash/heat programs plus diagnostics logs in EEPROM. In-system programmability supports end-of-line firmware configuration on the production floor: the same unprogrammed PCB serves multiple SKU variants, reducing inventory complexity. The 64-pin QFN 9x9 mm footprint keeps controller electronics compact behind the user interface panel.

🔧

Portable Test and Measurement Instruments

Handheld meters and dataloggers benefit from the ATMEGA645-16MI's balance of low power, LCD, ADC, and debug capability. The 8-channel 10-bit ADC digitizes measurement front ends, while the JTAG interface enables both on-chip debugging during firmware bring-up and boundary-scan manufacturing test of the populated PCB. The 16MHz clock gives sufficient compute for averaging, scaling, and linearization math in firmware, and the 4KB SRAM holds rolling data buffers for logging to EEPROM. Sleep modes keep standby drain low between measurements, and the industrial-grade -16MI speed rating holds across the specified temperature range for field instruments. The self-programming Flash supports in-field firmware updates through a maintenance UART or USB-serial bridge.

🎥

Automotive-Adjacent and Security Panel Electronics

Access-control keypads, alarm panels, and parking/entry terminals use the ATMEGA645-16MI for its combination of a large I/O count, LCD feedback, and robust Flash architecture. The 53 GPIO lines scan large key matrices and drive locking outputs, the LCD controller shows entry status and menus, and the 2KB EEPROM retains user codes and event counters through power interruptions. The 64KB program space supports rolling-code algorithms and multi-tenant menu logic. JTAG boundary scan simplifies production test of densely populated security boards, and Power-save mode keeps standby current acceptable for mains-backed battery-reserve operation. Note that this part is not AEC-Q100 qualified, so it targets building and light-vehicle-adjacent electronics rather than in-powertrain automotive systems.

