Microchip Technology

ATSAMC21N18A-ANT - 48MHz Cortex-M0+ MCU 256KB Flash TQFP-100 | Microchip

MPN: ATSAMC21N18A-ANT ✓ Active
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2.7 V to 5.5 V Vdss 100-pin TQFP (14x14 mm) Package 48 MHz Speed 256 KB (in-system self-programmable) Memory
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Price updated: 2026-09-20
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10 $5.45 $54.50
100 $4.88 $488.00
500 $4.46 $2,230.00
1,000 $4.12 $4,120.00
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ATSAMC21N18A-ANT Overview

The Microchip ATSAMC21N18A-ANT is an ARM Cortex-M0+ 32-bit microcontroller in the SAM C21 family, operating at up to 48 MHz with 256 KB of in-system self-programmable Flash and 32 KB SRAM in a 100-pin TQFP (14x14 mm) package. It is designed for 5V-tolerant industrial and commercial applications in electrically noisy environments and integrates a CAN-FD controller alongside the SERCOM configurable serial communication blocks. The -ANT suffix denotes the tape-and-reel packaging variant for high-volume production, and the device is rated for the -40C to +105C industrial temperature range.

A microcontroller (MCU) is a single-chip computer that integrates a CPU core, program and data memory, peripherals, and I/O into one package. The Cortex-M0+ is the most energy-efficient core in the ARM Cortex-M family, designed for deterministic interrupt response, low gate count, and ultra-low power operation. Microcontrollers sit at the lowest tier of embedded compute, beneath microprocessors and application processors, and are the workhorse of industrial control, motor drive, and IoT edge nodes.

Key features of the ATSAMC21N18A-ANT include 256 KB Flash plus 8 KB independent Flash for EEPROM emulation, 32 KB SRAM, a Peripheral Touch Controller (PTC) for capacitive touch interfaces, advanced analog (12-bit ADC, 10-bit DAC, analog comparators, op-amps), and Functional Safety (FuSa) support. The device supports up to 6 SERCOM modules (UART/SPI/I2C configurable), one CAN-FD, USB, I2S, and up to 84 GPIO. Hardware features include a single-cycle multiplier, Micro Trace Buffer, and Memory Protection Unit (MPU).

The architecture pairs a 2-stage pipelined Cortex-M0+ core with a 7-channel DMA, dual-bank Flash with read-while-write, and a low-power RTC. The 5V-tolerant I/O bank and ESD protection (HBM 4 kV) target industrial robustness. The device operates from 2.7V to 5.5V, allowing direct connection to legacy 5V logic without level shifters.

Typical applications include industrial CAN-FD nodes, motor control (BLDC/PMSM FOC), smart energy metering, building automation, capacitive touch human-machine interfaces, and functional-safety subsystems. Automotive body and chassis modules are supported within the broader SAM C21 family. Compared with a discrete microcontroller plus external CAN transceiver, the integrated CAN-FD reduces BOM count and PCB area.

When designing with this part, allocate adequate decoupling on all VDD pins (100 nF + bulk), connect unused inputs to defined logic levels, and follow Microchip EMC guidelines for 5V noisy environments. The device is supported by MPLAB X IDE, Atmel Studio 7, and the MPLAB Harmony v3 framework with code generators for SERCOM, CAN-FD, and PTC peripherals.

Drop-in alternatives for ATSAMC21N18A-ANT — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with ATSAMC21N18A-ANT (same form factor and footprint) — differing in Package, Operating Temperature, RoHS Status, ADC, Core.

