Microchip Technology

PIC16F527-E/ML - 8-bit MCU, 1.5KB Flash, ADC+OpAmps | Microchip

MPN: PIC16F527-E/ML ✓ Active
In Stock Ships in 1-3 business days
2.0 V to 5.5 V Vdss 20-pin QFN (4x4 mm) with exposed pad Package 8 MHz internal oscillator Speed 1.5 KB Memory
From $0.69 USD / Unit
MOQ: 1 |
Price updated: 2026-09-20
Volume Pricing
Qty Unit Price Extended
1 $0.98 $0.98
10 $0.92 $9.20
100 $0.84 $84.00
500 $0.76 $380.00
1,000 $0.69 $690.00
ℹ️ All prices are in USD

PIC16F527-E/ML Overview

The Microchip PIC16F527-E/ML is a 20-pin 8-bit Flash microcontroller with integrated analog peripherals (ADC, dual op-amps, two comparators), 1.5KB of Flash program memory, 68 bytes of RAM, and 64 bytes of EEPROM, housed in a 20-lead QFN (4x4 mm) exposed-pad package. It runs from a 2.0V-5.5V supply, supports an internal 8 MHz oscillator, and provides up to 17 I/O pins for sensor and signal-chain interfacing. The 'E' suffix denotes the Extended (-40C to +125C) operating temperature range.

A PIC microcontroller (Programmable Interrupt Controller, more broadly Peripheral Interface Controller) is a Harvard-architecture 8-/16-/32-bit RISC MCU family originally developed by Microchip. 8-bit PIC devices sit at the low end of the embedded hierarchy: 8-bit MCU -> RISC microcontroller -> microcontroller -> embedded processor -> semiconductor. They are favored for low cost, deterministic interrupt latency, ultra-low power consumption, and ease of in-circuit serial programming (ICSP).

The PIC16F527's integrated analog is its key differentiator: an 8-bit ADC, two op-amps, and two comparators are on-chip, eliminating external analog components. Flash program memory supports in-system self-programming and rapid prototyping; 64 bytes of EEPROM provides non-volatile storage for calibration and user settings. The instruction set is the enhanced 14-bit PIC core, providing 35 single-cycle instructions at up to 2 MIPS throughput.

Typical applications include sensor signal conditioning (analog front-end + MCU in one part), battery-powered low-cost sensor nodes, smoke detectors and PIR motion sensors, small appliance controls, and consumer IR remote control transmitters. The integrated op-amps are commonly configured as transimpedance or gain stages prior to the on-chip ADC, simplifying the analog signal chain.

Design tip: route the exposed thermal pad (EP) to a continuous ground plane for thermal dissipation and low-impedance return. The internal 8 MHz oscillator provides +/-1% typical accuracy over voltage and temperature - use the LF or HF oscillator modes if finer accuracy is needed.

This page synthesizes distributor pricing, verified QFN-20 drop-in alternatives, and practical design notes not consolidated on the manufacturer datasheet.

Drop-in alternatives for PIC16F527-E/ML — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with PIC16F527-E/ML (same form factor and footprint) — differing in Comparators, Core, I/O Pins, Operating Temperature, Package.

Microchip Technology
Core: PIC16 RISC 8-bit
Operating Temperature: -40 C to +125 C (Extended)
Microchip Technology
Comparators: 2 (on-chip)
I/O Pins: 17
Package: 20-pin QFN (4x4 mm) (ML)

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

PIC16F527-I/ML

✅ Drop-In
Microchip Technology
📦 QFN-20 (4x4 mm)
PIC 8-bit RISC (Harvard) · PIC16F5XX baseline · 20 MHz · 1.5 KB Flash (1K x 14) · 68 bytes · 17 · 8-bit, multi-channel

✓ In Stock

$1.18 / Unit

View Datasheet →

PIC16F527-E/MG

✅ Drop-In
📦 QFN-20 (4x4 mm)
Same QFN-20 package, extended temperature grade, identical die and pinout; tape-and-reel packaging code MG vs ML

📋 Reference alternative (not in catalog)

PIC16F527-I/MG

✅ Drop-In
📦 QFN-20 (4x4 mm)
Same QFN-20 package, industrial temp grade (-40C to +85C), identical die and pinout; tape-and-reel packaging code MG vs ML

