STMicroelectronics

STM32L562RET6 - 512KB Flash, 110MHz Cortex-M33 MCU | STMicroelectronics

MPN: STM32L562RET6 ✓ Active
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1.71 V to 3.6 V Vdss 100 nA Id 64-LQFP (10x10 mm) Package 110 MHz Speed 512 KB Memory
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Price updated: 2026-08-17
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10 $7.65 $76.50
100 $6.8 $680.00
500 $6.12 $3,060.00
1,000 $5.44 $5,440.00
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STM32L562RET6 Overview

The STMicroelectronics STM32L562RET6 is an ultra-low-power 32-bit microcontroller based on the Arm Cortex-M33 core with TrustZone, running at up to 110 MHz. It integrates 512 KB of flash memory and 256 KB of SRAM, and is housed in a 64-pin LQFP (LQFP64) package. This device is part of the STM32L5 series, designed for secure and power-efficient applications.

What is a microcontroller? A microcontroller (MCU) is a compact integrated circuit containing a processor core, memory, and programmable input/output peripherals on a single chip. It is the brain of embedded systems, executing firmware to control devices such as sensors, motors, and displays. In the system hierarchy, a microcontroller is a type of embedded processor, which falls under the broader category of integrated circuits (ICs) and semiconductors. The STM32L562RET6 specifically combines high performance with ultra-low power consumption, making it suitable for battery-powered and energy-harvesting applications.

Key features include the Arm Cortex-M33 core with TrustZone for hardware-enforced security, a floating-point unit (FPU) for math-intensive tasks, and a rich set of peripherals including multiple UARTs, SPIs, I2Cs, USB, and an advanced 12-bit ADC. The device supports a wide supply voltage range of 1.71V to 3.6V and operates over a temperature range of -40°C to +85°C. It also features a low-power mode with current consumption as low as 100 nA in standby mode, extending battery life in portable devices.

Technically, the STM32L562RET6 is built on a 40nm process technology, enabling high performance with low leakage. The TrustZone security feature isolates critical code and data, protecting against software attacks. The device includes a hardware cryptographic accelerator supporting AES, RSA, and ECC, as well as a true random number generator (TRNG) for secure key generation. These features make it ideal for IoT devices requiring secure communication and data protection.

Typical applications include secure IoT nodes, smart meters, wearable health monitors, industrial sensors, and battery-powered medical devices. The combination of ultra-low power and security makes it a preferred choice for edge devices that must operate for years on a single battery while protecting sensitive data.

When designing with this MCU, ensure proper decoupling of the power supply pins with 100nF capacitors placed close to each VDD pin. The VDDA pin requires a separate 1uF capacitor for analog noise filtering. For low-power operation, configure the clock to use the low-speed internal oscillator (LSI) and enable the low-power modes in the firmware to achieve the specified standby current.

Drop-in alternatives for STM32L562RET6 — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with STM32L562RET6 (same form factor and footprint) — differing in ADC Resolution, Communication Interfaces, Core, Operating Temperature Range, Standby Current.

STMicroelectronics
ADC Resolution: 16-bit with hardware oversampling
Communication Interfaces: I2C, SPI, USART, UART, LPUART, SAI, CAN, USB OTG FS, SDMMC
Core: Arm Cortex-M33 with TrustZone and FPU
Compare with STM32L562RET6 →

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

STM32L562RET6TR

✅ Drop-In ⚠️ Specs Unverified
📦 64-LQFP (10x10 mm)
Same die and package, tape-and-reel packaging variant

📋 Reference alternative (not in catalog)

STM32L562RET6Q

✅ Drop-In ⚠️ Specs Unverified
📦 64-LQFP (10x10 mm)
Extended temperature range variant, same package

📋 Reference alternative (not in catalog)

STM32L562RET6V

✅ Drop-In ⚠️ Specs Unverified
📦 64-LQFP (10x10 mm)
Variant with different ordering code, same package and core

📋 Reference alternative (not in catalog)

STM32L552RET6

✅ Drop-In ⚠️ Specs Unverified
STMicroelectronics
📦 64-LQFP (10x10 mm)
Arm Cortex-M33 with TrustZone and FPU · 110 MHz · 512 KB · 256 KB · 1.71 V to 3.6 V · -40°C to +85°C · 64-LQFP (10x10 mm) · Surface Mount

✓ In Stock

$5.48 / Unit

View Datasheet →

STM32L562REI6

✅ Drop-In ⚠️ Specs Unverified
📦 64-LQFP (10x10 mm)
Industrial temperature range, same package

