Microchip Technology

PIC32MX450F256H-V/MR - 80MHz 32-bit MCU 256KB Flash | Microchip

MPN: PIC32MX450F256H-V/MR ✓ Active
In Stock Ships in 1-3 business days
2.3V to 3.6V Vdss 64-QFN (9x9 mm) Package 80 MHz Speed 256 KB (256K x 8) Memory
From $4.15 USD / Unit
MOQ: 1 |
Price updated: 2026-10-02
Volume Pricing
Qty Unit Price Extended
1 $6.95 $6.95
10 $6.21 $62.10
100 $5.42 $542.00
500 $4.78 $2,390.00
1,000 $4.15 $4,150.00
ℹ️ All prices are in USD

PIC32MX450F256H-V/MR Overview

The Microchip PIC32MX450F256H-V/MR is a 32-bit MIPS M4K microcontroller running at 80 MHz, integrating 256 KB of Flash and 64 KB of SRAM in a 64-pin QFN (9x9 mm) package. It belongs to the PIC32MX3/4 family, which combines 32-bit performance, generous on-chip memory, and a rich peripheral set targeting cost-sensitive embedded designs.

What is a PIC32MX microcontroller? A PIC32MX is a 32-bit flash microcontroller from Microchip built on the MIPS32 M4K core architecture. Within the broader taxonomy, the PIC32MX sits as a mid-range 32-bit MCU -> 32-bit microcontroller -> embedded processor -> semiconductor. It typically offers higher performance and larger memory than 8/16-bit PIC MCUs while maintaining the MPLAB X toolchain and Harmony framework compatibility that simplify firmware migration.

Key differentiating features include two SPI/I2S interfaces for audio codec connectivity, an 8-bit Parallel Master Port (PMP) for graphics or external memory expansion, and a 10-bit 1 Msps ADC for high-speed analog sampling. USB 2.0 full-speed (device/host/OTG) is integrated along with two I2C, two UART, and a 16-bit timer/capture/PWM block, enabling the device to act as a single-chip HMI or audio processing controller.

The architecture pairs the M4K core with a multi-vector interrupt controller, a 5-stage pipeline, and a hardware multiply/divide unit, delivering 1.56 DMIPS/MHz. The wide 80 MHz operating point gives up to ~125 DMIPS, sufficient for graphical user interfaces, USB stacks, and modest DSP workloads without resorting to external coprocessors.

Typical applications include USB audio interfaces, HMI panels with TFT displays, industrial sensor hubs with USB diagnostics, point-of-sale terminals, and low-cost data loggers. The "-V" suffix denotes the -40C to +105C extended industrial temperature range, and the /MR suffix indicates the 64-pin QFN package on tape-and-reel.

When designing with this part, reserve the I2S and PMP pins early in pin planning - they share alternate-function mappings that can complicate later PCB revisions. Use MPLAB X IDE with the Harmony framework to accelerate peripheral configuration.

This page synthesizes distributor pricing, drop-in alternatives within the PIC32MX family, and practical design notes not found in the manufacturer datasheet alone.

Drop-in alternatives for PIC32MX450F256H-V/MR — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with PIC32MX450F256H-V/MR (same form factor and footprint) — differing in Package, ADC, Timers, Operating Temperature, Core Architecture.

Microchip Technology
Package: 64-pin QFN (MR), 9x9 mm with exposed pad
ADC: 10-bit, up to 16 channels, 1 Msps
Timers: 5 x 16-bit, plus RTCC
Microchip Technology
Package: 64-pin QFN (9x9 mm), MR suffix
ADC: 10-bit, 16 channels, 1 Msps
Timers: 5 x 16-bit
Microchip Technology
Package: 64-QFN (9x9 mm) with exposed pad
ADC: 10-bit, 1 Msps, up to 28 channels
Microchip Technology
Package: 64-QFN (9x9 mm) with exposed pad
ADC: 10-bit, 1 Msps, up to 28 channels
Timers: 5 x 16-bit
Microchip Technology
Package: 64-QFN (MR) 9x9 mm with exposed pad
ADC: 10-bit 1 Msps, up to 28 input channels
Timers: 5x 16-bit, plus 16-bit timer/counter module
Microchip Technology
Package: 64-VFQFN (9x9 mm) with exposed pad
ADC: 10-bit ADC
Timers: 5 x 16-bit Timer/Counter
Microchip Technology
Package: 64-pin VQFN (MR) 9x9 mm with EP
ADC: 10-bit, 16 channels, 1 Msps
Timers: 5 x 16-bit
Microchip Technology
ADC: 10-bit, 16 channels, 1 Msps
Timers: 4x 16-bit, 5x 16-bit Compare/PWM

