STM32L4R5ZIT6 - 32-bit ARM Cortex-M4 MCU 120MHz 2MB Flash LQFP-144 | STMicroelectronics
MPN: STM32L4R5ZIT6 ✓ Active| Qty | Unit Price | Extended |
|---|---|---|
| 1 | $18.5 | $18.50 |
| 10 | $16.4 | $164.00 |
| 100 | $14.2 | $1,420.00 |
| 500 | $12.85 | $6,425.00 |
| 1,000 | $11.4 | $11,400.00 |
STM32L4R5ZIT6 Overview
An ARM Cortex-M4 microcontroller (MCU) is a 32-bit RISC processor core designed by Arm Holdings for embedded applications. It combines high computational performance with low power consumption, and the M4 variant adds a single-precision floating-point unit (FPU) plus DSP extensions. In the broader taxonomy, the STM32L4R5 belongs to the ultra-low-power microcontroller family (STM32L series), which sits below the mainstream STM32F series and above the ultra-low-power STM32L0 in ST's power-versus-performance spectrum. The "plus" designation (STM32L4+) indicates the higher-performance 120 MHz sub-family with Chrom-GRC graphics support.
Key features of the STM32L4R5ZIT6 include a FlexPowerControl architecture with multiple low-power modes (Shutdown at 33 nA, VBAT mode at 305 nA, Batch Acquisition Mode for partial wake-up), USB OTG with internal PHY, and a DFSDM (Digital Filter for Sigma-Delta Modulators) peripheral for sensor hub applications. It also features a Chrom-ART Accelerator for 2D graphics and an Octo-SPI interface for high-speed external Flash, along with cryptographic and AES-256 hardware accelerators for IoT security.
The device integrates the Cortex-M4 core with FPU and Memory Protection Unit, plus ST's ART Accelerator (Adaptive Real-Time memory accelerator) that allows 0-wait-state execution from Flash at the full 120 MHz clock speed. Up to 640 KB SRAM includes 32 KB of SRAM2 with parity check, retained in Standby mode and accessible via SRAM-based boot for secure firmware update. The LQFP-144 package exposes the full STM32L4R5 peripheral set: 3x 12-bit ADC (16-bit with oversampling), 2x DAC, 4x op-amps, 2x comparators, multiple timers, TFT controller, and MIPI-DSI support requires the larger BGA package.
Typical applications include wearable health monitors, smart sensors, IoT edge nodes, industrial HMI panels, low-power wireless modules (BLE/LoRa companion), battery-powered data loggers, and energy-harvesting systems. The 2 MB Flash supports over-the-air firmware updates and rich graphical user interfaces on small TFT displays without external memory.
When designing with the STM32L4R5ZIT6, use ST's STM32CubeMX and STM32CubeIDE toolchain for code generation, pin multiplexing, and power-consumption profiling. Source decoupling requires 100 nF X7R ceramic on every VDD/VDDA pair; the integrated SMPS step-down converter (when present on L4+ variants) should be configured with a 10 µH inductor per the application note AN4621. The LQFP-144 thermal performance typically permits 500 mA peak current draw at 120 MHz with a 2-layer FR4 board.
This page synthesizes distributor pricing tiers, drop-in compatible same-family STM32 alternatives, application-tailored companion MPNs, and practical low-power design guidance that complements the manufacturer datasheet.
Drop-in alternatives for STM32L4R5ZIT6 — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.
Variants in this series
Same-series models that are drop-in compatible with STM32L4R5ZIT6 (same form factor and footprint) — differing in Package, ADC, Core, DAC, Graphics Accelerator.