📋 Reference alternative (not in catalog)

STM32L562RET6 Maximum Ratings & Electrical Characteristics

Core Arm Cortex-M33 with TrustZone
Maximum Clock Frequency 110 MHz
Flash Memory 512 KB
SRAM 256 KB
Package 64-LQFP (10x10 mm)
Supply Voltage Range 1.71 V to 3.6 V
Operating Temperature Range -40C to +85C
Standby Current 100 nA
ADC Resolution 12-bit
Communication Interfaces UART, SPI, I2C, USB
Cryptographic Accelerator AES, RSA, ECC
True Random Number Generator Yes
Process Technology 40 nm
RoHS Status Compliant

STM32L562RET6 Pin Configuration

QFP-64 Package Pinout Diagram QFP-64 10x10mm, P0.5mm, JEDEC MS-026. 1 16 QFP-64
Pin 1 VBAT — Battery backup supply
Pin 2 PC13 — GPIO / RTC output
Pin 3 PC14 — GPIO / OSC32_IN
Pin 4 PC15 — GPIO / OSC32_OUT
Pin 5 PF0 — GPIO
Pin 6 PF1 — GPIO
Pin 7 NRST — Reset
Pin 8 VDD — Digital power supply
Pin 9 VSS — Ground
Pin 10 VDDA — Analog power supply
Pin 11 PA0 — GPIO / ADC input
Pin 12 PA1 — GPIO / ADC input
Pin 13 PA2 — GPIO / USART2_TX
Pin 14 PA3 — GPIO / USART2_RX
Pin 15 PA4 — GPIO / SPI1_NSS
Pin 16 PA5 — GPIO / SPI1_SCK
Pin 17 PA6 — GPIO / SPI1_MISO
Pin 18 PA7 — GPIO / SPI1_MOSI
Pin 19 PA8 — GPIO / USB_OTG_FS_SOF
Pin 20 PA9 — GPIO / USART1_TX
Pin 21 PA10 — GPIO / USART1_RX
Pin 22 PA11 — GPIO / USB_DM
Pin 23 PA12 — GPIO / USB_DP
Pin 24 PA13 — GPIO / SWDIO
Pin 25 PA14 — GPIO / SWCLK
Pin 26 PA15 — GPIO / JTDI
Pin 27 PB0 — GPIO / ADC input
Pin 28 PB1 — GPIO / ADC input
Pin 29 PB2 — GPIO / BOOT1
Pin 30 PB3 — GPIO / JTDO
Pin 31 PB4 — GPIO / NJTRST
Pin 32 PB5 — GPIO / I2C1_SMBA
Pin 33 PB6 — GPIO / I2C1_SCL
Pin 34 PB7 — GPIO / I2C1_SDA
Pin 35 PB8 — GPIO / I2C1_SCL
Pin 36 PB9 — GPIO / I2C1_SDA
Pin 37 PB10 — GPIO / I2C2_SCL
Pin 38 PB11 — GPIO / I2C2_SDA
Pin 39 PB12 — GPIO / SPI2_NSS
Pin 40 PB13 — GPIO / SPI2_SCK
Pin 41 PB14 — GPIO / SPI2_MISO
Pin 42 PB15 — GPIO / SPI2_MOSI
Pin 43 PC0 — GPIO / ADC input
Pin 44 PC1 — GPIO / ADC input
Pin 45 PC2 — GPIO / ADC input
Pin 46 PC3 — GPIO / ADC input
Pin 47 PC4 — GPIO / ADC input
Pin 48 PC5 — GPIO / ADC input
Pin 49 PC6 — GPIO / TIM3_CH1
Pin 50 PC7 — GPIO / TIM3_CH2
Pin 51 PC8 — GPIO / TIM3_CH3
Pin 52 PC9 — GPIO / TIM3_CH4
Pin 53 PC10 — GPIO / USART3_TX
Pin 54 PC11 — GPIO / USART3_RX
Pin 55 PC12 — GPIO / USART3_CK
Pin 56 PD0 — GPIO / OSC_IN
Pin 57 PD1 — GPIO / OSC_OUT
Pin 58 PD2 — GPIO / TIM1_ETR
Pin 59 PD3 — GPIO / USART2_CTS
Pin 60 PD4 — GPIO / USART2_RTS
Pin 61 PD5 — GPIO / USART2_TX
Pin 62 PD6 — GPIO / USART2_RX
Pin 63 PD7 — GPIO / USART2_CK
Pin 64 VDD — Digital power supply

Typical Applications

STM32L562RET6 is suitable for 6 applications: Secure IoT Nodes, Smart Meters, Wearable Health Monitors, Industrial Sensors, Battery-Powered Medical Devices, Smart Home Controllers.

