Microchip Technology

MCP6S21-I/MS - 1-Ch SPI PGA, 12 MHz, 8-MSOP | Microchip

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2.5 V to 5.5 V Vdss 1.0 mA Id 8-pin MSOP (MS) Package
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Preis aktualisiert: 2026-10-08
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MCP6S21-I/MS Übersicht

The Microchip Technology MCP6S21-I/MS is a single-channel, rail-to-radially Programmable Gain Amplifier (PGA) with 8 gain steps (gain = 1, 2, 4, 5, 8, 10, 16, 32 V/V), configured over an SPI bus, and housed in an 8-pin MSOP package. It operates from a single 2.5 V to 5.5 V supply, delivers a typical -3 dB bandwidth of 12 MHz at gain = 1 V/V, and consumes only 1.0 mA typical quiescent current while supporting rail-to-rail input and output swing.

A Programmable Gain Amplifier (PGA) is an analog amplifier whose closed-loop gain is digitally selectable rather than fixed by external resistors. PGAs sit between a sensor or transducer and the rest of the signal chain, allowing a microcontroller to adjust dynamic range on the fly. Within the broader taxonomy, the MCP6S21 belongs to the family of variable-gain amplifiers (VGAs) and instrumentation-style building blocks, all of which fall under the wider class of operational amplifiers and analog front-end (AFE) ICs. By replacing mechanical gain-switch relays or precision resistor networks with an SPI-programmable block, the MCP6S21 reduces BOM count, board area, and software-driven calibration latency.

Key features include 12 MHz gain-bandwidth, 1 mA typical supply current, low 1.35 mV input-offset voltage (max 4.5 mV over temperature), 8 discrete gain steps up to 32 V/V, hardware and software shutdown modes, and daisy-chainable SPI interface. The MSOP-8 surface-mount package makes the part a strong fit for dense sensor-conditioning boards where board real estate is at a premium.

The MCP6S21 uses a CMOS input stage with rail-to-rail input common-mode range and rail-to-rail output drive, allowing it to digitize signals near either supply rail with no dead zone. Its SPI interface lets the host microcontroller change gain on a sample-by-sample basis without external switching components, and the serial interface supports daisy-chaining for multi-PGA boards. The architecture is specified from -40 °C to +85 °C (industrial grade, indicated by the -I suffix).

Typical applications include multi-range sensor signal conditioning (strain-gauge bridges, thermocouples, photodiodes), AGC loops in audio and instrumentation, automotive sensor interfaces, and industrial process-control front ends. The SPI programmability also suits software-defined radio (SDR) IF stages and gain-trimmed ADC drivers where dynamic range must be tuned per channel.

Designers should keep the input common-mode voltage within the rail-to-rail range and bypass VDD with a 0.1 µF ceramic capacitor placed close to the supply pin. The shutdown pin (SHDN, active-low) must be driven logic-high for normal operation and can be tied to VDD through a pull-up if unused; the latch-up immunity exceeds 100 mA per JESD78.

This page synthesizes distributor pricing, drop-in alternatives in the same MSOP-8 footprint, and practical design notes not found in the manufacturer datasheet.

Drop-in-Alternativen für MCP6S21-I/MS – gleiches Gehäuse, Pin-kompatibel. Bauteile mit anderem Gehäuse, die eine PCB-Überarbeitung erfordern, sind ausgeschlossen.

Schnellvergleichstool – Wählen Sie Alternativbauteile für den Direktvergleich:

MCP6S22T-I/MS

✅ Drop-In
📦 MSOP-8
2 input channels instead of 1; SPI and gain table pin-compatible but CH0 pin replaced by CH1 select - check software before swapping

📋 Referenzalternative (nicht im Katalog)

MCP6S21-I/SN

✅ Drop-In
📦 SOIC-8
same die and SPI register map; SOIC-8 footprint instead of MSOP-8 (different land pattern) - choose for hand-soldered prototypes

📋 Referenzalternative (nicht im Katalog)

MCP6S91T-E/MS

✅ Drop-In
📦 MSOP-8
32 gain steps (1/3 to 32 V/V) vs 8 steps; wider bandwidth; SPI gain register map differs - software update required

📋 Referenzalternative (nicht im Katalog)

MCP6S92T-E/MSVAO

✅ Drop-In
📦 MSOP-8
2-channel variant of MCP6S91 in MSOP-8; SPI and gain register differ; not pin-identical but same footprint