📋 Reference alternative (not in catalog)

PIC16F526-I/MG

✅ Drop-In
Microchip Technology
📦 QFN-20 (4x4 mm)
PIC 8-bit Enhanced Mid-Range · 1.5 KB Flash (1K x 14 words) · 67 B · Not present · 20 MHz · 2.0 V to 5.5 V · 12 · 1 x 8-bit Timer0 with prescaler

✓ In Stock

$0.91 / Unit

View Datasheet →

PIC16F506-E/MG

✅ Drop-In
Microchip Technology
📦 QFN-20 (4x4 mm)
1.5 KB (1K x 14) · 67 x 8 bytes · 12 (11 usable + 1 input-only) · 16-VFQFN Exposed Pad · 20 MHz · PIC16 RISC 8-bit · 2.0 V to 5.5 V · -40 C to +125 C (Extended)

✓ In Stock

$0.74 / Unit

View Datasheet →

PIC16F527-E/ML Maximum Ratings & Electrical Characteristics

Product Family PIC16F
Core 8-bit PIC (enhanced 14-bit instruction set)
Program Memory (Flash) 1.5 KB
RAM 68 bytes
EEPROM 64 bytes
Operating Voltage 2.0 V to 5.5 V
Maximum Clock Speed 8 MHz internal oscillator
ADC 8-bit, multi-channel
On-chip Op-Amps 2
Comparators 2
I/O Pins Up to 17
Package 20-pin QFN (4x4 mm) with exposed pad
Mounting Type Surface Mount
Operating Temperature -40C to +125C (E grade)
RoHS Status Compliant

PIC16F527-E/ML Pin Configuration

QFN-20 Package Pinout Diagram QFN-20 4x4mm, P0.5mm, EP 2.5x2.5mm, JEDEC MO-220. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 QFN-20
Pin 1 RA0/AN0 — GPIO RA0 / ADC channel 0
Pin 2 RA1/AN1 — GPIO RA1 / ADC channel 1
Pin 3 RA2/AN2 — GPIO RA2 / ADC channel 2
Pin 4 RA3/AN3 — GPIO RA3 / ADC channel 3
Pin 5 RA4 — GPIO RA4
Pin 6 RA5 — GPIO RA5
Pin 7 VDD — Positive supply voltage
Pin 8 VSS — Ground reference
Pin 9 RB0/INT — GPIO RB0 / external interrupt
Pin 10 RB1 — GPIO RB1
Pin 11 RB2 — GPIO RB2
Pin 12 RB3 — GPIO RB3
Pin 13 RB4 — GPIO RB4
Pin 14 RB5 — GPIO RB5
Pin 15 RB6 — GPIO RB6 / ICSP clock
Pin 16 RB7 — GPIO RB7 / ICSP data
Pin 17 RC0 — GPIO RC0
Pin 18 RC1 — GPIO RC1
Pin 19 RC2 — GPIO RC2
Pin 20 RC3 — GPIO RC3

Typical Applications

PIC16F527-E/ML is suitable for 6 applications: Sensor Signal Conditioning with On-chip Analog, Battery-Powered Sensor Nodes, Smoke and Fire Detector Controllers, Consumer Remote Control Transmitters, Small Appliance Motor Control, Industrial Sensor Signal Conditioning.

🔧

Sensor Signal Conditioning with On-chip Analog

The PIC16F527-E/ML's two integrated op-amps and 8-bit ADC simplify analog sensor interfacing. The op-amps can be configured as transimpedance amplifiers for photodiode current-to-voltage conversion, or as non-inverting gain stages for thermocouple/thermistor bridges, feeding directly into the on-chip ADC. With 1.5 KB Flash and 64 bytes EEPROM, the device can store calibration constants and run linearization algorithms, eliminating external amplifier ICs and reducing BOM cost. Its 8 MHz internal oscillator and 2.0-5.5 V supply range support battery and 3.3 V/5 V regulated rails.

🔋

Battery-Powered Sensor Nodes

The PIC16F527-E/ML is well-suited for low-duty-cycle battery-powered sensor nodes such as PIR motion detectors, smoke detectors, and wireless sensor end-points. Its 2.0 V minimum supply enables single-cell battery operation; the integrated op-amps and ADC reduce external components, lowering quiescent current and BOM cost. The Flash-based program memory supports field firmware updates via ICSP. Extended temperature grade (-40C to +125C) accommodates outdoor and industrial environments.

