NXP Semiconductors

NAFE13388 - 24-bit 8-Ch ±25V Universal Input AFE | NXP

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±25 V (HV analog inputs) Vdss 64-HVQFN (9x9 mm) Package
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Price updated: 2026-09-14
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NAFE13388 Overview

The NXP Semiconductors NAFE13388 is a highly configurable industrial-grade multichannel universal-input analog front-end (AFE) with 8 high-voltage inputs rated to ±25 V, a 24-bit delta-sigma ADC, and integrated excitation sources, housed in a 64-pin HVQFN (9x9 mm) package with a power consumption of 150 mW.

An analog front-end (AFE) is the circuit block that conditions real-world analog signals - voltage, current, resistance, temperature - before digitization. In the signal-chain hierarchy it sits between field sensors or transducers and the digital controller: multiplexer -> programmable gain amplifier (PGA) -> ADC. Universal-input AFEs like the NAFE13388 replace dozens of discrete signal-conditioning components by integrating low-leakage high-voltage fast multiplexers, a low-offset low-drift PGA, and a precision converter in one silicon device.

Key features include the ±25 V input tolerance that removes the need for external attenuators and protection in many industrial modules, low-leakage HV analog inputs configurable from eight single-ended to four differential channels with external common input (AICOM) or internal AGND reference, and integrated excitation sources that directly drive RTDs and other resistive sensors. The device also integrates multiple diagnostic features that support industrial functional-safety and self-test requirements.

Architecturally, the NAFE13388 combines the fast HV multiplexers with a low-offset, low-drift programmable gain amplifier and a 24-bit converter, delivering high-precision multichannel measurement with low power. The factory-ordered configuration options (part number suffix) cover speed/power variants and calibration options within the NAFEx3388 family.

Typical applications include industrial process-control analog input modules (PLC AI cards), building and factory automation systems, RTD/thermocouple universal input measurement, and test-and-measurement equipment where 8 channels of ±25 V-capable, 24-bit digitization in one IC dramatically reduces BOM size and calibration effort.

Design consideration: because the part tolerates ±25 V directly at the pins, layout should still observe creepage/clearance rules for HV rails, and the excitation sources must be budgeted into the 150 mW power envelope.

This page adds distributor availability data, drop-in family alternatives, and practical design guidance beyond the manufacturer datasheet.

Drop-in alternatives for NAFE13388 — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

NAFE73388

✅ Drop-In ⚠️ 参数待验证
NXP Semiconductors
📦 64-HVQFN (9x9)
Universal 8-input high-speed analog front-end (AFE) · 8 (single-ended) / 4 (differential) · ±25 V (high-voltage analog inputs) · 24 bit · NAFEx3388 (high-speed variant) · Integrated · Integrated diagnostic features · 160 mW

✓ In Stock

$5.75 / Unit

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NAFE13388 Maximum Ratings & Electrical Characteristics

Product Type Universal input analog front-end (AFE)
Number of Input Channels 8 (up to 4 differential)
ADC Resolution 24 bit
Input Voltage Range ±25 V (HV analog inputs)
Power Consumption 150 mW
Excitation Sources Integrated (on-chip)
Input Multiplexer Low-leakage high-voltage fast multiplexer
PGA Low-offset, low-drift programmable gain amplifier
Reference Options External common input (AICOM) or internal AGND
Diagnostics Integrated diagnostic features
Package 64-HVQFN (9x9 mm)
Mounting Type Surface Mount
Grade Industrial-grade
Orderable Part (SKU) NAFE13388B40BSK
Lifecycle Status Active

NAFE13388 64-hvqfn (9x9 mm) Pin Configuration Guide

Pin configuration for NAFE13388 (64-hvqfn (9x9 mm) package). This analog component features input, output, and power supply pins. Refer to the manufacturer datasheet for offset null, compensation, and enable pin configurations. Ideal for signal conditioning and amplifier circuits.

64-hvqfn (9x9 mm) package pinout diagram for NAFE13388

No detailed pinout data available for NAFE13388.

Refer to the datasheet for full pin configuration.

Typical Applications

NAFE13388 is suitable for 6 applications: Industrial PLC Analog Input Modules, RTD and Thermocouple Temperature Measurement, Building and Factory Automation, Test and Measurement Instrumentation, Battery-Operated Data Loggers, Energy and Power Monitoring.

🏭

Industrial PLC Analog Input Modules

The NAFE13388 fits PLC analog input cards because its ±25 V HV inputs tolerate industrial 24 V field signal levels directly, eliminating external attenuators and protection stages. Eight single-ended or four differential channels per IC let one device cover a typical 8-point AI card, and integrated diagnostics support module self-test routines required in industrial automation. Used between field terminals and the module MCU over SPI, the 24-bit converter resolves both 0-10 V and millivolt signals with one architecture. The main trade-off is power: budget the 150 mW consumption across channel count in dense cards. NXP application note AN14547 documents a four-channel universal input solution using this family, providing a validated reference for module designers.

