NXP Semiconductors

MCF52210CAE66 - 32-Bit 66 MHz ColdFire MCU | NXP

MPN: MCF52210CAE66 ✗ End of Life
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3.3 V Vdss 64-LQFP (10 x 10 mm) Package 66 MHz Speed 64 KB Memory
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Price updated: 2026-10-21
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MCF52210CAE66 Overview

The NXP Semiconductors MCF52210CAE66 is a 32-bit ColdFire V2 microcontroller operating at 66 MHz with 64 KB of Flash memory and a 64-LQFP package measuring 10 x 10 mm. It is designed for embedded control systems requiring a 32-bit RISC core, integrated USB connectivity, and a compact surface-mount package.

A ColdFire microcontroller is a 32-bit embedded processor architecture used in control-oriented products such as industrial equipment, communications modules, human-machine interfaces, and USB peripherals. The ColdFire V2 core provides a deterministic instruction set and a conventional microcontroller integration model, allowing firmware to control memory-mapped peripherals, communications interfaces, timers, and external devices.

The supplied product data identifies the MCF52210CAE66 as a ColdFire V2 MCF5221x device with 66 MHz operation, 64 KB Flash, and a 64-LQFP package. The NXP product listing also describes it as a 32-bit microcontroller with USB capability. These characteristics make the device suitable for embedded USB controllers, peripheral hubs, industrial controllers, and compact communication equipment where a higher-performance 32-bit core is useful without adopting a larger MCU package.

The 64 KB Flash memory provides on-chip nonvolatile program storage, reducing the need for an external program-memory device in firmware-contained designs. The 10 x 10 mm LQFP provides 64 leads for power, ground, communications, control, and peripheral connectivity. Because the verified excerpt does not specify the complete electrical limits or pin-level multiplexing, engineers should use the manufacturer datasheet before finalizing power, clock, USB, and signal-integrity implementation details.

Typical design work includes confirming the required USB interface, validating the clock source and reset behavior, checking peripheral pin multiplexing, and planning programming and test access. LQFP packages also require adequate soldering and inspection practices during manufacturing. The compact 10 x 10 mm footprint helps reduce board area but does not eliminate thermal or routing constraints.

This product page distinguishes the MCF52210CAE66 from broader cross-reference candidates by focusing on the verified 32-bit ColdFire V2 architecture, 66 MHz frequency, 64 KB Flash configuration, USB association, and 64-LQFP package. Confirm current lifecycle, pinout, electrical limits, and availability with NXP or an authorized distributor before committing to a production design.

Drop-in alternatives for MCF52210CAE66 — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with MCF52210CAE66 (same form factor and footprint) — differing in Package, Core, RAM, Supply Voltage, Flash Memory.

NXP Semiconductors
Package: 64-pin LQFP (10x10 mm)
RAM: Up to 16 KB
Supply Voltage: 3.0 V to 3.6 V
Compare with MCF52210CAE66 →
NXP Semiconductors
Package: 64-LQFP (10 mm x 10 mm)
Core: ColdFire V2 (32-bit)
RAM: 16 KB
Compare with MCF52210CAE66 →
NXP Semiconductors
Package: 64-LQFP (10x10 mm)
Compare with MCF52210CAE66 →
NXP Semiconductors
Core: ColdFire V2 (32-bit RISC, 68k-derived)
RAM: 8 KB (8K x 8)
Compare with MCF52210CAE66 →
NXP Semiconductors
Package: 64-LQFP (10mm × 10mm)
Flash Memory: 128KB (128K × 8)
Compare with MCF52210CAE66 →

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

MCF52100CAE66

✅ Drop-In
NXP Semiconductors
📦 64-LQFP (10 x 10 mm)
ColdFire V2 · 32-bit · 66 MHz · 76 MIPS · 64 KB (64K x 8) · Up to 16 KB · 3.0 V to 3.6 V · -40 C to +85 C (industrial)

✓ In Stock

$5.09 / Unit

View Datasheet →

MCF52110CAE66

✅ Drop-In
NXP Semiconductors
📦 64-LQFP (10 x 10 mm)
ColdFire V2 (32-bit) · MCF521xx · 66 MHz · 128 KB Flash (128K x 8) · 16 KB · 3.3 V · 64-LQFP (10 mm x 10 mm) · Surface Mount

