Microchip Technology

ATSAMD21E18A-AFT - 48MHz Cortex-M0+ MCU, 256KB Flash | Microchip

MPN: ATSAMD21E18A-AFT ✓ Active
In Stock Ships in 1-3 business days
1.62 V to 3.63 V Vdss 32-TQFP (7x7 mm) Package 48 MHz Speed 256 KB (256K x 8) Memory
From $2.72 USD / Unit
MOQ: 1 |
Price updated: 2026-09-21
Volume Pricing
Qty Unit Price Extended
1 $4.2 $4.20
10 $3.78 $37.80
100 $3.4 $340.00
500 $3.05 $1,525.00
1,000 $2.72 $2,720.00
ℹ️ All prices are in USD

ATSAMD21E18A-AFT Overview

The Microchip Technology ATSAMD21E18A-AFT is a 32-bit ARM Cortex-M0+ microcontroller from the SAM D21E family, featuring 256KB of Flash, 32KB of SRAM, and a maximum CPU clock of 48MHz in a 32-pin TQFP (7x7 mm) package. It operates from 1.62V to 3.63V and integrates Functional Safety (FuSa) features targeted at industrial and consumer applications. The device is tape-and-reel packaged (-AFT suffix) and qualified to 125C operating junction temperature.

A microcontroller (MCU) is a single-chip computer that integrates a CPU core, memory, and programmable peripherals. The ARM Cortex-M0+ is the smallest and most energy-efficient ARM core, designed for deeply embedded applications where deterministic interrupt response, low active power, and a compact instruction set are critical. SAM D21 devices sit in the Cortex-M0+ family as low-power, high-performance variants and target USB-equipped and analog-rich designs.

Key features of the ATSAMD21E18A-AFT include the Cortex-M0+ core reaching 2.46 CoreMark/MHz, a 12-channel Event System, a full-speed USB 2.0 device with integrated transceiver, up to six SERCOM configurable serial interfaces (UART/SPI/I2C), a 12-bit ADC with up to 20 channels, two analog comparators, and a 16-bit timer/counter for control loops. The Peripheral Touch Controller (PTC) supports capacitive touch buttons, sliders, and proximity sensing.

The architecture pairs a single-cycle hardware multiplier with the Cortex-M0+ core, and the SAM D21 family shares a linear address map and hex-compatible code across pin counts, simplifying migration between 32-, 48-, and 64-pin members. The integrated Full-Speed USB transceiver eliminates the need for external crystal or pull-up resistors on most designs.

Typical applications include home automation nodes, smart metering, industrial sensor hubs, USB HID peripherals, wearable fitness bands, consumer appliances, and capacitive touch user interfaces. The wide 1.62V-3.63V supply range and low-power Sleep/Idle modes support battery-powered deployments.

When designing with this part, allocate the 32-pin TQFP footprint carefully because several peripheral functions share pins (the SERCOMs are highly multiplexed). For new designs, plan to use Atmel/Microchip START or MPLAB X with MCC to configure pin assignments and clock tree.

This page synthesizes current distributor pricing, drop-in alternatives, and practical design notes beyond what the manufacturer datasheet alone provides, enabling faster BOM decisions and supply-chain resilience.

Drop-in alternatives for ATSAMD21E18A-AFT — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with ATSAMD21E18A-AFT (same form factor and footprint) — differing in Package, ADC, USB, MSL Level, Operating Temperature Range.

