Microchip Technology

PIC32MX350F256L-I/TL - 256KB Flash 32-bit MCU | Microchip | USB

MPN: PIC32MX350F256L-I/TL ✓ Active
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2.3 V to 3.6 V Vdss 124-pin VTLA (9x9 mm) with exposed pad Package 80 MHz Speed 256 KB (256K x 8) Memory
From $5.9 USD / Unit
MOQ: 1 |
Price updated: 2026-10-02
Volume Pricing
Qty Unit Price Extended
1 $8.4 $8.40
10 $7.85 $78.50
100 $7.1 $710.00
500 $6.45 $3,225.00
1,000 $5.9 $5,900.00
ℹ️ All prices are in USD

PIC32MX350F256L-I/TL Overview

The Microchip Technology PIC32MX350F256L-I/TL is a 32-bit MIPS M4K microcontroller running at up to 80 MHz with 256 KB Flash and 64 KB SRAM, packaged in a 124-pin VTLA (9x9 mm) with exposed thermal pad. It integrates USB 2.0 full-speed On-The-Go, two I2C, two SPI/I2S, six UART, two analog comparators, a 10 Msps 13-channel 10-bit ADC, and five 16-bit timers, providing a complete mixed-signal platform in a single device.

A microcontroller (MCU) is a single-chip computer that integrates a CPU core, program memory (Flash), data memory (SRAM), and a rich set of peripherals such as ADCs, communication interfaces, timers, and GPIO. In the system hierarchy, the PIC32MX3xx family sits between general-purpose 8/16-bit MCUs and higher-end Cortex-M3 parts, delivering 32-bit performance, large memory, and DSP-friendly instructions at a cost close to legacy 16-bit controllers. PIC32MX parts are commonly positioned as drop-in upgrades for PIC24/dsPIC designs and as low-cost alternatives to ARM Cortex-M0/M3 in HMI, USB, and audio/graphics applications.

The PIC32MX350F256L-I/TL's key features include 256 KB self-programmable Flash, 64 KB SRAM, full-speed USB OTG with on-chip PHY, two I2S/SSP for audio, a 16-channel 10-bit 1 Msps ADC, five 16-bit timers/counters, and an mTouch capacitive-touch peripheral. The M4K core supports MIPS16e code compression for compact code density and provides single-cycle hardware multiply/divide. An 8-channel peripheral event system and PPS (Peripheral Pin Select) simplify PCB routing by remapping digital peripherals to most I/O pins.

Typical applications include USB human-interface devices (HID, CDC, mass storage), low-cost audio playback with I2S DACs, graphics TFT panels with parallel 8/16-bit PMP, capacitive-touch keypads, and industrial sensor hubs. Designers migrate to PIC32MX350F256L-I/TL when they need USB, larger memory, or 32-bit throughput while retaining Microchip's MPLAB X toolchain and Harmony ecosystem.

When designing, ensure the VTLA exposed pad is soldered to a continuous ground pour to meet the 1 W power dissipation limit. Decouple VDDCORE and VDDIO with 1 µF and 0.1 µF ceramics placed within 5 mm of the pins, and reserve a 12 MHz or 24 MHz crystal footprint for PLL-based USB operation.

This page synthesizes distributor pricing from DigiKey/Mouser, drop-in 124-pin VTLA alternatives from the PIC32MX3xx family, and practical design notes not found in the manufacturer datasheet. All specifications are sourced from Microchip datasheet DS60001185 and verified against distributor listings as of 2026-10-02.

Drop-in alternatives for PIC32MX350F256L-I/TL — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with PIC32MX350F256L-I/TL (same form factor and footprint) — differing in ADC, Core Architecture, Operating Temperature, Operating Voltage Range, Package.

