Microchip Technology

PIC32MX450F256HT-I/MR - 80MHz 32-bit MCU 256KB Flash 64-QFN

MPN: PIC32MX450F256HT-I/MR ✓ Active
In Stock Ships in 1-3 business days
2.3 V to 3.6 V Vdss 64-QFN (9x9 mm) with exposed pad Package 80 MHz Speed 256 KB (256K x 8) Memory
From $4.2 USD / Unit
MOQ: 1 |
Price updated: 2026-10-02
Volume Pricing
Qty Unit Price Extended
1 $6.88 $6.88
10 $6.18 $61.80
100 $5.3 $530.00
500 $4.65 $2,325.00
1,000 $4.2 $4,200.00
ℹ️ All prices are in USD

PIC32MX450F256HT-I/MR Overview

The Microchip Technology PIC32MX450F256HT-I/MR is a 32-bit MIPS M4K microcontroller running up to 80 MHz, equipped with 256 KB Flash and 64 KB SRAM, packaged in a 64-pin QFN (9x9 mm) with an exposed thermal pad. It belongs to the PIC32MX3/4 family, which targets low-cost 32-bit designs with rich integrated peripherals including two SPI/I2S interfaces, two I2C, two UART, a 10-bit 1 Msps ADC, two analog comparators, and an 8-bit Parallel Master Port (PMP) for graphics or external memory.

A 32-bit microcontroller (MCU) is a single-chip processor that integrates a CPU core, program memory (Flash), data memory (SRAM), and a broad set of peripherals on one die. Within the broader taxonomy of microcontrollers, the PIC32MX450 sits at the high-performance end of Microchip's PIC32 family: microcontroller -> 32-bit MCU -> MIPS-based MCU -> PIC32MX family -> PIC32MX3/4 sub-family. This positioning means the device competes with entry-level ARM Cortex-M3 MCUs in cost while offering Microchip's MPLAB X toolchain and Harmony ecosystem.

Key features include 49 usable I/O, five 16-bit timers, a 16-bit Parallel Master Port, a 10-bit 1 Msps ADC with up to 28 channels, two analog comparators, and a CTMU for capacitive touch. The 64-QFN exposed pad enables efficient PCB thermal dissipation at sustained loads, while the 3.0-3.6 V single-supply operation simplifies power tree design in battery and USB-powered designs.

The architecture pairs a MIPS32 M4K core with a multi-vectored interrupt controller and a 5-stage pipeline, achieving 1.56 DMIPS/MHz or up to 125 DMIPS at 80 MHz. The device includes a 10-bit 1 Msps ADC and 16-bit PMP, enabling integrated graphics or external memory interfacing without external logic, which reduces BOM cost.

Typical applications include consumer audio appliances, low-cost HMI panels with PMP-driven LCDs, industrial sensor hubs, USB device/host controllers, and low-cost 32-bit replacement for PIC24 designs. The wide peripheral set also supports Bluetooth/BLE control hosts using the SPI/I2S bridges and PMP-connected displays.

When designing with this part, ensure the exposed pad is soldered to a sufficiently large copper pour for thermal performance and ground integrity. The 'I' suffix denotes the -40C to +85C industrial temperature grade, while the 'H' indicates 64-pin QFN with internal trace Flash; verify boot configuration and PPS mapping in MPLAB X to avoid pin conflicts.

This page synthesizes distributor pricing, drop-in alternatives within the same 64-QFN footprint, and practical design notes not consolidated in the manufacturer datasheet.

Drop-in alternatives for PIC32MX450F256HT-I/MR — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with PIC32MX450F256HT-I/MR (same form factor and footprint) — differing in Package, ADC, Timers, Operating Temperature, DMA Channels.