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

PIC32MX450F256HT-V/MR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9 mm)
MIPS32 M4K · 32-bit · 80 MHz · 150 DMIPS (estimated from PIC32MX3/4 family) · 256 KB (256K x 8) · 64 KB · 2.3 V to 3.6 V · 64-QFN (MR) 9x9 mm with exposed pad

✓ In Stock

$3.05 / Unit

View Datasheet →

PIC32MX450F256H-120/MR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9 mm)
MIPS32 M4K (PIC32MX) · 120 MHz · 150 DMIPS · 256 KB (256K x 8) · 64 KB · 2.3 V to 3.6 V · 49 · 6

✓ In Stock

$4.55 / Unit

View Datasheet →

PIC32MX450F256H-50I/MR

✅ Drop-In
📦 64-QFN (9x9 mm)
Same 64-QFN /MR die and memory, but downgraded to 50 MHz speed grade (-37.5%); pin-to-pin compatible

📋 Reference alternative (not in catalog)

PIC32MX440F256H-80I/MR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9 mm)
MIPS32 M4K (Harvard, 5-stage pipeline) · 80 MHz (105 DMIPS) · MIPS32 with MIPS16e compression · 256 KB · 32 KB · USB 2.0 OTG with integrated PHY and dedicated DMA · 2.3 V to 3.6 V · 53

✓ In Stock

$5.35 / Unit

View Datasheet →

PIC32MX450F256HT-I/MR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9 mm)
MIPS32 M4K · 32-Bit Single-Core · 80 MHz · 256 KB (256K x 8) · 64 KB · 49 · 2.3 V to 3.6 V · 10-bit, 1 Msps, up to 28 channels

✓ In Stock

$4.2 / Unit

View Datasheet →

PIC32MX450F256HT-120/MR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9 mm)
MIPS32 M4K · 32-Bit · 120 MHz · 150 DMIPS · 256 KB (256K x 8) Flash · 64 KB · 49 · 2.3 V to 3.6 V

✓ In Stock

$3.27 / Unit

View Datasheet →

PIC32MX450F256H-V/MR Maximum Ratings & Electrical Characteristics

Core Architecture MIPS32 M4K
Core Count Single-core
Data Bus Width 32-bit
Maximum Clock Frequency 80 MHz
Program Memory (Flash) 256 KB (256K x 8)
SRAM 64 KB
Package 64-QFN (9x9 mm)
Pin Count 64
Mounting Type Surface Mount
Operating Temperature -40C to +105C (industrial "-V" grade)
Supply Voltage 2.3V to 3.6V
ADC 10-bit, 1 Msps, 28 channels
USB USB 2.0 Full-Speed Device/Host/OTG
SPI/I2S Interfaces 2
I2C Interfaces 2
UART Interfaces 2
Parallel Master Port (PMP) 8-bit
Timers 16-bit, 5 channels
Comparators 2 analog
RoHS Status Compliant
Lead-Free Yes
MSL Level 3

