NXP Semiconductors

NAFE33352B40BS - 24-bit Universal AIO-AFE | NXP Semiconductors

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Integrated low-drift voltage reference Vdss 40-HVQFN (6x6 mm) Package
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NAFE33352B40BS Overview

The NXP Semiconductors NAFE33352 (ordering code NAFE33352B40BS) is a software-configurable universal analog input and output (AIO) analog front-end (AFE) that integrates a 24-bit ADC, a precision 14/16/18-bit DAC, a low-drift voltage reference, low-offset drift buffers, and a high-voltage amplifier in a 40-pin HVQFN (6x6 mm) package.

An analog front-end (AFE) is the circuit block that conditions and converts real-world analog signals - voltages, currents, and resistances from sensors and actuators - into digital data and back again, sitting between raw field signals and a processor in industrial measurement and control systems. Within the power and signal-chain hierarchy, the AFE occupies the layer above the ADC and DAC themselves, integrating conversion, referencing, amplification, and multiplexing into a single programmable device.

Key features include two universal analog input channels plus one combined analog input/output channel, a 24-bit ADC for high-precision measurement, an integrated precision DAC for signal generation, and a readback path (Vsense, Isense) that measures voltage and current output. An LVMUX connection allows the ADC to digitize external and internal signals for condition monitoring. The combination of current output and voltage input enables resistance and temperature measurement using RTD or thermistor sensors.

The NAFE33352 is the low-power member of the NAFEx3352 family; the NAFE93352 is the high-speed version. Its architecture pairs the precision DAC, low-drift reference, and high-voltage amplifier to generate both small and wide output signals, meeting industrial-grade accuracy requirements without multiple discrete components.

Typical applications include programmable logic controllers (PLCs), process control systems, I/O modules, and data loggers, where universal analog channels must be reconfigured in software for voltage, current, or resistive sensor interfaces.

When designing with this device, configure channel modes through its software interface early in the project, since the universal input structure replaces several fixed-function ICs and layout decisions (grounding, HV routing) should reflect the full configured operating range.

This page synthesizes verified distributor listings, drop-in alternative analysis, and practical design guidance not found in the manufacturer datasheet.

Drop-in alternatives for NAFE33352B40BS — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with NAFE33352B40BS (same form factor and footprint) — differing in Product Type.

NXP Semiconductors
Product Type: Software-configurable universal analog input/output analog front-end (AIO-AFE)
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NAFE93352B40BS

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NXP Semiconductors
📦 40-HVQFN (6x6)
Software-configurable universal analog input/output analog front-end (AIO-AFE) · 24 bit · 2 · Software-configurable universal input/output · High-speed version (NAFE33352 is the low-power version) · 40-HVQFN (6x6 mm) · Surface Mount · PLC, Process Control, I/O modules, data loggers

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$7.9 / Unit

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NAFE33350

✅ Drop-In
📦 40-HVQFN (6x6)
analog-output-focused AFE in the same family/EVB platform; input channel set reduced vs NAFE33352 (verify pin map on target revision)

📋 Reference alternative (not in catalog)

NAFE33352B40BS Maximum Ratings & Electrical Characteristics

Product Type Software-configurable universal AIO analog front-end (AFE)
ADC Resolution 24 bit
DAC Resolution Options 14 / 16 / 18 bit (integrated precision DAC)
Analog Input Channels 2 universal input channels
Analog Input/Output Channel 1 combined AIO channel
Voltage Reference Integrated low-drift voltage reference
Buffers Low-offset drift buffers
Output Amplifier Integrated high-voltage amplifier
Readback Path Vsense and Isense voltage/current output readback
Condition Monitoring LVMUX connection to ADC for external/internal signal digitization
Sensor Support RTD and thermistor (resistance/temperature measurement)
Family Position NAFE33352 = low-power version; NAFE93352 = high-speed version
Package 40-HVQFN (6x6 mm)
Mounting Type Surface Mount
Target Applications PLC, process control, I/O modules, data loggers

NAFE33352B40BS 40-hvqfn (6x6 mm) Pin Configuration Guide

Pin configuration for NAFE33352B40BS (40-hvqfn (6x6 mm) package). This analog component features input, output, and power supply pins. Refer to the manufacturer datasheet for offset null, compensation, and enable pin configurations. Ideal for signal conditioning and amplifier circuits.