✓ In Stock

$9.95 / Unit

View Datasheet →

MCF52211CAE66

✅ Drop-In
NXP Semiconductors
📦 64-LQFP (10 x 10 mm)
ColdFire V2 (VLRISC, 32-bit) · 66 MHz · 76 MIPS · 128 KB (128K x 8) · 3.3 V (typical, single supply) · USB 2.0 On-The-Go (OTG) with on-chip PHY · 3

✓ In Stock

$9.25 / Unit

View Datasheet →

MCF52212CAE50

✅ Drop-In
NXP Semiconductors
📦 LQFP
ColdFire V2 (32-bit RISC, 68k-derived) · 50 MHz · 64 KB (64K x 8) · 8 KB (8K x 8) · 56 · 64-LQFP (10x10 mm) · Surface Mount · USB On-The-Go (OTG) integrated

✓ In Stock

$6.74 / Unit

View Datasheet →

MCF52221CAE66

✅ Drop-In
NXP Semiconductors
📦 64-LQFP (10 x 10 mm)
32-bit microcontroller · ColdFire V2 · 66 MHz · Up to 76 MIPS at 80 MHz · 128KB (128K × 8) · 32-bit ColdFire RISC · USB full-speed OTG

✓ In Stock

Contact for price

View Datasheet →

MCF52210CAE66 Maximum Ratings & Electrical Characteristics

Microcontroller Type 32-bit ColdFire V2 microcontroller
Processor Architecture ColdFire V2 RISC
Maximum Clock Frequency 66 MHz
Flash Memory 64 KB
Program Memory Organization 64K x 8
USB Association USB
Package Type 64-LQFP (10 x 10 mm)
Package Pin Count 64 pins
Mounting Type Surface Mount
Core ColdFire V2
Supply Voltage 3.3 V
Manufacturer NXP Semiconductors
Legacy Manufacturer Freescale Semiconductor
Data Width 32-bit
Memory Type Flash
Product Category 32-bit Microcontroller IC

MCF52210CAE66 64 pins Pin Configuration Guide

Pin configuration for MCF52210CAE66 (64 pins package). This digital IC includes GPIO, communication interfaces (UART, SPI, I2C), and power pins. Refer to the manufacturer datasheet for alternate pin functions and configuration options. Essential for embedded system design and PCB layout.

64 pins package pinout diagram for MCF52210CAE66

No detailed pinout data available for MCF52210CAE66.

Refer to the datasheet for full pin configuration.

Typical Applications

MCF52210CAE66 is suitable for 7 applications: USB Embedded Peripheral Controller, Industrial Control Module, Human-Machine Interface Controller, USB Communication Gateway, Data Acquisition Front End, Programmable Automation Controller, Connected Service Interface.

🌐

USB Embedded Peripheral Controller

The MCF52210CAE66 fits a compact USB-enabled embedded peripheral when the product listing’s 66 MHz ColdFire V2 core and 64 KB Flash are sufficient for local control and firmware storage. The MCU can coordinate device state, protocol handling, configuration storage, and host-facing controls in a 10 x 10 mm LQFP footprint. Designers should verify USB device or host capability, transceiver dependency, power states, and exact pin assignments in the NXP datasheet. Keep USB routing short and controlled, and provide the required clock, reset, decoupling, and programming access according to the manufacturer guidance.

🏭

Industrial Control Module

The 32-bit ColdFire V2 architecture and 66 MHz operating frequency provide a practical basis for an industrial control module that coordinates digital I/O, communications, timers, and supervisory logic. Its 64 KB Flash allows a compact firmware image to be stored on-chip, while the 64-LQFP package preserves a relatively compact surface-mount footprint. The exact I/O count, peripheral availability, voltage limits, and pin multiplexing are not included in the supplied excerpts. Before schematic release, compare the complete datasheet against the required sensors, actuators, isolation boundaries, bus levels, and factory update method.

📺

Human-Machine Interface Controller

MCF52210CAE66 can serve as the central controller for a compact human-machine interface when the interface includes a display, keypad, status LEDs, and a communications link. Its verified 32-bit ColdFire V2 core and 66 MHz clock are useful for responsive event handling and peripheral coordination, while 64 KB Flash supports embedded control firmware. The designer must still verify available I/O pins, timing peripherals, external memory interfaces, and operating-temperature limits from the manufacturer datasheet. Use a defined ground and reset strategy, isolate display buses from USB or switching circuitry, and validate ESD protection at externally accessible connectors.