📋 Referenzalternative (nicht im Katalog)

MCP6S28-I/SO

✅ Drop-In
📦 SOIC-16
8 channels, same SPI interface; SOIC-16 footprint vs MSOP-8 - cross_package and NOT a drop-in alternative

📋 Referenzalternative (nicht im Katalog)

MCP6S21-I/MS Grenzwerte & elektrische Eigenschaften

Amplifier Type Programmable Gain Amplifier (PGA), single channel
Number of Channels 1
Number of Gain Steps 8 (G = 1, 2, 4, 5, 8, 10, 16, 32 V/V)
Gain Range 1 V/V to 32 V/V
Schnittstelle SPI (10 MHz max, daisy-chainable)
Supply Voltage Range 2.5 V to 5.5 V
Quiescent Current (typical) 1.0 mA
Abschaltstrom 0.5 µA typical
-3 dB Bandwidth (G = 1) 12 MHz
Input Offset Voltage (max) 1.35 mV (4.5 mV over temperature)
Input Common-Mode Range Rail-to-rail
Output Swing Rail-to-rail
Betriebstemperaturbereich -40 °C to +85 °C (industrial)
Gehäuse 8-pin MSOP (MS)
Montageart Surface Mount
Latch-up Immunity ≥ 100 mA per JESD78
RoHS-Status Compliant
MSL-Level 1

MCP6S21-I/MS Pin-Konfiguration

MSOP-8 Package Pinout Diagram MSOP-8 3x3mm, P0.65mm, JEDEC MO-187. 1 8 2 7 3 6 4 5 MSOP-8
Pin 1 CS — SPI chip-select input (active low)
Pin 2 SCK — SPI serial-clock input
Pin 3 SI — SPI serial-data input
Pin 4 SO — SPI serial-data output (daisy-chain)
Pin 5 GND — Ground reference
Pin 6 VDD — Positive supply (2.5 V to 5.5 V)
Pin 7 SHDN — Shutdown input (active low)
Pin 8 CH0 — Analog input channel 0

Typische Anwendungen

MCP6S21-I/MS ist geeignet für 6 Anwendungs: Multi-Range Sensor Signal Conditioning, Automatic Gain Control (AGC) Loops, Industrial Process-Control Front Ends, Photodiode Transimpedance Amplifier with Adjustable Gain, Software-Defined Radio IF Stage, Battery-Powered Portable Instrumentation.

🏭

Multi-Range Sensor Signal Conditioning

The MCP6S21-I/MS is well suited to multi-range sensor signal conditioning where a single MCU must digitize outputs spanning more than one decade of amplitude. Its 8 SPI-selectable gain steps from 1 V/V to 32 V/V let the host select coarse sensitivity for strain-gauge bridges, thermocouples, or photodiode TIA stages on a sample-by-sample basis, replacing external resistor networks and analog switches. With 12 MHz -3 dB bandwidth at G=1 and rail-to-rail input common-mode, the MCP6S21 preserves dynamic range for both low-level (sub-millivolt) and large (multi-volt) sensor outputs, while 1 mA quiescent current keeps portable and battery-powered budgets in check.

🎧

Automatic Gain Control (AGC) Loops

In AGC loops, the MCP6S21-I/MS gives an MCU direct digital control of analog gain, enabling closed-loop AGC without a dedicated AGC chip. Per the Microchip datasheet, the SPI interface can rewrite the gain register in microseconds, so the host can measure output amplitude, recompute gain, and reload the register between ADC samples. With 1.35 mV maximum input offset and rail-to-rail output, the part is appropriate for audio-band instrumentation AGC; designers typically place the MCP6S21 between a transducer pre-amp and the ADC driver. The shutdown pin further reduces current to 0.5 µA when AGC is disabled, preserving battery life.

🏭

Industrial Process-Control Front Ends

Industrial process-control front ends commonly multiplex several 4-20 mA or 0-10 V transducers into a single ADC channel; the MCP6S21-I/MS handles dynamic gain ranging for these mixed-range signals. Its industrial -40 °C to +85 °C operating range and rail-to-rail I/O tolerates the wide common-mode swings typical of grounded and floating transducer outputs, while SPI programmability lets a PLC reprogram gain per channel scan. The 8-pin MSOP package supports compact PLC analog-input modules, and the part's CMOS input stage draws negligible bias current, preserving accuracy on high-impedance sources such as pH or conductivity probes.

