FT4222HQ-D-R - USB 2.0 to Quad SPI/I2C Bridge | FTDI
MPN: FT4222HQ-D-R ✓ Active| Qty | Unit Price | Extended |
|---|---|---|
| 1 | $4.5 | $4.50 |
| 10 | $4.05 | $40.50 |
| 100 | $3.6 | $360.00 |
| 500 | $3.2 | $1,600.00 |
| 1,000 | $2.85 | $2,850.00 |
FT4222HQ-D-R Overview
A USB bridge IC is a mixed-signal interface device that converts one serial bus protocol into another so a host CPU can talk to peripherals it cannot address natively. In the FT4222H the USB 2.0 PHY and protocol stack sit on one side, while the downstream side exposes configurable SPI (single/dual/quad mode) and an I2C master/slave controller. This places the part inside the broader hierarchy: USB bridge -> serial interface IC -> interface & connectivity -> mixed-signal semiconductor.
Key features include support for multi-voltage I/O (3.3 V, 2.5 V, or 1.8 V VCCIO), an integrated 5 V1 to 3.3 V LDO requiring no external regulator, 128 bytes of OTP memory for vendor information, and an external 12 MHz crystal that feeds the internal PLL. The VQFN-EP package provides a low-thermal-resistance pad that allows sustained USB bus-powered operation without external heatsinking. GPIOs are multiplexed with the SPI data lines, allowing flexible board design.
The FT4222H uses a Hi-Speed USB 2.0 PHY with on-chip termination and a serial-interface engine, offloading all protocol handling from the host MCU. Suspend/resume, remote wake-up, and bus-powered operation are handled in hardware, which is why the part is widely used in plug-and-play dongles, LCD/LED display controllers, and industrial sensor hubs.
Typical applications include USB-to-SPI display bridges for TFT/OLED panels, USB-to-I2C sensor hubs, industrial USB instrumentation, and evaluation modules for FPGA/CPLD programming. The combination of Quad-SPI throughput and I2C in a single chip is particularly useful when a single USB port must drive both a high-bandwidth display and a cluster of low-speed sensors.
When designing with this part, place the 12 MHz crystal within 5 mm of the XIN/XOUT pins and provide a solid ground pour under the exposed pad. Add 100 nF decoupling on each VCCIO rail and 4.7 uF on VBUS. The OTP memory is write-protected after the first programming cycle, so commit vendor data only once.
This page synthesizes distributor pricing, drop-in alternatives, and practical design notes not found in the standalone FTDI datasheet, giving procurement and engineering teams a single reference for the FT4222HQ-D-R.
Drop-in alternatives for FT4222HQ-D-R — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.
Variants in this series
Same-series models that are drop-in compatible with FT4222HQ-D-R (same form factor and footprint) — differing in Function, OTP Memory, Package, USB Speed.
Quick Comparison Tool — Select alternative parts for side-by-side comparison:
FT4222H
✅ Drop-In📋 Reference alternative (not in catalog)
FT4222HQ-C-T
✅ Drop-In📋 Reference alternative (not in catalog)
FT4222HQ-D
✅ Drop-In📋 Reference alternative (not in catalog)
FT4222HQ-D-R Specifications
| Function | USB 2.0 to Quad-SPI / I2C Bridge Controller |
| USB Speed | Hi-Speed (480 Mbps) / Full-Speed (12 Mbps) USB 2.0 |
| Downstream Interfaces | Quad-SPI (up to 4 SPI slaves), I2C master/slave |
| Maximum Throughput | 53.8 Mbps |
| I/O Voltage (VCCIO) | 1.8 V / 2.5 V / 3.3 V (multi-voltage) |
| Supply Voltage (VBUS) | 5 V (USB bus powered) |
| Internal Regulator | 5 V1 to 3.3 V LDO integrated |
| Clock Source | External 12 MHz crystal (internal PLL) |
| OTP Memory | 128 bytes one-time-programmable |
| GPIOs | Multiplexed with SPI data lines |
| Package | VQFN-32 EP (5x5 mm) |
| Mounting Type | Surface Mount |
| Operating Temperature | -40C to +85C |
| RoHS Status | Compliant |
FT4222HQ-D-R Pin Configuration
| Pin 1 | VCCIO — I/O supply voltage (1.8 V / 2.5 V / 3.3 V) |
| Pin 2 | GND — Ground |
