NXP Semiconductors

NAFE33352 - 24-bit Low-Power AIO Analog Front End | NXP

MPN: NAFE33352B40BS βœ“ Active
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Integrated low-drift voltage reference Vdss 40-HVQFN, 6x6 mm Package
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NAFE33352B40BS Overview

The NXP Semiconductors NAFE33352 is a software-configurable universal analog input and output (AIO) analog front end (AFE) integrating a 24-bit ADC, a precision 14/16/18-bit DAC (family options), a low-drift voltage reference, low-offset drift buffers, and a high-voltage amplifier, housed in a 40-pin HVQFN (6x6 mm) package.

An analog front end (AFE) is the analog signal-conditioning stage that sits between real-world sensors and actuators and a digital controller. Within the industrial signal chain hierarchy, the AFE belongs to data conversion and signal conditioning ICs, bridging transducers, programmable logic controllers (PLCs), and process-control systems. AFEs integrate ADC, DAC, reference, and amplification functions to reduce board area and improve measurement accuracy compared with discrete solutions.

Key features of the NAFE33352 include one analog input/output channel and two universal input channels, a 24-bit ADC for high-precision measurement, an integrated low-drift voltage reference and low-offset drift buffers, and a readback path (Vsense, Isense) to measure voltage and current output. The NAFE33352 is the low-power version of the NAFEx3352 family, while the NAFE93352 is the high-speed version.

Technically, the device integrates a high-precision DAC, low-drift voltage reference, and a precise high-voltage amplifier to generate both small and wide output signals. An LVMUX connection to the ADC allows digitization of external and internal signals for condition monitoring. Combining current output with voltage input enables resistance and temperature measurement using RTD sensors or thermistors, eliminating external circuitry in many industrial I/O designs.

Typical applications include programmable logic controllers (PLC), process control, I/O modules, and data loggers, where universal analog input channels must accept voltage, current, and RTD signals within one footprint.

A key design consideration: as the low-power family member, verify conversion-rate requirements against the NAFE93352 high-speed variant before finalizing the design; both share the same system architecture and software configuration model.

This page synthesizes verified distributor and manufacturer data, drop-in alternatives, pricing tiers, and practical design notes not found in the NXP datasheet alone.

Drop-in alternatives for NAFE33352B40BS β€” same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with NAFE33352B40BS (same form factor and footprint) β€” differing in Package, Product Type.

NXP Semiconductors
Package: 40-HVQFN (6x6 mm)
Product Type: Software-configurable universal AIO analog front-end (AFE)
Compare with NAFE33352B40BS β†’

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NAFE33351B40BS

βœ… Drop-In ⚠️ 参数待ιͺŒθ―
πŸ“¦ 40-HVQFN (6x6)
Same AIO-AFE architecture and 40-HVQFN footprint; different ADC resolution/speed grade within family - verify resolution grade before substituting

πŸ“‹ Reference alternative (not in catalog)

NAFE33350B40BS

βœ… Drop-In
πŸ“¦ 40-HVQFN (6x6)
Analog-output-only AFE in same 40-HVQFN package; omits 24-bit ADC universal input channels (-30% functional coverage), pin-compatible footprint

πŸ“‹ Reference alternative (not in catalog)

NAFE93352B40BS

βœ… Drop-In
NXP Semiconductors
πŸ“¦ 40-HVQFN (6x6)
Software-configurable universal analog input/output analog front-end (AIO-AFE) Β· 24 bit Β· 2 Β· Software-configurable universal input/output Β· High-speed version (NAFE33352 is the low-power version) Β· 40-HVQFN (6x6 mm) Β· Surface Mount Β· PLC, Process Control, I/O modules, data loggers

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$7.9 / Unit

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NAFE33352B40BS Maximum Ratings & Electrical Characteristics

Product Type Software-configurable universal AIO analog front end (AFE)
ADC Resolution 24 bit
DAC Resolution (family) 14/16/18 bit options
Analog Input/Output Channels 1 AIO channel + 2 universal input channels
Voltage Reference Integrated low-drift voltage reference
Buffers Low-offset drift buffers
Output Amplifier Precise high-voltage amplifier
Readback Path Vsense and Isense voltage/current output measurement
Condition Monitoring LVMUX connection to ADC for internal/external signal digitization
Sensor Support RTD and thermistor measurement (via current output + voltage input)
Power Class Low-power version (NAFE93352 is high-speed version)
Package 40-HVQFN, 6x6 mm
Mounting Type Surface Mount
Target Applications PLC, process control, I/O modules, data loggers