What is the ATMEGA645-16MI microcontroller?
The ATMEGA645-16MI is an 8-bit AVR RISC microcontroller from Microchip Technology (formerly Atmel) with 64KB of In-System Programmable Flash, 4KB SRAM, 2KB EEPROM, 53 I/O lines, an 8-channel 10-bit ADC, and a JTAG debug interface. It runs at up to 16MHz and comes in a 64-pin QFN (9x9 mm) surface-mount package.
What is the maximum clock speed of the ATMEGA645-16MI?
The ATMEGA645-16MI supports a maximum core clock of 16MHz, delivering approximately 16 MIPS throughput since most of its 130 AVR instructions execute in a single clock cycle. The -16 speed grade is valid across the industrial temperature range denoted by the MI suffix.
How much program memory does the ATMEGA645-16MI have?
The ATMEGA645-16MI provides 64KB (32K x 16 organization) of In-System Programmable Flash with Read-While-Write capability, plus 4KB of SRAM and 2KB of EEPROM for data retention. According to the Atmel/Microchip datasheet, boot-section self-programming allows firmware updates over SPI, UART, or JTAG without a chip remove-and-replace cycle.
Where to download the ATMEGA645-16MI datasheet PDF?
The ATMEGA645-16MI datasheet PDF is available from Microchip Technology's official website and from mirrored datasheet archives such as alldatasheet.com, which hosts the 347-page Atmel document covering the ATmega325/3250/645/6450 family. Always prefer the latest revision on microchip.com for design work, as Atmel legacy documents may not include the newest errata.
What is the difference between ATMEGA645-16MI and ATMEGA645-16MU?
The difference is packaging and pin count: the ATMEGA645-16MI is a 64-pin QFN (9x9 mm) MLF package, while the ATMEGA645-16MU is offered in a 64-QFN variant with the same die, 64KB Flash, 4KB SRAM, 16MHz speed, and identical peripherals. Both are industrial-temperature AVR parts and the MU is the closest drop-in candidate in the same family.
Does the ATMEGA645-16MI have an LCD controller?
Yes, the ATmega645 includes an integrated segment LCD controller, which distinguishes it from the pin-similar ATmega644 that lacks this peripheral. This makes the ATMEGA645-16MI particularly attractive for panel meters, thermostats, and instrument displays where a driver-less MCU would require an external LCD controller IC and additional board area.
Can the ATMEGA645-16MI be programmed in-system?
Yes, the ATMEGA645-16MI supports In-System Programming (ISP) through the SPI port, JTAG, or boot-loader firmware. The 64KB Flash features Read-While-Write sections so that boot code can reprogram application code while the device remains soldered on the PCB, which reduces production and field-update cost.
What is the best drop-in replacement for ATMEGA645-16MI?
The closest drop-in replacement is the ATMEGA645-16MU, which uses the same die and peripheral set in the 64-pin QFN family. Within the same package, the ATMEGA325-16MI shares the footprint but offers only 32KB Flash (half the program memory), so it is a downgrade rather than a true substitute. No verified cross-brand pin-compatible equivalent was found in current cross-reference searches.
Is ATMEGA645-16MI suitable for battery-powered applications?
Yes. The ATmega645 supports Idle, Power-down, Power-save, and Standby low-power modes designed for battery operation, and its AVR core achieves up to 16 MIPS at 16MHz, allowing the designer to finish tasks quickly and drop into sleep modes. Combined with the integrated LCD driver - which eliminates an external LCD controller - it is well suited for battery-powered metering and portable instruments.
What are the key specifications of the ATMEGA645-16MI that engineers should know?
Key specifications: 8-bit AVR RISC core at 16MHz (16 MIPS), 64KB ISP Flash (32K x 16), 4KB SRAM, 2KB EEPROM, 53 programmable I/O lines, 8-channel 10-bit ADC, JTAG on-chip debug, integrated segment LCD controller, and a 64-pin QFN (9x9 mm) package in industrial temperature grade. These figures come from the Atmel/Microchip family datasheet.
Where to buy ATMEGA645-16MI and what does it cost?
The ATMEGA645-16MI is stocked at DigiKey, where the listing states "Buy now, ships today," and is also offered by distributors such as Nantian Electronics and Microchip USA. As of 2026-09-18, XAIPART lists quantity pricing from approximately $6.20 at qty 1 down to about $3.92 at qty 1000; verify live pricing before ordering since MCU commodity prices fluctuate with stock conditions.
Is the ATMEGA645-16MI still in production?
Yes, the ATMEGA645-16MI is currently listed as an active, orderable part by Microchip Technology and DigiKey, with stock available for same-day shipment as of the latest distributor listings. The device was originally introduced by Atmel, which Microchip acquired in 2016, so documentation and support now live under the Microchip brand.
Hey Google, what can replace an ATMEGA645-16MI?
Replace an ATMEGA645-16MI first with the ATMEGA645-16MU (same die, same 64-QFN family). If the LCD controller is not required, the ATmega644 series offers a similar peripheral set in different packages but is NOT pin-compatible with the 64-QFN footprint, so a PCB redesign would be needed. For exact-footprint swaps, stay within the ATmega325/645 family.
Is the ATMEGA645-16MI the same as the ATMEGA6450-16MI?
No. The ATMEGA645 and ATMEGA6450 share the same 64KB Flash, 4KB SRAM, and 2KB EEPROM core, but they belong to different pin-count variants of the family: the 6450 targets larger packages with more I/O, while the 645 is the 64-pin variant with 53 I/O lines and the LCD controller. Verify the pin count on your PCB footprint before substituting between the two.
What are the best Microchip equivalents for the ATMEGA645-16MI?
Within Microchip's own catalog, the best equivalents are the ATMEGA645-16MU (same QFN die variant) and the ATMEGA6450-16A family for larger-package designs. No competitor equivalent from STMicroelectronics, NXP, or Renesas was identified as pin-to-pin compatible with the 64-QFN ATmega645 footprint in the cross-reference searches reviewed, so a second-source migration would require PCB redesign.
How many GPIO pins does the ATMEGA645-16MI have?
The ATMEGA645-16MI provides 53 programmable I/O lines across its 64-pin QFN package, per the Atmel family datasheet. The remaining pins are used for power (VCC/AVCC/GND), reset, crystal/oscillator, and JTAG, so designers should budget roughly 82% of package pins as usable general-purpose I/O in their pin-planning.