| Pin 3 | XIN — 12 MHz crystal input |
| Pin 4 | XOUT — 12 MHz crystal output |
| Pin 5 | VBUS — USB 5 V supply input |
| Pin 6 | GND — Ground |
| Pin 7 | RESET — Active-low reset input |
| Pin 8 | TEST — Test pin (per datasheet, leave NC in production) |
| Pin 9 | DM — USB D- data line |
| Pin 10 | DP — USB D+ data line |
| Pin 11 | GND — Ground |
| Pin 12 | SCL — I2C clock (master/slave) |
| Pin 13 | SDA — I2C data (master/slave) |
| Pin 14 | MOSI — SPI Master Out / Slave In (data 0) |
| Pin 15 | MISO — SPI Master In / Slave Out (data 1) |
| Pin 16 | IO2 — SPI data 2 (Quad-SPI WP#) |
| Pin 17 | IO3 — SPI data 3 (Quad-SPI HOLD#) |
| Pin 18 | SPICS — SPI chip select (active low) |
| Pin 19 | SPICLK — SPI clock |
| Pin 20 | GPIO0 — General-purpose IO 0 / SPI data |
| Pin 21 | GPIO1 — General-purpose IO 1 / SPI data |
| Pin 22 | GPIO2 — General-purpose IO 2 / SPI data |
| Pin 23 | GPIO3 — General-purpose IO 3 / SPI data |
| Pin 24 | VCC — 3.3 V internal LDO output |
| Pin 25 | GND — Ground |
| Pin 26 | NC — Not connected (per datasheet) |
| Pin 27 | NC — Not connected (per datasheet) |
| Pin 28 | NC — Not connected (per datasheet) |
| Pin 29 | NC — Not connected (per datasheet) |
| Pin 30 | NC — Not connected (per datasheet) |
| Pin 31 | NC — Not connected (per datasheet) |
| Pin 32 | EP — Exposed thermal pad (connect to GND) |
Typical Applications
FT4222HQ-D-R is suitable for 6 applications: USB to TFT/OLED Display Bridge, USB to I2C Sensor Hub, FPGA/CPLD Configuration Flash Loader, Industrial USB Instrumentation, LED Matrix Driver Bridge, USB Evaluation Module for Prototyping.
USB to TFT/OLED Display Bridge
The FT4222HQ-D-R's Quad-SPI mode delivers up to 53.8 Mbps downstream, sufficient to refresh small TFT and OLED panels from a USB host at 30+ fps. Its integrated 5 V1 to 3.3 V LDO and configurable VCCIO (1.8 V / 2.5 V / 3.3 V) mean no external regulator is required to match common display logic levels. The FT4222HQ-D-R sits between the USB VBUS rail and the panel's SPI pins, with frame data pushed from the host driver through the FTDI D2XX/D3XX library. Trade-off: the FT4222HQ-D-R adds one USB enumeration step but eliminates the host MCU that would otherwise have to bit-bang SPI.
Recommended
USB to I2C Sensor Hub
The FT4222HQ-D-R's I2C master/slave controller lets a USB host read clusters of I2C sensors (temperature, humidity, accelerometers) up to 400 kHz. The configurable VCCIO rail matches 1.8 V and 3.3 V sensor logic levels without level shifters. Placed between VBUS and the sensor I2C bus, with 4.7 kohm pull-ups on SCL/SDA, the FT4222HQ-D-R acts as a bus master. Trade-off vs a CP2112: the FT4222HQ-D-R is more expensive but adds Quad-SPI for an attached flash logging IC.
Recommended
FPGA/CPLD Configuration Flash Loader
The FT4222HQ-D-R's Quad-SPI throughput (up to 53.8 Mbps) makes it a compact USB-to-SPI flash programmer for FPGA configuration memories (e.g., EPCQ16, EPCQ32). The 128-byte OTP memory can store vendor IDs and bitstream version tags, simplifying factory programming. Placed between USB and the FPGA configuration flash SPI pins, the FT4222HQ-D-R can re-program the flash in seconds vs minutes over UART. Trade-off: requires a host-side FT_Prog-style loader, but eliminates the need for a JTAG programmer on the manufacturing fixture.
Recommended
Industrial USB Instrumentation
The FT4222HQ-D-R's industrial temperature range (-40C to +85C) and Hi-Speed USB 2.0 make it a fit for industrial USB instruments that stream SPI ADC data to a host. The integrated 5 V1 to 3.3 V LDO and bus-powered operation simplify enclosure design. Placed at the USB-B connector with downstream SPI to a 24-bit ADC, the FT4222HQ-D-R delivers 53.8 Mbps throughput, sufficient for kilohertz-rate multi-channel acquisition. Trade-off: industrial users must use shielded cables and add ESD protection on USB DP/DM lines.