Microchip Technology
Package: 32-pin TQFP (7x7 mm)
ADC: 12-bit, up to 14 channels
MSL Level: MSL3 (per JEDEC J-STD-020)
Compare with ATSAMD21E18A-AFT →
Microchip Technology
Package: 32-pin TQFP (7x7 mm)
USB: USB 2.0 Full-Speed Device
Operating Temperature Range: -40 C to +125 C (125C GREEN)
Compare with ATSAMD21E18A-AFT →
Microchip Technology
Package: 32-pin TQFP (7x7 mm), 0.8 mm pitch
ADC: 12-bit, up to 350 ksps, up to 20 channels
MSL Level: 3 (per JEDEC J-STD-020)
Compare with ATSAMD21E18A-AFT →
Microchip Technology
Package: 32-VQFN (5x5 mm)
ADC: 12-bit, up to 12 channels
USB: USB 2.0 Full-Speed Device/Host
Compare with ATSAMD21E18A-AFT →
Microchip Technology
Package: 32-pin QFN (5x5 mm)
USB: USB 2.0 Full-Speed Device
Operating Temperature Range: -40C to +125C
Compare with ATSAMD21E18A-AFT →
Microchip Technology
Package: 48-TQFP (7x7 mm)
ADC: 12-bit
USB: USB 2.0 Full-Speed device/host
Compare with ATSAMD21E18A-AFT →
Microchip Technology
Package: 48-pin QFN (7x7 mm)
ADC: 12-bit, up to 350 ksps, 12 channels
USB: USB 2.0 Full-Speed Device/Host/OTG
Compare with ATSAMD21E18A-AFT →

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

ATSAMD21E17A-AF

✅ Drop-In
Microchip Technology
📦 32-TQFP (7x7 mm)
ARM Cortex-M0+ (32-bit) · SAM D21 / SAM D21E sub-family · 48 MHz · 128 KB · 16 KB · 4 KB auxiliary flash · 1.62 V to 3.63 V · -40 C to +125 C (125C GREEN)

✓ In Stock

$2.34 / Unit

View Datasheet →

ATSAMD21E16A-AF

✅ Drop-In
📦 32-TQFP (7x7 mm)
Flash 64 KB vs 256 KB (-75%); SRAM 8 KB vs 32 KB (-75%); same TQFP-32 footprint

📋 Reference alternative (not in catalog)

ATSAMD21E15A-AF

✅ Drop-In
📦 32-TQFP (7x7 mm)
Flash 32 KB vs 256 KB (-87%); SRAM 4 KB vs 32 KB (-87%); same TQFP-32 footprint

📋 Reference alternative (not in catalog)

ATSAMD21E17A-AU

✅ Drop-In
Microchip Technology
📦 32-TQFP (7x7 mm)
ARM Cortex-M0+ (SAM D21E family) · 32-bit · 48 MHz · 2.46 · 128 KB (128K x 8) · 4 KB · 16 KB · 1.62 V to 3.63 V

✓ In Stock

$2.3 / Unit

View Datasheet →

ATSAMD21E17A-MFT

✅ Drop-In
Microchip Technology
📦 32-TQFP (7x7 mm)
ARM Cortex-M0+ · 32-bit · 48 MHz · 128 KB (128K x 8) · 16 KB · 1.6 V to 3.6 V · -40 °C to +125 °C · 32-VQFN (5x5 mm)

✓ In Stock

$2.55 / Unit

View Datasheet →

ATSAMD21E15B-AFT

✅ Drop-In
Microchip Technology
📦 32-TQFP (7x7 mm)
ARM Cortex-M0+ · 32-bit · 48 MHz · 32 KB (32K x 8) · 4 KB · 1.62 V to 3.63 V · 26 (max) · 32-pin TQFP (7x7 mm)

✓ In Stock

$1.96 / Unit

View Datasheet →

ATSAMD21E18A-AFT Maximum Ratings & Electrical Characteristics

Core ARM Cortex-M0+ (32-bit)
Series SAM D21E (Functional Safety / FuSa)
Maximum CPU Clock 48 MHz
CoreMark Performance 2.46 CoreMark/MHz
Flash Memory 256 KB (256K x 8)
SRAM 32 KB
Operating Voltage 1.62 V to 3.63 V
Operating Temperature -40 C to +125 C
Package 32-TQFP (7x7 mm)
Mounting Type Surface Mount (Tape & Reel)
USB Full-Speed USB 2.0 Device with integrated transceiver
Serial Interfaces (SERCOM) Up to 6 (configurable UART/SPI/I2C)
ADC 12-bit, up to 20 channels
Analog Comparators 2
Timers 16-bit TC modules and TCC for PWM
Touch Controller Peripheral Touch Controller (PTC) - capacitive touch
Event System 12-channel
MSL Level 3
RoHS Status Compliant

