Analog Devices

AD8221ARZ - Precision Instrumentation Amplifier | Analog Devices

MPN: AD8221ARZ βœ“ Active
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60 Β΅V (max) Vdss 500 pA (max) Id 8-Lead SOIC (R-8) Package
From $3.29 USD / Unit
MOQ: 1 |
Price updated: 2026-08-21
Volume Pricing
Qty Unit Price Extended
1 $4.86 $4.86
10 $4.36 $43.60
100 $3.88 $388.00
500 $3.49 $1,745.00
1,000 $3.29 $3,290.00
ℹ️ All prices are in USD

Drop-in alternatives for AD8221ARZ β€” same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Quick Comparison Tool β€” Select alternative parts for side-by-side comparison:

AD8221BRZ

βœ… Drop-In
πŸ“¦ 8-Lead SOIC
Higher precision grade with lower offset voltage and drift

πŸ“‹ Reference alternative (not in catalog)

AD8221ARZ-RL

βœ… Drop-In
πŸ“¦ 8-Lead SOIC
Same die, tape and reel packaging variant

πŸ“‹ Reference alternative (not in catalog)

AD8221ARZ-R7

βœ… Drop-In
πŸ“¦ 8-Lead SOIC
Same die, tape and reel packaging variant (7-inch reel)

πŸ“‹ Reference alternative (not in catalog)

AD8422ARZ

βœ… Drop-In
πŸ“¦ 8-Lead SOIC
Pin-to-pin compatible but different gain equation, requires Rg adjustment

πŸ“‹ Reference alternative (not in catalog)

AD8223BRZ

βœ… Drop-In
πŸ“¦ 8-Lead SOIC
Lower bandwidth and higher noise, but pin-compatible

πŸ“‹ Reference alternative (not in catalog)

INA128UA

βœ… Drop-In
πŸ“¦ 8-Lead SOIC
Cross-brand, similar precision but different pinout (check compatibility)

πŸ“‹ Reference alternative (not in catalog)

AD8221ARZ Maximum Ratings & Electrical Characteristics

Number of Channels 1
Gain Range 1 to 1000
Input Offset Voltage 60 Β΅V (max)
Input Bias Current 500 pA (max)
Bandwidth 825 kHz (G=1)
Slew Rate 2 V/Β΅s
CMRR 90 dB (min) at 60 Hz, 80 dB (min) at 10 kHz
Supply Voltage Range 4.5 V to 36 V (single), Β±2.25 V to Β±18 V (dual)
Quiescent Current 1.2 mA (max)
Operating Temperature Range -40Β°C to +85Β°C
Package 8-Lead SOIC (R-8)
Mounting Type Surface Mount
RoHS Status Compliant
REACH Status Compliant
MSL Level 1 (unlimited)

AD8221ARZ Pin Configuration

SOP-8 Package Pinout Diagram SOP-8 8-pin small outline, 3.9x4.9mm, P1.27mm, JEDEC MS-012. 1 8 2 7 3 6 4 5 SOP-8
Pin 1 RG β€” Gain setting resistor connection
Pin 2 -IN β€” Inverting input
Pin 3 +IN β€” Non-inverting input
Pin 4 V- β€” Negative supply
Pin 5 REF β€” Reference voltage for output level shifting
Pin 6 OUT β€” Amplifier output
Pin 7 V+ β€” Positive supply
Pin 8 RG β€” Gain setting resistor connection

Safe Operating Area (SOA) & Thermal Characteristics

Safe Operating Area Chart Default safe operating area chart for AD8221ARZ Drain-to-Source Voltage (Vds) Drain Current (Id)

No official SOA curve available for this component. Always operate within absolute maximum ratings specified in the datasheet. Ensure adequate cooling and derate as needed.

Typical Applications

AD8221ARZ is suitable for 6 applications: Medical Instrumentation (ECG/EEG), Industrial Process Control, Bridge Amplifier, Data Acquisition Systems, Precision Sensor Interface, Audio Test Equipment.