Microchip Technology
RoHS Status: Compliant (Green, lead-free)
ADC: 12-bit
Core: ARM Cortex-M0+ (32-bit)
Compare with ATSAMC21N18A-ANT →
Microchip Technology
Package: 48-TQFP (7x7 mm)
Operating Temperature: -40C to +105C
RoHS Status: Compliant
Compare with ATSAMC21N18A-ANT →
Microchip Technology
Package: 64-VQFN (9x9 mm) with exposed pad
Operating Temperature: -40C to +85C (industrial)
RoHS Status: Compliant
Compare with ATSAMC21N18A-ANT →
Microchip Technology
Package: 100-pin TQFP, 14x14 mm, 0.5 mm pitch
Operating Temperature: -40 °C to +105 °C (industrial)
RoHS Status: Compliant (Green, lead-free)
Compare with ATSAMC21N18A-ANT →

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

ATSAMC21N18A-AN

✅ Drop-In
Microchip Technology
📦 TQFP-100 (14x14)
ARM Cortex-M0+ (32-bit) · SAM C21 (Functional Safety / FuSa) · 48 MHz · 256 KB (256K x 8), in-system self-programmable · 32 KB · 8 KB independent self-programmable Flash · 2.7 V to 5.5 V · -40 °C to +105 °C (industrial)

✓ In Stock

$3.99 / Unit

View Datasheet →

ATSAMC21N17A-ANT

✅ Drop-In
📦 TQFP-100 (14x14)
128 KB Flash vs 256 KB Flash (-50%), 32 KB SRAM identical, same TQFP-100 footprint and pinout

📋 Reference alternative (not in catalog)

ATSAMC21G18A-ANT

✅ Drop-In ⚠️ 参数待验证
Microchip Technology
📦 TQFP-48
ARM Cortex-M0+ · 32-bit · 48 MHz · 256 KB (256K x 8) · 32 KB · 8 KB · 2.7 V to 5.5 V · -40C to +105C

✓ In Stock

$4.62 / Unit

View Datasheet →

ATSAMC21J18A-MUT64

✅ Drop-In ⚠️ 参数待验证
Microchip Technology
📦 QFN-64
ARM Cortex-M0+ (32-bit) · 48 MHz · 256 KB · 32 KB · 8 KB (independent self-programmable) · 2.7 V to 5.5 V · 1.62 V to 3.6 V (5V-tolerant I/O) · 52 (approx., 64-VQFN)

✓ In Stock

$2.85 / Unit

View Datasheet →

ATSAMC21N18A-ANT Maximum Ratings & Electrical Characteristics

Core ARM Cortex-M0+ (32-bit, single-core)
Maximum CPU Clock 48 MHz
Flash Memory 256 KB (in-system self-programmable)
EEPROM Emulation Flash 8 KB (independent self-programmable)
SRAM 32 KB
Supply Voltage (VDD) 2.7 V to 5.5 V
Operating Temperature -40C to +105C (industrial)
Package 100-pin TQFP (14x14 mm)
GPIO Count Up to 84
Communication Interfaces 6x SERCOM (UART/SPI/I2C), 1x CAN-FD, USB, I2S
Analog Peripherals 12-bit ADC, 10-bit DAC, comparators, op-amps, PTC
DMA Channels 7
Multipliers Single-cycle hardware multiplier
Memory Protection Unit (MPU) Yes
Micro Trace Buffer Yes
Functional Safety (FuSa) Yes
RoHS Status Compliant (Green)
Mounting Type Surface Mount

ATSAMC21N18A-ANT 100-pin tqfp (14x14 mm) Pin Configuration Guide

Pin configuration for ATSAMC21N18A-ANT (100-pin tqfp (14x14 mm) package). This digital IC includes GPIO, communication interfaces (UART, SPI, I2C), and power pins. Refer to the manufacturer datasheet for alternate pin functions and configuration options. Essential for embedded system design and PCB layout.

100-pin tqfp (14x14 mm) package pinout diagram for ATSAMC21N18A-ANT

No detailed pinout data available for ATSAMC21N18A-ANT.

Refer to the datasheet for full pin configuration.

Typical Applications

ATSAMC21N18A-ANT is suitable for 6 applications: Industrial CAN-FD Node, BLDC / PMSM Motor Control, Capacitive Touch HMI, Smart Energy Metering, Building Automation Controller, USB-CDC Service / Debug Port.