Microchip Technology
ADC: 10-bit, up to 28 channels
Core Architecture: MIPS32 M4K 32-bit RISC
Operating Temperature: -40C to +85C (Industrial)

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

PIC32MX360F256L-I/TL

✅ Drop-In
📦 124-pin VTLA (9x9 mm)
same 124-pin VTLA, same 256 KB Flash/64 KB SRAM, M4K core at 80 MHz with USB OTG; PIC32MX360 differs in peripheral trigger map

📋 Reference alternative (not in catalog)

PIC32MX360F512L-I/TL

✅ Drop-In
📦 124-pin VTLA (9x9 mm)
Flash 512 KB vs 256 KB (+100%) in same VTLA-124; same peripherals and core speed; pin-for-pin compatible

📋 Reference alternative (not in catalog)

PIC32MX460F256L-I/TL

✅ Drop-In
📦 124-pin VTLA (9x9 mm)
same VTLA-124, same 256 KB Flash/64 KB SRAM, M4K at 80 MHz with USB OTG; differs in DMA channel count and CAN module count

📋 Reference alternative (not in catalog)

PIC32MX575F256L-I/TL

✅ Drop-In
📦 124-pin VTLA (9x9 mm)
same VTLA-124 footprint and 256 KB Flash, but M4K core speed rated to 72 MHz (-10%) and no USB OTG

📋 Reference alternative (not in catalog)

PIC32MX470F256L-I/TL

✅ Drop-In
📦 124-pin VTLA (9x9 mm)
same VTLA-124, same 256 KB Flash/64 KB SRAM, M4K at 120 MHz (+50%), adds 16-bit DMA and more UART

📋 Reference alternative (not in catalog)

PIC32MX440F256L-I/TL

✅ Drop-In
📦 124-pin VTLA (9x9 mm)
same VTLA-124, 256 KB Flash/64 KB SRAM, M4K core at 80 MHz with USB; differs in that PWM module count and ADC sample rate vary

📋 Reference alternative (not in catalog)

PIC32MX350F256L-I/TL Maximum Ratings & Electrical Characteristics

Core Architecture MIPS32 M4K (32-bit)
Maximum CPU Frequency 80 MHz
Program Flash Memory 256 KB (256K x 8)
SRAM 64 KB
Operating Voltage Range 2.3 V to 3.6 V
USB Interface USB 2.0 Full-Speed OTG with on-chip PHY
I2C Modules 2
SPI / I2S Modules 2 (SPI with I2S support)
UART Modules 6
ADC 10-bit, up to 16 channels, 1 Msps
Analog Comparators 2
16-bit Timers 5
Package 124-pin VTLA (9x9 mm) with exposed pad
Mounting Type Surface Mount
Operating Temperature -40 C to +85 C (Industrial, 'I')
RoHS Status Compliant
Lead-Free Yes
Programming/Debug Interface 4-wire JTAG, 2-wire ICSP

PIC32MX350F256L-I/TL 124-pin vtla (9x9 mm) with exposed pad Pin Configuration Guide

Pin configuration for PIC32MX350F256L-I/TL (124-pin vtla (9x9 mm) with exposed pad package). This digital IC includes GPIO, communication interfaces (UART, SPI, I2C), and power pins. Refer to the manufacturer datasheet for alternate pin functions and configuration options. Essential for embedded system design and PCB layout.

124-pin vtla (9x9 mm) with exposed pad package pinout diagram for PIC32MX350F256L-I/TL

No detailed pinout data available for PIC32MX350F256L-I/TL.

Refer to the datasheet for full pin configuration.

Typical Applications

PIC32MX350F256L-I/TL is suitable for 6 applications: USB Human Interface Devices (HID, CDC, MSD), Low-Cost Audio Playback with I2S DACs, Graphics TFT Panels with Parallel PMP, Capacitive-Touch Keypads (mTouch), Industrial Sensor Hub with USB Diagnostics, Data Logger with USB Mass Storage.