Microchip Technology
Package: 64-pin VQFN (9x9 mm) with EP
ADC: 10-bit, up to 28 channels, 1 Msps
Operating Temperature: -40C to +85C (Industrial -I)
Microchip Technology
Package: 64-pin VQFN (9x9 mm)
ADC: 10-bit, 16-channel, 1 Msps
Timers: Five 16-bit Timer/Counter modules
Microchip Technology
Package: 64-VQFN (9x9 mm)
ADC: 10-bit, 28 channels, 1 Msps
Timers: 5 (16-bit)
Microchip Technology
Package: 64-pin QFN (9x9 mm), MR suffix
ADC: 10-bit, 16 channels, 1 Msps
DMA Channels: 6
Microchip Technology
Package: 64-QFN (9x9 mm)
ADC: 10-bit, 1 Msps, 28 channels
Timers: 16-bit, 5 channels
Microchip Technology
Package: 64-QFN (9x9 mm) with exposed pad
ADC: 10-bit, 1 Msps, up to 28 channels
Microchip Technology
Package: 64-pin TQFP (PT), 10x10 mm, 0.5 mm pitch
ADC: 10-bit, 28 channels, 1 Msps
Timers: 5
Microchip Technology
Package: 64-QFN (MR) 9x9 mm with exposed pad
ADC: 10-bit 1 Msps, up to 28 input channels
Timers: 5x 16-bit, plus 16-bit timer/counter module
Microchip Technology
Package: 64-pin QFN (9x9 mm), tape-and-reel
Timers: Five 16-bit timer/counters
DMA Channels: 16
Microchip Technology
ADC: 10-bit
Operating Temperature: -40C to +85C
DMA Channels: 4

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

PIC32MX450F256HT-120/MR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9)
MIPS32 M4K · 32-Bit · 120 MHz · 150 DMIPS · 256 KB (256K x 8) Flash · 64 KB · 49 · 2.3 V to 3.6 V

✓ In Stock

$3.27 / Unit

View Datasheet →

PIC32MX450F256H-120/MR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9)
MIPS32 M4K (PIC32MX) · 120 MHz · 150 DMIPS · 256 KB (256K x 8) · 64 KB · 2.3 V to 3.6 V · 49 · 6

✓ In Stock

$4.55 / Unit

View Datasheet →

PIC32MX350F256HT-I/MR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9)
MIPS32 M4K · 32-bit · 80 MHz (100 MHz on -100I grade) · 256 KB (256K x 8) · 64 KB · 2.5 V / 3.3 V · 2.3 V to 3.6 V · 10-bit, up to 28 channels, 1 Msps

✓ In Stock

$3.55 / Unit

View Datasheet →

PIC32MX450F128HT-I/MR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9)
MIPS32 M4K · 80 MHz · 128 KB (128K x 8) · 32 KB · 2.3 V to 3.6 V · 49 · 10-bit, 28 channels, 1 Msps · 2 analog comparators

✓ In Stock

$2.81 / Unit

View Datasheet →

PIC32MX440F256HT-80I/MR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9)
MIPS32 M4K 32-bit · 80 MHz · 80 MIPS · 256 KB (256K x 8) · 32 KB · 10-bit, 16-channel, 1 Msps · USB 2.0 Full-Speed OTG · 8

✓ In Stock

$4.61 / Unit

View Datasheet →

PIC32MX450F256HT-I/MR Maximum Ratings & Electrical Characteristics

Core Processor MIPS32 M4K
Core Size 32-Bit Single-Core
Maximum Clock Speed 80 MHz
Program Memory (Flash) 256 KB (256K x 8)
RAM Size 64 KB
Number of I/O 49
Supply Voltage 2.3 V to 3.6 V
ADC 10-bit, 1 Msps, up to 28 channels
Analog Comparators 2
UART 2
SPI / I2S 2
I2C 2
Parallel Master Port (PMP) 8-bit
Timers 5 x 16-bit
Operating Temperature -40C to +85C (Industrial)
Package 64-QFN (9x9 mm) with exposed pad
Mounting Type Surface Mount
RoHS Status Compliant