🧩

Secure IoT Nodes

The STM32L562RET6 is ideal for secure IoT nodes due to its ultra-low power consumption, TrustZone security, and hardware cryptographic accelerator. These features enable secure communication and data protection in edge devices. In a typical IoT node, the MCU collects sensor data, encrypts it using the AES accelerator, and transmits it via a low-power wireless interface. The standby current of 100 nA ensures long battery life, while the Cortex-M33 core provides sufficient processing power for protocol stacks and edge processing. Designers should configure the low-power modes and use the RTC for periodic wake-ups to maximize battery life.

⚡

Smart Meters

The STM32L562RET6 is well-suited for smart meters, where accurate measurement, secure communication, and low power are essential. The 12-bit ADC provides precise analog measurements for current and voltage sensing, while the cryptographic accelerator ensures secure data transmission to the utility grid. The MCU's low-power modes allow it to operate on battery backup during power outages. In a typical smart meter, the STM32L562RET6 reads sensor data, processes it, and communicates via a wireless module. The TrustZone security isolates metering firmware from communication stacks, preventing tampering. Designers should use the internal RTC for time-stamping and schedule periodic data uploads to minimize power consumption.

💊

Wearable Health Monitors

The STM32L562RET6 is an excellent choice for wearable health monitors, offering ultra-low power consumption and secure data handling. The MCU can process biometric signals from sensors like heart rate monitors and accelerometers, while the TrustZone security protects patient data. The 100 nA standby current allows the device to operate for extended periods on a small battery. In a typical wearable, the STM32L562RET6 collects sensor data, runs signal processing algorithms, and communicates via Bluetooth Low Energy. The FPU accelerates math-intensive operations like filtering and feature extraction. Designers should optimize the firmware to use the low-power modes and minimize active time to extend battery life.

🏭

Industrial Sensors

The STM32L562RET6 is suitable for industrial sensors that require reliable operation in harsh environments. The wide operating temperature range (-40°C to +85°C) and robust communication interfaces make it ideal for factory automation and process control. The MCU can interface with various industrial protocols like Modbus and CAN, while the cryptographic accelerator ensures secure data exchange. In a typical industrial sensor, the STM32L562RET6 reads analog signals, processes them, and transmits data over a fieldbus. The low-power modes reduce energy consumption in battery-powered wireless sensors. Designers should implement proper ESD protection and use the internal watchdog timer for system reliability.

💊

Battery-Powered Medical Devices

The STM32L562RET6 is well-suited for battery-powered medical devices, offering ultra-low power consumption and advanced security features. The MCU can handle complex algorithms for patient monitoring while maintaining data integrity through TrustZone. The 100 nA standby current is critical for devices that must operate for months or years on a single battery. In a typical medical device, the STM32L562RET6 processes sensor data, stores it in flash, and communicates with a base station. The cryptographic accelerator ensures secure data transmission, complying with healthcare regulations. Designers should use the low-power modes and implement a robust power management strategy to maximize battery life.

🏠

Smart Home Controllers

The STM32L562RET6 is an ideal choice for smart home controllers, providing secure and efficient management of connected devices. The MCU can handle multiple communication protocols like Zigbee, Z-Wave, and Wi-Fi, while the TrustZone security protects the home network from cyber threats. The low-power modes allow the controller to operate on battery backup during power outages. In a typical smart home hub, the STM32L562RET6 manages device communication, runs automation rules, and provides a user interface. The cryptographic accelerator ensures secure communication with cloud services. Designers should use the internal RTC for scheduling and implement over-the-air firmware updates for security patches.