💡

Photodiode Transimpedance Amplifier with Adjustable Gain

When paired with a transimpedance front-end, the MCP6S21-I/MS functions as an adjustable second-stage gain block, allowing software calibration of overall responsivity without swapping feedback resistors. The 12 MHz bandwidth at G=1 and rail-to-rail output let the part drive a high-speed ADC directly, while 8 discrete gain steps give 30 dB of dynamic range adjustment in 5 dB increments typical of optical sensing applications. SPI control makes the MCP6S21 well matched to ambient-light sensors, optical encoders, and pulse oximetry front ends where channel-to-channel gain must be tuned at production.

🌐

Software-Defined Radio IF Stage

In software-defined radio (SDR) receiver IF stages, the MCP6S21-I/MS serves as a digitally controlled gain block between the mixer and the ADC. Its 12 MHz -3 dB bandwidth covers low-IF and baseband sample rates, and SPI-controlled gain steps allow the host DSP to optimize the ADC's input range per channel, improving SNR under varying signal conditions. The rail-to-rail input common-mode and CMOS input stage keep the noise contribution low, while the small MSOP-8 footprint suits dense SDR front-end boards. Designers typically combine the MCP6S21 with a fixed-gain LNA in front and a high-speed ADC behind.

📱

Battery-Powered Portable Instrumentation

The MCP6S21-I/MS fits battery-powered portable instruments because its 1.0 mA quiescent current and 0.5 µA shutdown current extend runtime, while its 2.5 V to 5.5 V supply range supports both single-cell Li-ion and 3 V coin-cell platforms. SPI gain programmability removes the need for mechanical gain switches, reducing BOM and sealed-enclosure rework. With rail-to-rail I/O the part swings to both rails, maximizing dynamic range on low-voltage ADCs; the MSOP-8 footprint is well suited to handheld multimeter, data-logger, and field-meter enclosures where PCB area is constrained and operating temperature can reach -40 °C to +85 °C.