🔌

USB Communication Gateway

The product is a logical candidate for a USB communication gateway because the verified distributor data identifies USB capability alongside a 32-bit ColdFire V2 processor at 66 MHz. The controller can bridge a local serial or industrial interface to a USB-connected host while maintaining protocol state and diagnostics in its 64 KB Flash. The actual gateway architecture depends on the selected USB mode, available communications peripherals, and required transceiver components, none of which are fully specified in the supplied snippets. Validate signal integrity, ESD protection, bus termination, firmware update strategy, and enumeration behavior before production release.

📡

Data Acquisition Front End

MCF52210CAE66 can coordinate a compact data-acquisition front end that gathers digital measurements and passes processed data through a communications interface. The 32-bit architecture and 66 MHz operating point provide a stronger control platform than an 8- or 16-bit MCU for multi-step sampling coordination, buffering, and protocol formatting, while 64 KB Flash limits the available program and constant-data space to the designer. ADC characteristics, timer channels, sensor interfaces, and memory details are not present in the supplied data. Confirm them in the manufacturer datasheet and design input filtering and grounding around the actual sensor requirements.

⚙️

Programmable Automation Controller

The MCF52210CAE66 is suitable for a small programmable automation controller when the application needs a 32-bit control core, on-chip Flash, and a compact LQFP footprint. It can manage discrete I/O, sequence logic, communications, and fault reporting, provided the selected pinout and peripheral resources satisfy the machine requirements. The verified material does not establish isolated I/O channels, safety rating, motion-control features, or environmental limits, so those requirements must be treated as external interface and system-level design tasks. Validate startup behavior, watchdog requirements, brownout behavior, and field programming access against the final product specification.

🧩

Connected Service Interface

MCF52210CAE66 can be integrated into a connected service interface that exposes configuration, diagnostics, or firmware-update functions through USB or another communications channel. Its 66 MHz ColdFire V2 core can handle protocol tasks and control logic, while 64 KB Flash may be adequate for a focused firmware image. The design should use a separate service connector protection strategy, robust ground and power sequencing, and a controlled bootloader path. The verified results identify USB association but do not provide security capabilities, update endurance, authentication features, or exact USB electrical requirements; those items must be confirmed from the full NXP documentation.