Quick Comparison Tool — Select alternative parts for side-by-side comparison:
STM32L4R7ZIT6
✅ Drop-In📋 Reference alternative (not in catalog)
STM32L4S5ZIT6
✅ Drop-In📋 Reference alternative (not in catalog)
STM32L4R5ZIT6P
✅ Drop-In✓ In Stock
$9.3 / Unit
View Datasheet →STM32L4R5ZGT6
✅ Drop-In📋 Reference alternative (not in catalog)
STM32L4R9ZIT6
✅ Drop-In✓ In Stock
$7.2 / Unit
View Datasheet →STM32L4R5ZIT6 Maximum Ratings & Electrical Characteristics
| Core | ARM Cortex-M4 with FPU |
| Maximum Clock Frequency | 120 MHz |
| Performance | 150 DMIPS / 273 CoreMark |
| Program Memory Size | 2 MB (2 M x 8) Flash |
| RAM Size | 640 KB |
| Supply Voltage Range | 1.71 V to 3.6 V |
| Operating Temperature Range | -40 °C to +85 °C (grade 6), -40 °C to +125 °C (grade 7) |
| Package | 144-LQFP (20 x 20 mm) |
| Pin Count | 144 |
| Mounting Type | Surface Mount |
| ADC | 3 x 12-bit (up to 16-bit with hardware oversampling) |
| DAC | 2 x 12-bit |
| USB | USB OTG Full-Speed with internal PHY |
| Low-Power Modes | Shutdown 33 nA, VBAT mode 305 nA, Standby with RTC |
| External Memory Bus | Octo-SPI, FMC, SDMMC |
| MSL Level | 3 (168 hours) |
| RoHS Status | Compliant |
STM32L4R5ZIT6 Pin Configuration
| Pin 1 | PE2 — GPIO PE2, TRACECLK |
| Pin 2 | PE3 — GPIO PE3, TRACED0 |
| Pin 3 | PE4 — GPIO PE4, TRACED1 |
| Pin 4 | PE5 — GPIO PE5, TRACED2 |
| Pin 5 | PE6 — GPIO PE6, TRACED3 |
| Pin 6 | VBAT — RTC backup power supply |
| Pin 7 | PC13 — GPIO PC13 (Tamper-RTC) |
| Pin 8 | PC14 — GPIO PC14 / OSC32_IN |
| Pin 9 | PC15 — GPIO PC15 / OSC32_OUT |
| Pin 10 | VSS — Ground |
| Pin 11 | VDD — Digital supply voltage |
| Pin 12 | PH0 — GPIO PH0 / OSC_IN |
| Pin 13 | PH1 — GPIO PH1 / OSC_OUT |
| Pin 14 | NRST — Reset input (active low) |
| Pin 15 | PC0 — GPIO PC0, ADC1_IN6 |
| Pin 16 | PC1 — GPIO PC1, ADC1_IN7 |
| Pin 17 | PC2 — GPIO PC2, ADC1_IN8 |
| Pin 18 | PC3 — GPIO PC3, ADC1_IN9 |
| Pin 19 | VSSA — Analog ground |
| Pin 20 | VDDA — Analog supply voltage |
| Pin 21 | PA0 — GPIO PA0, ADC1_IN5, UART4_TX |
| Pin 22 | PA1 — GPIO PA1, ADC1_IN6, UART4_RX |
| Pin 23 | PA2 — GPIO PA2, USART2_TX |
| Pin 24 | PA3 — GPIO PA3, USART2_RX |
| Pin 25 | VSS — Ground |
| Pin 26 | VDD — Digital supply voltage |
| Pin 27 | PA4 — GPIO PA4, SPI1_NSS, DAC_OUT1 |
| Pin 28 | PA5 — GPIO PA5, SPI1_SCK, DAC_OUT2 |
| Pin 29 | PA6 — GPIO PA6, SPI1_MISO, ADC1_IN11 |
| Pin 30 | PA7 — GPIO PA7, SPI1_MOSI, ADC1_IN12 |
| Pin 31 | PC4 — GPIO PC4, ADC1_IN13 |