ATSAMD21E18A-AFT Pin Configuration

TQFP-32 (7x7mm) Package Pinout Diagram TQFP-32 7x7mm, P0.8mm, JEDEC MS-026. Pin 1 by dot. TQFP-32 (7x7mm) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32
Pin 1 PA00 — General-purpose I/O / SERCOM / ADC
Pin 2 PA01 — General-purpose I/O / SERCOM / ADC
Pin 3 PA02 — Analog comparator / ADC
Pin 4 PA03 — Analog comparator / ADC / DAC
Pin 5 PA04 — SERCOM / ADC
Pin 6 PA05 — SERCOM / ADC
Pin 7 PA06 — SERCOM / ADC
Pin 8 PA07 — SERCOM / ADC
Pin 9 VDDIO — Digital I/O supply (1.62-3.63V)
Pin 10 GND — Common ground
Pin 11 PA08 — SERCOM / NMI / pin X / pin 0
Pin 12 PA09 — SERCOM / pin 1
Pin 13 PA10 — SERCOM / pin 2
Pin 14 PA11 — SERCOM / pin 3
Pin 15 PA12 — SERCOM / pin 4
Pin 16 PA13 — SERCOM / pin 5
Pin 17 PA20 — USB D-
Pin 18 PA21 — USB D+
Pin 19 PA22 — SERCOM / I2S SCK
Pin 20 PA23 — SERCOM / I2S FS
Pin 21 PA24 — SERCOM / USB ID
Pin 22 PA25 — SERCOM / USB VBUS
Pin 23 RESETN — Active-low reset input
Pin 24 PA27 — SERCOM / pin 11
Pin 25 PA28 — SERCOM / pin 12 / Wake
Pin 26 PA30 — SERCOM / SWCLK (programming)
Pin 27 PA31 — SERCOM / SWDIO (programming)
Pin 28 VDDANA — Analog supply (1.62-3.63V)
Pin 29 GND — Common ground
Pin 30 VBUS — USB VBUS detect (5V tolerant)
Pin 31 XIN32 — 32.768 kHz crystal input
Pin 32 XOUT32 — 32.768 kHz crystal output

Typical Applications

ATSAMD21E18A-AFT is suitable for 6 applications: Home Automation Hub, USB HID Peripheral (Keyboard/Mouse/HID Gamepad), Industrial Sensor Node / Smart Metering, Capacitive Touch User Interface, Wearable Fitness Band, Consumer Appliance Control Board.

🧩

Home Automation Hub

The ATSAMD21E18A-AFT fits home automation hubs because it combines 256 KB Flash for gateway stacks, the integrated Full-Speed USB device for wired upstream links, and 32 KB SRAM to buffer MQTT and Zigbee/BLE bridge messages. Its 1.62-3.63V supply range supports direct battery or 3.3V LDO rails, and the 48 MHz Cortex-M0+ core executes FreeRTOS task switches with deterministic latency. The 12-channel Event System lets sensor interrupts wake the MCU from Sleep without CPU overhead, extending coin-cell runtimes in wall-mounted switches and PIR motion nodes.

⌨️

USB HID Peripheral (Keyboard/Mouse/HID Gamepad)

The ATSAMD21E18A-AFT integrates a Full-Speed USB 2.0 device with on-chip transceiver, so a USB HID keyboard, mouse, or gamepad needs no external PHY or precision pull-up. With 256 KB Flash it stores large HID descriptor sets and macro/mapping logic, while 32 KB SRAM handles USB endpoint buffering and key-scan queues. Up to six SERCOMs provide flexible SPI/I2C/UART connectivity to RGB LED drivers, NFC tags, or wireless modules.

🏭

Industrial Sensor Node / Smart Metering

The ATSAMD21E18A-AFT, an FuSa variant of the SAM D21E family, supports IEC 60730 Class B safety libraries for industrial sensor nodes and smart metering. Its 12-bit ADC with up to 20 channels reads thermistor, current-sense, and voltage-divider signals for energy measurement, while the two analog comparators handle zero-cross detection. The 1.62-3.63V range and 48 MHz core enable real-time power-quality calculations within sub-millisecond cycles.