🏭

Industrial CAN-FD Node

The ATSAMC21N18A-ANT integrates a CAN-FD controller (ISO 11898-1:2015) with 5V-tolerant I/O and 84 GPIO, making it ideal for industrial CAN nodes such as PLC I/O modules, sensor concentrators, and building automation gateways. Its 256 KB Flash supports complex CANopen or J1939 protocol stacks, while 32 KB SRAM buffers inbound frames without dropping. Pair with an external CAN transceiver (e.g., MCP2562FD) for a complete isolated or non-isolated node.

BLDC / PMSM Motor Control

The ATSAMC21N18A-ANT delivers 48 MHz Cortex-M0+ performance with a 12-bit ADC, 10-bit DAC, and analog comparators, sufficient to implement sensorless FOC on a BLDC or PMSM motor up to several hundred watts. Its 5V I/O eliminates level shifters to 5V gate drivers, and the integrated PTC frees GPIO for PWM channels. The 32 KB SRAM fits classic FOC libraries, while 256 KB Flash reserves room for application profiles and diagnostics.

🧩

Capacitive Touch HMI

The integrated Peripheral Touch Controller (PTC) supports driven-shield and mutual-capacitance touch sensing without an external touch IC, enabling sealed glass-front HMIs for appliances, industrial controls, and medical devices. The 256 KB Flash accommodates touch algorithms and UI state machines, while the Cortex-M0+ core leaves headroom for host communication. The -40C to +105C rating suits outdoor and appliance-front environments.

💡

Smart Energy Metering

The ATSAMC21N18A-ANT's 12-bit ADC, dual op-amps, and analog comparators implement single-phase energy measurement for residential or industrial metering. The 5V supply range allows direct connection to mains-derived DC rails without LDO chains, and 256 KB Flash supports DLMS/COSEM or Modbus stacks. The RTC with calendar and the low-power run modes help meet standby targets under IEC 62053-21.

🌐

Building Automation Controller

With 6 SERCOM channels (UART/SPI/I2C configurable), CAN-FD, and USB, the ATSAMC21N18A-ANT acts as a unified controller for HVAC, lighting, and access-control subsystems. The 84 GPIO handle multiple keypad/LED matrices, while the 5V-tolerant I/O directly drives relays without drivers. Functional Safety (FuSa) features support safety-integrity requirements for elevators, fire dampers, and certified appliances.

📱

USB-CDC Service / Debug Port

The integrated USB 2.0 Full-Speed peripheral with on-chip transceiver enables USB-CDC virtual COM ports for firmware updates, log streaming, or field service without external PHY. The 256 KB Flash supports USB MSD bootloaders (e.g., Microchip's Unified Bootloader Host application), and the 5V-tolerant PB22/PB23 USB pins simplify bus-powered designs with direct 5V VBUS sense without resistor dividers.