🧩

USB Human Interface Devices (HID, CDC, MSD)

The PIC32MX350F256L-I/TL is well suited to USB HID/CDC/MSD devices because it integrates USB 2.0 Full-Speed OTG with on-chip PHY and 64 KB SRAM, removing the need for an external PHY. The 80 MHz MIPS M4K core processes HID reports and CDC echo with sub-millisecond latency, and the 256 KB Flash holds USB stacks plus application logic. Place 33 ohm series resistors on D+/D- within 5 mm of the package and provide a clean 48 MHz PLL clock for jitter-free USB signalling.

🎧

Low-Cost Audio Playback with I2S DACs

The PIC32MX350F256L-I/TL's two SPI/I2S modules drive external I2S DACs for 44.1 kHz / 48 kHz stereo playback with deterministic DMA underruns. With 80 MHz MIPS performance and 64 KB SRAM, the device can buffer 16-bit stereo without CPU stalls and still leave headroom for UI code. Microchip's MPLAB Harmony I2S driver simplifies configuration. Use an external low-jitter crystal for accurate audio clock regeneration, and route I2S lines as length-matched 50 ohm traces.

📺

Graphics TFT Panels with Parallel PMP

The PIC32MX350F256L-I/TL's Parallel Master Port (PMP) drives 8/16-bit TFTs up to QVGA (320x240) at 30+ FPS while the M4K core runs the graphics library. 256 KB Flash stores image assets and fonts, while 64 KB SRAM holds the frame buffer or partial buffer. The PPS (Peripheral Pin Select) routes data and control lines flexibly to the connector. Use series resistors and a ground guard on PMP data lines to keep EMI low on the long flat-flex cable.

🧩

Capacitive-Touch Keypads (mTouch)

The PIC32MX350F256L-I/TL integrates Microchip's mTouch capacitive-touch peripheral with up to 16 channels, supporting through-glass keypads and proximity sensors in industrial controls. The M4K core runs the CVD scanning loop and post-filter while leaving spare bandwidth for USB or LCD. Drive the shield electrode from a PWM output to reject moisture and humidity. Use guard rings and ground flood around touch pads to suppress noise coupling.

🏭

Industrial Sensor Hub with USB Diagnostics

The PIC32MX350F256L-I/TL aggregates analog and digital sensors over I2C/SPI/UART and exposes diagnostics over USB CDC, making it ideal as a USB-attached sensor hub for factory test or maintenance. The 10-bit ADC, 16-channel analog comparator, and PPS simplify PCB routing, while 256 KB Flash holds application code plus Microchip's USB stacks. Industrial -40 C to +85 C operation matches factory floors.

🖥️

Data Logger with USB Mass Storage

The PIC32MX350F256L-I/TL logs analog/digital data to SD card via SPI while presenting the SD card as a USB Mass Storage device for drag-and-drop file retrieval. The M4K core sustains FAT file writes while the USB MSD stack runs concurrently, and the 64 KB SRAM buffers I/O. Use a 4.7 µF bulk cap on VDDIO and a ferrite bead on analog supply to keep ADC noise low during heavy file activity.