📱

Capacitive Touch User Interface

The ATSAMD21E18A-AFT integrates the Peripheral Touch Controller (PTC) which supports capacitive touch buttons, sliders, and proximity sensors without an external touch IC. The 256 KB Flash stores robust touch libraries, gesture recognition, and noise-immune scanning algorithms. Operating from 1.62-3.63V enables direct Li-ion or 3.3V supply to the touch panel in white goods and kitchen appliances.

📱

Wearable Fitness Band

The ATSAMD21E18A-AFT targets wearable fitness bands where low Sleep current and a small 32-pin TQFP footprint matter most. Its Sleep/Idle modes below 10uA extend coin-cell battery life, while 256 KB Flash stores pedometer, heart-rate, and BLE protocol stack code. The 12-bit ADC reads Li-ion battery voltage and PPG signals, and integrated USB simplifies firmware updates or charging dock enumeration.

🏭

Consumer Appliance Control Board

The ATSAMD21E18A-AFT serves in consumer appliance control boards such as coffee machines, washing machines, and HVAC indoor units where Functional Safety libraries help meet IEC 60730 Class B. Up to six SERCOMs drive motor-control BLDC drivers via SPI, read encoders, and manage the user display. The 32-pin TQFP footprint fits compact control modules and the 125C operating temperature supports enclosed appliance environments.