| Pin 32 | PC5 — GPIO PC5, ADC1_IN14 |
| Pin 33 | PB0 — GPIO PB0, ADC1_IN15, TIM3_CH3 |
| Pin 34 | PB1 — GPIO PB1, ADC1_IN16, TIM3_CH4 |
| Pin 35 | PB2 — GPIO PB2, BOOT1 |
| Pin 36 | PE7 — GPIO PE7 |
| Pin 37 | PE8 — GPIO PE8 |
| Pin 38 | PE9 — GPIO PE9 |
| Pin 39 | PE10 — GPIO PE10 |
| Pin 40 | PE11 — GPIO PE11 |
| Pin 41 | PE12 — GPIO PE12 |
| Pin 42 | PE13 — GPIO PE13 |
| Pin 43 | PE14 — GPIO PE14 |
| Pin 44 | PE15 — GPIO PE15 |
| Pin 45 | PB10 — GPIO PB10, I2C2_SCL, USART3_TX |
| Pin 46 | PB11 — GPIO PB11, I2C2_SDA, USART3_RX |
| Pin 47 | VSS — Ground |
| Pin 48 | VDD — Digital supply voltage |
| Pin 49 | PB12 — GPIO PB12, SPI2_NSS, TIM1_BKIN |
| Pin 50 | PB13 — GPIO PB13, SPI2_SCK, USART3_CTS |
| Pin 51 | PB14 — GPIO PB14, SPI2_MISO, USART3_RTS |
| Pin 52 | PB15 — GPIO PB15, SPI2_MOSI, TIM1_CH3N |
| Pin 53 | PD8 — GPIO PD8 |
| Pin 54 | PD9 — GPIO PD9 |
| Pin 55 | PD10 — GPIO PD10 |
| Pin 56 | PD11 — GPIO PD11 |
| Pin 57 | PD12 — GPIO PD12 |
| Pin 58 | PD13 — GPIO PD13 |
| Pin 59 | PD14 — GPIO PD14 |
| Pin 60 | PD15 — GPIO PD15 |
| Pin 61 | PC6 — GPIO PC6, USART6_TX, TIM3_CH1 |
| Pin 62 | PC7 — GPIO PC7, USART6_RX, TIM3_CH2 |
| Pin 63 | PC8 — GPIO PC8, SDMMC_D0, TIM3_CH3 |
| Pin 64 | PC9 — GPIO PC9, SDMMC_D1, TIM3_CH4 |
| Pin 65 | PA8 — GPIO PA8, USART1_CK, TIM1_CH1, MCO |
| Pin 66 | PA9 — GPIO PA9, USART1_TX, TIM1_CH2 |
| Pin 67 | PA10 — GPIO PA10, USART1_RX, TIM1_CH3 |
| Pin 68 | PA11 — GPIO PA11, USB_OTG_FS_DM |
| Pin 69 | PA12 — GPIO PA12, USB_OTG_FS_DP |
| Pin 70 | PA13 — GPIO PA13, SWDIO |
| Pin 71 | PA14 — GPIO PA14, SWCLK |
| Pin 72 | PA15 — GPIO PA15, SPI1_NSS, TIM2_CH1 |
| Pin 73 | PC10 — GPIO PC10, USART3_TX, SDMMC_D2 |
| Pin 74 | PC11 — GPIO PC11, USART3_RX, SDMMC_D3 |
| Pin 75 | PC12 — GPIO PC12, USART3_CK, SDMMC_CK |
| Pin 76 | PD0 — GPIO PD0, CAN1_RX, FMC_D2 |
| Pin 77 | PD1 — GPIO PD1, CAN1_TX, FMC_D3 |
| Pin 78 | PD2 — GPIO PD2, SDMMC_CMD, TIM3_ETR |
| Pin 79 | PD3 — GPIO PD3, USART2_CTS, FMC_CLK |
| Pin 80 | PD4 — GPIO PD4, USART2_RTS, FMC_NOE |
| Pin 81 | PD5 — GPIO PD5, USART2_TX, FMC_NWE |
| Pin 82 | VSS — Ground |
| Pin 83 | VDD — Digital supply voltage |
| Pin 84 | PD6 — GPIO PD6, USART2_RX, FMC_NWAIT |
| Pin 85 | PD7 — GPIO PD7, USART2_CK, FMC_NE1 |
| Pin 86 | PB3 — GPIO PB3, SPI1_SCK, TIM2_CH2 |
| Pin 87 | PB4 — GPIO PB4, SPI1_MISO, TIM3_CH1 |
| Pin 88 | PB5 — GPIO PB5, SPI1_MOSI, I2C1_SMBA, TIM3_CH2 |
| Pin 89 | PB6 — GPIO PB6, I2C1_SCL, USART1_TX |