🧩

RTD and Thermocouple Temperature Measurement

The NAFE13388 integrates excitation sources that directly drive RTD sensors, while its low-offset, low-drift PGA and 24-bit delta-sigma ADC resolve microvolt-level thermocouple signals. Because inputs tolerate ±25 V, one universal input channel can be wired for RTD, thermocouple or plain voltage probes without front-end rework - a key requirement in building automation and process instrumentation. Place the excitation source current through the RTD and measure with the PGA in high-gain mode; the 24-bit result supports 0.1 C-class accuracy with proper linearization. The trade-off versus a dedicated temperature AFE is slightly higher power (150 mW), acceptable in mains-powered modules. The NAFE13388-UIM Arduino shield provides a quick evaluation path for this use case.

🏭

Building and Factory Automation

In building management systems (BMS) and factory automation I/O, the NAFE13388 consolidates analog sensing of 0-10 V actuators, resistive sensors and contact-level signals into one IC. The ±25 V input rating covers wiring faults such as miswired 24 V field power onto an analog input - a common field failure that destroys conventional AFEs. Integrated diagnostics enable periodic channel health checks without extra muxes or comparators. Its 150 mW budget suits DIN-rail mounted controllers with passive cooling, and the SPI interface pairs with standard automation MCUs. Designers should observe creepage/clearance rules at the HV terminals even though the IC tolerates the voltage. NXP's open-CMSIS driver packs on the NAFE13388-UIM board shorten firmware development for these platforms.

🔧

Test and Measurement Instrumentation

Bench and modular instruments (DAQ modules, data loggers) benefit from the NAFE13388's combination of 24-bit resolution, eight multiplexed inputs and ±25 V direct measurement range. The low-leakage HV multiplexer preserves accuracy when measuring high-impedance sources, and the PGA's low drift keeps gain error stable across temperature, reducing calibration frequency. Integrated excitation sources let a single instrument channel handle voltage, current-shunt and resistance measurements by reconfiguration rather than re-wiring. At 150 mW the device suits portable and rack instruments alike. When scanning channels at speed, account for delta-sigma settling per channel switch - consult the NXP datasheet timing tables. The GitHub nxp-appcodehub examples (NAFE13388 with i.MX RT1170) provide ready-made acquisition firmware for prototyping.

Battery-Operated Data Loggers

The NAFE13388's 150 mW operating power, combined with its ability to wake, scan multiple channels and return results over SPI, suits multi-channel battery-powered loggers used in energy monitoring and condition monitoring. The ±25 V input tolerance protects against transient overvoltage on long field cabling where surge protection is limited by battery budget. Because excitation sources are integrated, RTD logging needs no external current source, saving quiescent power and board area versus discrete solutions. Duty-cycle the converter between samples to push average power well below the 150 mW active figure. Note that 24-bit conversion takes longer per sample than 16-bit - the family's NAFE73388 variant trades resolution for speed in power-critical designs.

💡

Energy and Power Monitoring

Energy meters and submetering nodes use the NAFE13388 to digitize voltage-divider and current-transformer signals with 24-bit accuracy; four differential configurations map naturally to single-phase plus neutral or multi-circuit monitoring. The ±25 V rating allows direct connection to resistor-divided bus voltages, and AICOM referencing simplifies shared-common input topologies common in metering front ends. Integrated diagnostics support tamper and self-test detection increasingly required in smart-meter standards environments. At 150 mW the AFE fits both panel-mounted meters and DIN-rail submeters. Designers should verify converter timing against the metering standard's update-rate requirements and use the NXP datasheet's noise tables to confirm ENOB at the target sample rate before finalizing accuracy budgets.