What is the maximum CPU clock speed of the ATSAMD21E18A-AFT?
The ATSAMD21E18A-AFT runs at a maximum 48 MHz CPU clock on its Cortex-M0+ core, achieving up to 2.46 CoreMark/MHz. According to the Microchip SAM D21 family datasheet, this clock is sourced from the internal 48 MHz DFLL or an external crystal and feeds the bus matrix, peripherals, and NVM controller.
How much Flash and SRAM does the ATSAMD21E18A-AFT have?
The ATSAMD21E18A-AFT integrates 256 KB of in-application-programmable Flash and 32 KB of SRAM. According to the Microchip datasheet, the Flash is organized as 256K x 8 and is paired with a separate 8 KB bootloader area for dual-bank or protected firmware upgrades on selected family members.
What is the operating voltage range of the ATSAMD21E18A-AFT?
The ATSAMD21E18A-AFT operates from 1.62 V to 3.63 V across the -40C to +125C range. According to the Microchip datasheet, a single internal voltage regulator generates the core 1.2 V supply from VDDIO, and a separate VDDANA rail powers the ADC and analog comparators for cleaner conversion results.
Does the ATSAMD21E18A-AFT have integrated USB?
Yes. The ATSAMD21E18A-AFT integrates a Full-Speed USB 2.0 device controller with an on-chip transceiver. According to the Microchip datasheet, no external USB crystal or precision pull-up resistor is required on most designs, but a 1uF capacitor on VBUS and ESD protection are recommended.
What package does the ATSAMD21E18A-AFT use?
The ATSAMD21E18A-AFT ships in a 32-pin TQFP package (7x7 mm, 0.8 mm pitch). The suffix -AFT in Microchip nomenclature means the device is delivered in 7-inch Tape & Reel format for surface-mount assembly, and the A revision denotes the latest silicon mask.
Is there an AEC-Q100 qualified variant of the ATSAMD21E18?
Yes. The ATSAMD21E18A-MFT and ATSAMD21E18A-AFT are functional-safety (-AFT) variants. According to Microchip product documentation, the SAM D21 family includes AEC-Q100 Grade 1 qualified members in larger QFN/TQFP packages; verify the exact grade on the device-specific data sheet before automotive deployment.
What are good drop-in replacements for the ATSAMD21E18A-AFT?
The best drop-in replacements come from the same SAM D21 family with identical 32-pin TQFP (7x7 mm) footprint: ATSAMD21E17A-AF (128 KB Flash), ATSAMD21E16A-AF (64 KB Flash), and ATSAMD21E15A-AF (32 KB Flash). According to the Microchip SAM D21 datasheet, these parts are pin-to-pin compatible, sharing SERCOM mapping and identical peripheral IP.
Where can I download the ATSAMD21E18A-AFT datasheet PDF?
The official ATSAMD21E18A-AFT datasheet (SAM D21E/G/J family datasheet, DS 40001882) is hosted at https://www.microchip.com/content/dam/mchp/documents/OTH/ProductDocuments/DataSheets/40001882A.pdf and via the Microchip product page. According to Microchip, the datasheet is shared across the entire SAM D21 family because of pin-compatible, hex-compatible migration.
What is the pinout of the ATSAMD21E18A-AFT 32-TQFP?
The 32-pin TQFP pinout is documented in the SAM D21E datasheet table. According to the Microchip datasheet, pin 1 is PA00, the SERCOM/peripheral mux is configurable in software, and pins 17 (PA20/PA21) are used for the integrated USB D-/D+ signals; verify each pin against the latest errata before PCB layout.
ATSAMD21E18A-AFT vs ATSAMD21E17A-AF - which should I choose?
Choose ATSAMD21E18A-AFT for 256 KB Flash / 32 KB SRAM and choose ATSAMD21E17A-AF for 128 KB Flash / 16 KB SRAM when cost-sensitive. According to the Microchip datasheet, both share the same 32-pin TQFP footprint, identical peripheral set, and 48 MHz clock, so they are drop-in compatible with only the firmware image size differing.
How much does the ATSAMD21E18A-AFT cost and is it in stock?
As of 2026-09-21, the ATSAMD21E18A-AFT is priced around $4.20 at qty 1 on DigiKey and Mouser, falling to roughly $2.72 per unit at 1000 pieces. According to DigiKey listings, the part is shown in stock with same-day shipping on many tape-and-reel quantities; lead time can extend during industry-wide MCU shortages.
What is the lead time for ordering ATSAMD21E18A-AFT in volume?
As of 2026-09-21, DigiKey and Mouser list the ATSAMD21E18A-AFT with immediate stock for common reel quantities. According to distributor inventory pages, Microchip's direct-factory lead time is typically 6-12 weeks on allocation during shortage cycles, so qualifying a second source is recommended for production runs.
What tools support the ATSAMD21E18A-AFT?
The ATSAMD21E18A-AFT is supported by Microchip MPLAB X IDE, MPLAB Harmony v3, Atmel START, and the MPLAB Code Configurator (MCC). According to Microchip, MPLAB Harmony v3 provides peripheral libraries, USB stacks, and FreeRTOS ports, while Atmel START exports MPLAB X projects for fast prototype setup.
Can ATSAMD20J18A be a drop-in replacement for ATSAMD21E18A-AFT?
No. ATSAMD20J18A and ATSAMD21E18A-AFT are different pin-count packages (64-pin QFN vs 32-pin TQFP) and lack the integrated Full-Speed USB transceiver. According to Microchip's SAM D20 vs SAM D21 comparison, the SAMD21 adds USB and an extra SERCOM, so the SAMD20 is not pin-compatible drop-in for this footprint.
What is the Functional Safety (FuSa) variant feature in SAM D21E?
The SAM D21E FuSa variant adds diagnostic libraries, lock-step capable peripherals, and documentation packages supporting IEC 60730 Class B and similar safety standards. According to Microchip's Functional Safety collateral, this enables designers building home appliances, white goods, and industrial sensors to meet safety certification with reduced external component count.
What development board works with the ATSAMD21E18A-AFT?
The Microchip ATSAMD20-XPRO and SAMD21E Xplained Pro development boards (ATSAMD21E-XPRO) provide Arduino shield headers, an on-board debugger, and access to all device pins. According to Microchip, the ATSAMD21E-XPRO is the most direct match because it carries the same 32-pin E variant and shares the same QFN/TQFP reference design.

Engineering reference data for ATSAMD21E18A-AFT — comparison, design guidance, and compliance information.

Selection Guide

Choose ATSAMD21E18A-AFT when you need the maximum 256 KB Flash in a 32-pin TQFP and require Functional Safety libraries for IEC 60730 Class B home appliances or industrial sensors. Choose ATSAMD21E17A-AF for cost-optimized 128 KB designs that don't need FuSa, and ATSAMD21E16A-AF or ATSAMD21E15A-AF for low-cost consumer devices with smaller firmware footprints. For 64-pin QFN designs with more GPIO, migrate up to SAM D21G; for ultra-low-power without USB, the ATSAMD20E18A-AU provides a compatible Cortex-M0+ pinout. All the listed drop-in alternatives share the same 32-TQFP footprint, allowing firmware reuse with only Flash sizing considerations.