PIC32MX450F256H-V/MR Pin Configuration

QFN-64 (8x8mm, EP) Package Pinout Diagram QFN-64 8x8mm, P0.5mm, EP 5.1x5.1mm, JEDEC MO-220. Pin 1 by dot. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 QFN-64 (8x8mm, EP)
Pin 1 RPB0 — Remappable peripheral B0 / INT0
Pin 2 RPB1 — Remappable peripheral B1
Pin 3 RPB2 — Remappable peripheral B2 / SDA2
Pin 4 RPB3 — Remappable peripheral B3 / SCL2
Pin 5 VSS — Ground
Pin 6 VDD — Positive supply (2.3V-3.6V)
Pin 7 RPB4 — Remappable peripheral B4
Pin 8 RPB5 — Remappable peripheral B5
Pin 9 RPB6 — Remappable peripheral B6
Pin 10 RPB7 — Remappable peripheral B7
Pin 11 RPC0 — Remappable peripheral C0
Pin 12 RPC1 — Remappable peripheral C1
Pin 13 RPC2 — Remappable peripheral C2
Pin 14 RPC3 — Remappable peripheral C3
Pin 15 VSS — Ground
Pin 16 VDD — Positive supply
Pin 17 RPC4 — Remappable peripheral C4
Pin 18 RPC5 — Remappable peripheral C5
Pin 19 RPC6 — Remappable peripheral C6
Pin 20 RPC7 — Remappable peripheral C7
Pin 21 RPC8 — Remappable peripheral C8
Pin 22 RPC9 — Remappable peripheral C9
Pin 23 VDD — Positive supply
Pin 24 VSS — Ground
Pin 25 RPD0 — Remappable peripheral D0 / INT1
Pin 26 RPD1 — Remappable peripheral D1
Pin 27 RPD2 — Remappable peripheral D2
Pin 28 RPD3 — Remappable peripheral D3
Pin 29 RPD4 — Remappable peripheral D4
Pin 30 RPD5 — Remappable peripheral D5
Pin 31 VSS — Ground
Pin 32 VDD — Positive supply
Pin 33 RPD6 — Remappable peripheral D6
Pin 34 RPD7 — Remappable peripheral D7
Pin 35 RPD8 — Remappable peripheral D8 / RTCC
Pin 36 RPD9 — Remappable peripheral D9
Pin 37 RPD10 — Remappable peripheral D10
Pin 38 RPD11 — Remappable peripheral D11
Pin 39 RPD12 — Remappable peripheral D12
Pin 40 RPD13 — Remappable peripheral D13
Pin 41 RPD14 — Remappable peripheral D14
Pin 42 RPD15 — Remappable peripheral D15
Pin 43 VSS — Ground
Pin 44 VDD — Positive supply
Pin 45 RPE0 — Remappable peripheral E0 / PMD0
Pin 46 RPE1 — Remappable peripheral E1 / PMD1
Pin 47 RPE2 — Remappable peripheral E2 / PMD2
Pin 48 RPE3 — Remappable peripheral E3 / PMD3
Pin 49 RPE4 — Remappable peripheral E4 / PMD4
Pin 50 RPE5 — Remappable peripheral E5 / PMD5
Pin 51 RPE6 — Remappable peripheral E6 / PMD6
Pin 52 RPE7 — Remappable peripheral E7 / PMD7
Pin 53 RPE8 — Remappable peripheral E8
Pin 54 RPE9 — Remappable peripheral E9
Pin 55 VSS — Ground
Pin 56 VDD — Positive supply
Pin 57 AVDD — Analog positive supply
Pin 58 AVSS — Analog ground
Pin 59 RPF0 — Remappable peripheral F0
Pin 60 RPF1 — Remappable peripheral F1
Pin 61 RPF2 — Remappable peripheral F2
Pin 62 RPF3 — Remappable peripheral F3
Pin 63 RPF4 — Remappable peripheral F4 / USBID
Pin 64 RPF5 — Remappable peripheral F5 / VBUS
Pin 65 EP — Exposed thermal pad - connect to VSS (ground)

Typical Applications

PIC32MX450F256H-V/MR is suitable for 7 applications: USB Audio Interface, Human-Machine Interface (HMI) Panels, Industrial Sensor Hub with USB Diagnostics, Point-of-Sale (POS) Terminal, Portable Data Logger, Consumer Audio Streaming Dongle, IoT Edge Sensor Node.

🎧

USB Audio Interface

The PIC32MX450F256H-V/MR is purpose-built for USB audio applications, integrating USB 2.0 Full-Speed device/host/OTG alongside two SPI/I2S interfaces that directly connect to audio codecs such as the SGTL5000 or WM8960. The 256 KB Flash accommodates the full USB audio class driver plus audio processing firmware, while the 64 KB SRAM handles stereo 48 kHz / 24-bit sample buffers (about 11 KB for double-buffered stereo). With 80 MHz of MIPS headroom, the device can run USB polling and audio streaming simultaneously without dropping samples. Engineers can leverage the Microchip Harmony USB Audio framework to shorten firmware development.

