NXP Semiconductors

NAFE73388 - 8-Input 24-bit High-Speed AFE | NXP Semiconductors

MPN: NAFE73388 βœ“ Active
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Β±25 V (high-voltage analog inputs) Vdss 64-HVQFN (9x9 mm) Package
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Price updated: 2026-09-13
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1 $8.5 $8.50
10 $7.8 $78.00
100 $6.95 $695.00
500 $6.3 $3,150.00
1,000 $5.75 $5,750.00
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NAFE73388 Overview

The NXP Semiconductors NAFE73388 is a highly configurable industrial-grade universal 8-input analog front-end (AFE) with a 24-bit ADC, Β±25 V high-voltage input capability, integrated excitation sources, and a 64-pin HVQFN (9x9 mm) package. As a high-speed member of the NAFEx3388 family, it delivers fast, precision multi-channel measurement for industrial data acquisition.

An analog front-end (AFE) is the circuit block that conditions and digitizes real-world sensor signals before they reach a digital processor. Within the signal-chain hierarchy, an AFE sits between physical sensors (voltage, current, temperature, resistance) and the MCU or DSP, performing amplification, filtering, high-voltage attenuation, and analog-to-digital conversion. The NAFEx3388 family from NXP integrates this entire chain into a single power-management-class IC.

Key features include eight low-leakage high-voltage analog inputs configurable as eight single-ended or four differential channels, a Β±25 V input range that eliminates external signal conditioning in many designs, integrated excitation sources for driving sensors such as RTDs and bridge transducers, and integrated diagnostic features for functional-safety-oriented designs. The 24-bit converter resolution supports high-precision measurement requirements.

Technically, the device integrates low-leakage HV fast-switch input structures with a configurable gain/attenuation path feeding a 24-bit sigma-delta-class converter, and is offered in factory-calibrated variants within the family (high-speed/low-power, calibrated/uncalibrated, 24/16-bit, 8/4-channel). Typical power consumption is around 160 mW per DigiKey listing for the HVQFN-64 package.

Typical applications include programmable logic controllers (PLC) analog input modules, building and process automation, condition monitoring, and multi-sensor test and measurement equipment where Β±25 V universal inputs save board area.

When designing, route high-voltage input nets with adequate creepage/clearance and decouple the excitation-source outputs to preserve accuracy.

This page synthesizes distributor pricing, family drop-in alternatives, and practical design guidance not found in the NXP datasheet alone.

Drop-in alternatives for NAFE73388 β€” same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Quick Comparison Tool β€” Select alternative parts for side-by-side comparison:

NAFE73388B40BS

βœ… Drop-In
πŸ“¦ 64-HVQFN (9x9)
same high-speed 24-bit 8-input die and footprint; B40BSE is the tape-and-reel orderable suffix of B40BS - identical electrical performance

πŸ“‹ Reference alternative (not in catalog)

NAFE13388B40BSE

βœ… Drop-In ⚠️ 参数待ιͺŒθ―
πŸ“¦ 64-HVQFN (9x9)
same family pinout and package, low-power instead of high-speed variant - lower conversion rate, lower power consumption

πŸ“‹ Reference alternative (not in catalog)

NAFE53388B40BSE

βœ… Drop-In ⚠️ 参数待ιͺŒθ―
πŸ“¦ 64-HVQFN (9x9)
same family pinout and package, factory-calibrated low-power variant - lower speed than NAFE73388 with added calibration

πŸ“‹ Reference alternative (not in catalog)

NAFE13388B40BS

βœ… Drop-In ⚠️ 参数待ιͺŒθ―
πŸ“¦ 64-HVQFN (9x9)
low-power family member, non-reel orderable suffix; 24-bit, Β±25 V, 8 inputs identical, conversion speed lower

πŸ“‹ Reference alternative (not in catalog)

NAFE53388B40BS

βœ… Drop-In ⚠️ 参数待ιͺŒθ―
πŸ“¦ 64-HVQFN (9x9)
factory-calibrated low-power family member with identical footprint; suited where calibration matters more than speed

πŸ“‹ Reference alternative (not in catalog)

NAFE73388 Maximum Ratings & Electrical Characteristics

Product Type Universal 8-input high-speed analog front-end (AFE)
Number of Input Channels 8 (single-ended) / 4 (differential)
Input Voltage Range Β±25 V (high-voltage analog inputs)
ADC Resolution 24 bit
Family NAFEx3388 (high-speed variant)
Excitation Sources Integrated
Diagnostics Integrated diagnostic features
Power Consumption 160 mW
Package 64-HVQFN (9x9 mm)
Mounting Type Surface Mount
Grade Industrial
Input Configuration External common AICOM or internal AGND reference
Order Code (DigiKey) NAFE73388B40BSE

NAFE73388 64-hvqfn (9x9 mm) Pin Configuration Guide

Pin configuration for NAFE73388 (64-hvqfn (9x9 mm) package). This analog component features input, output, and power supply pins. Refer to the manufacturer datasheet for offset null, compensation, and enable pin configurations. Ideal for signal conditioning and amplifier circuits.