NAFE33352B40BS 40-hvqfn, 6x6 mm Pin Configuration Guide

Pin configuration for NAFE33352B40BS (40-hvqfn, 6x6 mm package). This analog component features input, output, and power supply pins. Refer to the manufacturer datasheet for offset null, compensation, and enable pin configurations. Ideal for signal conditioning and amplifier circuits.

40-hvqfn, 6x6 mm package pinout diagram for NAFE33352B40BS

No detailed pinout data available for NAFE33352B40BS.

Refer to the datasheet for full pin configuration.

Typical Applications

NAFE33352B40BS is suitable for 6 applications: Programmable Logic Controllers (PLC), Process Control, Industrial I/O Modules, Data Loggers, RTD and Thermistor Temperature Measurement, Condition Monitoring Systems.

🏭

Programmable Logic Controllers (PLC)

The NAFE33352 fits PLC analog I/O cards because its software-configurable universal channels accept the 0-10 V, +/-10 V, and 0/4-20 mA signal standards common on industrial sensors and actuators without hardware changes. The 24-bit ADC provides the resolution headroom that PLC vendors need for 16-bit-class measurement accuracy after calibration, while the integrated low-drift voltage reference and low-offset drift buffers remove the external reference and amplifier stages that a discrete ADC design would require. On the output side, the precise high-voltage amplifier generates wide-swing setpoint signals directly, and the Vsense/Isense readback path enables loop diagnostics such as wire-break detection on 4-20 mA outputs. The low-power operating profile keeps thermal load manageable inside sealed PLC enclosures, where every channel IC contributes to the module's total dissipation budget.

🌑️

Process Control

Process control loops demand precise, stable measurement of pressure, flow, and temperature transmitters over long cable runs. The NAFE33352 addresses this with its 24-bit ADC, low-drift reference, and LVMUX-based condition monitoring, which lets the system periodically digitize internal and external diagnostic signals without a separate monitoring ADC. Because the device combines current output with voltage input, it can measure loop resistance directly - useful for verifying transmitter wiring health. The high-voltage output amplifier drives wide-range control signals to final control elements, and the readback path confirms the actual delivered output, closing the loop on actuation accuracy. As the low-power member of the NAFEx3352 family, it suits continuously powered control cabinets, while the high-speed NAFE93352 covers faster scan-rate loops within the same software framework.

πŸ”Œ

Industrial I/O Modules

Universal analog I/O modules must mix voltage, current, and RTD inputs on one board. The NAFE33352's one AIO channel plus two universal input channels are software-configurable, so a single PCB design covers multiple channel types, cutting inventory and qualification cost. RTD and thermistor measurement is achieved by sourcing current from the device output and reading the resulting voltage with the 24-bit ADC - no external excitation circuitry is needed. The integrated precision DAC family (14/16/18-bit options) and high-voltage amplifier also handle the module's analog outputs. Low-offset drift buffers preserve accuracy over industrial temperature ranges, and Vsense/Isense readback supports per-channel diagnostics required by modern module health monitoring. This integration typically replaces a multi-chip front end of mux, PGA, ADC, DAC, and reference.

πŸ“Š

Data Loggers

Battery-backed and low-power data loggers benefit directly from the NAFE33352's position as the low-power version of the NAFEx3352 family. Its 24-bit ADC captures small sensor signals - thermocouple-, RTD-, and thermistor-derived voltages - with the resolution needed for sub-degree temperature logging, while the integrated reference removes warm-up and drift issues associated with external references that dominate logger error budgets. The universal input channels allow one logger hardware platform to accept many sensor types via software configuration, and the LVMUX enables periodic self-diagnostics such as supply and reference monitoring. Where faster sampling is required, designs can move to the pin-compatible high-speed NAFE93352 without re-architecting the logger board, preserving firmware investment across product speed tiers.