What is MCF52210CAE66?
MCF52210CAE66 is a 32-bit ColdFire V2 microcontroller from NXP Semiconductors, listed by distributors as the MCF5221x family device with USB capability. The verified product descriptions identify a 66 MHz operating frequency, 64 KB Flash memory organized as 64K x 8, and a 64-LQFP package measuring 10 x 10 mm. It is intended for embedded control and communications designs rather than general-purpose computing.
What are the key specifications engineers should know about MCF52210CAE66?
The verified specifications identify MCF52210CAE66 as a 32-bit ColdFire V2 microcontroller with a 66 MHz maximum clock, 64 KB Flash, USB association, and a 64-LQFP package measuring 10 x 10 mm. The product listing from DigiKey describes it as a 32-bit 66 MHz MCU with 64K x 8 Flash, while Mouser identifies the part as an NXP 32-bit MCU with USB. Pin-level electrical limits are not included in the supplied excerpts.
Where can I download the MCF52210CAE66 datasheet?
The MCF52210CAE66 datasheet is available through the NXP-oriented datasheet index at https://www.datasheets.com/nxp/mcf52210cae66. Additional datasheet references appear on DigiKey and third-party document indexes. Use the manufacturer datasheet as the controlling document for pin assignments, clock requirements, USB behavior, electrical limits, memory maps, and recommended application circuits because those details are not fully present in the supplied search snippets.
What is the pinout of MCF52210CAE66?
The supplied search results confirm that MCF52210CAE66 uses a 64-LQFP package, but they do not provide the complete numbered pin assignments. The pinout therefore cannot be safely reconstructed from the available snippets. Obtain the manufacturer datasheet before connecting power, USB, clock, reset, programming, or peripheral signals; use the package diagram only as a secondary reference after cross-checking every pin against the specific device revision.
How much does MCF52210CAE66 cost?
The supplied Heisener listing reports a unit price of $6.4464 for MCF52210CAE66, as of 2026-10-21. That is a distributor reference price rather than a universal market price, and the same listing states lead time is to be confirmed. DigiKey and Mouser product pages provide additional commercial sources, but no quantity-break pricing for 10, 100, 500, or 1000 units was included in the verified data.
Is MCF52210CAE66 in stock?
The verified Heisener result states 2,672 pieces are in stock and identifies the part as available for reference, while also stating that lead time is to be confirmed. This should be treated as a point-in-time distributor listing fetched on 2026-10-21, not a guaranteed allocation. Confirm live inventory, authorized-channel status, and delivery terms with the seller before purchasing, especially for production quantities.
What is the lead time for MCF52210CAE66?
The verified Heisener result says that lead time is to be confirmed and provides an estimated delivery window of March 25 through March 30 in the displayed listing. Because the result does not identify a year or provide a confirmed factory lead time, engineers should request a written quotation and current delivery commitment. Distributor inventory can change after the 2026-10-21 data retrieval date.
MCF52210CAE66 vs MCF52100CAE66: which is more suitable?
MCF52210CAE66 and MCF52100CAE66 are both listed in the supplied cross-reference results as ColdFire microcontroller candidates, but the available snippets do not provide a complete pinout, memory, clock, and peripheral comparison. MCF52210CAE66 is specifically verified as a 66 MHz, 64 KB Flash, 64-LQFP MCF5221x device. Choose it only after checking the original schematic and datasheet for USB, pin multiplexing, memory, and peripheral differences.
MCF52210CAE66 vs MCF52211CAE66: can the MCF52211 part replace it?
The supplied cross-reference data lists MCF52211CAE66 as a comparison candidate, but it does not establish that the two devices are pin-to-pin compatible or electrically identical. MCF52210CAE66 is verified as a 66 MHz, 64 KB Flash, 64-LQFP ColdFire V2 MCU, while the candidate’s detailed specifications are absent. Treat the relationship as a comparison lead, not a drop-in replacement, until the manufacturer pin tables and electrical limits are reviewed.
What can replace MCF52210CAE66 in an existing design?
The verified cross-reference search does not confirm any drop-in replacement for MCF52210CAE66. The only named comparison candidates are MCF52110CAE66, MCF52100CAE66, and MCF52211CAE66, and the snippets do not prove identical pinout, USB behavior, memory mapping, or peripheral availability. For a replacement, compare the complete NXP datasheet, validate the package and pin mapping, and recompile or retest firmware and USB enumeration before release.
When should I choose MCF52210CAE66 over another ColdFire MCU?
Choose MCF52210CAE66 when the design specifically requires a verified 66 MHz ColdFire V2 controller with 64 KB Flash, USB association, and a 64-LQFP 10 x 10 mm footprint. The device is a fit when its exact pin multiplexing, memory map, USB implementation, electrical limits, and software support match the system requirements. It is not automatically preferable when a candidate has a different package, wider I/O requirements, or different firmware assumptions.
Is MCF52210CAE66 suitable for USB peripheral applications?
MCF52210CAE66 is suitable for USB-related embedded applications when the specific USB requirements match the device datasheet. The Mouser listing describes it as an NXP 32-bit MCU with USB, and the product descriptions identify a 66 MHz ColdFire V2 core with 64 KB Flash. USB host or device operation, speed, transceiver requirements, power states, and pin mapping must be confirmed in the manufacturer datasheet before layout approval.
What design considerations apply when placing MCF52210CAE66?
Place the 64-LQFP device on a PCB with a defined land pattern that matches the 10 x 10 mm package, and route USB, clock, reset, and programming signals away from noisy switching nodes. Keep the power and ground connections short and follow the manufacturer’s decoupling and layout recommendations. Because those recommendations are not present in the supplied snippets, do not invent capacitor values or trace dimensions; use the full datasheet.
What is the lifecycle status of MCF52210CAE66?
The supplied distributor search results show that MCF52210CAE66 is offered for purchase, but they do not explicitly state whether the part is active, NRND, or obsolete. Its lifecycle status should therefore be treated as unknown until confirmed through the NXP product page or an authorized distributor. Check the latest manufacturer status before starting a new design or placing long-term production orders.
Where can I buy MCF52210CAE66 online?
MCF52210CAE66 can be found through the verified DigiKey, Mouser, Heisener, and datasheet-index listings. DigiKey lists the part under Rochester Electronics and NXP USA Inc., Mouser lists NXP Semiconductors, and Heisener reports a reference unit price of $6.4464 plus a stated inventory figure as of 2026-10-21. Confirm seller authorization, stock, price, and delivery terms directly before ordering.
Does MCF52210CAE66 use a 32-bit RISC processor?
Yes. The verified distributor descriptions identify MCF52210CAE66 as a 32-bit ColdFire V2 microcontroller, and ColdFire V2 is the processor architecture associated with this part. The same descriptions specify 66 MHz operation and 64 KB Flash. Architecture compatibility alone does not guarantee software or pin compatibility with another ColdFire model, so firmware, memory-map, and peripheral differences still require verification.