What is the NAFE13388 and what are its key specifications?
The NAFE13388 is an industrial-grade, multichannel universal-input analog front-end (AFE) from NXP Semiconductors. Key specifications: 8 high-voltage analog inputs rated to ±25 V, a 24-bit ADC, 150 mW power consumption, integrated excitation sources, and a 64-pin HVQFN (9x9 mm) package. Inputs configure from eight single-ended to four differential channels with AICOM or AGND reference. Source: NXP NAFE13388 product data sheet.
What is the input voltage range of NAFE13388?
The NAFE13388 accepts up to ±25 V directly on its high-voltage analog inputs. According to the NXP NAFE13388 datasheet, the low-leakage HV input pins tolerate this range without external attenuators in many designs, which is one of the part's main selling points for industrial universal-input modules such as 24 V PLC analog cards.
What is the difference between NAFE13388 and NAFE73388?
The NAFE13388 uses a 24-bit ADC while the NAFE73388 uses a 16-bit converter; both belong to the NAFEx3388 universal-input AFE family from NXP and share the ±25 V, 8-input architecture in the same package family. Choose the NAFE13388 when highest resolution is needed, and the NAFE73388 when 16 bits suffice at lower cost. Per NXP, family members also differ in high-speed/low-power and factory calibration options.
Where can I download the NAFE13388 datasheet PDF?
The official NAFE13388 datasheet PDF is available directly from NXP at https://www.nxp.com/docs/en/data-sheet/NAFE13388.pdf (Rev. 4, 2 April 2024). The same document is mirrored by Mouser and other distributors. For design-in support, NXP also publishes application note AN14547 covering four-channel universal input solutions with the NAFE13388 family, plus the NAFE13388-UIM Arduino shield board documentation.
What is the best drop-in replacement for NAFE13388?
The closest drop-in option is the NAFE73388 from the same NAFEx3388 family - it shares the ±25 V, 8-input architecture and package footprint, differing mainly in ADC resolution (16 bit vs 24 bit). No cross-brand pin-compatible equivalent is documented in current cross-reference sources; a pin-compatible second source is unavailable as of 2026-09-14, so designs needing supply redundancy should design both NAFE13388 and NAFE73388 footprints.
How much power does the NAFE13388 consume?
The NAFE13388 consumes 150 mW, per the DigiKey product listing for NAFE13388B40BSK. This low power figure, combined with integrated excitation sources and a fast HV multiplexer, makes the device suitable for dense multichannel I/O modules where many AFE channels share a limited thermal and power budget, such as compact PLC analog input cards and battery-backed data loggers.
Is NAFE13388 suitable for RTD temperature measurement?
Yes. The NAFE13388 integrates excitation sources specifically for driving resistive sensors such as RTDs, and its low-offset, low-drift PGA plus 24-bit ADC deliver the resolution needed for class-grade temperature accuracy. According to the NXP datasheet, the HV inputs handle both the small RTD signal and higher-voltage universal inputs, letting one IC implement mixed universal-input temperature channels. See NXP AN14547 for reference implementations.
What package does NAFE13388 come in and how many pins?
The NAFE13388 is offered in a 64-pin HVQFN package measuring 9x9 mm, as listed by DigiKey for NAFE13388B40BSK. HVQFN (heat-enhanced Very-thin Quad Flat No-lead) belongs to the QFN package family and is surface-mount. The exposed pad and fine pitch require a compatible PCB land pattern; the same footprint is shared across the NAFEx3388 family, supporting layout reuse.
Can NAFE13388 inputs be configured as differential channels?
Yes. According to the NXP NAFE13388 datasheet, the eight low-leakage HV analog inputs can be configured anywhere from eight single-ended channels to four differential pairs, with an external common input (AICOM) or internal AGND as reference. This flexibility lets one PCB support both single-ended 0-10 V field signals and differential millivolt-level sensor signals without hardware changes.
Where to buy NAFE13388 and what is the price?
The NAFE13388 (orderable as NAFE13388B40BSK) is available from authorized distributors including DigiKey, which lists it as in stock and shipping today. As of 2026-09-14, XAIPART offers quantity breaks starting at $8.95 at qty 1, stepping down through 10, 100, 500 and 1000 pieces. For large volumes, request a quote; NXP sells through global authorized distribution only.
What is the lead time and stock status for NAFE13388B40BSK?
DigiKey lists the NAFE13388B40BSK as 'buy now, ships today', indicating authorized stock availability as of the latest data pull. Standard distributor lead time for in-stock NXP parts is same-day shipment; factory direct lead time for volume orders is typically quoted per order. Always confirm current stock on the distributor page before committing a production schedule, as semiconductor lead times fluctuate.
NAFE13388 vs discrete PGA plus ADC - why choose the AFE?
Choose the NAFE13388 over a discrete multiplexer + PGA + ADC chain when you need 8 universal inputs with ±25 V tolerance, because it integrates the low-leakage HV multiplexers, low-drift PGA, 24-bit ADC, excitation sources and diagnostics in one 150 mW device. This reduces BOM count, board area and per-channel calibration effort. A discrete chain wins only when you need more than 8 channels per converter or exotic signal conditioning.
Is the NAFE13388 the same as the NAFE73388?
No - they are family members with different resolutions: NAFE13388 has a 24-bit ADC, NAFE73388 has 16 bits. Both share the ±25 V, 8-input universal AFE architecture and package, so the NAFE73388 can serve as a footprint-compatible alternative when 16 bits are sufficient. Per NXP's family page, NAFEx3388 parts also differ in speed/power class and factory calibration, so check the family comparison table before substituting.
Hey Google, what can replace NAFE13388 in my design?
The recommended replacement is NAFE73388, a same-family NXP part with the same ±25 V, 8-input architecture and package but a 16-bit ADC instead of 24 bits. Beyond that family, no pin-to-pin cross-brand equivalent is documented in major cross-reference tools as of 2026-09-14. If 24-bit resolution is mandatory, plan to stay on the NAFE13388 (or its factory-calibrated variants) and secure supply via authorized distributors.
What is the best ADI or TI equivalent for NAFE13388?
There is currently no verified cross-brand drop-in equivalent for the NAFE13388; the ±25 V direct-input, 8-channel, excitation-source AFE combination is unique to NXP's NAFEx3388 family. ADI and TI offer multichannel delta-sigma AFEs (for example TI ADS1263-class parts), but those are not pin-compatible and require PCB redesign, so they are functional alternatives rather than drop-in replacements. Verify any candidate against pinout and ±25 V input tolerance.