🏭

Human-Machine Interface (HMI) Panels

For HMI panels with TFT LCDs and touch input, the PIC32MX450F256H-V/MR combines an 8-bit Parallel Master Port (PMP) for direct TFT interfacing, USB for firmware updates, and the 10-bit 1 Msps ADC for touch-sense or analog keypad inputs. The 256 KB Flash stores graphical assets, fonts, and menu structures; the 64 KB SRAM buffers frame updates. The -40C to +105C operating range makes it suitable for industrial control panels deployed in factories, EV charging stations, or outdoor kiosks. Designers can use the Microchip MPLAB Harmony Graphics Suite to build rich UIs.

🏭

Industrial Sensor Hub with USB Diagnostics

The PIC32MX450F256H-V/MR integrates 28 ADC channels at 1 Msps, two UART, two I2C, and two SPI, allowing it to consolidate data from multiple sensors (temperature, pressure, accelerometers, gas sensors) into a single processor. The USB port provides diagnostics, configuration, and data logging to a host PC. The 256 KB Flash can store calibration coefficients and lookup tables for sensor linearization, while the 64 KB SRAM accommodates circular sample buffers. The industrial temperature grade (-40C to +105C) supports deployment in factories, process control cabinets, and remote monitoring stations.

🖥️

Point-of-Sale (POS) Terminal

POS terminals require USB for barcode scanners and receipt printers, UART for legacy peripherals, and enough Flash to host application logic, encryption, and UI rendering. The PIC32MX450F256H-V/MR fits this role with 256 KB Flash (enough for embedded TLS stacks, payment flows, and graphics), 64 KB SRAM, and the integrated USB 2.0 Full-Speed port. The QFN-64 package keeps the BOM compact for handheld form factors. The device's two I2C buses can drive NFC readers and secure EEPROM for transaction logging.

📱

Portable Data Logger

Battery-powered data loggers benefit from the PIC32MX450F256H-V/MR's integrated peripherals that eliminate external components: USB for charging and data offload, ADC for sensor inputs, and 64 KB SRAM for buffering logged samples. The 2.3V to 3.6V supply range matches single-cell Li-ion chemistry directly. The industrial -40C to +105C temperature grade allows deployment in environmental monitoring, refrigerated transport, and field telemetry. The 256 KB Flash can store configuration firmware plus several hours of compressed logs before offload.

🎧

Consumer Audio Streaming Dongle

USB audio dongles that stream audio from a host PC to speakers or headphones require a USB device port, an I2S link to a DAC, and sufficient MIPS for sample-rate conversion. The PIC32MX450F256H-V/MR handles this with its USB 2.0 Full-Speed device port and two SPI/I2S ports, plus 80 MHz of processing headroom for SRC and volume control. The 64 KB SRAM accommodates double-buffered audio streams at 96 kHz / 24-bit (about 18 KB). The compact 9x9 mm QFN-64 footprint enables small-form-factor dongle designs.

🧩

IoT Edge Sensor Node

For IoT edge nodes that aggregate multiple sensor types, the PIC32MX450F256H-V/MR's 28 ADC channels, two I2C buses, and two SPI ports provide the connectivity to bridge analog and digital sensors to a USB or UART host. The 256 KB Flash hosts the application logic plus over-the-air update firmware (bootloader), and the 64 KB SRAM buffers sensor frames before transmission. The QFN-64 package and industrial temperature range suit deployment in smart-building controllers, asset trackers, and HVAC monitoring systems.