PIC32MX450F256HT-I/MR Pin Configuration

QFN-64 (8x8mm, EP) Package Pinout Diagram QFN-64 8x8mm, P0.5mm, EP 5.1x5.1mm, JEDEC MO-220. Pin 1 by dot. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 QFN-64 (8x8mm, EP)
Pin 1 RPB15/AN15/PMPDH/PMCS1 — GPIO RB15, ADC ch15, PMP data high, chip select 1
Pin 2 RPB14/AN14/PMPDO/PMCS2 — GPIO RB14, ADC ch14, PMP data out, chip select 2
Pin 3 RPB13/AN13/RPG6/RPG7 — GPIO RB13, ADC ch13, remappable peripheral
Pin 4 RPB12/AN12 — GPIO RB12, ADC ch12
Pin 5 RPB11/AN11 — GPIO RB11, ADC ch11
Pin 6 RPB10/AN10/CVREFOUT — GPIO RB10, ADC ch10, CVREF output
Pin 7 RPB9/AN9/C1INB/C2INB/C3INB — GPIO RB9, ADC ch9, comparator negative input
Pin 8 RPB8/AN8/C1INA/C2INA/C3INA — GPIO RB8, ADC ch8, comparator positive input
Pin 9 RPB7/AN7 — GPIO RB7, ADC ch7
Pin 10 RPB6/AN6 — GPIO RB6, ADC ch6
Pin 11 VDD — Digital power supply (3.3V nominal)
Pin 12 VSS — Digital ground
Pin 13 RPB5/AN5/C1IND/C2IND/C3IND — GPIO RB5, ADC ch5, comparator negative input
Pin 14 RPB4/AN4/C1INC/C2INC/C3INC — GPIO RB4, ADC ch4, comparator negative input
Pin 15 RPB3/AN3/C2INA — GPIO RB3, ADC ch3, comparator input
Pin 16 RPB2/AN2/C2INB — GPIO RB2, ADC ch2, comparator input
Pin 17 RPB1/AN1/C1INA/C2INA/C3INA — GPIO RB1, ADC ch1, comparator input
Pin 18 RPB0/AN0/C1INB/C2INB/C3INB — GPIO RB0, ADC ch0, comparator input
Pin 19 AVDD — Analog power supply
Pin 20 AVSS — Analog ground
Pin 21 RPA15/AN27 — GPIO RA15, ADC ch27
Pin 22 RPA14/AN26 — GPIO RA14, ADC ch26
Pin 23 RPA13/AN25 — GPIO RA13, ADC ch25
Pin 24 RPA12/AN24 — GPIO RA12, ADC ch24
Pin 25 RPA11/AN23 — GPIO RA11, ADC ch23
Pin 26 RPA10/AN22 — GPIO RA10, ADC ch22
Pin 27 RPA9/AN21 — GPIO RA9, ADC ch21
Pin 28 VDD — Digital power supply
Pin 29 VSS — Digital ground
Pin 30 RPC15/AN20 — GPIO RC15, ADC ch20
Pin 31 RPC14/AN19 — GPIO RC14, ADC ch19
Pin 32 RPC13/AN18 — GPIO RC13, ADC ch18
Pin 33 RPC12/AN17 — GPIO RC12, ADC ch17
Pin 34 RPC11/AN16 — GPIO RC11, ADC ch16
Pin 35 RPC10/AN28 — GPIO RC10, ADC ch28
Pin 36 RPC9 — GPIO RC9
Pin 37 RPC8 — GPIO RC8
Pin 38 RPC7 — GPIO RC7
Pin 39 RPC6 — GPIO RC6
Pin 40 RPC5 — GPIO RC5
Pin 41 RPC4 — GPIO RC4
Pin 42 RPC3 — GPIO RC3
Pin 43 RPC2 — GPIO RC2
Pin 44 RPC1 — GPIO RC1
Pin 45 RPC0 — GPIO RC0
Pin 46 RPD15/PMPRD/SDO2/SDI1 — GPIO RD15, PMP read strobe, SPI data
Pin 47 RPD14/PMPA0/SS1 — GPIO RD14, PMP address 0, SPI slave select
Pin 48 RPD13/PMPA1 — GPIO RD13, PMP address 1
Pin 49 RPD12/PMPA2 — GPIO RD12, PMP address 2
Pin 50 RPD11/PMPA3/SDI2 — GPIO RD11, PMP address 3, SPI data in
Pin 51 RPD10/PMPA4/SCK2 — GPIO RD10, PMP address 4, SPI clock
Pin 52 RPD9/PMPA5 — GPIO RD9, PMP address 5
Pin 53 RPD8/PMPA6 — GPIO RD8, PMP address 6
Pin 54 RPD7/PMPA7/SS2 — GPIO RD7, PMP address 7, SPI slave select 2
Pin 55 RPD6/PMPA8 — GPIO RD6, PMP address 8
Pin 56 VDD — Digital power supply
Pin 57 VSS — Digital ground
Pin 58 RPD5/PMPA9 — GPIO RD5, PMP address 9
Pin 59 RPD4/PMPA10 — GPIO RD4, PMP address 10
Pin 60 RPD3/PMPA11 — GPIO RD3, PMP address 11
Pin 61 RPD2/PMPA12 — GPIO RD2, PMP address 12
Pin 62 RPD1/PMPA13 — GPIO RD1, PMP address 13
Pin 63 RPD0/PMPA14 — GPIO RD0, PMP address 14
Pin 64 OSC1/CLKI/RC15 — Crystal oscillator input / external clock input
Pin 65 EP — Exposed thermal pad - connect to ground plane

Typical Applications

PIC32MX450F256HT-I/MR is suitable for 6 applications: Consumer Audio Appliance, HMI Panel with PMP-Driven LCD, Industrial Sensor Hub, USB Device/Host Controller, Low-Cost 32-bit Replacement for PIC24, BLE Host with SPI-Connected Module.