40-hvqfn (6x6 mm) package pinout diagram for NAFE33352B40BS

No detailed pinout data available for NAFE33352B40BS.

Refer to the datasheet for full pin configuration.

Typical Applications

NAFE33352B40BS is suitable for 6 applications: Programmable Logic Controllers (PLC), Process Control Systems, Industrial I/O Modules, Data Loggers, RTD and Thermistor Temperature Measurement, Condition Monitoring Systems.

🏭

Programmable Logic Controllers (PLC)

The NAFE33352 fits PLC analog I/O cards because its software-configurable universal channels replace multiple fixed-function conditioning ICs. Its 24-bit ADC provides the resolution margin industrial measurement demands, while the integrated 14/16/18-bit DAC and high-voltage amplifier generate control outputs across small and wide signal ranges. Because channel behavior is configured in software, one analog module design can serve voltage, current, and RTD/thermistor input types selected at commissioning. The Vsense/Isense readback path lets the PLC's processor verify output integrity continuously, improving diagnostics coverage. Placing the AFE close to the field connector with short high-voltage traces minimizes noise pickup, and the integrated low-drift reference removes a separate precision-reference component from the analog card BOM.

⚙️

Process Control Systems

In process control, the NAFE33352's combination of 24-bit measurement and precise signal generation suits closed-loop control of temperature, pressure, and flow variables. The low-drift voltage reference and low-offset drift buffers maintain accuracy over long periods between calibration cycles, which is critical in continuous process environments. Its current output capability drives standard current-loop actuators while the voltage input channels read transmitters, and the RTD/thermistor support covers direct temperature sensing without additional excitation circuitry. The LVMUX condition-monitoring path lets the same device track loop health signals, supporting predictive maintenance in the control system. For high-speed process loops requiring faster scanning, NXP's NAFE93352 high-speed family member is the designated upgrade path within the same architecture.

🧩

Industrial I/O Modules

Universal I/O modules benefit directly from the NAFE33352's architecture: two universal input channels plus one combined analog input/output channel let a single footprint support mixed-channel configurations (e.g., 3 voltage inputs plus 1 current output) without hardware changes. The 24-bit ADC digitizes low-level sensor signals with adequate headroom for industrial accuracy classes, and the integrated high-voltage amplifier produces wider output ranges required by actuators. Software configuration means the same PCB supports multiple SKU variants, reducing inventory complexity for module vendors. The Vsense/Isense readback provides per-channel diagnostics needed for module-level health reporting in Industry 4.0 deployments, and the 40-HVQFN (6x6 mm) package keeps channel density high on standard module form factors.

📊

Data Loggers

The NAFE33352 is the low-power member of the NAFEx3352 family, making it appropriate for battery-powered and low-power data loggers that must run for months on limited energy. Its 24-bit ADC captures slow-moving process signals with high resolution, and the two universal inputs plus AIO channel cover the typical logger channel mix of sensor inputs and an occasional excitation or control output. RTD and thermistor support enables temperature logging using the device's own current output and voltage input combination, eliminating external excitation circuitry and its associated quiescent draw. The LVMUX condition-monitoring input can also record supply or diagnostic signals. Where logging requires faster scan rates, the NAFE93352 high-speed variant is the in-family alternative at the cost of higher power consumption.

🌡️

RTD and Thermistor Temperature Measurement

The NAFE33352 measures resistance and temperature using RTD or thermistor sensors by combining its current output with its voltage input: the DAC-driven current excites the sensor, and the 24-bit ADC digitizes the resulting voltage, from which resistance is computed. This integrated approach removes the discrete excitation current source, instrumentation amplifier, and separate ADC that a traditional RTD front-end requires, cutting component count and error-budget terms. The low-drift voltage reference directly limits gain-error drift in the resistance calculation, and the Vsense/Isense readback verifies excitation accuracy in-situ. In multi-channel temperature modules, the software-configurable channel structure lets one board support 2-wire, 3-wire, and thermistor input types selected at configuration time, simplifying product variants.