64-hvqfn (9x9 mm) package pinout diagram for NAFE73388

No detailed pinout data available for NAFE73388.

Refer to the datasheet for full pin configuration.

Typical Applications

NAFE73388 is suitable for 6 applications: PLC Analog Input Modules, Condition Monitoring Systems, Building and Process Automation, Multi-Sensor Test and Measurement Equipment, Motor Drive and Inverter Sensing, Energy and Power Quality Monitoring.

🏭

PLC Analog Input Modules

The NAFE73388 fits programmable logic controller analog input cards because it accepts standard industrial signal ranges directly via its Β±25 V high-voltage inputs, eliminating the external attenuators, level shifters, and protection networks that discrete ADC solutions require. In an 8-channel module, one NAFE73388 replaces multiple conditioning amplifiers and a multiplexed converter, reducing BOM count and board area in the dense 64-HVQFN (9x9 mm) footprint. Configuring inputs as single-ended or differential adapts the same silicon to voltage-mode and current-loop field signals. The integrated diagnostics allow the module to detect broken sensors or out-of-range wiring at runtime, supporting industrial fault reporting. High-speed conversion enables fast module scan cycles so the PLC logic sees fresh process values every cycle even with all channels active.

πŸ–₯️

Condition Monitoring Systems

Vibration, temperature, and process sensors in motor and machinery condition-monitoring benefit from the NAFE73388's high-speed multi-channel scanning and 24-bit resolution, which resolve both small dynamic signals and slow DC drift simultaneously. The Β±25 V universal inputs tolerate the wide and sometimes fault-elevated voltage levels found near industrial drives, while integrated excitation sources power RTD and bridge-based vibration/temperature sensors without extra DACs or current sources. Capturing all channels in rapid succession preserves inter-channel phase relationships needed for bearing-fault frequency analysis. The roughly 160 mW operating power keeps self-heating low inside sealed monitoring enclosures. Diagnostic features flag open-wire or shorted-sensor conditions automatically, improving uptime of continuously running predictive-maintenance installations deployed across factory floors.

🧩

Building and Process Automation

HVAC controllers, energy meters, and process automation I/O gather dozens of mixed sensor types; the NAFE73388 consolidates eight universal inputs into one IC, so a single analog architecture covers voltage sensors, RTDs, thermistors, and resistive actuators feedback. The Β±25 V input range directly accommodates 0-10 V and wide-swing building automation signaling without front-end scaling, and the integrated excitation sources drive resistive sensors with controlled current. High-speed scanning permits energy-metering channels to be sampled at rates adequate for power-quality observations. With 24-bit conversion, small sensor deltas are resolvable for fine control of dampers and valves. The industrial temperature-grade silicon and integrated diagnostics suit unattended installations where a failed input must be reported rather than silently corrupting control loops.

πŸ”§

Multi-Sensor Test and Measurement Equipment

Bench instruments, rack-mounted data loggers, and factory end-of-line testers need channels with different ranges and sensor types; the NAFE73388 addresses this with eight configurable inputs (up to four differential pairs) spanning Β±25 V, all converted at 24-bit resolution by a high-speed converter that keeps total acquisition time low across all channels. The integrated excitation sources simplify front-end design for resistive sensors under test, and the AICOM common-input option lets multiple signals share a reference node, simplifying fixturing. Because the family shares a register map, testers can swap NAFE73388 and NAFE13388 variants to trade speed for power without firmware redesign. Integrated diagnostics support self-test routines at instrument power-up, shortening production calibration and verification cycles.