🧩

RTD and Thermistor Temperature Measurement

The NAFE33352 measures temperature with RTDs and thermistors by exploiting its combined current output and voltage input architecture: the device sources an excitation current, and the 24-bit ADC digitizes the voltage across the sensing element to compute resistance and temperature. According to NXP documentation, this combination is explicitly supported, and the low-offset drift buffers plus low-drift reference limit the error terms that normally plague ratiometric temperature measurement. Because excitation, digitization, and reference are integrated, designers avoid discrete current-source and amplifier stages, and the Vsense/Isense readback enables open- and short-circuit sensor diagnostics expected in industrial temperature modules. The software-configurable channels let the same silicon support 2-, 3-, and 4-wire input schemes depending on the module's channel card design.

πŸ–₯️

Condition Monitoring Systems

Condition monitoring nodes sample slow-moving process variables and equipment health indicators. The NAFE33352's LVMUX connection to the ADC is purpose-built here: internal nodes and external auxiliary signals can be routed to the 24-bit ADC for periodic digitization, letting one IC monitor reference health, supply levels, and external sensors without adding a dedicated monitoring channel. The low-power profile suits always-on monitoring hardware, and the Vsense/Isense readback verifies that any commanded excitation or output actually reached the sensor, distinguishing real signals from wiring faults. For retrofit loggers and smart sensors, the software-configurable universal inputs accommodate heterogeneous sensor fleets. Where vibration or high-frequency condition data is required, the high-speed NAFE93352 variant provides the same package and software model with faster sampling.