Recommended Products Summary

MCP2562FD External CAN-FD transceiver for physical bus Used in: Industrial CAN-FD Node, Building Automation Controller ATSAMC21MOTOR Microchip Technology Used in: Industrial CAN-FD Node, BLDC / PMSM Motor Control MCP8024 Three-phase BLDC gate driver companion Used in: BLDC / PMSM Motor Control AT42QT2120 External I2C touch IC for very high channel counts Used in: Capacitive Touch HMI MCP2518FD External CAN-FD controller if migrating to non-SAM MCU Used in: Capacitive Touch HMI MCP3911 Companion energy-metering AFE for three-phase designs Used in: Smart Energy Metering ATSAMR30 Wireless sub-GHz module for AMI network connectivity Used in: Smart Energy Metering ATECC608B Cryptographic authentication and secure element Used in: Building Automation Controller FUSB302 USB Type-C CC logic companion for USB-C hosts Used in: USB-CDC Service / Debug Port MCP2221A USB-to-UART bridge alternative if MCU USB pins are unavailable Used in: USB-CDC Service / Debug Port
What is the operating voltage of the ATSAMC21N18A-ANT?
The ATSAMC21N18A-ANT operates from 2.7V to 5.5V supply on VDDIN/VDDIO, per the manufacturer datasheet. This wide 5V-tolerant range allows direct interface to legacy 5V logic without external level shifters, simplifying industrial designs. Decoupling on every VDD pin is recommended.
How much Flash and SRAM does the ATSAMC21N18A-ANT have?
The ATSAMC21N18A-ANT integrates 256 KB of in-system self-programmable Flash plus 8 KB of independent Flash for EEPROM emulation, backed by 32 KB SRAM. This is the highest-memory variant of the SAM C21N family and supports dual-bank read-while-write firmware updates.
Does the ATSAMC21N18A-ANT support CAN-FD?
Yes. The ATSAMC21N18A-ANT integrates a CAN-FD controller compliant with ISO 11898-1:2015, supporting both classic CAN 2.0B and CAN-FD frames with higher data-rate payloads. An external CAN transceiver (e.g., MCP2562FD or TLE7250-3GE) is required to connect to the physical bus.
What is the difference between ATSAMC21N18A-ANT and ATSAMC21N18A-AN?
Both parts share identical silicon, pinout, and electrical specifications in the 100-pin TQFP package; the -ANT suffix designates tape-and-reel packaging for production, while -AN is supplied in tray. Functionally they are drop-in interchangeable on the same PCB footprint and BOM.
Where can I download the ATSAMC21N18A-ANT datasheet PDF?
The official Microchip ATSAMC21N18A-ANT datasheet PDF is available on the Microchip product page (microchip.com/en-us/product/ATSAMC21N18A) and at distributors such as DigiKey and Mouser. Search the Microchip document library for DS60001879 to retrieve the latest revision directly.
Where to buy ATSAMC21N18A-ANT online?
The ATSAMC21N18A-ANT can be purchased directly from Microchip via microchipDIRECT, or from authorized distributors including DigiKey (stock check on the ATSAMC21N18A-ANT product page) and Mouser Electronics. LCSC also lists the part starting around USD 4.88 as of 2026-09-21. Lead time varies with order quantity.
What is the price of the ATSAMC21N18A-ANT?
As of 2026-09-21, ATSAMC21N18A-ANT prices start at approximately USD 4.88 at LCSC for 100-piece quantities, and USD 6.05 at 1-piece break. Volume pricing on Mouser and DigiKey drops below USD 4.50 at 1000-piece reels. Pricing fluctuates with distributor stock and demand.
What is the lead time for the ATSAMC21N18A-ANT?