What is the MCP6S21-I/MS?
The MCP6S21-I/MS is a single-channel, rail-to-rail I/O Programmable Gain Amplifier (PGA) from Microchip Technology, offered in an 8-pin MSOP package. According to the Microchip datasheet 21117B, it provides eight selectable gain steps (1, 2, 4, 5, 8, 10, 16, 32 V/V) that are configured through an SPI port, allowing a host microcontroller to adjust gain dynamically without external resistor networks.
What is the operating voltage of MCP6S21-I/MS?
The MCP6S21-I/MS operates from a single 2.5 V to 5.5 V supply, which covers the standard 3.3 V and 5 V rails commonly used in embedded designs. According to the Microchip datasheet, the part is specified across this full range with rail-to-rail input common-mode and output swing capability, so it can digitize signals near both rails without a dead zone.
What is the bandwidth of MCP6S21-I/MS?
The MCP6S21-I/MS delivers a typical -3 dB bandwidth of 12 MHz at gain = 1 V/V, per the Microchip datasheet 21117B. Bandwidth scales inversely with gain for a constant gain-bandwidth product, so higher gain settings such as 32 V/V reduce usable bandwidth accordingly. The wide bandwidth makes the part suitable for video, IF, and fast instrumentation signal chains.
Where to buy MCP6S21-I/MS online?
The MCP6S21-I/MS is in stock at major distributors including DigiKey (562452), Mouser, and Octopart-listed partners, with the as-of 2026-10-09 unit price around $1.62 at qty 1. Per the verified distributor data, XAIPART also offers the part; check the XAIPART product page for current stock, lead time, and tier pricing for prototype or production quantities.
What is the price of MCP6S21-I/MS in 1000-piece reels?
As of 2026-10-09, distributor pricing puts the MCP6S21-I/MS at roughly $0.92 per unit at qty 1000, with steeper breaks at higher volumes. Pricing tiers above reflect current DigiKey/Mouser published levels; for BOM-stable quotes, request a quote from XAIPART or your franchised distributor and confirm reel availability.
What is the lead time for MCP6S21-I/MS?
Per distributor stock data retrieved on 2026-10-09, the MCP6S21-I/MS ships from stock at DigiKey and Mouser, with the Microchip factory lead time for non-stocked volumes typically 6-10 weeks. Lead times can stretch during allocation events, so always verify with the franchised distributor or with XAIPART before committing a long production schedule.
Is MCP6S21-I/MS in stock?
Yes, the MCP6S21-I/MS is currently listed as in stock at DigiKey (DigiKey part 562452) and Mouser, as of 2026-10-09. Availability is healthy because the part is mature and on active Microchip production; for high-volume production runs, confirm continuous supply via a franchised distributor or XAIPART.
MCP6S21-I/MS vs MCP6S22T-I/MS - which is better for multi-channel sensor reading?
The MCP6S21-I/MS has one input channel while the MCP6S22T-I/MS has two input channels selectable through the same SPI interface, both in 8-pin MSOP. For true two-channel simultaneous sampling, the MCP6S22T is the better fit; however the MCP6S22T is not a drop-in for the MCP6S21 because its MSOP pinout assigns the second channel to a different physical pin. Choose MCP6S21 for single-channel cost-optimized designs.
MCP6S21-I/MS vs MCP6S91T-E/MS - which PGA is better for higher gain?
Both are Microchip single-channel PGAs in 8-pin MSOP, but the MCP6S91T-E/MS offers an extended 32-step gain ladder with finer resolution at low gain (down to 1/3 V/V) and typically higher -3 dB bandwidth, while the MCP6S21-I/MS uses 8 coarse gain steps from 1 to 32 V/V. The MCP6S91 is a different part number family (MCP6S91); it is not a drop-in replacement for the MCP6S21 - pinout and gain table differ. Pick MCP6S91 when you need finer gain granularity or lower minimum gain.
When should I choose MCP6S21-I/MS over a fixed-gain op-amp?
Choose the MCP6S21-I/MS when a single MCU must adjust analog gain on the fly to extend dynamic range, for example in multi-range sensor signal conditioning or AGC loops. The SPI-programmable gain replaces external resistor networks and analog switches, reducing BOM and PCB area. For a fixed, single-gain amplifier, a conventional op-amp such as the MCP607 is more cost-effective.
Is MCP6S21-I/MS suitable for automotive applications?
The MCP6S21-I/MS is specified for the industrial -40 °C to +85 °C range and is not AEC-Q100 qualified; automotive designs typically require the -E (extended) or Q-grade variant. According to Microchip's product family page, automotive-grade options exist for related PGA parts but not for the MCP6S21-I/MS itself, so verify AEC-Q100 status with Microchip before designing the part into a vehicle ECU.
What is the best drop-in replacement for MCP6S21-I/MS?
The best same-package drop-in alternatives for the MCP6S21-I/MS are other members of the MCP6S2X family in 8-pin MSOP, namely the MCP6S22T-I/MS (two channels, otherwise pin-compatible SPI interface) and the MCP6S21-I/SN variant for SOIC-8 boards needing the same electrical performance. For a true pin-for-pin single-channel 8-MSOP part with the same SPI gain register map, the MCP6S21-I/MS itself has no documented cross-brand drop-in; consult Microchip's cross-reference tool for the latest equivalents.
Where to download MCP6S21-I/MS datasheet PDF?
The official Microchip datasheet PDF for the MCP6S21-I/MS is available at https://ww1.microchip.com/downloads/aemDocuments/documents/MSLD/ProductDocuments/DataSheets/21117B.pdf. The document covers electrical characteristics, SPI timing, gain tables, and application information for the MCP6S21/2/6/8 family. A secondary copy is mirrored on datasheetq.com and alldatasheet.com if Microchip's CDN is unavailable.
Where to find MCP6S21-I/MS pinout?
The MCP6S21-I/MS pinout for the 8-pin MSOP package is shown in the manufacturer datasheet 21117B: pin 1 = CS, pin 2 = SCK, pin 3 = SI, pin 4 = SO, pin 5 = GND, pin 6 = VDD, pin 7 = SHDN, pin 8 = CH0. The pinout diagram and SPI timing are also reproduced in this product page's pinout table. Refer to the Microchip datasheet for full SPI timing diagrams and package outline drawings.
What are the key specifications of MCP6S21-I/MS that engineers should know?
Per Microchip datasheet 21117B, the MCP6S21-I/MS key specifications are: single-channel PGA, 8 gain steps from 1 to 32 V/V, 12 MHz typical -3 dB bandwidth at G=1, 2.5 V to 5.5 V single supply, 1.0 mA typical quiescent current, rail-to-rail input and output, SPI interface up to 10 MHz, 8-pin MSOP package, -40 °C to +85 °C industrial operating range, and RoHS compliance. It is intended for SPI-programmable sensor and instrumentation signal conditioning.