πŸ’Š

Medical Instrumentation (ECG/EEG)

The AD8221ARZ is ideal for ECG and EEG systems due to its low input offset voltage of 60 Β΅V and high CMRR of 90 dB at 60 Hz. These parameters ensure accurate amplification of bio-potential signals while rejecting power-line interference. The low input bias current of 500 pA minimizes loading on high-impedance electrodes, preserving signal integrity. In an ECG front-end, the AD8221ARZ amplifies the differential signal from electrodes, providing a clean output for further processing. Its bandwidth of 825 kHz is sufficient for ECG signals, which are typically below 100 Hz. The device's low power consumption (1.2 mA) is beneficial for portable monitors. For optimal performance, use shielded cables and proper grounding to maintain high CMRR.

🏭

Industrial Process Control

In industrial process control, the AD8221ARZ provides precise amplification of sensor signals from bridges, thermocouples, and strain gauges. Its high CMRR of 80 dB at 10 kHz rejects common-mode noise from long cable runs and motor drives. The gain range of 1 to 1000 allows flexible scaling of sensor outputs to match ADC input ranges. The device operates from a wide supply range (up to 36 V), making it compatible with 24 V industrial buses. Its low offset voltage (60 Β΅V) ensures accurate measurement of small sensor signals. The AD8221ARZ's robust design and wide temperature range (-40Β°C to +85Β°C) make it suitable for harsh factory environments. For best results, use twisted-pair wiring and proper shielding to minimize electromagnetic interference.

πŸ”§

Bridge Amplifier

The AD8221ARZ is well-suited for bridge amplifier applications, such as load cells and pressure sensors. Its low input bias current (500 pA) minimizes errors caused by source impedance imbalance in bridge circuits. The high CMRR ensures that common-mode voltage variations, often present in bridge excitation, are rejected. The gain is easily set with a single resistor, allowing calibration for different bridge sensitivities. The device's bandwidth of 825 kHz supports dynamic measurements, such as vibration monitoring. The AD8221ARZ's low offset voltage (60 Β΅V) reduces zero-error, improving measurement accuracy. For bridge applications, use precision resistors for the bridge and a stable excitation voltage to achieve optimal performance.

πŸ–₯️

Data Acquisition Systems

In data acquisition systems, the AD8221ARZ conditions analog signals before ADC conversion. Its low noise and high bandwidth (825 kHz) preserve signal fidelity, while the gain range allows matching signal levels to ADC input ranges. The high CMRR reduces interference from digital circuits and power supplies. The device's small SOIC package enables dense PCB layouts in multi-channel systems. The AD8221ARZ's low power consumption (1.2 mA) is advantageous for portable data loggers. For high-resolution measurements, pair the AD8221ARZ with a high-resolution ADC and use proper anti-aliasing filters. The device's wide supply range supports various system power architectures.

🧩

Precision Sensor Interface

The AD8221ARZ is ideal for precision sensor interfaces, including temperature, pressure, and position sensors. Its low offset voltage (60 Β΅V) and low bias current (500 pA) ensure accurate signal conditioning from high-impedance sensors. The high CMRR rejects common-mode noise, which is critical in noisy environments. The gain range of 1 to 1000 allows amplification of small sensor signals to usable levels. The device's wide supply range and low power consumption make it suitable for battery-powered sensors. For optimal performance, use a stable reference voltage and proper PCB layout to minimize parasitic capacitance. The AD8221ARZ's small package and surface-mount design facilitate integration into compact sensor modules.

🎧

Audio Test Equipment

The AD8221ARZ can be used in audio test equipment for measuring differential signals with high accuracy. Its low distortion and high bandwidth (825 kHz) make it suitable for audio frequency range measurements. The high CMRR ensures rejection of common-mode noise, which is important in balanced audio connections. The gain range allows adjusting sensitivity for different signal levels. The device's low noise performance is critical for audio measurements. The AD8221ARZ's small package and low power consumption are beneficial for portable test instruments. For audio applications, use high-quality input coupling capacitors and proper shielding to minimize interference.