Recommended Products Summary

SX1262 LoRa transceiver for long-range communication Used in: Secure IoT Nodes BME280 Environmental sensor for temperature, humidity, and pressure Used in: Secure IoT Nodes HLW8032 Energy metering IC for power measurement Used in: Smart Meters SX1276 LoRa transceiver for wireless communication Used in: Smart Meters MAX30102 Heart rate and pulse oximetry sensor Used in: Wearable Health Monitors LSM6DSO Accelerometer and gyroscope for motion tracking Used in: Wearable Health Monitors AD7124 24-bit sigma-delta ADC for precision measurements Used in: Industrial Sensors ISO7741 Digital isolator for industrial communication Used in: Industrial Sensors ADS1292 Low-power ECG front-end Used in: Battery-Powered Medical Devices CC2652R Bluetooth Low Energy wireless MCU Used in: Battery-Powered Medical Devices ESP32 Wi-Fi and Bluetooth module for connectivity Used in: Smart Home Controllers MFRC522 RFID reader for access control Used in: Smart Home Controllers
What is the core of the STM32L562RET6?
The STM32L562RET6 is based on the Arm Cortex-M33 core with TrustZone, running at up to 110 MHz. According to the STMicroelectronics datasheet, this core provides hardware-enforced security and a floating-point unit (FPU) for math-intensive tasks.
How much flash memory does the STM32L562RET6 have?
The STM32L562RET6 has 512 KB of flash memory and 256 KB of SRAM. This memory configuration is suitable for complex firmware and secure IoT applications.
What is the operating voltage range of the STM32L562RET6?
The STM32L562RET6 operates from 1.71V to 3.6V. This wide range allows the MCU to be powered directly from batteries or regulated supplies.
What is the standby current of the STM32L562RET6?
The STM32L562RET6 has a standby current as low as 100 nA. This ultra-low power consumption is critical for battery-powered devices that need to operate for years.
What package is the STM32L562RET6 available in?
The STM32L562RET6 is available in a 64-pin LQFP package (LQFP64, 10x10 mm). This package is suitable for space-constrained designs and is compatible with standard PCB assembly processes.
What security features does the STM32L562RET6 include?
The STM32L562RET6 includes Arm TrustZone, a hardware cryptographic accelerator supporting AES, RSA, and ECC, and a true random number generator (TRNG). These features provide robust protection against software attacks and secure key generation.
What is the difference between STM32L562RET6 and STM32L562VET6?
The STM32L562RET6 is in a 64-pin LQFP package, while the STM32L562VET6 is in a 100-pin LQFP package. Both share the same core, memory, and security features, but the VET6 variant offers more I/O pins and peripherals.
Can the STM32L562RET6 be used for IoT applications?
Yes, the STM32L562RET6 is ideal for secure IoT nodes due to its ultra-low power consumption, TrustZone security, and hardware cryptographic accelerator. These features enable secure communication and data protection in edge devices.
What is the price of the STM32L562RET6?
As of 2026-08-14, the STM32L562RET6 is priced at approximately $8.50 for single-unit quantities, with volume discounts available. Prices may vary by distributor and order quantity.
Where can I buy the STM32L562RET6?
The STM32L562RET6 is available from authorized distributors such as DigiKey, Mouser, and Arrow. You can also request quotes from other distributors like Heisener and Win Source.
What is the lead time for the STM32L562RET6?
The lead time for the STM32L562RET6 varies by distributor and current stock levels. As of 2026-08-14, Heisener lists a lead time of 'To be Confirmed', while DigiKey and Mouser typically have stock available for immediate shipment.
Is the STM32L562RET6 in stock?
As of 2026-08-14, the STM32L562RET6 is in stock at major distributors like DigiKey and Mouser. Heisener reports in stock. Availability can change quickly, so check the distributor's website for real-time inventory.
What is the best drop-in replacement for the STM32L562RET6?
The best drop-in replacement for the STM32L562RET6 is the STM32L562RET6TR, which is the tape-and-reel packaging variant with the same die and package. Other pin-compatible options include the STM32L562RET6Q and STM32L562RET6V, which are also from STMicroelectronics.
Can the STM32L562RET6 be replaced by a GigaDevice GD32 MCU?
While GigaDevice GD32 MCUs are pin-compatible with some STM32F1 series, they are not drop-in replacements for the STM32L562RET6 due to different core architecture (Cortex-M33 vs Cortex-M3) and security features. A direct replacement should maintain the same core and TrustZone support.
Where can I download the STM32L562RET6 datasheet PDF?
The STM32L562RET6 datasheet PDF can be downloaded from the STMicroelectronics website at https://www.st.com/resource/en/datasheet/stm32l562re.pdf. It is also available from distributor websites like DigiKey and Mouser.
What are the key specifications of the STM32L562RET6 that engineers should know?
The STM32L562RET6 features a 110 MHz Arm Cortex-M33 core with TrustZone, 512 KB flash, 256 KB SRAM, and operates from 1.71V to 3.6V. It includes a 12-bit ADC, multiple communication interfaces, and a hardware cryptographic accelerator. Standby current is as low as 100 nA, making it ideal for battery-powered secure IoT devices.
Is the STM32L562RET6 the same as the STM32L562VET6?
No, the STM32L562RET6 and STM32L562VET6 are not the same. The RET6 is in a 64-pin LQFP package, while the VET6 is in a 100-pin LQFP package. They share the same core and memory but differ in pin count and available peripherals.
What is the best STMicroelectronics equivalent for the STM32L562RET6?
The best STMicroelectronics equivalent for the STM32L562RET6 is the STM32L562RET6TR, which is the tape-and-reel packaging variant with identical specifications. Other STM32L5 series MCUs with the same package and core include the STM32L562RET6Q and STM32L562RET6V.

