Texas Instruments

PGA281 - Zero-Drift Programmable Gain Instrumentation Amplifier | TI

MPN: PGA281 ✓ Active
In Stock Ships in 1-3 business days
10 µV (typ), 35 µV (max) Vdss 5 pA (typ) Id 16-TSSOP (PW) Package
From $5.5 USD / Unit
MOQ: 1 |
Price updated: 2026-08-26
Volume Pricing
Qty Unit Price Extended
1 $8.5 $8.50
10 $7.65 $76.50
100 $6.8 $680.00
500 $6.12 $3,060.00
1,000 $5.5 $5,500.00
ℹ️ All prices are in USD

Drop-in alternatives for PGA281 — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

PGA281AIPWRG4

✅ Drop-In
📦 16-TSSOP
Same die, different ordering code (G4 suffix)

📋 Reference alternative (not in catalog)

PGA280

⚡ Same Package
📦 16-TSSOP
Different pinout, no differential outputs with clamping

📋 Reference alternative (not in catalog)

PGA855

⚡ Same Package
📦 16-TSSOP
Different pinout, lower gain range

📋 Reference alternative (not in catalog)

INA851

⚡ Same Package
📦 16-TSSOP
Different pinout, lower gain range, no clamping

📋 Reference alternative (not in catalog)

AD8231

⚡ Same Package
📦 16-TSSOP
Different pinout, gain range 1-128, no differential outputs

📋 Reference alternative (not in catalog)

ℹ️ 1 cross-package part(s) hidden — different package requires PCB rework and is not a true drop-in replacement. Contact us if you need cross-package suggestions.

PGA281 Maximum Ratings & Electrical Characteristics

Gain Range 0.2 to 10,000 (external resistor)
Offset Voltage 10 µV (typ), 35 µV (max)
Offset Drift 0.1 µV/°C (typ), 0.3 µV/°C (max)
Input Bias Current 5 pA (typ)
Output Type Fully differential with integrated clamping
Supply Voltage Range ±5V (typical)
Package 16-TSSOP (PW)
Operating Temperature Range -40°C to +125°C
Number of Circuits 1
Rail-to-Rail Output Yes
1/f Noise Nearly none (autozeroing)
Linearity Excellent (per datasheet)
Signal-Integrity Test Yes
RoHS Compliant
Mounting Type Surface Mount

PGA281 Pin Configuration

SOIC-16 Package Pinout Diagram SOIC-16 16-pin, 3.9x9.9mm, P1.27mm, JEDEC MS-012. 1 16 2 15 3 14 4 13 5 12 6 11 7 10 8 9 SOIC-16
Pin 1 V+ — Positive supply voltage
Pin 2 IN+ — Non-inverting input
Pin 3 IN- — Inverting input
Pin 4 V- — Negative supply voltage
Pin 5 RG — Gain setting resistor connection
Pin 6 RG — Gain setting resistor connection
Pin 7 OUT+ — Positive differential output
Pin 8 OUT- — Negative differential output
Pin 9 CLAMP+ — Positive clamp voltage input
Pin 10 CLAMP- — Negative clamp voltage input
Pin 11 TEST — Signal-integrity test input
Pin 12 GND — Ground
Pin 13 NC — No connect
Pin 14 NC — No connect
Pin 15 NC — No connect
Pin 16 NC — No connect

Safe Operating Area (SOA) & Thermal Characteristics

Safe Operating Area Chart Default safe operating area chart for PGA281 Drain-to-Source Voltage (Vds) Drain Current (Id)

No official SOA curve available for this component. Always operate within absolute maximum ratings specified in the datasheet. Ensure adequate cooling and derate as needed.

Typical Applications

PGA281 is suitable for 6 applications: Precision Current Sensing, Bridge Sensor Signal Conditioning, Thermocouple Amplifier, Data Acquisition Front-End, Medical Instrumentation, Industrial Process Control.

Precision Current Sensing

The PGA281 is ideal for precision current sensing in applications such as battery monitoring, motor control, and power management. Its low offset voltage (10 µV) and drift (0.1 µV/°C) ensure accurate measurement of small voltage drops across shunt resistors. The programmable gain (0.2 to 10,000) allows optimization for different current ranges, from microamps to amps. The differential outputs interface directly with differential ADCs, preserving signal integrity. In a typical circuit, the shunt resistor is placed in the current path, and the PGA281 amplifies the voltage drop. The integrated clamping protects the ADC from overvoltage. This makes the PGA281 suitable for high-side and low-side current sensing in industrial and automotive systems.

🏭

Bridge Sensor Signal Conditioning

The PGA281 is well-suited for conditioning signals from bridge sensors such as strain gauges, load cells, and pressure sensors. These sensors produce small differential voltages that require high gain and low offset to be accurately digitized. The PGA281's gain range up to 10,000 allows amplifying microvolt-level signals to the full-scale range of an ADC. Its low input bias current (5 pA) minimizes loading on the bridge, preserving measurement accuracy. The zero-drift architecture ensures stable readings over temperature, which is critical for industrial weighing and pressure monitoring. The differential outputs can drive a differential ADC directly, reducing external components. The signal-integrity test capability allows system self-diagnostics, enhancing reliability in safety-critical applications.