Recommended Products Summary

AD8232 ECG front-end IC that can be used with AD8221 for signal conditioning Used in: Medical Instrumentation (ECG/EEG) ADuCM360 Precision analog microcontroller for sensor interfacing Used in: Medical Instrumentation (ECG/EEG) AD7793 24-bit sigma-delta ADC for sensor signal digitization Used in: Industrial Process Control ADuM1201ARZ Digital isolator for galvanic isolation in industrial systems Used in: Industrial Process Control AD7190 Low-noise, 24-bit ADC for bridge sensor interfaces Used in: Bridge Amplifier ADR4525 Precision voltage reference for bridge excitation Used in: Bridge Amplifier AD7606BSTZ Analog Devices Used in: Data Acquisition Systems AD7176-2BRUZ Analog Devices Used in: Data Acquisition Systems ADT7420 Digital temperature sensor with I2C interface Used in: Precision Sensor Interface ADXL345 3-axis accelerometer for motion sensing Used in: Precision Sensor Interface AD797 Ultralow distortion op amp for audio signal processing Used in: Audio Test Equipment ADAU1452 Audio DSP for advanced signal processing Used in: Audio Test Equipment
What is the input offset voltage of AD8221ARZ?
The AD8221ARZ has a maximum input offset voltage of 60 Β΅V. According to the Analog Devices AD8221 datasheet (Rev. C), this low offset minimizes errors in precision measurement applications, ensuring accurate signal conditioning.
What is the CMRR of AD8221ARZ at 60 Hz?
The AD8221ARZ has a minimum CMRR of 90 dB at 60 Hz. This high common-mode rejection ratio ensures excellent rejection of power-line interference, making it ideal for medical and industrial applications where noise rejection is critical.
What is the bandwidth of AD8221ARZ?
The AD8221ARZ has a bandwidth of 825 kHz at a gain of 1. This wide bandwidth allows it to amplify high-frequency signals accurately, making it suitable for data acquisition and high-speed measurement systems.
What is the supply voltage range of AD8221ARZ?
The AD8221ARZ operates from a single supply of 4.5 V to 36 V or dual supplies of Β±2.25 V to Β±18 V. This wide range provides flexibility in various power supply configurations, from battery-powered devices to industrial systems.
What is the input bias current of AD8221ARZ?
The AD8221ARZ has a maximum input bias current of 500 pA. This low bias current minimizes errors when interfacing with high-impedance sources, such as sensors and electrodes, ensuring accurate signal measurement.
What is the gain range of AD8221ARZ?
The AD8221ARZ has a gain range of 1 to 1000, set by a single external resistor. This flexibility allows designers to configure the amplifier for various signal levels without additional components.
What is the slew rate of AD8221ARZ?
The AD8221ARZ has a slew rate of 2 V/Β΅s. This fast slew rate ensures that the amplifier can track rapid changes in input signals, making it suitable for high-speed applications such as waveform amplification.
What is the quiescent current of AD8221ARZ?
The AD8221ARZ has a maximum quiescent current of 1.2 mA. This low power consumption makes it suitable for battery-powered and portable applications where power efficiency is important.
What is the operating temperature range of AD8221ARZ?
The AD8221ARZ operates over a temperature range of -40Β°C to +85Β°C. This wide range ensures reliable performance in harsh industrial and automotive environments.
What is the package type of AD8221ARZ?
The AD8221ARZ is available in an 8-lead SOIC package. This surface-mount package is compact and suitable for automated assembly, making it ideal for high-volume production.
Is AD8221ARZ RoHS compliant?
Yes, the AD8221ARZ is RoHS compliant. According to the Analog Devices product page, the device meets the Restriction of Hazardous Substances directive, ensuring environmental compliance.
What is the difference between AD8221ARZ and AD8221BRZ?
The AD8221ARZ and AD8221BRZ are both precision instrumentation amplifiers from Analog Devices, but they differ in grade. The AD8221BRZ has tighter specifications, such as lower offset voltage and drift, making it suitable for higher-precision applications. The ARZ grade is more cost-effective for general-purpose use.
Can AD8221ARZ be used in medical applications?
Yes, the AD8221ARZ is suitable for medical applications such as ECG and EEG monitoring. Its low offset voltage, low bias current, and high CMRR ensure accurate measurement of bio-potential signals, which are typically low-amplitude and prone to interference.
What is the best drop-in replacement for AD8221ARZ?
The AD8221BRZ is a drop-in replacement for AD8221ARZ, as it is pin-compatible and has the same package. However, it offers better precision. The AD8422 is also pin-to-pin compatible but has a different gain equation, so the gain resistor value must be adjusted.
Where can I buy AD8221ARZ online?
AD8221ARZ is available from authorized distributors such as DigiKey, Mouser, and LCSC. As of 2026-08-21, DigiKey lists it in stock with pricing starting at $4.86 for single units. You can also purchase directly from Analog Devices' website.