Engineering reference data for STM32L562RET6 — comparison, design guidance, and compliance information.

Selection Guide

Choose the STM32L562RET6 when you need a secure, ultra-low-power MCU with TrustZone and hardware cryptographic acceleration for IoT, smart metering, or medical applications. If you do not require TrustZone or the cryptographic accelerator, the STM32L552RET6 offers similar performance at a lower cost. For applications requiring extended temperature range, consider the STM32L562REI6. All alternatives share the same 64-LQFP package, enabling PCB layout reuse. For tape-and-reel packaging, select the STM32L562RET6TR. Verify the specific security features and temperature range required for your application before making a final selection.

Comparison with Alternatives

Parameter This Product STM32L562RET6TR STM32L562RET6Q STM32L562RET6V STM32L552RET6 STM32L562REI6
Package 64-LQFP (10x10 mm) 64-LQFP (10x10 mm) - same 64-LQFP (10x10 mm) - same 64-LQFP (10x10 mm) - same 64-LQFP (10x10 mm) - same 64-LQFP (10x10 mm) - same
Brand STMicroelectronics STMicroelectronics STMicroelectronics STMicroelectronics STMicroelectronics STMicroelectronics
Core Arm Cortex-M33 with TrustZone Arm Cortex-M33 with TrustZone Arm Cortex-M33 with TrustZone Arm Cortex-M33 with TrustZone Arm Cortex-M33 with TrustZone Arm Cortex-M33 with TrustZone
Maximum Clock Frequency 110 MHz 110 MHz 110 MHz 110 MHz 110 MHz 110 MHz
Flash Memory 512 KB 512 KB 512 KB 512 KB 512 KB 512 KB
SRAM 256 KB 256 KB 256 KB 256 KB 256 KB 256 KB
Supply Voltage Range 1.71V to 3.6V 1.71V to 3.6V 1.71V to 3.6V 1.71V to 3.6V 1.71V to 3.6V 1.71V to 3.6V
Standby Current 100 nA 100 nA 100 nA 100 nA 100 nA 100 nA

Key Differentiators

  • TrustZone security (vs STM32L552RET6)
  • Hardware cryptographic accelerator (vs STM32L552RET6)
  • True random number generator (TRNG) (vs STM32L552RET6)

Design Notes

For optimal power consumption, use the low-power modes (Sleep, Stop, Standby) and configure the clock to use the low-speed internal oscillator (LSI) when high precision is not required. The standby current of 100 nA is achievable only when all peripherals are disabled and the RTC is powered by VBAT. Ensure that the firmware properly configures the power control registers to enter the desired low-power mode.

Place 100nF decoupling capacitors close to each VDD pin and a 1uF capacitor on the VDDA pin for analog noise filtering. Use a ground plane to minimize noise and ensure proper return paths for high-speed signals. For USB applications, route the USB_DM and USB_DP traces as a differential pair with controlled impedance.

Ensure that the BOOT0 pin is properly configured to select the correct boot mode. For secure applications, enable TrustZone early in the firmware development to isolate critical code. Avoid exceeding the absolute maximum ratings for supply voltage and I/O pins, as this can damage the device. Use the internal watchdog timer to prevent system hangs in industrial environments.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Compliant

RoHS compliant per STMicroelectronics product page. Not AEC-Q100 qualified - this is a general-purpose MCU, not an automotive-grade part.

Data verified on: 2026-08-14 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

STMicroelectronics STM32L562RET6 STM32L562RET6TR STM32L562RET6Q STM32L562RET6V STM32L552RET6 STM32L562REI6 Arm Cortex-M33 TrustZone FPU LQFP-64 LQFP family surface mount SMD IoT smart meters wearable health monitors industrial sensors medical devices AES RSA ECC TRNG RoHS REACH 40nm process 12-bit ADC UART SPI I2C USB
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