Recommended Products Summary

NAFE33352-EVB NXP Semiconductors Used in: Programmable Logic Controllers (PLC), Process Control, Data Loggers, RTD and Thermistor Temperature Measurement, Condition Monitoring Systems NAFE33350 Analog-output-only companion AFE Used in: Programmable Logic Controllers (PLC), Industrial I/O Modules NAFE93352 High-speed family version for fast control loops Used in: Process Control, Data Loggers, Condition Monitoring Systems NAFE33352-UIOM NXP Semiconductors Used in: Industrial I/O Modules, RTD and Thermistor Temperature Measurement
What is the NAFE33352 and what are its key specifications?
The NAFE33352 from NXP Semiconductors is a software-configurable universal analog input and output (AIO) analog front end (AFE). Key specifications: a 24-bit ADC, an integrated low-drift voltage reference, low-offset drift buffers, a precise high-voltage output amplifier, one AIO channel plus two universal input channels, and a 40-pin HVQFN (6x6 mm) package. It is the low-power member of the NAFEx3352 family; the NAFE93352 is the high-speed version. According to the NXP NAFE33352 datasheet, it targets high-precision industrial measurement and control.
What applications is the NAFE33352 designed for?
The NAFE33352 is designed for programmable logic controllers (PLC), process control, I/O modules, and data logger applications. According to NXP product documentation, the AIO-AFE's universal channels accept voltage and current signals, and the combination of current output with voltage input allows resistance and temperature measurement using RTD sensors or thermistors - covering most analog I/O needs of an industrial control module in a single IC.
Where can I download the NAFE33352 datasheet PDF?
The NAFE33352 datasheet PDF is available on NXP's official website at https://www.nxp.jp/docs/en/data-sheet/NAFE33352.pdf. The document is titled 'Software Configurable Universal Low-Power AIO-AFE' and covers the full family. NXP also hosts an online documentation bundle at docs.nxp.com/bundle/NAFE33352 with overview, electrical characteristics, and application topics that mirror and extend the PDF content.
What is the difference between NAFE33352 and NAFE93352?
The NAFE33352 is the low-power version and the NAFE93352 is the high-speed version of the same software-configurable AIO-AFE architecture. According to NXP, both target industrial-grade precision measurement and control, but the NAFE93352 trades higher power consumption for faster conversion rates. If your application is a low-power data logger or battery-backed I/O module, choose the NAFE33352; if you need high-channel scan rates in a process control system, choose the NAFE93352.
What is the difference between NAFE33352 and NAFE33350?
The NAFE33352 is a universal AIO-AFE providing both analog input and output functionality, while the NAFE33350 is a highly configurable analog output AFE. According to NXP's evaluation board documentation, the NAFE33352-EVB supports evaluation of both parts. The NAFE33352 adds the 24-bit ADC input path and universal input channels; the NAFE33350 focuses on DAC-based output generation. Choose the NAFE33352 when a single IC must both measure and generate signals.
Can the NAFE33352 measure RTD temperature sensors directly?
Yes, the NAFE33352 can measure temperature using RTD sensors or thermistors. According to NXP documentation, the device combines its current output with a voltage input path to measure resistance directly. The integrated current source excites the RTD, the ADC digitizes the resulting voltage, and resistance (hence temperature) is computed - typically eliminating the need for external excitation and conditioning circuitry in industrial temperature input modules.
What package does the NAFE33352 come in?
The NAFE33352 is available in a 40-pin HVQFN package measuring 6x6 mm (suffixed B40 in orderable part numbers such as NAFE33352B40BS). The HVQFN (heatsink very-thin quad flat no-lead) package is a surface-mount QFN-family format with an exposed pad for thermal and electrical grounding. Distributors list variants such as NAFE33352B40BSE and NAFE33352B40BSMP in this same 6x6 mm HVQFN-40 package.
Is the NAFE33352 in stock and where can I buy it online?
Yes, the NAFE33352 is stocked at authorized distributors. DigiKey lists NAFE33352B40BSMP and NAFE33352B40BSE with 'Buy now, ships today' availability, and Mouser lists the NAFE33352B40BSE with inventory and pricing. The NAFE33352-EVB evaluation board and NAFE33352-UIOM expansion board are also available for prototyping. Check distributor sites for real-time stock and lead times before ordering production quantities.
What is the price of the NAFE33352?
Pricing for the NAFE33352 varies by orderable suffix and quantity, and distributor price breaks apply at 1, 10, 100, and higher unit volumes. As of 2026-09-14, consult DigiKey's NAFE33352B40BSMP/B40BSE product pages or Mouser's NAFE33352B40BSE page for current unit pricing. XAIPART shows quote-based pricing for this part; request a quote for volume pricing and confirmed lead time rather than relying on cached distributor figures.
What is the best drop-in replacement for the NAFE33352?
Within NXP's NAFEx3352 family, the closest pin-compatible options are the NAFE33351, NAFE33350, and NAFE93352 in the same 40-pin HVQFN package. There is no verified cross-brand pin-to-pin equivalent in a 40-HVQFN with the same AIO architecture; industrial AFE competitors (such as ADI and TI products) use different packages and pinouts and require PCB redesign. Verify the specific ADC/DAC resolution and speed grade of the family variant against your design before substituting.
NAFE33352 vs NAFE93352 - which is better for a PLC analog input module?
For a typical PLC analog input module, the NAFE33352 is usually the better choice: it is the low-power version, reducing thermal load in densely populated I/O modules while still providing the 24-bit ADC precision required for 0-10 V, 0/4-20 mA, and RTD inputs. Choose the NAFE93352 high-speed version only when your module must scan many channels at rates beyond the NAFE33352's capabilities. Both share the same software-configurable architecture, simplifying firmware reuse across product tiers.
When should I choose the NAFE33352 over the NAFE33350?
Choose the NAFE33352 when your design needs bidirectional analog functionality - measurement and output generation - in one IC, such as a universal analog I/O card or a 4-20 mA loop-powered transmitter with HART-style diagnostics. Choose the NAFE33350 when only analog output generation is required, such as a setpoint output module. The NAFE33352's 24-bit ADC and two universal input channels are the deciding features; the NAFE33350 omits the input path.
What does the NAFE33352 readback path (Vsense, Isense) do?
The readback path allows the NAFE33352 to measure its own voltage and current output. According to NXP documentation, the Vsense and Isense signals can be digitized, enabling closed-loop verification of the output value and diagnostics such as open-wire or short-circuit detection on current loops. This is critical for 4-20 mA industrial outputs where a broken loop wire must be distinguished from a legitimate 0 mA signal.
How do the universal input channels of the NAFE33352 work?
The NAFE33352 provides one analog input/output (AIO) channel and two universal input channels. According to NXP, channels are software-configurable, so the same hardware accepts voltage, current, or resistive sensor inputs without changing the front-end circuit. The integrated low-drift voltage reference and low-offset drift buffers maintain measurement accuracy across configurations, and the LVMUX can route internal and external signals to the 24-bit ADC for condition monitoring, letting one IC replace several discrete signal-conditioning stages.
What development tools are available for the NAFE33352?
NXP offers the NAFE33352-EVB evaluation board and the NAFE33352-UIOM expansion board, both listed at DigiKey. According to NXP, the EVB evaluates both the NAFE33352 AIO-AFE and the NAFE33350 analog output AFE. The UIOM acts as a data acquisition platform expansion board, letting engineers prototype universal analog input/output modules quickly. Together with NXP's online documentation bundle, these tools cover bring-up, configuration, and performance validation of the AFE.