🎥

Condition Monitoring Systems

The NAFE33352 supports condition-monitoring functions through its LVMUX connection to the ADC, which digitizes both external and internal signals for diagnostics. In industrial monitoring nodes, this allows the same AFE performing routine analog I/O to also track equipment health signals - supply rails, internal reference levels, or external monitor points - without a second data-acquisition device. The 24-bit resolution captures small signal drifts early, and the Vsense/Isense readback path confirms that command outputs are actually being delivered, detecting wiring faults or actuator degradation. Because the NAFE33352 is the low-power family member, it suits continuously powered monitoring nodes, while the NAFE93352 serves high-speed vibration-oriented monitoring where sample rate dominates power considerations.

Recommended Products Summary

NAFE33352-EVB NXP Semiconductors Used in: Programmable Logic Controllers (PLC), Process Control Systems, Data Loggers, RTD and Thermistor Temperature Measurement, Condition Monitoring Systems NAFE33350 Companion analog-output AFE in the same family Used in: Programmable Logic Controllers (PLC), Industrial I/O Modules, RTD and Thermistor Temperature Measurement NAFE93352 High-speed family version for fast process loops Used in: Process Control Systems, Data Loggers, Condition Monitoring Systems NAFE33352-UIOM NXP Semiconductors Used in: Industrial I/O Modules
What is the NAFE33352?
The NAFE33352 is a software-configurable universal analog input and output (AIO) analog front-end (AFE) from NXP Semiconductors for high-precision industrial measurement and control. It integrates a 24-bit ADC, a 14/16/18-bit DAC, a low-drift voltage reference, low-offset drift buffers, and a high-voltage amplifier in a 40-pin HVQFN (6x6 mm) package. According to the NXP product page, it targets PLC, process control, I/O module, and data logger applications.
What is the difference between NAFE33352 and NAFE93352?
The NAFE33352 is the low-power version of the NAFEx3352 family, while the NAFE93352 is the high-speed version. According to NXP's product information page, both share the universal AIO-AFE architecture with the integrated 24-bit ADC and precision DAC, so the choice depends on whether power consumption or conversion speed is the dominant requirement in your I/O module or process control design.
What are the key specifications of NAFE33352 that engineers should know?
The NAFE33352 offers a 24-bit ADC, an integrated 14/16/18-bit precision DAC, two universal analog input channels plus one analog input/output channel, a low-drift voltage reference, low-offset drift buffers, and a high-voltage amplifier, all in a 40-pin HVQFN (6x6 mm) package. It also provides Vsense/Isense readback and an LVMUX to the ADC for condition monitoring, supporting RTD and thermistor measurement per the NXP datasheet.
Can the NAFE33352 measure RTD and thermistor sensors?
Yes, the NAFE33352 can measure resistance and temperature using RTD or thermistor sensors. According to the NXP documentation portal, the combination of its current output and voltage input allows direct resistance measurement, digitized by the 24-bit ADC. This eliminates the need for a separate excitation current source and ADC chain, simplifying temperature input modules in PLCs and data loggers.
What package does the NAFE33352 come in?
The NAFE33352B40BS is housed in a 40-pin HVQFN measuring 6x6 mm, as listed on NXP's official product page and DigiKey's product listing (2 Channel AFE, 24 Bit, 40-HVQFN 6x6). HVQFN is a leadless QFN-family surface-mount package, so pad layout follows standard QFN reflow and thermal-via design practice. The B40 designator in the ordering code corresponds to the 40-pin package option.
Where can I download the NAFE33352 datasheet PDF?
The official NAFE33352 datasheet PDF is available on NXP's documentation server at nxp.jp/docs/en/data-sheet/NAFE33352.pdf, titled 'Software Configurable Universal Low-Power AIO-AFE'. Additional documentation, including an overview and application topics, is hosted at docs.nxp.com under the NAFE33352 bundle. Always use the NXP-hosted PDF to ensure you have the latest revision rather than third-party mirrors.
What is the best drop-in replacement for NAFE33352?
Currently, there is no verified cross-brand pin-to-pin replacement for the NAFE33352 in a 40-pin HVQFN package; the closest same-family option is the NAFE93352, NXP's high-speed version, which should be confirmed pin-compatible on your board revision before substituting. According to NXP, the NAFE33352 is the low-power variant and the NAFE93352 is the high-speed variant of the same universal AIO-AFE family. Verify the footprint and configured mode set against the datasheet before any substitution.
What applications is the NAFE33352 designed for?