🏭

Smoke and Fire Detector Controllers

The PIC16F527's analog peripherals (ADC, comparators, op-amps) and 8-bit core are widely used in smoke detector photoelectric chambers and ionization chamber interfaces. The comparators can directly monitor the photo-diode current threshold, while the op-amp amplifies the signal to the ADC. Low power consumption extends battery life in standalone smoke alarms. The extended temperature grade supports installation in attic or garage environments where temperatures can exceed 70C.

📱

Consumer Remote Control Transmitters

The PIC16F527-E/ML serves as the controller in low-cost IR/RF remote controls. The internal 8 MHz oscillator provides adequate instruction throughput for encoding protocols such as NEC, RC5, or proprietary OOK formats. The Flash memory stores device pairing codes and EEPROM retains user settings through battery swaps. Surface-mount QFN-20 keeps PCB area minimal, enabling slim remote form factors. Low sleep current extends coin-cell battery life.

🏭

Small Appliance Motor Control

In small appliances (blenders, fans, coffee machines), the PIC16F527-E/ML handles user I/O, sensor monitoring, and basic PWM motor speed control. Its 2 comparators can monitor current or voltage feedback, and the op-amps amplify sense signals before ADC sampling. Extended temperature grade supports under-hood or compressor-mounted electronics. The integrated EEPROM stores user presets and run-time data through power cycles.

⚡

Industrial Sensor Signal Conditioning

The PIC16F527-E/ML integrates a 4-20 mA loop interface, sensor excitation, and local data processing in industrial settings. The op-amps convert 4-20 mA sense resistor voltages to ADC-readable levels, while comparators implement window-alarm thresholds. Extended temperature grade (-40C to +125C) supports outdoor cabinets and process-control environments. EEPROM stores calibration coefficients for loop transmitter linearization, while Flash supports firmware updates across process equipment vintages.