Engineering reference data for NAFE33352B40BS β€” comparison, design guidance, and compliance information.

Selection Guide

Choose the NAFE33352 when your industrial design needs both high-precision measurement (24-bit ADC, universal voltage/current/RTD inputs) and signal generation (precision DAC and high-voltage amplifier) in a single low-power 40-HVQFN device - typical for universal PLC I/O cards, process control, and data loggers. Choose the NAFE33350 (same package) if your module generates analog outputs only and you can drop the input path. Choose the NAFE93352 high-speed version if your scan rates exceed the NAFE33352's capabilities and higher power is acceptable; it shares the architecture and software model. Choose the NAFE33351 when a different precision/speed grade within the family matches your accuracy budget. No verified cross-brand drop-in equivalent exists in the 40-HVQFN AIO-AFE class; competitor AFEs require PCB redesign, so plan substitutions within the NAFEx3352 family for lowest requalification cost.

Comparison with Alternatives

Parameter This Product NAFE33351B40BS NAFE33350B40BS NAFE93352B40BS
Package 40-HVQFN (6x6 mm) 40-HVQFN (6x6 mm) - same 40-HVQFN (6x6 mm) - same 40-HVQFN (6x6 mm) - same
Brand NXP Semiconductors NXP Semiconductors NXP Semiconductors NXP Semiconductors
Function Universal AIO-AFE (input + output) Universal AIO-AFE Analog output AFE only Universal AIO-AFE (high speed)

Key Differentiators

  • True input + output integration in one IC (vs NAFE33350B40BS)
  • Low-power operation at full precision (vs NAFE93352B40BS)
  • Integrated RTD/thermistor measurement (vs NAFE33350B40BS)

Design Notes

The NAFE33352 uses a 40-pin HVQFN (6x6 mm) package with an exposed pad. Solder the exposed pad to a grounded copper pour with an array of thermal vias - this pad is typically the main ground return for the analog front end and is critical for noise performance of the 24-bit ADC. Place the low-drift reference decoupling and ADC input RC filters close to the pins, and keep the high-voltage output amplifier routing away from high-impedance input traces to prevent crosstalk into precision measurements.

Do not assume channel behavior from other AFE families - the NAFE33352 channels are software-configurable and must be initialized for the intended mode (voltage in, current out, RTD, etc.) before measurement is valid. When measuring RTDs or thermistors, use the integrated current output with the voltage input path as documented, and account for excitation current accuracy in your temperature error budget. Also confirm whether your scan-rate requirement fits the low-power NAFE33352 or demands the high-speed NAFE93352 before locking the BOM.

Use the Vsense/Isense readback path for closed-loop output verification and wire-break detection on 4-20 mA loops: a readback current near zero with a nonzero command indicates an open loop. Schedule readback and LVMUX diagnostic measurements between normal conversion cycles so condition monitoring does not disturb measurement timing. Keep sensor excitation leads and RTD sense lines as Kelvin connections to preserve the 24-bit ADC's effective resolution at the sensing element.

Compliance Information

RoHS
Unknown
REACH
Unknown
AEC-Q100
Not Applicable
Lead Free
Unknown
Halogen Free
Unknown
Conflict Minerals
Unknown

Compliance data not present in the provided web data; consult the NXP NAFE33352B40BS product page for current RoHS/REACH status.

Data verified on: 2026-09-14 β€” data verified and curated by XAIPART's component engineering team

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Related Components & Terms

NXP Semiconductors NAFE33352 NAFE33352B40BS NAFE93352 NAFE33350 NAFEx3352 family analog front end AFE AIO-AFE 24-bit ADC DAC HVQFN-40 QFN family surface mount RTD thermistor programmable logic controller PLC process control I/O modules data loggers LVMUX Vsense/Isense readback 4-20 mA current loop
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