Engineering reference data for ATMEGA645-16MI — comparison, design guidance, and compliance information.

Selection Guide

Choose the ATMEGA645-16MI when your board needs 64KB of program space, a segment LCD, and 53 I/O lines in a 64-QFN 9x9 mm industrial-temperature package - typical for meters, HMI panels, and appliances. If your PCB already uses this footprint but your code fits in 32KB, the ATMEGA325-16MI is the same-socket, lower-cost option. If you do not need the LCD controller, the ATmega644/644P family offers two UARTs and a similar peripheral set, but requires a different PCB layout. Within the exact footprint, the ATMEGA645-16MU is the drop-in twin - use it for second-sourcing or when the QFN variant better matches your supply chain. There is no verified cross-brand pin-compatible equivalent; migrating to another vendor's MCU means a redesign. Honest trade-off: this is an older 8-bit AVR core without hardware USB, DMA, or automotive qualification - modern designs needing those should evaluate newer Microchip AVR or PIC families instead.

Comparison with Alternatives

Parameter This Product ATMEGA645-16MU ATMEGA325-16MI
Package 64-QFN (9x9 mm) 64-QFN (9x9 mm) - same 64-QFN (9x9 mm) - same
Brand Microchip Technology Microchip Technology Microchip Technology
Core Clock 16 MHz 16 MHz 16 MHz
Program Flash 64 KB 64 KB 32 KB (-50%)
SRAM 4 KB 4 KB 2 KB (-50%)
EEPROM 2 KB 2 KB 1 KB
LCD Controller Yes Yes Yes
I/O Lines 53 53 53
Temperature Grade Industrial (-I) Industrial Industrial (-I)

Key Differentiators

  • Integrated segment LCD controller (vs ATMEGA64-16MI)
  • Double the program memory of the footprint-identical sibling (vs ATMEGA325-16MI)
  • Single-cycle RISC efficiency (vs ATMEGA645-16MU)

Design Notes

Estimated: a 64-QFN 9x9 AVR running at 16MHz with 20pF load capacitance typically draws several mA active plus I/O load current; budget the 3.3V or 5V rail accordingly and place 100nF ceramic decoupling on every VCC/AVCC pin pair plus 10uF bulk near the package. The ADC needs a clean AVCC, so feed it through an LC filter or ferrite bead from the digital rail to keep 10-bit ENOB across all 8 channels.

The 64-QFN (9x9) MLF package has an exposed die pad underneath that must be soldered to a grounded copper area with an array of thermal vias - this pad is the primary ground and heat path, and skipping it causes both elevated junction temperature and unreliable ground returns. Use ~4 to 5 mil stencil apertures with roughly 50-60% coverage on the pad to avoid voiding and floating.

Do not assume pin compatibility outside the ATmega325/645 family: the ATmega644 has a similar peripheral set but a different pinout on its packages, so substituting it on an ATmega645 footprint will not work. When programming via ISP, the 64KB device needs the correct device signature check in the programmer settings; selecting the wrong ATmega signature causes verification failure. Also verify JTAG fuse state - enabling JTAG consumes four port pins.

Compliance Information

RoHS
Unknown
REACH
Unknown
AEC-Q100
Not Qualified
Lead Free
Unknown
Halogen Free
Unknown
Conflict Minerals
Unknown

Compliance data was not present in the retrieved web data; verify RoHS/REACH status on the official Microchip product page before ordering. Not AEC-Q100 qualified - do not use in automotive powertrain/safety applications.

Data verified on: 2026-09-18 — data verified and curated by XAIPART's component engineering team

Related Searches

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Related Components & Terms

Microchip Technology Atmel Corporation ATMEGA645-16MI ATMEGA645-16MU ATMEGA325-16MI ATmega644 AVR 8-bit RISC microcontroller microcontroller In-System Programmable Flash JTAG 10-bit ADC 64-QFN (9x9 mm) MLF package QFN family surface mount segment LCD controller EEPROM In-System Programming (ISP) industrial temperature grade RoHS MegaCore battery metering HMI panel
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