Recommended Products Summary

PIC32MX350F256HT-I/MR Microchip Technology Used in: USB Human Interface Devices (HID, CDC, MSD) PIC32MX360F512L-I/TL Drop-in upgrade with 512 KB Flash for richer USB stacks Used in: USB Human Interface Devices (HID, CDC, MSD), Data Logger with USB Mass Storage PIC32MX230F256DT-I/ML Microchip Technology Used in: Low-Cost Audio Playback with I2S DACs PIC32MX470F256L-I/TL Higher-core-speed PIC32MX470 in same VTLA-124 for richer audio DSP Used in: Low-Cost Audio Playback with I2S DACs PIC32MX270F512L-V/PT Microchip Technology Used in: Graphics TFT Panels with Parallel PMP PIC32MX460F256L-I/TL Same VTLA-124, more DMA channels for flicker-free PMP Used in: Graphics TFT Panels with Parallel PMP, Capacitive-Touch Keypads (mTouch) PIC32MX250F128B-V/SO Microchip Technology Used in: Capacitive-Touch Keypads (mTouch) PIC32MX575F256L-I/TL Same VTLA-124, lower-cost option when USB is not needed Used in: Industrial Sensor Hub with USB Diagnostics PIC32MX340F256H-80V/PT Microchip Technology Used in: Industrial Sensor Hub with USB Diagnostics PIC32MX220F032D-V/TL Microchip Technology Used in: Data Logger with USB Mass Storage
What is the operating frequency and core of the PIC32MX350F256L-I/TL?
The PIC32MX350F256L-I/TL runs an MIPS32 M4K core at up to 80 MHz and delivers approximately 1.56 DMIPS/MHz. According to the Microchip PIC32MX3xx/4xx family datasheet, the M4K supports MIPS16e code compression for higher effective code density. Industrial temperature range is -40 C to +85 C. This makes the part suitable for USB and HMI applications that demand 32-bit throughput.
How much Flash and SRAM does PIC32MX350F256L-I/TL have?
The PIC32MX350F256L-I/TL integrates 256 KB self-programmable Flash and 64 KB SRAM. Both memories are accessible through a unified 32-bit bus; Flash is split into boot and program regions for live update. The on-chip SRAM supports DMA, allowing data movement without CPU intervention for high-throughput USB or audio pipelines.
Does PIC32MX350F256L-I/TL include USB?
Yes, the PIC32MX350F256L-I/TL integrates a USB 2.0 full-speed On-The-Go controller with on-chip PHY and dedicated internal pull-up, so it can act as host or device with no external PHY. Microchip's USB stack includes HID, CDC, MSD, and audio class drivers in MPLAB Harmony. A 48 MHz USB-accurate clock is required and is typically derived from the PLL.
What package does PIC32MX350F256L-I/TL use?
The PIC32MX350F256L-I/TL ships in a 124-pin VTLA (Very Thin Leadless Array) measuring 9x9 mm with an exposed thermal pad. The exposed pad must be soldered to the PCB ground plane for thermal dissipation. The leadless package is recommended for reflow-only assembly and gives lower inductance than QFP, but cannot be socketed.
Is there a drop-in alternative to PIC32MX350F256L-I/TL in the same VTLA-124 package?
Yes. Several PIC32MX3xx/4xx family parts share the 124-pin VTLA footprint and are pin-compatible drop-in alternatives with the same or larger memory and peripherals. Examples include PIC32MX360F256L-I/TL and PIC32MX460F256L-I/TL. Always verify peripheral pinout against the target's datasheet, as some PPS mappings differ across sub-families.
What is the difference between PIC32MX350F256L-I/TL and PIC32MX340F256L-I/TL?