Recommended Products Summary

SGTL5000 Low-power stereo audio codec with line/headphone outputs Used in: USB Audio Interface PIC32MX450F256HT-V/MR Microchip Technology Used in: USB Audio Interface PIC32MX450F256H-120/MR Microchip Technology Used in: Human-Machine Interface (HMI) Panels, Consumer Audio Streaming Dongle FT810 Embedded video engine for TFT touch displays Used in: Human-Machine Interface (HMI) Panels MCP9700 Analog temperature sensor for ADC input Used in: Industrial Sensor Hub with USB Diagnostics PIC32MX440F256H-80I/MR Microchip Technology Used in: Industrial Sensor Hub with USB Diagnostics AT24C256 I2C EEPROM for transaction logging Used in: Point-of-Sale (POS) Terminal PIC32MX450F256HT-I/MR Microchip Technology Used in: Point-of-Sale (POS) Terminal MCP3421 18-bit delta-sigma ADC for precision analog inputs Used in: Portable Data Logger PIC32MX450F256H-50I/MR 50 MHz variant for power-constrained designs Used in: Portable Data Logger PCM5102A 32-bit stereo DAC with I2S input Used in: Consumer Audio Streaming Dongle BME280 I2C temperature/humidity/pressure sensor Used in: IoT Edge Sensor Node PIC32MX450F256HT-120/MR Microchip Technology Used in: IoT Edge Sensor Node
What is the maximum operating frequency of PIC32MX450F256H-V/MR?
The PIC32MX450F256H-V/MR operates at a maximum clock frequency of 80 MHz, delivering up to 125 DMIPS (1.56 DMIPS/MHz). According to the Microchip PIC32MX3XX/4XX family datasheet, the 80 MHz variants in this family use the MIPS32 M4K core with a 5-stage pipeline. Engineers evaluating higher throughput should consider the 120 MHz / 150 DMIPS variants in the same family.
How much Flash and SRAM does PIC32MX450F256H-V/MR have?
The PIC32MX450F256H-V/MR integrates 256 KB of Flash program memory (organized as 256K x 8) and 64 KB of SRAM. This memory ratio is suitable for USB stacks, graphical user interfaces, and audio buffering applications. The Flash endurance is rated for a minimum of 20,000 erase/write cycles per the Microchip datasheet.
What package does PIC32MX450F256H-V/MR use?
The PIC32MX450F256H-V/MR ships in a 64-pin QFN package measuring 9x9 mm (Microchip package designator /MR). The package includes an exposed thermal pad (EP) that must be soldered to the PCB ground plane for proper thermal dissipation and electrical performance. The QFN footprint is also used by other PIC32MX3/4 family members, simplifying drop-in migration across memory and speed grades.
Does PIC32MX450F256H-V/MR support USB?
Yes, the PIC32MX450F256H-V/MR integrates a USB 2.0 Full-Speed controller that supports device, host, and OTG operation. The USB module includes an on-chip transceiver and dedicated DMA channels, eliminating the need for an external PHY in most designs. Firmware developers can leverage the Microchip Harmony USB stack to implement CDC, HID, MSD, and audio class drivers.
What is the operating temperature range of PIC32MX450F256H-V/MR?
The PIC32MX450F256H-V/MR operates across the -40C to +105C industrial temperature range, indicated by the "-V" suffix in Microchip's part numbering convention. This range covers industrial, automotive interior, and outdoor equipment use cases. For extended 125C operation, designers should consider the "-E" grade variants in the same PIC32MX3/4 family.
What is the difference between PIC32MX450F256H-V/MR and PIC32MX450F256HT-V/MR?
The PIC32MX450F256H-V/MR is supplied in tray packaging, while the PIC32MX450F256HT-V/MR is supplied in tape-and-reel packaging for SMT pick-and-place lines. Both parts share the same die, 256 KB Flash, 64 KB SRAM, 64-QFN package, and 80 MHz speed grade, making them functionally identical drop-in alternatives differing only in packaging format.
Can PIC32MX450F256H-V/MR be replaced with a 120 MHz variant in the same package?
Yes, the PIC32MX450F256H-120/MR is a 120 MHz speed-grade upgrade in the same 64-QFN package with identical memory, peripherals, and pinout. According to Microchip's PIC32MX3/4 family datasheet, parts sharing the same package designator and memory suffix are drop-in pin-compatible. Designers can substitute the higher-speed variant to gain 50% more MIPS without PCB changes.
Where can I buy PIC32MX450F256H-V/MR at the best price?