| Pin 90 | PB7 — GPIO PB7, I2C1_SDA, USART1_RX |
| Pin 91 | BOOT0 — Boot mode select |
| Pin 92 | PB8 — GPIO PB8, I2C1_SCL, TIM4_CH3 |
| Pin 93 | PB9 — GPIO PB9, I2C1_SDA, TIM4_CH4 |
| Pin 94 | PE0 — GPIO PE0, TIM4_ETR |
| Pin 95 | PE1 — GPIO PE1 |
| Pin 96 | VSS — Ground |
| Pin 97 | VDD — Digital supply voltage |
| Pin 98 | PF6 — GPIO PF6, TIM5_CH1, ADC3_IN4 |
| Pin 99 | PF7 — GPIO PF7, TIM5_CH2, ADC3_IN5 |
| Pin 100 | PF8 — GPIO PF8, TIM5_CH3, ADC3_IN6 |
| Pin 101 | PF9 — GPIO PF9, TIM5_CH4, ADC3_IN7 |
| Pin 102 | PF10 — GPIO PF10, ADC3_IN8 |
| Pin 103 | PF11 — GPIO PF11, ADC3_IN9 |
| Pin 104 | VSS — Ground |
| Pin 105 | VDD — Digital supply voltage |
| Pin 106 | PF12 — GPIO PF12, FSMC_A6 |
| Pin 107 | PF13 — GPIO PF13, FSMC_A7 |
| Pin 108 | PF14 — GPIO PF14, FSMC_A8 |
| Pin 109 | PF15 — GPIO PF15, FSMC_A9 |
| Pin 110 | PG0 — GPIO PG0, FSMC_A10 |
| Pin 111 | PG1 — GPIO PG1, FSMC_A11 |
| Pin 112 | PE2 — GPIO PE2, TRACECLK (alt) |
| Pin 113 | PE3 — GPIO PE3, TRACED0 (alt) |
| Pin 114 | PE4 — GPIO PE4, TRACED1 (alt) |
| Pin 115 | PE5 — GPIO PE5, TRACED2 (alt) |
| Pin 116 | PG2 — GPIO PG2, FSMC_A12 |
| Pin 117 | PG3 — GPIO PG3, FSMC_A13 |
| Pin 118 | PG4 — GPIO PG4, FSMC_A14 |
| Pin 119 | PG5 — GPIO PG5, FSMC_A15 |
| Pin 120 | PG6 — GPIO PG6 |
| Pin 121 | PG7 — GPIO PG7 |
| Pin 122 | PG8 — GPIO PG8 |
| Pin 123 | VSS — Ground |
| Pin 124 | VDD — Digital supply voltage |
| Pin 125 | PG9 — GPIO PG9, USART6_RX, FSMC_NE3 |
| Pin 126 | PG10 — GPIO PG10, FSMC_NE4 |
| Pin 127 | PG11 — GPIO PG11, FSMC_A24 |
| Pin 128 | PG12 — GPIO PG12, FSMC_NE1 |
| Pin 129 | PG13 — GPIO PG13, FSMC_A26 |
| Pin 130 | PG14 — GPIO PG14, FSMC_A27 |
| Pin 131 | VSS — Ground |
| Pin 132 | VDD — Digital supply voltage |
| Pin 133 | PG15 — GPIO PG15 |
| Pin 134 | PB3 — GPIO PB3, JTDO, SPI1_SCK |
| Pin 135 | PB4 — GPIO PB4, NJTRST, SPI1_MISO |
| Pin 136 | PB5 — GPIO PB5, SPI1_MOSI |
| Pin 137 | PB6 — GPIO PB6, USART1_TX |
| Pin 138 | PB7 — GPIO PB7, USART1_RX |
| Pin 139 | PB8 — GPIO PB8, I2C1_SCL |
| Pin 140 | PB9 — GPIO PB9, I2C1_SDA |
| Pin 141 | PE0 — GPIO PE0, TIM4_ETR |
| Pin 142 | PE1 — GPIO PE1 |
| Pin 143 | VSS — Ground |
| Pin 144 | VDD — Digital supply voltage |
Typical Applications
STM32L4R5ZIT6 is suitable for 6 applications: Wearable Health Monitor, Industrial HMI Control Panel, Battery-Powered IoT Sensor Hub, Smart Energy Metering, Medical Infusion Pump Controller, Smart Sensor Hub for Predictive Maintenance.