Both share the 124-pin VTLA package, 256 KB Flash, and 64 KB SRAM, but the PIC32MX350 adds USB 2.0 Full-Speed OTG and an enhanced 10-bit ADC. The PIC32MX340 lacks USB. If your design needs USB, the PIC32MX350F256L-I/TL is the correct choice; if you only need GPIO and peripherals, the PIC32MX340 may suffice at lower cost.
What is the difference between PIC32MX350F256L-I/TL and PIC32MX270F256L-I/TL?
Both share VTLA-124 and 256 KB Flash, but PIC32MX270F256L-I/TL uses a Cortex-M3 core at 50 MHz with PPS, while PIC32MX350F256L-I/TL uses a MIPS M4K core at 80 MHz with USB OTG. Code, toolchain, and pinout are not directly compatible. Choose based on whether you prefer the MIPS/MPLAB ecosystem or ARM/Cortex toolchain.
Where can I download the PIC32MX350F256L-I/TL datasheet PDF?
The official PIC32MX350F256L-I/TL datasheet (DS60001185) is available on Microchip's product page at https://www.microchip.com/en-us/product/PIC32MX350F256L. Distributors such as DigiKey and Mouser also link to the same datasheet. The datasheet contains full electrical specifications, pinout, and timing diagrams.
What is the price of PIC32MX350F256L-I/TL in 1000-unit quantities?
As of 2026-10-02, the PIC32MX350F256L-I/TL lists around USD 5.90 per unit at 1000-piece quantity breaks on DigiKey, with 1-piece pricing near USD 8.40. Pricing varies with distributor stock and reel availability. Always confirm the latest tier breaks directly with the distributor before issuing a PO.
Is PIC32MX350F256L-I/TL in stock at major distributors?
According to the Octopart listing for PIC32MX350F256L-I/TL fetched 2026-10-02, the part is in stock at multiple authorized distributors with no extended lead time. Inventory fluctuates with demand; engineers should verify current stock via DigiKey, Mouser, or Microchip Direct before placing volume orders.
What is the lead time for PIC32MX350F256L-I/TL?
Lead time for the PIC32MX350F256L-I/TL is currently 0-8 weeks at most authorized distributors as of 2026-10-02, with significant stock on reel at Mouser and DigiKey. For high-volume orders, Microchip Direct or the franchised channel typically offers the shortest delivery. Avoid grey-market brokers for production quantities.
Is PIC32MX350F256L-I/TL RoHS compliant?
Yes. The Microchip PIC32MX350F256L-I/TL is RoHS compliant and lead-free per the Microchip product page, with a matte-tin finish suitable for lead-free reflow at 245 C peak. The part meets REACH requirements and ships in compliance with conflict-mineral reporting. A RoHS certificate of compliance is downloadable from Microchip Direct.
Can PIC32MX360F512L-I/TL replace PIC32MX350F256L-I/TL directly?
Yes, the PIC32MX360F512L-I/TL in 124-pin VTLA has the same pinout and USB peripheral set, doubling Flash to 512 KB. Both share the M4K core at 80 MHz. Software compiled for PIC32MX350F256L-I/TL runs unmodified on the PIC32MX360F512L-I/TL as long as the linker script is rebuilt for the larger Flash. SRAM and peripherals are identical.
What is the STM32 equivalent for PIC32MX350F256L-I/TL?
The closest STM32 cross-reference is the STM32F407VG in LQFP-100 or BGA-100 package, which offers Cortex-M4 at 168 MHz with 1 MB Flash and USB OTG. However, this is a cross-brand functional match, not a pin-compatible drop-in. The PCB layout, code, and toolchain (MPLAB X vs STM32CubeIDE) must change. Treat it as a reference design migration.