As of 2026-10-03, PIC32MX450F256H-V/MR is stocked at DigiKey, Mouser, LCSC, and Microchip Direct. LCSC lists a starting unit price around $2.56 for higher volumes, while DigiKey and Mouser list approximately $6.95 at quantity 1. For prototype quantities, Mouser typically ships same-day; for production volumes, Microchip Direct offers factory-direct pricing with longer lead times.
What is the lead time for PIC32MX450F256H-V/MR?
As of 2026-10-03, distributor listings show PIC32MX450F256H-V/MR generally ships same-day or within 1-2 weeks from authorized distributors (DigiKey, Mouser, Microchip Direct). Production orders through Microchip Direct may have 8-12 week lead times for large quantities. For urgent requirements, distributors maintain buffer stock, but engineers should plan ahead for high-volume production schedules.
Is PIC32MX450F256H-V/MR in stock and available for immediate shipment?
Yes, DigiKey's product page states "Buy now, ships today" for PIC32MX450F256H-V/MR as of the last verified date (2026-10-03). Mouser and LCSC also list inventory. The part is in active production status with Microchip Technology and is not flagged as end-of-life or obsolete in the verified distributor data.
What is the difference between PIC32MX450F256H-V/MR and PIC32MX440F256H-80I/MR?
Both parts share the same 64-QFN /MR package and 256 KB Flash, but the PIC32MX450 variant runs at 80 MHz with USB 2.0 Full-Speed, while the PIC32MX440F256H-80I/MR runs at 80 MHz with USB 2.0 Full-Speed as well. The MX450 vs MX440 difference is primarily in peripheral mix - the 450 adds additional features like the 10-bit 1 Msps ADC configuration. Both are drop-in compatible in the same footprint.
Which is better for USB audio design, PIC32MX450F256H-V/MR or PIC32MX450F128H-I/MR?
For USB audio designs requiring DSP buffering or larger firmware images, PIC32MX450F256H-V/MR (256 KB Flash, 64 KB SRAM) is preferable over the PIC32MX450F128H-I/MR (128 KB Flash, lower RAM). The 256 KB variant provides room for USB audio class drivers, sample buffers, and DSP algorithms. For simpler HID-only USB applications, the 128 KB variant offers cost savings in the same QFN-64 footprint.
When should I choose PIC32MX450F256H-V/MR over PIC32MX370F512L-V/TL?
Choose PIC32MX450F256H-V/MR when the design needs USB, two I2S audio interfaces, and 256 KB Flash in a compact 64-QFN package. Choose PIC32MX370F512L-V/TL when the design needs 512 KB Flash and 128 KB SRAM for larger firmware images and can use the 100-pin TQFP package. The MX370 has more memory but lacks the MX450's integrated USB controller.
What is the best drop-in replacement for PIC32MX450F256H-V/MR?
The best drop-in replacement is PIC32MX450F256HT-V/MR, which shares identical silicon but ships on tape-and-reel for SMT assembly. For higher performance, PIC32MX450F256H-120/MR runs at 120 MHz in the same 64-QFN package. For memory upgrades within the same package, PIC32MX450F512H-V/MR (when available) provides 512 KB Flash. All three are pin-to-pin compatible with the original /MR footprint.
Where can I download the PIC32MX450F256H-V/MR datasheet PDF?
The official PIC32MX450F256H family datasheet is hosted on Microchip's document server at the URL listed in the datasheet_url field above. The document covers 344 pages of electrical specifications, peripheral details, and register definitions for the entire PIC32MX3XX/4XX family. Designers should also reference DS60001168 revision L for the latest errata and specifications.
Where can I find the PIC32MX450F256H-V/MR pinout?
The PIC32MX450F256H-V/MR pinout is documented in section 10 of the PIC32MX3XX/4XX family datasheet, which provides a detailed 64-QFN pin assignment table. The Microchip product page also includes a pin summary. For PCB layout, the 9x9 mm QFN package uses standard 0.5 mm pitch with an exposed thermal pad (EP) on pin 65 that must be soldered to the ground plane.
What is the best cross-brand equivalent for PIC32MX450F256H-V/MR?
There is no true cross-brand drop-in replacement for PIC32MX450F256H-V/MR because the MIPS32 M4K core, MPLAB X toolchain, and Harmony peripheral library are Microchip-specific. Cross-brand migration requires firmware rewrite. For pinout-similar alternatives, STM32F4 series and NXP LPC4000 series offer comparable 32-bit performance in 64-pin QFN but require architectural migration, which is not drop-in.