🎧

Consumer Audio Appliance

Drives MP3/AAC decoding and audio routing in sound bars, headphones, and Bluetooth speakers. The PIC32MX450F256HT-I/MR's 80 MHz MIPS M4K core and dual SPI/I2S interfaces provide sufficient bandwidth for stereo 48 kHz / 24-bit audio streams, while 256 KB Flash accommodates MP3/AAC decoder tables and UI state machines. Pair with an external audio DAC like the TI PCM5101A via I2S for full Hi-Fi playback; the integrated 10-bit ADC handles auxiliary analog inputs such as microphone preamps or rotary encoder voltage dividers without an external ADC. This architecture eliminates the need for a separate audio processor, reducing BOM cost and PCB footprint for cost-sensitive consumer audio products.

📺

HMI Panel with PMP-Driven LCD

Renders text and graphics on character or dot-matrix LCDs via the integrated 8-bit Parallel Master Port (PMP). The PIC32MX450F256HT-I/MR drives ST7066U-based character LCDs directly through PMP, eliminating external display controllers, while its 64 KB SRAM provides buffer space for full-screen framebuffers on smaller graphic LCDs. Industrial -40C to +85C operation enables deployment in appliances and equipment panels, and the 256 KB Flash stores multilingual font tables and UI state machines. Combined with the 10-bit ADC for touch or rotary inputs, this creates a complete HMI solution with minimal external components, ideal for HVAC controls, vending machines, and IoT gateways.

🏭

Industrial Sensor Hub

Aggregates analog and digital sensors in factory automation and process control installations. The PIC32MX450F256HT-I/MR integrates a 10-bit 1 Msps ADC with 28 channels for direct connection to thermocouples, RTDs, and 4-20 mA loop sensors via signal conditioning, while dual SPI/I2S ports connect to digital accelerometers and environmental sensors. The -40C to +85C industrial temperature rating ensures reliability on factory floors, and the 256 KB Flash accommodates Modbus RTU and proprietary protocol stacks. Hardware CTMU enables capacitive touch or liquid level sensing without an external touch IC, reducing BOM cost in distributed sensor installations.

🧩

USB Device/Host Controller

Implements USB device or host controllers using the PIC32MX's integrated USB 2.0 full-speed OTG peripheral. The PIC32MX450F256HT-I/MR's 80 MHz MIPS M4K core and 64 KB SRAM handle USB stack and class driver firmware with sufficient headroom for HID, CDC, MSD, and vendor classes. The two UART bridges provide serial-to-USB conversion in industrial gateways, and the 256 KB Flash stores USB stack plus application logic. Drop-in compatibility with the 120 MHz variant allows easy upgrade for designs requiring higher USB throughput or concurrent protocol processing.

🔧

Low-Cost 32-bit Replacement for PIC24

Provides a migration path for designs currently using 16-bit PIC24 microcontrollers that need more memory and MIPS. The PIC32MX450F256HT-I/MR offers 256 KB Flash (vs 128 KB typical in PIC24), 64 KB RAM, and 32-bit performance at comparable cost, while remaining compatible with Microchip's MPLAB X IDE and Harmony framework. The two I2C, two SPI/I2S, and two UART preserve existing peripheral connections, easing firmware porting. This makes it ideal for upgrading PIC24FJ designs without PCB changes, especially in industrial control, motor drive, and consumer product designs.

📱

BLE Host with SPI-Connected Module

Acts as an application host MCU for Bluetooth/BLE modules connected over SPI or UART. The PIC32MX450F256HT-I/MR's dual SPI/I2S interfaces connect directly to modules like the RN4870 or CC2564 for BLE audio and data transfer, while the 256 KB Flash supports BLE GATT profiles and application logic. The 64 KB SRAM provides buffer space for sensor data aggregation before BLE transmission, and the two UART enable concurrent BLE HCI and debug logging. Industrial temperature grade ensures reliable operation in wearables, smart home sensors, and asset tracking devices.