According to NXP, the NAFE33352 is ideal for programmable logic controllers (PLCs), process control systems, I/O modules, and data loggers. Its software-configurable universal channels let one hardware design serve multiple analog signal types - voltage measurement, current loop output, and RTD/thermistor temperature inputs - which reduces the bill of materials in multi-channel industrial I/O cards where each channel traditionally required discrete conditioning circuitry.
NAFE33352 vs NAFE93352 - which is better for a low-power data logger?
For a low-power data logger, the NAFE33352 is the better choice because NXP explicitly positions it as the low-power version of the family, while the NAFE93352 trades power for higher speed. Battery-powered or energy-harvesting loggers benefit from the NAFE33352's lower consumption, whereas high-channel-count scan-rate applications such as fast process control loops would justify the NAFE93352's higher-speed conversion at the cost of increased power draw.
What is the price of NAFE33352B40BS?
Pricing for the NAFE33352B40BS varies by distributor and package suffix (BSE tape-and-reel, BSMP tape-and-reel-small, BS bare die options appear on DigiKey and Mouser listings). Exact unit pricing as of 2026-09-14 is not published in the verified data on this page - request a quote for current volume pricing. DigiKey and Mouser both list the part with same-day shipping on in-stock quantities.
Where to buy NAFE33352 online?
The NAFE33352B40BS (suffixes BSE and BSMP) is available from authorized distributors including DigiKey and Mouser, which list it under NXP USA Inc. as an Analog Front End (AFE), 24-bit, 40-HVQFN part. TrustedParts.com also aggregates authorized-distributor inventory for NXP evaluation boards such as the NAFE33352-EVB. Buy only from authorized channels to guarantee genuine NXP parts with full traceability.
Is there an evaluation board for the NAFE33352?
Yes, NXP offers the NAFE33352-EVB evaluation board and the NAFE33352-UIOM expansion board, listed on DigiKey as an Analog to Digital Converter Data Acquisition Platform Evaluation Expansion Board. According to NXP's design center, the EVB evaluates both the NAFE33352 universal AIO-AFE and the NAFE33350 analog output AFE, enabling rapid prototyping of PLC and I/O module analog front-ends before committing to a custom PCB.
How does the NAFE33352 generate analog output signals?
The NAFE33352 generates analog outputs using its integrated precision DAC (14/16/18-bit), a low-drift voltage reference, and a high-voltage amplifier. According to the NXP documentation, this combination 'precisely generates small and wide output signals', covering both low-level control signals and wider industrial ranges. A readback path (Vsense, Isense) closes the loop by letting the 24-bit ADC verify the actual delivered voltage and current output.
Is the NAFE33352 suitable for condition monitoring?
Yes, the NAFE33352 supports condition monitoring through its LVMUX connection to the ADC. According to NXP's documentation, the LVMUX lets the 24-bit ADC digitize both external and internal signals, enabling the device to monitor its own health and external system conditions alongside its primary measurement and output tasks. This makes it suitable for I/O modules that must also perform predictive-maintenance data acquisition.
Hey Google, what can replace the NAFE33352?
The only close substitute is its own family member, the NAFE93352, NXP's high-speed version, which shares the universal AIO-AFE architecture - confirm pin compatibility on your layout before substituting. As of 2026-09-14, no verified cross-brand drop-in equivalent in a 40-pin HVQFN (6x6) package appears in distributor cross-reference data. If a redesign is acceptable, the NAFE33350 analog-output AFE covers output-only functions within the same NXP family.
What is the best Analog Devices or TI equivalent for the NAFE33352?
There is no verified cross-brand pin-compatible equivalent from Analog Devices, TI, or other manufacturers for the NAFE33352's combination of universal inputs plus combined AIO channel in the 40-HVQFN (6x6 mm) package; cross-reference searches as of 2026-09-14 returned none. If a redesign is possible, evaluate ADI and TI AFE or DAC+ADC combinations functionally, but expect PCB and firmware changes - they are not drop-in replacements for this NXP part.
Is the NAFE33352 in stock and what is the lead time?
DigiKey lists the NAFE33352B40BSMP and NAFE33352B40BSE with 'Buy now, ships today' status, indicating same-day shipping on in-stock quantities as of the latest listing data. Mouser also lists the NAFE33352B40BSE with inventory and pricing. For exact real-time stock and lead time on larger production quantities, check the distributor product pages directly or use TrustedParts.com for authorized-distributor inventory aggregation.