Wearable Health Monitor
The STM32L4R5ZIT6 fits wearable health monitors due to its Cortex-M4F at 120 MHz capable of running heart-rate and motion-fusion DSP, plus 33 nA Shutdown current for multi-day battery life. Placed as the system MCU between a Li-Po cell and the analog front-end, it directly drives PPG/AFE signal chains via the four integrated op-amps and three 12-bit ADCs. Compared to Cortex-M0/M0+ alternatives it provides DSP and FPU on the same footprint, enabling step-count and ECG-R-peak detection without external DSP. The 2 MB Flash supports over-the-air firmware updates while the 640 KB SRAM buffers minutes of raw sensor data for later BLE upload.
Recommended
Industrial HMI Control Panel
For industrial HMI panels, the STM32L4R5ZIT6 provides 120 MHz Cortex-M4 performance with Chrom-ART 2D acceleration to drive small TFT displays via SPI/8080 interfaces, plus FMC external bus for parallel memory expansion. Placed between the 24 V isolated supply and a 3.3 V LDO, it directly controls buttons, rotary encoders, and RS-485/Modbus via UART plus 50 MHz SPI. The 2 MB Flash hosts full graphics and a Chinese-English/Unicode character table. Compared to plain Cortex-M0 designs, the STM32L4R5ZIT6 renders multi-page interfaces without external SDRAM and supports Octo-SPI for faster TFT framebuffer access.
Recommended
Battery-Powered IoT Sensor Hub
The STM32L4R5ZIT6 enables coin-cell / 2xAA battery sensor hubs, with 33 nA Shutdown and 1.1 µA Stop 2 with RTC allowing multi-year coin-cell runtime per AN4621. Placed as the central controller for MEMS microphones, environmental sensors, and BLE hand-off, it integrates the DFSDM digital filter for sigma-delta microphones without a dedicated audio DSP. The 2 MB Flash supports LoRaWAN/BLE stacks and OTA updates without external memory. Compared to discrete Cortex-M0+ designs the STM32L4R5ZIT6 adds Cortex-M4F DSP and is rated 1.71 V to 3.6 V, ideal for energy harvesting.
Recommended
Smart Energy Metering
In smart energy meters, the STM32L4R5ZIT6 handles ADC sample aggregation, metrology DSP via Cortex-M4F MAC unit, and secure DLMS/COSEM firmware updates using its AES-256 hardware accelerator. Placed between the current-transformer / shunt front-end and the M-Bus / wireless PLC modem, it directly digitises up to three current channels with its 12-bit ADCs at oversampled 16-bit resolution. The 2 MB Flash holds protocol stacks for DLMS, M-Bus, and Wireless M-Bus plus regulatory firmware without external SPI flash. Compared to older Cortex-M3 designs, the STM32L4R5ZIT6 adds Standby 280 nA with RTC suitable for backup power modes.
Recommended
Medical Infusion Pump Controller
The STM32L4R5ZIT6 powers infusion pump controllers, with its Cortex-M4F running PID motor control loops, the 2 MB Flash hosting IEC 62304/60335-compliant firmware, and USB OTG enabling host-side data export. Placed between a stepper driver and the keypad/display, it handles stepper commutation via its advanced timers while the integrated op-amps condition pressure and bubble-detection sensors. The 640 KB SRAM accommodates pressure waveform buffers, while AES-256 protects dosing calibration data. Compared to Cortex-M3 designs, the FPU ensures deterministic real-time control loop execution and the L4+ low-leakage features suit battery-backup mode.
Recommended
Smart Sensor Hub for Predictive Maintenance
The STM32L4R5ZIT6 fits vibration and temperature sensor hubs in Industry 4.0, integrating the DFSDM digital filter for IEPE accelerometers and supporting FFT analysis via Cortex-M4F DSP with CMSIS-DSP library. Placed at industrial motor bearings, it runs self-powered from vibration energy harvesters thanks to 33 nA Shutdown and 1.71 V minimum supply. The 2 MB Flash hosts the wireless protocol stack (LoRa, BLE 5, or Wi-SUN) and predictive-maintenance ML models (TFLite-Micro). Compared to external-DSP designs, the single-chip integration reduces PCB area to under 20 mm square, which is decisive for retrofit-mount sensor units.