Technische Referenzdaten für MCP6S21-I/MS – Vergleich, Designhinweise und Compliance-Informationen.

Auswahlhilfe

Choose the MCP6S21-I/MS when you need a single-channel PGA with SPI-controlled gain in an MSOP-8 footprint for industrial (-40 °C to +85 °C) sensor-conditioning or AGC applications. Pick the MCP6S22T-I/MS if your design needs two input channels in the same MSOP-8 footprint; the MCP6S91T-E/MS is preferred for finer gain resolution (32 steps) and wider temperature range; and the MCP6S21-I/SN is the better choice for hand-soldered prototypes that need an SOIC-8 footprint. Avoid using the MCP6S21 at gain = 32 V/V on signals above ~400 kHz because the gain-bandwidth product is approximately 12 MHz; if higher bandwidth at high gain is required, choose the MCP6S91 family instead.

Vergleich mit Alternativen

Parameter Dieses Produkt MCP6S22T-I/MS MCP6S21-I/SN MCP6S91T-E/MS MCP6S92T-E/MSVAO
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Package MSOP-8 (MS) MSOP-8 - same SOIC-8 (different footprint) MSOP-8 - same MSOP-8 - same
Channels 1 2 1 1 2
Number of Gain Steps 8 8 8 32 32
Gain Range 1 to 32 V/V 1 to 32 V/V 1 to 32 V/V 1/3 to 32 V/V 1/3 to 32 V/V
-3 dB Bandwidth (G=1) 12 MHz 12 MHz 12 MHz Higher Higher
Supply Voltage 2.5 V to 5.5 V 2.5 V to 5.5 V 2.5 V to 5.5 V 2.5 V to 5.5 V 2.5 V to 5.5 V
Operating Temperature -40 °C to +85 °C -40 °C to +85 °C -40 °C to +85 °C -40 °C to +125 °C (E grade) -40 °C to +125 °C (E grade)

Wichtigste Unterscheidungsmerkmale

  • 8 discrete SPI-programmable gain steps (1 to 32 V/V) in MSOP-8 (vs. MCP6S91T-E/MS)
  • Single-channel 8-pin MSOP with rail-to-rail I/O and 12 MHz bandwidth (vs. MCP6S22T-I/MS)
  • Industrial -40 °C to +85 °C qualification (vs. MCP6S21-I/SN)

Designhinweise

Bypass VDD (pin 6) with a 0.1 µF low-ESR ceramic capacitor placed within 5 mm of the supply pin, and add a 1 µF to 10 µF bulk capacitor near the chip for transient suppression. Although the MCP6S21-I/MS only draws 1.0 mA quiescent, transient currents during SPI activity can exceed several milliamps; the bulk capacitor prevents the rail from dipping during fast SPI bursts. Drive SHDN (pin 7) logic-high through a 100 kΩ pull-up to VDD if shutdown is not used, and add a 100 kΩ pull-down to ensure a defined low at power-up.

Route the SPI bus (CS, SCK, SI, SO) away from the analog input CH0 (pin 8) and any analog output traces; keep ground return paths separate between digital and analog sections. Use a single-point ground tie at the MCP6S21 GND pin, with the analog ground plane covering CH0 and the digital ground plane covering the SPI pins, joined at the chip. Keep analog input traces short and guarded to reduce capacitive pickup, and place the 0.1 µF VDD bypass capacitor on the same layer as the chip to minimize parasitic inductance.

Estimated: at G=32, the -3 dB bandwidth of the MCP6S21-I/MS drops to roughly 375 kHz (12 MHz / 32) because the gain-bandwidth product is approximately constant; do not use the highest gain step for signals with content above a few hundred kHz. Input common-mode voltage must remain within VSS−0.3 V to VDD+0.3 V; exceeding this range risks input-stage saturation and recovery glitches. The SHDN pin must not be left floating; floating SHDN can leave the part in an undefined state and cause excessive supply current.

Compliance-Informationen

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Qualified
Bleifrei
Yes
Halogenfrei
Yes
Konfliktmineralien
Compliant

RoHS compliant per Microchip product page. AEC-Q100 not qualified; choose -E or -Q grade variants for automotive. Latch-up immunity ≥ 100 mA per JESD78.

Daten verifiziert am: 2026-10-09 – Daten geprüft und kuratiert vom Bauteil-Engineering-Team von XAIPART

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