Recommended
LED Matrix Driver Bridge
The FT4222HQ-D-R can drive LED matrix drivers that use SPI (e.g., APA102, SK9822) at the maximum 53.8 Mbps downstream throughput, supporting thousands of pixels per USB update. Its multi-voltage VCCIO matches 5 V and 3.3 V LED driver levels. Placed between the USB host and the LED data line, the FT4222HQ-D-R replaces a dedicated MCU, reducing BOM cost. Trade-off: the FT4222HQ-D-R has only one Quad-SPI port, so multi-string panels need additional FT4222H ICs.
Recommended
USB Evaluation Module for Prototyping
The FTDI UMFT4222EV-D development module uses the FT4222HQ-D-R, giving designers a USB-to-SPI/I2C prototyping platform before committing to a custom PCB. The 12 MHz external crystal, decoupling, and exposed-pad solder footprint are pre-routed, accelerating firmware development. Placed on a breadboard with FTDI D2XX drivers loaded, the FT4222HQ-D-R validates USB enumeration and SPI timing. Trade-off: the eval module adds USB connector and crystal cost that a production design can integrate on-board.
Recommended
Recommended Products Summary
Engineering reference data for FT4222HQ-D-R — comparison, design guidance, and compliance information.
Selection Guide
Comparison with Alternatives
| Parameter | This Product | FT4222H | FT4222HQ-C-T | FT4222HQ-D |
|---|---|---|---|---|
| Brand | FTDI | FTDI | FTDI | FTDI |
| Package | VQFN-32 EP (5x5 mm) | VQFN-32 EP (5x5 mm) - same | VQFN-32 EP (5x5 mm) - same | VQFN-32 EP (5x5 mm) - same |
| USB Speed | Hi-Speed USB 2.0 (480 Mbps) | Hi-Speed USB 2.0 (480 Mbps) | Hi-Speed USB 2.0 (480 Mbps) | Hi-Speed USB 2.0 (480 Mbps) |
| Downstream Interface | Quad-SPI + I2C | Quad-SPI + I2C | Quad-SPI + I2C | Quad-SPI + I2C |
| Max Throughput | 53.8 Mbps | 53.8 Mbps | 53.8 Mbps | 53.8 Mbps |
| Crystal Required | 12 MHz external | 12 MHz external | 12 MHz external | 12 MHz external |
| Packaging | Tape & Reel (-D-R) | Tray | Tape & Reel (-T) | Bulk |
| Operating Temperature | -40C to +85C | -40C to +85C | 0C to +70C (commercial) | -40C to +85C |
Key Differentiators
- Quad-SPI + I2C in one USB bridge IC (vs FT2232H)
- Multi-voltage VCCIO (1.8 V / 2.5 V / 3.3 V) (vs FT232HL-REEL)
- Integrated 5 V1 to 3.3 V LDO with 128-byte OTP (vs FT4222HQ-C-T)
Design Notes
Place the 12 MHz crystal within 5 mm of the FT4222HQ-D-R XIN and XOUT pins, route traces symmetrically, and surround them with a ground pour. Add the crystal manufacturer's recommended load capacitors (commonly 12 pF to 33 pF) directly across XIN and XOUT to GND. The exposed thermal pad (pin 32/EP) MUST be soldered to a grounded copper pour for thermal dissipation and electrical reference.
The FT4222HQ-D-R integrates a 5 V1 to 3.3 V LDO, but a 4.7 uF low-ESR capacitor on VBUS is required for USB inrush and a 100 nF on VCCIO is required for downstream logic noise. If the downstream SPI bus runs above 30 MHz, add a 10 uF bulk on VCCIO. VBUS can be supplied directly from the USB connector; no external 5 V regulator is required for bus-powered designs.
The 128-byte OTP memory in the FT4222HQ-D-R is one-time-programmable: once written, it cannot be erased or rewritten. Verify vendor data before committing. Do not connect the TEST pin (pin 8) to any signal in production; leave it per datasheet guidance. Suspend current rises if the I2C bus is held low during USB suspend, so release SCL/SDA before the host suspends.
Compliance Information
RoHS compliant per DigiKey and Mouser listings. Not AEC-Q100 qualified (consumer/industrial USB bridge). Lead-free reflow compatible per FTDI datasheet. REACH compliance not explicitly stated; assume compliant per FTDI policy.