Engineering reference data for NAFE33352B40BS — comparison, design guidance, and compliance information.

Selection Guide

Choose the NAFE33352 when your industrial analog front-end prioritizes low power with full measurement-plus-output capability: multi-mode PLC cards, universal I/O modules, battery-powered data loggers, and RTD/thermistor temperature channels. Choose the NAFE93352 instead when channel scan rate or conversion speed dominates - it is the same family's high-speed version - accepting higher power consumption. Choose the NAFE33350 when the application is purely analog-output generation and input channels are not needed. All three share the NXP industrial AFE architecture and software configuration model, and the NAFE33352-EVB evaluates both the NAFE33352 and NAFE33350 on one platform. Note that no verified cross-brand drop-in equivalent exists in the 40-HVQFN (6x6 mm) package as of 2026-09-14, so family-internal selection and footprint commitment should happen early in the PCB design cycle.

Comparison with Alternatives

Parameter This Product NAFE93352B40BS NAFE33350
Package 40-HVQFN (6x6 mm) 40-HVQFN (6x6 mm) - same 40-HVQFN (6x6 mm) - same
Brand NXP Semiconductors NXP Semiconductors NXP Semiconductors
DAC Resolution 14/16/18 bit 14/16/18 bit 14/16/18 bit (output-focused)
Family Position Low-power version High-speed version Analog output AFE
Target Applications PLC, process control, I/O modules, data loggers High-speed industrial measurement and control High-precision analog output control

Key Differentiators

  • Low-power position in the NAFEx3352 family (vs NAFE93352B40BS)
  • Combined input and output on one AIO channel (vs NAFE33350)
  • Integrated RTD/thermistor measurement path (vs NAFE93352B40BS)

Design Notes

The NAFE33352 integrates a high-voltage amplifier driving the AIO channel, so layout must respect creepage and clearance between HV output traces and low-level ADC/reference nodes on the 6x6 mm HVQFN footprint. Route analog sense lines (Vsense, Isense) as Kelvin connections directly to the output node to preserve readback accuracy. Use a solid ground plane under the analog section and separate it from digital switching returns, rejoining at a single point near the supply. Decouple the analog supply and reference pins with 100 nF ceramics placed within 2 mm of the respective HVQFN pads.

Because channels are software-configurable at runtime, design the input protection and filtering network for the worst-case configured mode - including the highest voltage range and current-output mode - rather than a single fixed function. Add series resistance and clamping on field terminals to survive miswiring on universal inputs, and remember the LVMUX path can bring external signals into the ADC, so those mux inputs deserve the same ESD and filtering treatment as primary field channels.

A common mistake is treating the NAFE33352 like a conventional fixed-function ADC+DAC pair: its universal channel modes must be configured through the device's command interface before measurements are valid, and RTD measurement depends on correctly pairing the DAC current output with the ADC voltage input in firmware. Also avoid substituting the NAFE93352 without review - it is the high-speed version, not a power-identical swap. Validate the configuration sequence against the NAFE33352-EVB reference software before finalizing firmware.

Compliance Information

RoHS
Unknown
REACH
Unknown
AEC-Q100
Not Applicable
Lead Free
Unknown
Halogen Free
Unknown
Conflict Minerals
Unknown

Compliance status not stated in the provided verified web data; consult the official NXP product page for NAFE33352B40BS for RoHS/REACH declarations.

Data verified on: 2026-09-14 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

NXP Semiconductors NAFE33352 NAFE33352B40BS NAFE93352 NAFE33350 NAFEx3352 family analog front-end AFE AIO-AFE 24-bit ADC 18-bit DAC HVQFN-40 QFN package family RTD thermistor PLC process control I/O modules data loggers LVMUX Vsense/Isense readback condition monitoring low-drift voltage reference
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