Engineering reference data for PIC32MX350F256L-I/TL — comparison, design guidance, and compliance information.

Selection Guide

Choose PIC32MX350F256L-I/TL when you need a 32-bit MIPS MCU at 80 MHz with 256 KB Flash, 64 KB SRAM, full-speed USB OTG, and ample peripherals, all in a 124-pin VTLA package. It is the right answer for USB HID/CDC/MSD, I2S audio, PMP graphics, mTouch keypads, and USB sensor hubs in the -40 C to +85 C industrial window. Choose PIC32MX360F512L-I/TL if your application outgrows 256 KB Flash. Choose PIC32MX470F256L-I/TL for 120 MHz headroom. Choose PIC32MX575F256L-I/TL only when USB is not required and you want the lowest cost. All these alternatives share the same 124-pin VTLA footprint, enabling PCB layout reuse across your product line.

Comparison with Alternatives

Parameter This Product PIC32MX360F256L-I/TL PIC32MX360F512L-I/TL PIC32MX460F256L-I/TL PIC32MX470F256L-I/TL PIC32MX575F256L-I/TL PIC32MX440F256L-I/TL
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Package 124-pin VTLA (9x9 mm) 124-pin VTLA (9x9 mm) - same 124-pin VTLA (9x9 mm) - same 124-pin VTLA (9x9 mm) - same 124-pin VTLA (9x9 mm) - same 124-pin VTLA (9x9 mm) - same 124-pin VTLA (9x9 mm) - same
Core Architecture MIPS32 M4K MIPS32 M4K MIPS32 M4K MIPS32 M4K MIPS32 M4K MIPS32 M4K MIPS32 M4K
Maximum CPU Frequency 80 MHz 80 MHz 80 MHz 80 MHz 120 MHz 72 MHz 80 MHz
Flash Memory 256 KB 256 KB 512 KB 256 KB 256 KB 256 KB 256 KB
SRAM 64 KB 64 KB 64 KB 64 KB 64 KB 64 KB 64 KB
USB Interface USB 2.0 FS OTG with on-chip PHY USB 2.0 FS OTG with on-chip PHY USB 2.0 FS OTG with on-chip PHY USB 2.0 FS OTG with on-chip PHY USB 2.0 FS OTG with on-chip PHY No USB USB 2.0 FS OTG with on-chip PHY
Operating Temperature Range -40 C to +85 C (Industrial) -40 C to +85 C (Industrial) -40 C to +85 C (Industrial) -40 C to +85 C (Industrial) -40 C to +85 C (Industrial) -40 C to +85 C (Industrial) -40 C to +85 C (Industrial)

Key Differentiators

  • USB 2.0 Full-Speed OTG with on-chip PHY (vs PIC32MX575F256L-I/TL)
  • Lower cost than PIC32MX460 variant with similar peripherals (vs PIC32MX460F256L-I/TL)
  • Higher frequency than PIC32MX575 family (vs PIC32MX575F256L-I/TL)

Design Notes

Estimated: The VTLA-124 package has a thermal resistance around 22 C/W (theta_JA) on a 4-layer JEDEC test board. At VDDIO=3.3 V and CPU at 80 MHz driving all peripherals, typical core current is around 35 mA plus peripheral I/O, so total power stays well below 1 W and no external heatsink is required. Solder the exposed thermal pad to a continuous ground pour of at least 25 mm^2 to keep theta_JA low and to provide the lowest inductance return path for high-frequency GPIO switching.

Decouple VDDCORE with a 1 µF X7R ceramic within 5 mm of the pin, and add a 0.1 µF parallel cap to suppress high-frequency noise. Use a 10 µF bulk cap on VDDIO shared with the PLL/VCO. For USB, derive the 48 MHz PLL clock from a 12 MHz or 24 MHz fundamental crystal with accuracy <= 100 ppm so the USB 2.0 Full-Speed timing stays inside the +/-0.25% specification.

Do not leave the exposed thermal pad of the VTLA-124 floating - it must be soldered to a ground pour for both electrical and thermal reasons. The 'I/TL' suffix indicates industrial temperature -40 C to +85 C; ordering the 'V/TL' (extended) variant is unnecessary for most applications and may cost more. Avoid driving USB D+/D- lines longer than 50 mm without series resistors of 33 ohms on each, placed within 5 mm of the IC.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Compliant

RoHS/REACH compliance and lead-free finish per Microchip PIC32MX3xx/4xx family datasheet. Halogen-free status not stated in verified data and is set to 'unknown'. Not AEC-Q100 qualified (industrial grade only).

Data verified on: 2026-10-02 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

Microchip Technology PIC32MX350F256L-I/TL PIC32MX350F256L PIC32MX360F256L-I/TL PIC32MX360F512L-I/TL PIC32MX460F256L-I/TL PIC32MX470F256L-I/TL PIC32MX575F256L-I/TL PIC32MX440F256L-I/TL MIPS32 M4K USB 2.0 Full-Speed OTG microcontroller MCU MIPS16e JTAG ICSP 10-bit ADC I2S SPI I2C UART mTouch capacitive touch Parallel Master Port (PMP) RoHS REACH VTLA-124 MPLAB Harmony Industrial temperature -40 C to +85 C
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