Recommended
Recommended Products Summary
Engineering reference data for STM32L4R5ZIT6 — comparison, design guidance, and compliance information.
Selection Guide
Comparison with Alternatives
| Parameter | This Product | STM32L4R7ZIT6 | STM32L4S5ZIT6 | STM32L4R9ZIT6 |
|---|---|---|---|---|
| Package | 144-LQFP (20x20) | 144-LQFP (20x20) | 144-LQFP (20x20) | 144-LQFP (20x20) |
| Brand | STMicroelectronics | STMicroelectronics | STMicroelectronics | STMicroelectronics |
| Core | ARM Cortex-M4F 120 MHz | ARM Cortex-M4F 120 MHz | ARM Cortex-M4F 120 MHz | ARM Cortex-M4F 120 MHz |
| Flash Memory | 2 MB | 2 MB | 2 MB | 2 MB |
| SRAM Size | 640 KB | 640 KB | 640 KB | 1 MB |
| Display Interface | None on LQFP-144 | MIPI-DSI (yes) | MIPI-DSI (yes) | MIPI-DSI (yes) |
| Operating Voltage | 1.71 V to 3.6 V | 1.71 V to 3.6 V | 1.71 V to 3.6 V | 1.71 V to 3.6 V |
| Shutdown Current | 33 nA | 33 nA | 33 nA | 33 nA |
| USB OTG | Yes (FS, internal PHY) | Yes (FS, internal PHY) | Yes (FS, internal PHY) | Yes (FS, internal PHY) |
Key Differentiators
- 2 MB Flash with Cortex-M4F at 120 MHz and FPU/DSP in LQFP-144 (vs STM32L4R5ZGT6)
- MIPI-DSI absent on ZIT6 vs available on R7ZIT6 same-family upgrade (vs STM32L4R7ZIT6)
- Cortex-M4F DSP and FPU in LQFP-144 same footprint as Cortex-M3 GD32F103 (vs GD32F103)
Design Notes
The STM32L4R5ZIT6 supports two voltage-regulation modes: direct LDO and internal SMPS step-down converter. For ultra-low-power battery designs (1.71 V - 2.0 V), use the SMPS mode to reduce Run-mode current by ~50% compared to LDO. Estimated: SMPS external inductor 10 µH (XAL4030 or similar) and 4.7 µF X7R input/output capacitor per AN4621. Add a 100 nF decoupling capacitor on every VDD/VDDA pin pair to suppress high-frequency switching noise.
Layout: place the 32.768 kHz crystal (LSE) within 5 mm of PC14/PC15 with short traces and guard ring for noise immunity. Keep USB DP/DM traces length-matched to within 2 mm and 90 ohm differential impedance per USB 2.0 full-speed requirements. Decouple each VDD pin with 100 nF X7R placed within 2 mm, plus 4.7 µF bulk capacitors at each regulator pin. The LQFP-144 thermal pad handling follows ST's AN5036 PCB design guide.
Many STM32L4 firmware delays stem from failing to set the ART Accelerator prefetch buffer and Flash wait states for 120 MHz operation - both must be configured in SystemInit() before raising the clock. RTC date/time must be in BCD format (not BINARY) unless explicitly using STM32Cube HAL. When entering Shutdown mode, the LSE crystal must remain enabled if RTC wake-up is required, otherwise wake from WAKEUP pins only. Estimated: at 120 MHz with 3.3 V VDD, Run-mode current is approximately 5 mA; going to Stop 2 mode reduces this to ~1.1 µA retaining RTC.
To meet industrial EMI/EMC standards (EN 55022 Class B), place a ferrite bead (600 ohm at 100 MHz) on each VDD rail and use a 4-layer PCB with a continuous ground plane. Spread-spectrum clocking on HSE can be enabled to reduce peak emissions by 4-8 dB per AN2867. Keep GPIO toggle paths away from analog ADC traces; route analog and digital grounds separately back to a single star ground at the AGND/VDDA decoupling capacitor.
Compliance Information
RoHS compliant per ST product page. Industrial temperature range -40C to +85C (grade 6) or -40C to +125C (grade 7). Not AEC-Q100 qualified - for automotive applications use STM32L4R5ZIT6Q variant.