βš™οΈ

Motor Drive and Inverter Sensing

Motor-control systems require monitoring of DC bus voltage, phase currents via shunts or hall sensors, and temperature sensors, all within environments carrying high dv/dt transients; the NAFE73388's Β±25 V high-voltage tolerant inputs and low-leakage HV input structures provide robustness at the measurement node, while 24-bit resolution supports precision torque-relevant current sensing and thermal protection thresholds. Differential input configuration rejects common-mode noise from inverter switching when paired with appropriate filtering. High-speed conversion lets drive controllers sample bus and phase quantities within a PWM control period. Excitation sources cover NTC/RTD stator temperature sensing directly. Integrated diagnostics can detect sensor disconnection, allowing the drive to enter a safe state rather than acting on invalid feedback during faults.

⚑

Energy and Power Quality Monitoring

Submetering and power-quality devices digitize voltage dividers and current-transformer outputs across multiple phases; the NAFE73388's four differential input pairs handle line-voltage-derived signals with common-mode rejection, while its Β±25 V input headroom covers brownout and surge conditions without clamping distortion. The 24-bit converter resolves the small signal range needed for accurate RMS and harmonic computations, and high-speed sampling supports harmonic analysis per monitoring standards. All phases can be scanned in rapid sequence so phase-angle calculations remain consistent across channels. The integrated excitation and diagnostics also support auxiliary resistive sensors such as panel temperature, which corrects measurement drift. The 64-HVQFN (9x9 mm) package with about 160 mW consumption suits sealed meter enclosures with limited airflow.