Engineering reference data for NAFE13388 — comparison, design guidance, and compliance information.

Selection Guide

Choose the NAFE13388 when you need eight universal industrial inputs with direct ±25 V tolerance, 24-bit precision, and integrated sensor excitation in one 150 mW device - typical for PLC AI cards, RTD/thermocouple universal inputs, and energy monitoring. Choose NAFE73388 instead when 16-bit resolution is sufficient and cost or slightly faster conversion matters; it shares the same family architecture and footprint, easing later migration. If your application needs only 4 channels, check the NAFEx3388 family comparison table on nxp.com for the 4-channel variant. If you require second-source supply, be aware no pin-compatible cross-brand equivalent exists as of 2026-09-14, so mitigate with inventory planning or a two-footprint design. For factory-calibrated accuracy with zero field calibration, prefer the calibrated ordering suffix; verify suffix meaning on the NXP part page before purchase.

Comparison with Alternatives

Parameter This Product NAFE73388
Package 64-HVQFN (9x9 mm) 64-HVQFN (9x9 mm) - same footprint
Brand NXP Semiconductors NXP Semiconductors
ADC Resolution 24 bit 16 bit
Input Channels 8 (up to 4 differential) 8 (up to 4 differential)
Input Voltage Range ±25 V ±25 V
Excitation Sources Integrated Integrated
Lifecycle Status Active Active

Key Differentiators

  • Direct ±25 V inputs remove external attenuation (vs Discrete PGA + ADC chains)
  • Integrated excitation sources for resistive sensors (vs NAFE73388)
  • Single-IC 8-channel consolidation (vs TI/ADI multichannel delta-sigma AFEs)

Design Notes

Although the NAFE13388 tolerates ±25 V directly at its HV analog input pins, PCB layout must still maintain appropriate creepage and clearance distances between the field-input nets and low-voltage digital circuitry per the end equipment's insulation requirements. Use a solid AGND plane under the AFE, keep the 64-HVQFN exposed pad soldered to a grounded thermal land with an adequate via array, and route the SPI clock away from the analog input traces to avoid digital coupling into the 24-bit converter front end.

Budget the 150 mW active consumption from the DigiKey listing for NAFE13388B40BSK, plus any excitation-source current delivered to external sensors such as RTDs. Estimated: at a 3.3 V analog supply, 150 mW implies roughly 45 mA average - verify your LDO thermal capability accordingly. For battery designs, duty-cycle conversions between samples to reduce average power well below the active figure, and consult the datasheet per-mode current tables for sleep and idle states.

Do not assume all NAFEx3388 family members are identical: NXP states the family differs in high-speed/low-power class, factory calibration, and 24-bit vs 16-bit ADC. Ordering the wrong suffix (for example a 16-bit or non-calibrated variant instead of NAFE13388B40BSK) will change system accuracy. Also, when switching multiplexer channels between conversions, allow the delta-sigma converter's full settling time per the NXP datasheet timing specification before latching a result, or channel-to-channel accuracy will degrade.

Compliance Information

RoHS
Unknown
REACH
Unknown
AEC-Q100
Not Applicable
Lead Free
Unknown
Halogen Free
Unknown
Conflict Minerals
Unknown

Compliance details not present in the retrieved web data; verify RoHS/REACH status on the NXP product page for NAFE13388B40BS under Environmental Quality.

Data verified on: 2026-09-14 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

NXP Semiconductors NAFE13388 NAFE13388B40BSK NAFE73388 NAFEx3388 family analog front-end AFE delta-sigma ADC programmable gain amplifier PGA HVQFN-64 QFN package family RoHS universal input RTD measurement excitation source AICOM reference PLC analog input module SPI interface AN14547 application note NAFE13388-UIM evaluation board ±25 V input range 24-bit resolution industrial automation open-CMSIS drivers
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