Engineering reference data for MCF52210CAE66 — comparison, design guidance, and compliance information.

Selection Guide

Choose MCF52210CAE66 when the product specification calls for a 32-bit ColdFire V2 MCU operating at 66 MHz, with 64 KB Flash, USB association, and a 64-LQFP 10 x 10 mm package. It is best suited to compact embedded control, USB peripheral, gateway, and industrial communication designs where the exact peripheral set and software support are acceptable. MCF52100CAE66, MCF52110CAE66, and MCF52211CAE66 may be useful comparison points, but the supplied data does not prove that they are drop-in replacements. MCF52212CAE50 and MCF52221CAE66 are also listed as related or site-listed candidates, yet their pin, memory, and electrical differences remain unverified. Before substitution, compare the package drawing, complete pin table, power limits, clock requirements, memory map, USB implementation, and firmware dependencies.

Comparison with Alternatives

Parameter This Product MCF52100CAE66 MCF52110CAE66 MCF52211CAE66 MCF52212CAE50 MCF52221CAE66
Brand NXP Semiconductors NXP Semiconductors NXP Semiconductors NXP Semiconductors NXP Semiconductors NXP Semiconductors
Package 64-LQFP (10 x 10 mm) 64-LQFP (10 x 10 mm) 64-LQFP (10 x 10 mm) 64-LQFP (10 x 10 mm) LQFP 64-LQFP (10 x 10 mm)

Key Differentiators

  • Verified 66 MHz operating frequency (vs MCF52100CAE66)
  • Verified 64 KB on-chip Flash (vs MCF52110CAE66)
  • USB-associated control positioning (vs MCF52211CAE66)
  • Documented package identity (vs MCF52212CAE50)

Design Notes

Use the manufacturer land pattern for the 64-LQFP 10 x 10 mm package rather than estimating dimensions from the distributor description. Confirm pad length, pad width, exposed thermal requirements if any, and solder-mask clearance against the package drawing. Place the MCU close to its clock, reset, decoupling, USB, and programming nets, and avoid routing high-current switching paths beneath sensitive signal traces.

The verified listing identifies a 3.3 V supply, but it does not provide the complete electrical limits or recommended decoupling values. Before power-up, verify supply range, absolute maximum ratings, input leakage, power sequencing, and ground requirements in the NXP datasheet. Use only manufacturer-recommended capacitor values and placement; do not substitute generic values when the device-specific power network has not been validated.

Do not treat a same-family or same-package MPN as a drop-in replacement without checking every pin and peripheral function. The verified data confirms the target’s 64-LQFP package and basic identity, but it does not establish identical USB routing, clock pins, memory mapping, interrupt vectors, or peripheral multiplexing for MCF52100CAE66, MCF52110CAE66, MCF52211CAE66, MCF52212CAE50, or MCF52221CAE66. Compare the complete datasheets and validate firmware after any substitution.

For USB-enabled use, keep the USB data path short, preserve the referenced ground connection, and separate the USB route from clocks, switching inductors, and high-current motor returns. Confirm whether the selected MCU variant uses an integrated transceiver or requires external components. Apply the manufacturer’s recommended termination and protection scheme; the supplied search snippets do not establish the exact USB electrical topology.

Although the target is a microcontroller rather than a power semiconductor, power dissipation still depends on clock activity, I/O loading, USB activity, and supply voltage. Estimate worst-case internal and I/O dissipation only after obtaining the datasheet current limits and operating modes. Provide adequate copper area and thermal relief according to the package drawing, and avoid using an assumed thermal resistance or junction-temperature rise for production safety decisions.

Compliance Information

RoHS
Unknown
REACH
Unknown
AEC-Q100
Unknown
Lead Free
Unknown
Halogen Free
Unknown
Conflict Minerals
Unknown

The supplied distributor snippets do not explicitly state RoHS, REACH, AEC-Q100, lead-free, halogen-free, or conflict-mineral status. Confirm current compliance and lifecycle information with NXP or an authorized distributor.

Related Searches

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Related Components & Terms

NXP Semiconductors Freescale Semiconductor MCF52210CAE66 MCF5221x ColdFire V2 32-bit RISC microcontroller embedded microcontroller USB 66 MHz 64 KB Flash 64K x 8 64-LQFP 10 x 10 mm package surface-mount package industrial control USB peripheral USB communication gateway human-machine interface data acquisition programmable automation MCF52100CAE66 MCF52110CAE66 MCF52211CAE66 RoHS REACH
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