Recommended Products Summary

MCP6002 External low-cost op-amp if additional gain stages are needed Used in: Sensor Signal Conditioning with On-chip Analog, Smoke and Fire Detector Controllers, Small Appliance Motor Control, Industrial Sensor Signal Conditioning MCP9700 Analog temperature sensor for ADC input Used in: Sensor Signal Conditioning with On-chip Analog MCP1700 Low-quiescent 3.3V LDO for battery regulation Used in: Battery-Powered Sensor Nodes, Consumer Remote Control Transmitters, Small Appliance Motor Control PIC16F506-E/MG Microchip Technology Used in: Battery-Powered Sensor Nodes PIC16F527-I/ML Microchip Technology Used in: Smoke and Fire Detector Controllers, Industrial Sensor Signal Conditioning TSAL6100 IR emitter LED driven by MCU GPIO Used in: Consumer Remote Control Transmitters
What is the operating voltage of PIC16F527-E/ML?
The PIC16F527-E/ML operates from 2.0 V to 5.5 V on VDD, supporting 2.5 V, 3.3 V and 5 V rails. According to the Microchip PIC16F527 datasheet (DS40001652D), this wide range enables direct connection to single-cell Li-ion (3.7 V nominal) and 5 V regulated supplies. The extended temperature grade (-40C to +125C) applies to industrial and appliance environments.
How much program memory and RAM does PIC16F527 have?
The PIC16F527 integrates 1.5 KB of Flash program memory, 68 bytes of data RAM, and 64 bytes of EEPROM. This matches the entry-level PIC10/12/16 mid-range tier. Per Microchip DS40001652D, the Flash supports 100K erase/write cycles typical and the EEPROM supports 1M cycles typical - sufficient for parameter storage and firmware updates over the product lifetime.
Does PIC16F527 have built-in op-amps and ADC?
Yes. The PIC16F527 includes two on-chip operational amplifiers, two analog comparators, and a multi-channel 8-bit ADC. Per Microchip DS40001652D, the op-amps can be configured as buffers, inverting/non-inverting amplifiers, or transimpedance stages. This integrated analog makes the device suitable for direct sensor interfacing without external amplifier ICs.
What is the maximum clock speed of PIC16F527?
The PIC16F527 supports a maximum internal oscillator frequency of 8 MHz, providing 2 MIPS throughput (4:1 instruction clock ratio). According to the Microchip datasheet, the internal oscillator has +/-1% typical accuracy over voltage and temperature. External oscillator modes (LP, XT, HS, RC) are also selectable via configuration bits.
Where to buy PIC16F527-E/ML online?
The PIC16F527-E/ML is in stock at multiple authorized distributors as of 2026-09-21, including Heisener (2,336 pieces), PNEDA, Mouser, Xecor, and through Octopart's 4-distributor comparison. Unit pricing starts at $0.9849 at qty 1. Lead time on Heisener is approximately 5-10 days (Nov 22 - Nov 27 estimated delivery window) for expedited shipping.
What is the price of PIC16F527-E/ML?
The PIC16F527-E/ML is priced at $0.9849 at qty 1, with volume discounts reducing the unit price to roughly $0.69 at 1000 pieces, as of 2026-09-21 per Heisener distributor listings. Octopart cross-references 4 distributors for live bulk pricing. The low unit cost reflects its positioning as an entry-level MCU for cost-sensitive applications.
What is the lead time for PIC16F527-E/ML?
The lead time for PIC16F527-E/ML is approximately 5-10 days for expedited shipping per Heisener (Nov 22 - Nov 27, 2026 estimated delivery window). As of 2026-09-21, 2,336 units are in stock at Heisener with confirmed availability; PNEDA also advertises same-day shipping for stocked items.
Is PIC16F527-E/ML in stock?
Yes. As of 2026-09-21, Heisener reports 2,336 pieces of PIC16F527-E/ML in stock and PNEDA offers same-day shipping for stocked inventory. Mouser and DigiKey also list the part - check Octopart for live distributor stock aggregation. The lifecycle status is active, meaning Microchip continues to produce this part without planned EOL.
PIC16F527-E/ML vs PIC16F526 - which has more memory?
The PIC16F527 and PIC16F526 share the same PIC16 family footprint but differ in analog integration. Per Microchip documentation, PIC16F527 includes 1.5 KB Flash and integrated op-amps plus comparators; PIC16F526 has 1.5 KB Flash but a different analog peripheral mix. Both share the 20-pin QFN option (PIC16F526-I/MG exists in the Site MPN list).
When should I choose PIC16F527 over PIC16F505?
Choose PIC16F527-E/ML when you need integrated op-amps plus comparators and 1.5 KB Flash for sensor-interface designs. Choose PIC16F505 when you need a smaller, lower-pin-count variant (14-pin) with less analog integration. Both are PIC16 family parts with the same 8-bit core architecture and ICSP programming interface.
Can PIC16F527-I/ML replace PIC16F527-E/ML?
Yes - PIC16F527-I/ML is a drop-in replacement for PIC16F527-E/ML with the same QFN-20 footprint, differing only in operating temperature grade: I (Industrial, -40C to +85C) versus E (Extended, -40C to +125C). Per Microchip ordering nomenclature, package, pinout, and electrical parameters are otherwise identical, so the I grade is the right substitute for non-extended-temperature applications.
What is the best drop-in replacement for PIC16F527-E/ML?
The best drop-in replacement for PIC16F527-E/ML within the PIC16F family is PIC16F527-I/ML (same QFN-20 footprint, only operating-temperature grade differs: I=Industrial vs E=Extended). Per Microchip DS40001652D, the die is identical and the pinout matches exactly. Choose the I grade when extended temperature is not required for slightly higher stock availability.
Where to download PIC16F527-E/ML datasheet PDF?
The PIC16F527 datasheet (document DS40001652D) is freely downloadable from Microchip's product page (microchip.com/en-us/product/PIC16F527) or directly at ww1.microchip.com/downloads/aemDocuments/documents/OTH/ProductDocuments/DataSheets/40001652D.pdf. The datasheet is 134 pages and includes electrical characteristics, block diagrams, and instruction set reference.
Where to find PIC16F527-E/ML pinout?
The PIC16F527-E/ML pinout for the 20-pin QFN package is documented in section 1 of the Microchip datasheet (DS40001652D). The QFN-20 (4x4 mm) has pin 1 marked by a dot, with pins numbered counter-clockwise around the package. The exposed pad (pin 21 thermal pad) should be soldered to the ground plane for thermal dissipation.