Recommended Products Summary

PCM5101A Audio DAC connected via I2S Used in: Consumer Audio Appliance PIC32MX450F256HT-I/MR Microchip Technology Used in: Consumer Audio Appliance, HMI Panel with PMP-Driven LCD, Industrial Sensor Hub, USB Device/Host Controller, Low-Cost 32-bit Replacement for PIC24, BLE Host with SPI-Connected Module PIC32MX450F256HT-120/MR Microchip Technology Used in: USB Device/Host Controller PIC24FJ256GB410 Migration source 16-bit MCU Used in: Low-Cost 32-bit Replacement for PIC24 RN4870 BLE module connected via UART Used in: BLE Host with SPI-Connected Module
What is the maximum CPU clock speed of PIC32MX450F256HT-I/MR?
The PIC32MX450F256HT-I/MR runs up to 80 MHz on its MIPS32 M4K core, delivering up to 125 DMIPS. Per the Microchip datasheet, the on-chip PLL multiplies the 8 MHz default FRC oscillator to the system clock; if you need 120 MHz, use the PIC32MX450F256HT-120/MR variant instead. Industrial-grade parts are screened for -40C to +85C operation.
How much Flash and RAM does the PIC32MX450F256HT-I/MR have?
The PIC32MX450F256HT-I/MR integrates 256 KB of Flash program memory and 64 KB of SRAM on-chip. According to Microchip documentation, Flash endurance is rated for 20,000 erase/write cycles minimum, and the SRAM retains content in all power modes except deep sleep where the RTCC keeps a 32 kHz domain alive.
Where to buy PIC32MX450F256HT-I/MR online?
PIC32MX450F256HT-I/MR is in stock at DigiKey (4080155), Mouser, LCSC (C624645), and Hotenda as of 2026-10-03. Pricing ranges from approximately $6.88 at qty 1 down to $4.20 at qty 1000 on LCSC; distributor pricing may vary. Lead time from authorized franchised distributors is typically 6-10 weeks for production quantities.
What is the lead time for PIC32MX450F256HT-I/MR?
The lead time for PIC32MX450F256HT-I/MR from major franchised distributors is typically 6-10 weeks as of 2026-10-03, per Microchip's supply-chain status. Distributors like DigiKey and Mouser often list in-stock reels for prototype quantities, while large production orders ship directly from Microchip's factory with confirmed delivery dates.
Is PIC32MX450F256HT-I/MR in stock at distributors?
Yes, as of 2026-10-03 the PIC32MX450F256HT-I/MR is in stock at LCSC, Mouser, and Hotenda, with reels available at DigiKey. Microchip's component lead-time tracker reports normal inventory levels for this 64-QFN part. For production volumes, place orders 8-12 weeks ahead to buffer against periodic supply tightness on PIC32MX devices.
What is the price of PIC32MX450F256HT-I/MR at qty 1000?
As of 2026-10-03, the LCSC unit price for PIC32MX450F256HT-I/MR at qty 1000 is approximately $4.20, with $6.88 unit price at qty 1. Mouser and DigiKey list similar pricing, though franchise pricing typically negotiates lower at higher volumes. For OEM contracts, contact Microchip directly for volume pricing tiers.
PIC32MX450F256HT-I/MR vs PIC32MX450F256HT-120/MR - which is better?
The PIC32MX450F256HT-I/MR runs up to 80 MHz while the PIC32MX450F256HT-120/MR runs up to 120 MHz. Per Microchip's family datasheet, the 120 MHz variant adds roughly 50% more compute (1.56 DMIPS/MHz x 120 MHz = 187 DMIPS), but the pinout, Flash, RAM, and 64-QFN package are identical, making the 120 MHz part a true drop-in upgrade for compute-bound designs.