Comparison with Alternatives

Parameter This Product ATSAMD21E17A-AF ATSAMD21E16A-AF ATSAMD21E15A-AF ATSAMD21E17A-MFT
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Package 32-TQFP (7x7 mm) 32-TQFP (7x7 mm) - same 32-TQFP (7x7 mm) - same 32-TQFP (7x7 mm) - same 32-TQFP (7x7 mm) - same
Flash Memory 256 KB 128 KB (-50%) 64 KB (-75%) 32 KB (-87%) 128 KB (-50%)
SRAM 32 KB 16 KB (-50%) 8 KB (-75%) 4 KB (-87%) 16 KB (-50%)
Maximum Clock 48 MHz 48 MHz 48 MHz 48 MHz 48 MHz
Operating Voltage 1.62 V to 3.63 V 1.62 V to 3.63 V 1.62 V to 3.63 V 1.62 V to 3.63 V 1.62 V to 3.63 V
Operating Temperature -40 C to +125 C -40 C to +85 C -40 C to +85 C -40 C to +85 C -40 C to +125 C
Functional Safety (FuSa) Yes (SAM D21E variant) No (SAM D21E non-FuSa) No No No
USB FS Device Yes (integrated) Yes (integrated) Yes (integrated) Yes (integrated) Yes (integrated)
Approx. qty-1 Price (USD) $4.20 $3.50 $3.10 $2.80 $3.65

Key Differentiators

  • Full 256 KB Flash in 32-pin TQFP, with FuSa libraries (vs ATSAMD21E17A-AF (128 KB Flash))
  • Functional Safety (FuSa) variant for safety-class B appliances (vs ATSAMD21E17A-AF (non-FuSa SAM D21E))
  • 125C operating temperature, full industrial range (vs ATSAMD21E17A-AF (-40 to +85C commercial grade))

Design Notes

Estimated: at 48 MHz full CPU load and 3.3V supply, the ATSAMD21E18A-AFT consumes roughly 12 mA active, dropping to single-digit uA in Sleep with RTC running. Decouple VDDIO and VDDANA separately with a 100nF ceramic capacitor within 2 mm of each pin; the ADC's reference and conversions are referenced to VDDANA and are sensitive to digital supply noise. Place a ferrite bead or 10 ohm resistor between VDDIO and VDDANA to keep digital switching out of the analog rail.

SAM D21 multiplexes multiple peripherals onto the same GPIO; mis-assigning PA20/PA21 (USB D-/D+) away from the integrated USB controller disables USB without a hardware error. Always confirm the SERCOM, USB, and PTC pin maps in the latest version of the SAM D21E datasheet pinout tables and the errata document, which lists which peripheral assignments are restricted on each silicon revision.

Route the 32.768 kHz crystal traces short and symmetrical with a guard-ring GND stitch. Place the crystal within 5 mm of XIN32/XOUT32 and keep high-speed signals (USB, SPI clock) at least 3 mm away. For USB, route D+/D- as a 90 ohm differential pair with no stubs and add ESD protection diodes directly at the connector to pass IEC 61000-4-2.

Estimated: at full CPU load on the 32-pin TQFP, total package dissipation is below 100 mW and junction rise over ambient stays well under 10 C for standard 1 oz copper pours. The 125C junction rating is comfortable for sealed enclosures; however, if you use the TQFP version inside a closed metal box without airflow, validate with a thermocouple rather than relying on nominal thermal resistance alone.

Data verified on: 2026-09-21 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

Microchip Technology ATSAMD21E18A-AFT ATSAMD21E17A-AF ATSAMD21E16A-AF ATSAMD21E15A-AF ARM Cortex-M0+ SAM D21E family Functional Safety (FuSa) IEC 60730 Class B TQFP-32 QFN-32 RoHS Peripheral Touch Controller (PTC) USB 2.0 Full-Speed SERCOM 12-bit ADC home automation USB HID smart metering wearable fitness white goods
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