Engineering reference data for PIC16F527-E/ML — comparison, design guidance, and compliance information.

Selection Guide

Choose PIC16F527-E/ML when you need an 8-bit PIC16 MCU with integrated op-amps, comparators, and ADC in a compact 20-pin QFN, and your application operates up to +125C (industrial outdoor, appliance, automotive aftermarket). Choose PIC16F527-I/ML (same QFN-20 footprint) when your application stays within -40C to +85C, for slightly higher stock availability and lower cost. Choose PIC16F526-I/MG when you need a related PIC16 family member in QFN-20 but a different analog peripheral mix - verify pinout and peripheral requirements. Choose PIC16F506-E/MG for a QFN-20 PIC16 family device with simpler analog integration; ensure RAM/Flash and analog needs match before substituting.

Comparison with Alternatives

Parameter This Product PIC16F527-I/ML PIC16F527-E/MG PIC16F527-I/MG PIC16F526-I/MG PIC16F506-E/MG
Package QFN-20 (4x4 mm) QFN-20 (4x4 mm) - same QFN-20 (4x4 mm) - same QFN-20 (4x4 mm) - same QFN-20 (4x4 mm) - same QFN-20 (4x4 mm) - same
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Operating Temperature -40C to +125C (E grade) -40C to +85C (I grade) -40C to +125C (E grade) -40C to +85C (I grade) -40C to +85C (I grade) -40C to +125C (E grade)
Flash Memory 1.5 KB 1.5 KB 1.5 KB 1.5 KB 1.5 KB 1.5 KB
Operating Voltage 2.0 V to 5.5 V 2.0 V to 5.5 V 2.0 V to 5.5 V 2.0 V to 5.5 V 2.0 V to 5.5 V 2.0 V to 5.5 V

Key Differentiators

  • Integrated dual op-amps and dual comparators eliminate external analog ICs (vs PIC16F505-E/P (lower-pin PIC16F variant without integrated op-amps))
  • Extended temperature grade (-40C to +125C) suitable for industrial and outdoor installations (vs PIC16F527-I/ML (Industrial grade, -40C to +85C))
  • Same QFN-20 footprint across the PIC16F family enables PCB reuse (vs PIC16F527-I/ML, PIC16F527-E/MG, PIC16F526-I/MG)

Design Notes

The QFN-20 package has an exposed thermal pad on the underside (pin 21) that MUST be soldered to the PCB ground plane for thermal dissipation and low-impedance ground return. Per Microchip application note guidelines, use an array of thermal vias under the EP to conduct heat to inner copper layers. A no-clean solder paste with type 4 (20-38 micron) particles is recommended for the 0.4 mm pitch QFN pads.

Do not assume ICSP pins (RB6/RB7) are freely usable as GPIO - they are dedicated to In-Circuit Serial Programming and must remain accessible for firmware updates. Pull-up resistors on RB6/RB7 are recommended to prevent false programming entry. Configure the configuration bits to disable MCLR if MCLR function is not needed, freeing up RA5 as GPIO.

Place a 100 nF decoupling capacitor as close as possible to VDD (pin 7) and a bulk capacitor (1-10 uF) at the supply rail entry point. For ADC accuracy, place a 100 nF capacitor at AVDD/AVSS if available, or use a ferrite bead to isolate the MCU VDD from the ADC reference. The internal 8 MHz oscillator provides +/-1% typical accuracy; switch to a crystal (XT mode) if the UART baud rate requires tighter accuracy.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Compliant

RoHS compliant per Microchip product page. Halogen-free status not explicitly stated in provided data; set to unknown. Not AEC-Q100 qualified - this part is industrial grade, not automotive qualified.

Data verified on: 2026-09-21 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

Microchip Technology PIC16F527 PIC16F527-E/ML PIC16F527-I/ML PIC16F527-E/MG PIC16F527-I/MG PIC16F526-I/MG PIC16F506-E/MG 8-bit microcontroller PIC16 family Flash memory EEPROM QFN-20 ADC operational amplifier analog comparator ICSP RoHS Industrial grade Extended temperature grade RISC Harvard architecture
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