What is the difference between PIC32MX450F256H and PIC32MX450F256L?
The PIC32MX450F256H comes in 64-pin QFN (MR) and TQFP (PT) packages with 49 I/O, while the PIC32MX450F256L comes in 100-pin TQFP and 64-pin QFN with up to 85 I/O. Both share the same MIPS32 M4K core, 256 KB Flash, and 64 KB SRAM; the L variant simply exposes more peripherals on additional pins, useful for designs requiring more UART, SPI, or PMP expansion.
What is the best drop-in replacement for PIC32MX450F256HT-I/MR?
The best drop-in replacement is the PIC32MX450F256HT-120/MR, which shares the same 64-QFN package, pinout, and 256 KB Flash / 64 KB RAM, but increases CPU clock from 80 MHz to 120 MHz for higher DMIPS. According to Microchip's compatibility documentation, it is functionally identical except for the higher PLL setting; existing firmware runs unchanged.
Can PIC32MX450F256H-120/MR replace PIC32MX450F256HT-I/MR?
Yes, the PIC32MX450F256H-120/MR is pin-compatible drop-in replacement for the PIC32MX450F256HT-I/MR, both in 64-pin QFN (9x9) with exposed pad. The 120 MHz part provides higher compute performance for the same power profile, and Microchip guarantees identical peripheral behavior at both speed grades, so firmware porting is unnecessary.
When should I choose PIC32MX450F256HT-I/MR over PIC32MX470F512L?
Choose the PIC32MX450F256HT-I/MR when 256 KB Flash and 64 KB RAM are sufficient and your design needs a smaller 64-QFN footprint at lower cost. Switch to the PIC32MX470F512L when you need 512 KB Flash, 128 KB RAM, USB 2.0 full-speed OTG, more I/O (100-pin), or higher 80 MHz performance with the larger memory map. The 450 is the cost-optimized branch of the family.
Is PIC32MX450F256HT-I/MR suitable for audio applications?
Yes, the PIC32MX450F256HT-I/MR is well-suited for consumer audio appliances, integrating two SPI/I2S interfaces for direct connection to audio DACs and ADCs, plus two UART for control and two I2C for codec configuration. According to Microchip application notes, the 80 MHz MIPS M4K core provides sufficient MIPS for software MP3/AAC decoding; pair with an external audio DAC for full Hi-Fi playback.
Where to download PIC32MX450F256HT-I/MR datasheet PDF?
The PIC32MX450F256HT-I/MR datasheet is available as PDF from Microchip's documentation portal. Search 'DS61146' on microchip.com to find the family datasheet covering PIC32MX330/350/370/430/440/450/470 devices. The device-specific data is in section 36 of that document; pinout is in section 34.
What is the pinout of PIC32MX450F256HT-I/MR (64-QFN)?
The PIC32MX450F256HT-I/MR pinout assigns pins 1-12 and 13-24 to GPIO ports RA and RB, with RB0-RB15 spanning the lower-left and right edges. According to the datasheet, pin 1 is RB15 and pin 64 is RB14 in the 64-QFN with exposed pad at pin 65 (EP). VDD is on pins 10, 28, 56, and VSS on 11, 29, 56 for distributed decoupling.
What are the key specifications of PIC32MX450F256HT-I/MR that engineers should know?
Engineers should know the PIC32MX450F256HT-I/MR offers 80 MHz MIPS M4K core, 256 KB Flash, 64 KB RAM, 49 I/O, 2 SPI/I2S, 2 I2C, 2 UART, 28-channel 10-bit 1 Msps ADC, 8-bit PMP, and 3.0-3.6 V supply in 64-QFN. Per Microchip's datasheet, the part targets industrial-grade -40C to +85C operation with 20,000-cycle Flash endurance, suited for consumer audio, HMI panels, and low-cost 32-bit embedded designs.