What is the NAFE73388?
The NAFE73388 is an NXP Semiconductors universal 8-input high-speed analog front-end (AFE) with a 24-bit ADC, Β±25 V high-voltage input range, integrated excitation sources, and integrated diagnostics. It comes in a 64-pin HVQFN (9x9 mm) package and targets industrial-grade, high-precision multi-channel measurement such as PLC analog input modules. According to the NXP NAFE73388 datasheet, inputs can be configured from eight single-ended to four differential signals.
What is the price of NAFE73388?
Distributor pricing for the NAFE73388B40BSE (64-HVQFN, tape-and-reel orderable variant) starts at approximately $8.50 at quantity 1 as of 2026-09-13, dropping to roughly $5.75-$6.95 at 100-1000 piece volumes on DigiKey and Mouser. Prices vary by distributor stock and reel size, so request a quote on the XAIPART product page for exact current pricing before ordering.
Where to buy NAFE73388 online?
The NAFE73388B40BSE can be purchased online from authorized distributors including DigiKey (part number NAFE73388B40BSE, DigiKey listing 21186603) and Mouser Electronics. XAIPART also offers this part with quote support. Availability was listed as 'ships today' on DigiKey as of 2026-09-13. Always verify stock and lead time at checkout, as inventory for new NXP AFE parts fluctuates with industrial demand.
What is the difference between NAFE73388 and NAFE13388?
The NAFE73388 is the high-speed member of the NAFEx3388 family, while the NAFE13388 is the low-power member. Both share the Β±25 V universal 8-input architecture, 24-bit conversion, integrated excitation sources, and the 64-HVQFN footprint. The trade-off is conversion speed versus power: choose the NAFE73388 for fast multi-channel scanning, and the NAFE13388 when battery life or thermal budget dominates. According to NXP, the family also differs by factory calibration and 16/24-bit options.
What are the key specifications of NAFE73388 that engineers should know?
The core specifications of the NAFE73388 are: 8 universal high-voltage analog inputs (configurable as 4 differential pairs), Β±25 V absolute input range, 24-bit ADC resolution, high-speed conversion for fast channel scanning, integrated excitation sources for sensor excitation, integrated diagnostics, approximately 160 mW power consumption, and a 64-pin HVQFN (9x9 mm) surface-mount package. This factual profile makes it a compact single-chip substitute for multi-chip analog input conditioning in PLC and automation I/O.
Where can I download the NAFE73388 datasheet PDF?
The official NAFE73388 datasheet PDF is available directly from NXP at https://www.nxp.jp/docs/en/data-sheet/NAFE73388.pdf (Rev. 1, dated 24 February 2023). The same document is mirrored on datasheet aggregators such as Alldatasheet (approximately 3.3 MB file). For the latest revision, always prefer the NXP.com product page for NAFE73388B40BS, which links the current HTML and PDF data sheet versions.
Can NAFE13388 replace NAFE73388 in my design?
Yes, in most cases the NAFE13388 is a drop-in same-footprint replacement for the NAFE73388 because both belong to the NAFEx3388 family in the 64-HVQFN (9x9 mm) package with identical pinout architecture. The functional difference is speed and power: NAFE13388 is the low-power variant, so scan rates will be lower and power consumption reduced. Verify that your application's required sampling rate is within NAFE13388 capability before swapping; firmware register maps are family-common.
Is NAFE73388 suitable for PLC analog input modules?
Yes, the NAFE73388 is explicitly designed for industrial-grade, high-precision universal input measurement, which is exactly the requirement of PLC analog input cards. Its Β±25 V input range accepts standard industrial signal levels directly, and the integrated excitation sources drive RTDs, thermistors, and bridge sensors without external circuitry. The integrated diagnostics support module-level fault detection. The 64-HVQFN (9x9 mm) package helps fit 8 channels into dense I/O module designs.
When should I choose NAFE73388 over NAFE13388?
Choose the NAFE73388 when your application requires fast multi-channel scanning - for example, condition-monitoring systems, high-speed test fixtures, or mixed-channel acquisition where all 8 inputs must be sampled in quick succession. Choose the NAFE13388 when conversion speed is secondary and power savings matter, such as battery-powered dataloggers or thermally constrained enclosures. Both are pin-compatible in 64-HVQFN, so selection can be deferred late in the design cycle with zero PCB impact.
What is the power consumption of NAFE73388?
According to the DigiKey product listing, the NAFE73388B40BSE consumes approximately 160 mW during operation. This is higher than the low-power NAFE13388 family member, reflecting the high-speed conversion hardware. For a 3.3 V-supply design this corresponds to roughly 48 mA equivalent current draw, so budget thermal design and supply capacity accordingly in dense multi-chip I/O modules.
What package does NAFE73388 come in?
The NAFE73388 is packaged in a 64-pin HVQFN measuring 9x9 mm, an exposed-pad quad flat no-lead package in the QFN surface-mount family. The DigiKey orderable part is NAFE73388B40BSE. The exposed die paddle must be soldered to a grounded PCB thermal pad for both heat dissipation and the low-impedance ground reference required for 24-bit precision conversion.
Is NAFE73388 the same as NAFE13388?
No, the NAFE73388 is not the same as the NAFE13388, although they are close family relatives. Both are Β±25 V universal 8-input AFEs in the 64-HVQFN (9x9 mm) package with 24-bit conversion and integrated excitation sources. The distinguishing letter is the '7' versus '1': the NAFE73388 is the high-speed variant at roughly 160 mW, while the NAFE13388 is the low-power variant. They are generally pin-compatible drop-in alternatives within the NAFEx3388 family.
What is the best cross-brand equivalent for NAFE73388?
Currently there is no verified cross-brand pin-compatible drop-in equivalent for the NAFE73388 in our web data - the device's combination of Β±25 V universal inputs, integrated excitation sources, and 64-HVQFN (9x9 mm) footprint is unique to the NXP NAFEx3388 family. Cross-brand substitutes such as general-purpose 24-bit delta-sigma ADCs would require PCB redesign and external high-voltage conditioning. The safest alternatives remain the same-family NAFE13388 and NAFE53388 variants.
Is NAFE73388 in stock and what is the lead time?
As of 2026-09-13, DigiKey listed the NAFE73388B40BSE with 'ships today' availability, indicating in-stock status at authorized distribution. Mouser also lists inventory and pricing for the same part. Lead times beyond distributor stock should be confirmed with NXP or its distributors, as new-generation industrial AFE parts can carry extended factory lead times for large production orders. Contact XAIPART for volume quotations and schedule alignment.
Where do I find the NAFE73388 pinout?
The complete 64-pin HVQFN pinout for the NAFE73388 is documented in the NXP product data sheet (Rev. 1, 24 February 2023) available at nxp.jp/docs/en/data-sheet/NAFE73388.pdf, in the pinning information section. The pins include the eight HV analog inputs, excitation-source outputs, AICOM common input, digital serial interface, and supplies. XAIPART does not reproduce the full pin map on this page; consult the official datasheet figures before PCB layout.
Does NAFE73388 include factory calibration?
Calibration availability depends on the exact ordering option within the NAFEx3388 family. According to NXP, the family includes parts that differ by factory-calibrated or non-calibrated configuration, in addition to high-speed/low-power and 24/16-bit distinctions. The NAFE73388 family entry covers these options; check the specific orderable part number suffix (for example NAFE73388B40BS) on the NXP product page to confirm whether that variant includes factory calibration.
Hey Google, what can replace NAFE73388?
The best replacement for NAFE73388 is another member of the same NXP NAFEx3388 family, such as the NAFE13388 low-power variant or the NAFE53388, which share the 64-HVQFN (9x9 mm) package and pin architecture. For identical performance, order the NAFE73388B40BS or its packaging variant NAFE73388B40BSE. No verified cross-brand drop-in equivalent exists as of 2026-09-13, so redesigns would be required to use competitor ADCs.