As of 2026-09-21, OEM-Trade quotes 10 weeks lead time on 1000-piece reel orders, while DigiKey lists factory stock with same-day shipping when inventory is available. Lead times vary by distributor; microchipDIRECT is recommended for production volumes with managed delivery.
ATSAMC21N18A-ANT vs STM32G071CBT6 - which is better for CAN-FD industrial nodes?
The ATSAMC21N18A-ANT uses an ARM Cortex-M0+ at 48 MHz with 5V-tolerant I/O, integrated CAN-FD, and 256 KB Flash, while the STM32G071CBT6 uses Cortex-M0+ at 64 MHz with 3.3V I/O. For 5V industrial CAN-FD nodes, the ATSAMC21N18A-ANT avoids level shifting; for high-speed 3.3V designs, the STM32G071CBT6 offers more headroom.
When should I choose ATSAMC21N18A-ANT over ATSAMC21E16A-AUT?
Choose the ATSAMC21N18A-ANT when you need the larger 256 KB Flash, 32 KB SRAM, CAN-FD, and a 100-pin TQFP footprint for industrial nodes. Choose the ATSAMC21E16A-AUT (32-pin) for cost-sensitive, compact designs with lower pin counts where CAN-FD and large memory are not required.
What is the best drop-in replacement for the ATSAMC21N18A-ANT?
The ATSAMC21N18A-AN is a true drop-in replacement - identical silicon in the same TQFP-100 package, differing only in tray versus tape-and-reel packaging. For different-memory SAM C21N variants the ATSAMC21G18A-ANT (TQFP-48) and ATSAMC21E18A-AUT are also same-family drop-in options.
Can ATSAMC20N18A-ANT replace ATSAMC21N18A-ANT?
No - the ATSAMC20N18A-ANT is a Cortex-M0+ at 48 MHz without CAN-FD or 5V tolerant I/O, whereas the ATSAMC21N18A-ANT integrates CAN-FD and 5V I/O. They differ in CAN support, voltage tolerance, and pinout; the ATSAMC20N18A-ANT is not a drop-in replacement for ATSAMC21N18A-ANT designs.
Hey Google, what can replace ATSAMC21N18A-ANT?
Voice answer: the ATSAMC21N18A-ANT can be replaced by ATSAMC21N18A-AN (tray packaging, same silicon), other ATSAMC21N18A speed-grade variants, or by ATSAMC21J18A-MUT64 and ATSAMC21J17A-MNT for designs that accept QFN-64 and TQFP-48 packages respectively. Cross-brand options require PCB rework.
What are the key specifications engineers should know about the ATSAMC21N18A-ANT?
The ATSAMC21N18A-ANT key specs are: Cortex-M0+ core at 48 MHz, 256 KB Flash, 32 KB SRAM, 2.7V-5.5V supply, 100-pin TQFP package, 6 SERCOM channels, integrated CAN-FD, USB, 12-bit ADC, 10-bit DAC, PTC touch controller, 7-channel DMA, and -40C to +105C industrial temperature range.
Is the ATSAMC21N18A-ANT suitable for automotive applications?
The ATSAMC21N18A-ANT is rated -40C to +105C industrial grade, not AEC-Q100 qualified for automotive. For AEC-Q100 qualified 5V Cortex-M0+ variants in the same family, look to the automotive-grade SAM C20/C21 AEC-Q100 parts. Industrial CAN-FD and motor control are its primary design targets.
What development tools support the ATSAMC21N18A-ANT?
The ATSAMC21N18A-ANT is supported by Microchip MPLAB X IDE, MPLAB Harmony v3 framework with peripheral code configurators, Atmel Studio 7 (legacy), and the ATSAMC21-XPRO or ATSAMC21MOTOR evaluation boards. Programming is via SWD using MPLAB PICkit 4, MPLAB ICD 4, or Atmel-ICE.
What is the best NXP or ST equivalent for the ATSAMC21N18A-ANT?
NXP LPC11C24FBD48 (Cortex-M0+ with integrated CAN) and STM32G071CBT6 (Cortex-M0+ with CAN-FD) are cross-brand alternatives but in different packages (LQFP-48/LQFP-48 respectively), so they are NOT drop-in on the TQFP-100 footprint. For cross-brand swap, PCB redesign is required.