Engineering reference data for AD8221ARZ β€” comparison, design guidance, and compliance information.

Selection Guide

Choose the AD8221ARZ when you need a precision instrumentation amplifier with high CMRR over frequency, low bias current, and wide bandwidth for general-purpose applications. If you require even lower offset voltage and drift, select the AD8221BRZ, which offers tighter specifications at a higher cost. For applications needing higher bandwidth (2.2 MHz), consider the AD8422ARZ, but note that its gain equation differs, requiring Rg adjustment. The AD8223BRZ is a lower-cost option with reduced bandwidth and higher offset, suitable for less demanding applications. For a cross-brand alternative, the INA128UA from Texas Instruments offers similar performance but has higher bias current and may require pinout verification. All alternatives are pin-compatible in the 8-lead SOIC package, but verify the gain equation and specifications before substitution.

Comparison with Alternatives

Parameter This Product AD8221BRZ AD8422ARZ AD8223BRZ INA128UA
Package 8-Lead SOIC 8-Lead SOIC 8-Lead SOIC 8-Lead SOIC 8-Lead SOIC
Brand Analog Devices Analog Devices Analog Devices Analog Devices Texas Instruments
Input Offset Voltage 60 Β΅V (max) 25 Β΅V (max) 60 Β΅V (max) 150 Β΅V (max) 50 Β΅V (max)
Input Bias Current 500 pA (max) 500 pA (max) 500 pA (max) 500 pA (max) 5 nA (max)
Bandwidth 825 kHz 825 kHz 2.2 MHz 200 kHz 200 kHz
CMRR at 60 Hz 90 dB (min) 100 dB (min) 90 dB (min) 80 dB (min) 90 dB (min)
Supply Voltage Range 4.5 V to 36 V 4.5 V to 36 V 4.5 V to 36 V 4.5 V to 36 V 4.5 V to 36 V
Quiescent Current 1.2 mA (max) 1.2 mA (max) 1.2 mA (max) 1.2 mA (max) 700 Β΅A (max)

Key Differentiators

  • Highest CMRR over frequency in its class (vs AD8223BRZ)
  • Low input bias current of 500 pA (vs INA128UA)
  • Wide bandwidth of 825 kHz (vs AD8223BRZ)

Design Notes

For optimal CMRR, ensure a solid ground plane and place decoupling capacitors (0.1 Β΅F ceramic and 10 Β΅F tantalum) close to the supply pins. Use guard traces around the inputs to minimize leakage currents. The reference pin (pin 5) should be bypassed with a capacitor to ground to reduce noise.

The gain resistor (RG) must be a precision resistor (0.1% tolerance or better) to maintain gain accuracy. Avoid using long traces for RG connections, as parasitic capacitance can affect bandwidth. Also, ensure the input common-mode voltage is within the specified range to avoid output saturation.

The AD8221ARZ dissipates minimal power (typically less than 50 mW), so thermal management is not critical. However, in high-temperature environments, ensure the junction temperature stays below 150Β°C. The SOIC package has a thermal resistance of approximately 100Β°C/W, so adequate airflow or copper pour is recommended for high ambient temperatures.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Unknown

RoHS and REACH compliance confirmed from Analog Devices product page. AEC-Q100 not applicable as this is not an automotive-grade part.

Data verified on: 2026-08-21
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