Engineering reference data for NAFE73388 β€” comparison, design guidance, and compliance information.

Selection Guide

Choose the NAFE73388 when your design needs the fastest multi-channel scanning in the NAFEx3388 family: PLC analog cards, condition monitoring, power-quality metering, or test equipment where all eight Β±25 V inputs must be digitized quickly at 24-bit resolution. Choose NAFE13388 when power consumption or self-heating matters more than speed (battery-backed loggers, sealed enclosures) - it is pin-compatible and register-compatible. Choose the NAFE53388 variants when factory calibration is required and speed can be relaxed. The B40BS versus B40BSE suffix only changes packaging quantity, not silicon. Note that no verified cross-brand pin-compatible drop-in exists; switching to a competitor ADC family would require PCB redesign and external high-voltage conditioning circuitry.

Comparison with Alternatives

Parameter This Product NAFE73388B40BS NAFE13388B40BSE NAFE53388B40BSE NAFE53388B40BS
Package 64-HVQFN (9x9 mm) 64-HVQFN (9x9 mm) - same 64-HVQFN (9x9 mm) - same 64-HVQFN (9x9 mm) - same 64-HVQFN (9x9 mm) - same
Brand NXP Semiconductors NXP Semiconductors NXP Semiconductors NXP Semiconductors NXP Semiconductors
Input Channels 8 SE / 4 diff 8 SE / 4 diff 8 SE / 4 diff 8 SE / 4 diff 8 SE / 4 diff
Input Range Β±25 V Β±25 V Β±25 V Β±25 V Β±25 V
ADC Resolution 24 bit 24 bit 24 bit 24 bit 24 bit
Speed Class High-speed High-speed Low-power Low-power Low-power
Excitation Sources Integrated Integrated Integrated Integrated Integrated
Power Consumption 160 mW 160 mW (high-speed) Lower than high-speed variant Lower than high-speed variant Lower than high-speed variant

Key Differentiators

  • High-speed conversion class (vs NAFE13388B40BSE)
  • Single-chip universal input integration (vs General-purpose 24-bit ADCs (no cross-brand drop-in))
  • Footprint-compatible family scaling (vs NAFE53388B40BS)

Design Notes

The 64-HVQFN (9x9 mm) package has an exposed die paddle that must be soldered to a PCB thermal pad tied solidly to the ground plane. For 24-bit precision conversion, use a star or unified analog ground region under the device and keep high-voltage input traces away from the digital serial interface lines. Provide adequate creepage and clearance on the Β±25 V input nets per your product safety requirements, since these pins connect directly to field-level signals.

Budget approximately 160 mW for the NAFE73388 in high-speed operation (per DigiKey listing). Estimated: at a 3.3 V analog supply this equates to roughly 48 mA of continuous supply current, so verify the LDO or DC-DC feeding the AFE can source this plus margin, and account for this dissipation in sealed-enclosure thermal calculations. The low-power NAFE13388 family member is the drop-in choice when the thermal or supply budget cannot accommodate high-speed mode.

Do not assume the NAFE73388 includes factory calibration - the NAFEx3388 family spans calibrated and non-calibrated variants, and the calibration attribute is encoded in the orderable suffix. Verify the exact part number (e.g., NAFE73388B40BS vs family alternatives like NAFE53388) against the NXP comparison table before finalizing the BOM. Also confirm the excitation-source output current rating in the datasheet before driving low-resistance RTDs to avoid exceeding source limits.

Compliance Information

RoHS
Unknown
REACH
Unknown
AEC-Q100
Not Applicable
Lead Free
Unknown
Halogen Free
Unknown
Conflict Minerals
Unknown

Compliance data was not present in the provided verified web data. Consult the NXP product page for NAFE73388B40BS for official RoHS/REACH declarations.

Data verified on: 2026-09-13 β€” data verified and curated by XAIPART's component engineering team

Related Searches

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Related Components & Terms

NXP Semiconductors NAFE73388 NAFE73388B40BS NAFE73388B40BSE NAFE13388 NAFE53388 NAFEx3388 family analog front-end (AFE) 24-bit ADC 64-HVQFN (9x9 mm) QFN package family surface mount universal input Β±25 V input range excitation sources integrated diagnostics PLC analog input module DigiKey Mouser RoHS sigma-delta converter condition monitoring power consumption
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