Engineering reference data for PIC32MX450F256H-V/MR — comparison, design guidance, and compliance information.

Selection Guide

Choose PIC32MX450F256H-V/MR when your design needs integrated USB 2.0 Full-Speed, dual I2S audio, and 28 ADC channels at 1 Msps in a 64-QFN footprint, particularly for USB audio interfaces, HMI panels, or industrial sensor hubs operating up to +105C. Upgrade to PIC32MX450F256H-120/MR (same package) if firmware requires more MIPS for DSP or higher frame-rate graphics. Downgrade to PIC32MX450F256H-50I/MR for power-constrained applications where 50 MHz is sufficient. Switch to PIC32MX440F256H-80I/MR if cost is the primary concern and you can accept reduced peripheral mix. Use PIC32MX370F512L-V/TL if you need 512 KB Flash for very large firmware images and do not need USB.

Comparison with Alternatives

Parameter This Product PIC32MX450F256HT-V/MR PIC32MX450F256H-120/MR PIC32MX450F256H-50I/MR PIC32MX440F256H-80I/MR
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Package 64-QFN (9x9 mm) /MR 64-QFN (9x9 mm) /MR - same 64-QFN (9x9 mm) /MR - same 64-QFN (9x9 mm) /MR - same 64-QFN (9x9 mm) /MR - same
Maximum Clock Frequency 80 MHz 80 MHz 120 MHz (+50%) 50 MHz (-37.5%) 80 MHz
Flash Memory 256 KB 256 KB 256 KB 256 KB 256 KB
SRAM 64 KB 64 KB 64 KB 64 KB 64 KB
Operating Temperature -40C to +105C (V grade) -40C to +105C -40C to +105C -40C to +85C (I grade) -40C to +85C (I grade)
Packaging Format Tray Tape and Reel Tray Tray Tray
USB Controller USB 2.0 Full-Speed USB 2.0 Full-Speed USB 2.0 Full-Speed USB 2.0 Full-Speed USB 2.0 Full-Speed
Approx. Unit Price (qty 1) $6.95 $6.95 $8.20 $6.10 $6.50

Key Differentiators

  • Integrated USB 2.0 Full-Speed with on-chip transceiver (vs PIC32MX370F512L-V/TL)
  • Dual I2S interfaces for stereo audio (vs PIC32MX340F128H-80I/MR)
  • Higher 10-bit ADC speed (1 Msps) (vs PIC32MX270F256H-50I/PT)
  • 80 MHz MIPS vs 50 MHz ARM Cortex in similar footprint (vs PIC32MX250F256H-50I/MR)

Design Notes

The 64-QFN /MR package has an exposed thermal pad (pin 65) that MUST be soldered to the PCB ground plane for both thermal dissipation and electrical performance. Use an array of thermal vias (typically 9 to 16 vias in a 3x3 or 4x4 grid) to conduct heat to internal ground planes. Per IPC-2222, the thermal pad land pattern should be at least 50% of the package body area to achieve rated thermal resistance. Missing the EP connection will result in thermal runaway under USB load conditions.

The PIC32MX450F256H-V/MR requires multiple decoupling capacitors on each VDD/VSS pair: a 100 nF ceramic (X7R) within 2 mm of each supply pin for high-frequency noise, plus a bulk 4.7 uF to 10 uF tantalum or ceramic near the device. The analog supply AVDD should have a ferrite bead or 10 ohm resistor plus 100 nF + 10 uF decoupling to isolate ADC noise from digital switching. USB VBUS sensing (RPF5) requires a 10 kohm pull-down to detect host disconnection per USB 2.0 spec.

Do not exceed the absolute maximum VDD of 3.6V - this part is NOT 5V tolerant on any I/O pin. Use level shifters for any 5V peripherals. The 80 MHz clock requires careful PLL configuration; the input crystal or external oscillator must meet the 12 MHz +/- 50 ppm accuracy spec for USB Full-Speed compliance. Always configure the JTAG pins as GPIOs in production firmware to free up the programming/debug interface pins (PGECx/PGEDx must be reassigned via config bits).

USB DP/DM traces should be routed as a 90 ohm differential pair with matched length within 150 mils, per USB 2.0 specification. Avoid routing USB signals across splits in the ground plane; the reference plane must be continuous under the USB traces. For the I2S audio interface, keep traces short (under 50 mm) and matched to within 5 mm to maintain bit-clock timing. Place a 33 ohm series resistor on each I2S data line near the MCU to dampen reflections if cable/connector length exceeds 25 mm.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Compliant

RoHS and lead-free compliant per Microchip product page. AEC-Q100 not applicable - this is an industrial-grade MCU; AEC-Q100 qualified automotive variants would carry a different part number suffix.

Data verified on: 2026-10-03 — data verified and curated by XAIPART's component engineering team

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