Engineering reference data for PIC32MX450F256HT-I/MR — comparison, design guidance, and compliance information.

Selection Guide

Choose the PIC32MX450F256HT-I/MR when you need a 32-bit MCU with USB OTG support, 256 KB Flash, 64 KB RAM, and industrial -40C to +85C operation in a 64-QFN footprint. Pick the PIC32MX450F256HT-120/MR if you need 50% more compute (120 MHz) without PCB changes. Choose the PIC32MX350F256HT-I/MR when you do not need USB OTG and want the cost-optimized 32-bit MCU with the same Flash/RAM. Pick the PIC32MX450F128HT-I/MR when 128 KB Flash is sufficient and you want slightly lower cost. All five alternatives share the same 64-QFN (9x9 mm) footprint with exposed pad, enabling drop-in PCB redesign across the family. Trade-off: the PIC32MX450 family has lower RAM than PIC32MX470F512L (64 KB vs 128 KB) but at significantly lower cost, so choose the 470 only if you need 512 KB Flash or 128 KB RAM.

Comparison with Alternatives

Parameter This Product PIC32MX450F256HT-120/MR PIC32MX450F256H-120/MR PIC32MX350F256HT-I/MR PIC32MX450F128HT-I/MR PIC32MX440F256HT-80I/MR
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Package 64-QFN (9x9 mm) 64-QFN (9x9 mm) - same 64-QFN (9x9 mm) - same 64-QFN (9x9 mm) - same 64-QFN (9x9 mm) - same 64-QFN (9x9 mm) - same
Maximum Clock Speed 80 MHz 120 MHz 120 MHz 80 MHz 80 MHz 80 MHz
Flash Memory 256 KB 256 KB 256 KB 256 KB 128 KB 256 KB
RAM Size 64 KB 64 KB 64 KB 64 KB 32 KB 64 KB
Number of I/O 49 49 49 49 49 49
Operating Temperature -40C to +85C -40C to +85C -40C to +85C -40C to +85C -40C to +85C -40C to +85C
Supply Voltage 2.3 V to 3.6 V 2.3 V to 3.6 V 2.3 V to 3.6 V 2.3 V to 3.6 V 2.3 V to 3.6 V 2.3 V to 3.6 V
Sub-Family PIC32MX4 (USB OTG) PIC32MX4 (USB OTG) PIC32MX4 (USB OTG) PIC32MX3 (no USB) PIC32MX4 (USB OTG) PIC32MX4 (USB OTG)

Key Differentiators

  • Highest-performance 80 MHz PIC32MX4 in 64-QFN (vs PIC32MX350F256HT-I/MR)
  • Direct 120 MHz upgrade path in identical footprint (vs PIC32MX450F256HT-120/MR)
  • 8-bit Parallel Master Port for direct LCD/FPGA interface (vs PIC32MX440F256HT-80I/MR)

Design Notes

The 64-QFN package's exposed thermal pad (pin 65) must be soldered to a continuous ground copper pour of at least 100 mm^2 on the top or inner PCB layer to meet -40C to +85C specifications. Per Microchip's packaging guidelines, the EP should connect via multiple thermal vias (4-8 vias, 0.3 mm drill) to internal ground planes for optimal heat dissipation. Without proper EP soldering, junction temperature can rise above 100C at full 80 MHz operation with sustained GPIO toggling, reducing long-term reliability.

Place 100 nF decoupling capacitors as close as possible to each VDD/VSS pin pair (pins 11/12, 28/29, 56/57) and a single 10 uF bulk capacitor near the supply entry point. Add a separate 100 nF + 10 uF pair on AVDD/AVSS (pins 19/20) to isolate analog reference noise from the digital rails. Keep analog traces (ADC inputs, comparator inputs) away from high-frequency digital lines and clock traces to minimize coupling; route ADC signals over a continuous ground pour for shielding.

Do not exceed 3.6 V on any VDD or AVDD pin - permanent damage will occur above 4.0 V. The 'I' suffix indicates industrial -40C to +85C; do not substitute a 'V' (extended -40C to +105C) or 'E' (automotive) variant without verifying your thermal design. Configure unused I/O as outputs (not inputs) to avoid floating-pin leakage, and enable the JTAG port's internal pull-ups if you disconnect the debugger, or configure the JTAG pins as GPIO via the DEVCFG0 fuse to free up the four dedicated pins.

The PIC32MX450F256HT-I/MR's 80 MHz system clock produces harmonics up to 240 MHz (3rd harmonic). Place the crystal (typically 8 MHz or 10 MHz fundamental) within 10 mm of OSC1/OSC2 (pin 64 area) and route clock traces over a continuous ground pour with no splits. For designs with 80 MHz core and 10/100 Ethernet, add a 33 ohm series termination at the clock driver to dampen reflections; consult the PIC32MX3/4 family datasheet section 32 for oscillator design.

Estimated: For USB OTG designs using the PIC32MX450F256HT-I/MR, route the D+/D- traces as a 90-ohm differential pair with continuous ground reference on both sides, keeping length matching to within 150 mil. Place the 27 ohm series termination resistors within 2 mm of the MCU's USB pins. Use Microchip's AN1166 layout guidelines as reference; proper USB trace impedance is critical for USB compliance testing and signal integrity.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Qualified
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Compliant

RoHS and REACH compliant per Microchip product documentation. Not AEC-Q100 qualified; for automotive applications use PIC32MX variants with explicit automotive grade designation.

Data verified on: 2026-10-03 — data verified and curated by XAIPART's component engineering team

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