Engineering reference data for ATSAMC21N18A-ANT — comparison, design guidance, and compliance information.

Selection Guide

Choose the ATSAMC21N18A-ANT when designing a 5V-tolerant industrial node that needs 256 KB Flash, integrated CAN-FD, and a 100-pin TQFP footprint. It is the highest-memory, full-pinout variant of the SAM C21N family and is optimal for CANopen/J1939 stacks, BLDC motor control, and capacitive-touch HMIs in noisy environments. Choose the ATSAMC21N18A-AN if you are prototyping in low volume and prefer tray packaging. Choose the ATSAMC21N17A-ANT if 128 KB Flash is sufficient (50% cost savings). For compact 48-pin designs, the ATSAMC21G18A-ANT (TQFP-48) shares the same 256 KB Flash but reduces GPIO count. For QFN-64 layouts, the ATSAMC21J18A-MUT64 is the same silicon with 64 pins. Cross-brand alternatives (NXP LPC11C24FBD48, STM32G071CBT6) require PCB redesign and are NOT drop-in replacements.

Comparison with Alternatives

Parameter This Product ATSAMC21N18A-AN ATSAMC21N17A-ANT ATSAMC21G18A-ANT ATSAMC21J18A-MUT64
Package TQFP-100 (14x14) TQFP-100 (14x14) - same TQFP-100 (14x14) - same TQFP-48 QFN-64
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Core ARM Cortex-M0+ 48 MHz ARM Cortex-M0+ 48 MHz ARM Cortex-M0+ 48 MHz ARM Cortex-M0+ 48 MHz ARM Cortex-M0+ 48 MHz
Flash 256 KB 256 KB 128 KB (-50%) 256 KB 256 KB
SRAM 32 KB 32 KB 32 KB 32 KB 32 KB
CAN-FD Yes (integrated) Yes Yes Yes Yes
Supply Voltage 2.7V - 5.5V (5V-tolerant I/O) 2.7V - 5.5V 2.7V - 5.5V 2.7V - 5.5V 2.7V - 5.5V
Operating Temperature -40C to +105C -40C to +105C -40C to +105C -40C to +105C -40C to +105C
Packaging Tape & Reel (-ANT) Tray (-AN) Tape & Reel Tape & Reel Tape & Reel
Pin Count 100 100 100 48 (-52%) 64 (-36%)

Key Differentiators

  • Integrated CAN-FD controller (ISO 11898-1:2015) (vs ATSAMC20N18A-ANT)
  • 5V-tolerant I/O across all 84 GPIO (vs ATSAMC21J18A-MUT64)
  • Higher memory variant with EEPROM emulation Flash (vs ATSAMC21N17A-ANT)
  • Tape-and-reel packaging for high-volume production (vs ATSAMC21N18A-AN)

Design Notes

The ATSAMC21N18A-ANT requires decoupling on every VDD pin pair: 100 nF X7R ceramic placed within 3 mm of each VDD pin, plus a single 4.7 uF bulk capacitor on the main 3.3V or 5V rail. Per the manufacturer datasheet, separate analog and digital supply pins (VDDANA/VDDIO) must be decoupled independently to keep ADC noise below 1 LSB at 12-bit resolution.

Route the 48 MHz main crystal traces symmetrically with ground guard traces on both sides and keep the trace length under 5 mm. Place C_LOAD capacitors at the XIN/XOUT pins, not at the crystal body. For 5V noisy environments, add a ferrite bead on VDDANA to suppress switching noise from injecting into the ADC reference path.

Do not leave any unused GPIO floating - the SAM C21 datasheet mandates every unused I/O be configured as output low or input with internal pull enabled to avoid parasitic current draws of several hundred microamps per pin. Configure the NVMCTRL write protection lockbits before deployment to prevent accidental Flash corruption from runaway code.

Separate analog and digital ground planes with a single-point bridge under the VDDANA decoupling capacitor. Keep high-speed SERCOM SPI traces short (<50 mm) and add 33 ohm source-series termination if the trace exceeds 25 mm. The CAN-FD TX/RX lines to the external transceiver must be length-matched within 5 mm to maintain signal symmetry up to 5 Mbps.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Qualified
Lead Free
Yes
Halogen Free
Yes
Conflict Minerals
Compliant

Industrial grade (-40C to +105C), not AEC-Q100 qualified for automotive. RoHS compliant and Green per Microchip product page.

Data verified on: 2026-09-21 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

Microchip Technology ATSAMC21N18A-ANT ATSAMC21N18A-AN ATSAMC21N17A-ANT ATSAMC20N18A-ANT ATSAMC21J18A-MUT64 ATSAMC21G18A-ANT ARM Cortex-M0+ 32-bit microcontroller SAM C21 family CAN-FD ISO 11898-1:2015 TQFP-100 package TQFP package family surface mount RoHS Functional Safety (FuSa) Peripheral Touch Controller (PTC) SERCOM USB 2.0 Full-Speed 12-bit ADC industrial CAN node BLDC motor control MPLAB Harmony v3
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