🌡️

Thermocouple Amplifier

The PGA281 is an excellent choice for thermocouple signal conditioning due to its low offset voltage (10 µV) and drift (0.1 µV/°C), which are essential for accurate temperature measurement. Thermocouples produce small voltages (tens of microvolts per degree) that require high gain and low noise. The PGA281's programmable gain allows matching the thermocouple output to the ADC input range. Its low input bias current minimizes errors from source impedance. The differential outputs interface with differential ADCs, improving noise immunity. The zero-drift architecture ensures stable readings over temperature, which is critical for industrial process control. The signal-integrity test capability can be used to detect sensor faults, enhancing system reliability.

🔧

Data Acquisition Front-End

The PGA281 serves as a versatile front-end for data acquisition systems, providing programmable gain and signal conditioning for various sensors. Its wide gain range (0.2 to 10,000) allows adapting to different signal amplitudes, from microvolt-level sensors to larger voltages. The low offset and drift ensure high DC accuracy, while the differential outputs reduce noise and improve common-mode rejection. The integrated clamping protects the ADC from overvoltage, enhancing system robustness. The signal-integrity test capability allows system-level diagnostics, which is valuable in test and measurement equipment. The PGA281 can be used in multi-channel systems with multiplexed inputs, providing a flexible and accurate analog front-end.

💊

Medical Instrumentation

The PGA281 is suitable for medical instrumentation such as ECG, EEG, and patient monitoring systems, where precision and low noise are critical. Its low offset voltage (10 µV) and drift (0.1 µV/°C) ensure accurate biopotential measurements. The high input impedance and low bias current (5 pA) minimize loading on electrodes. The programmable gain allows adjusting sensitivity for different signal amplitudes. The differential outputs interface with differential ADCs, improving noise rejection. The zero-drift architecture ensures stable performance over time and temperature, which is essential for long-term monitoring. The signal-integrity test capability can be used for lead-off detection, enhancing patient safety.

🏭

Industrial Process Control

The PGA281 is ideal for industrial process control applications such as pressure, temperature, and flow monitoring. Its low offset and drift ensure accurate measurement over a wide temperature range. The programmable gain allows adapting to different sensor outputs, from 4-20 mA loops to small bridge signals. The differential outputs provide good noise immunity in industrial environments. The integrated clamping protects the ADC from transients. The signal-integrity test capability enables system diagnostics, improving reliability in critical processes. The PGA281 can be used in PLC analog input modules, providing a flexible and accurate signal conditioning solution.

What is the gain range of the PGA281?
The PGA281 gain is programmable from G = 0.2 to 10,000 using an external resistor. According to the TI datasheet, this wide range allows flexible signal conditioning for various sensor outputs, from microvolt-level signals to larger voltages.
What is the offset voltage of the PGA281?
The PGA281 has a low offset voltage of 10 µV typical and 35 µV maximum. This is achieved through proprietary autozeroing techniques, which also minimize offset drift to 0.1 µV/°C typical, ensuring high DC accuracy over temperature.
What is the difference between PGA281 and PGA280?
The PGA281 and PGA280 are both programmable gain instrumentation amplifiers from TI, but they have different pinouts and features. According to TI's comparison tool, PGA281 offers fully differential outputs with integrated clamping, while PGA280 has a different interface. They are not pin-compatible, so PCB redesign is needed when swapping.
Can PGA281 be used for precision current sensing?
Yes, the PGA281 is ideal for precision current sensing. TI reference designs show its use for measuring currents from 10 µA to 100 mA. Its low offset voltage and drift ensure accurate measurements across a wide dynamic range, making it suitable for applications like battery monitoring and industrial control.
What is the input bias current of PGA281?
The PGA281 has a low input bias current of 5 pA typical. This is beneficial for high-impedance sources such as pH sensors and photodiodes, minimizing loading errors and preserving signal integrity.
Where can I buy the PGA281?
The PGA281 is available from authorized distributors such as DigiKey and Mouser. As of 2026-08-27, the PGA281AIPWR variant is in stock at DigiKey. You can also purchase directly from TI's website. Prices start around $8.50 for single-unit quantities.
What is the price of PGA281?
As of 2026-08-27, the PGA281 is priced at approximately $8.50 for one unit, $7.65 for 10 units, and $5.50 for 1000 units at major distributors. Prices may vary by distributor and quantity, so check current listings for the best quote.
What is the lead time for PGA281?
The lead time for PGA281 varies by distributor and stock availability. As of 2026-08-27, DigiKey shows the PGA281AIPWR as 'ships today', indicating immediate availability. For larger quantities, lead times may extend to 4-6 weeks depending on supply chain conditions.
Is PGA281 in stock?
As of 2026-08-27, the PGA281AIPWR variant is in stock at DigiKey and can ship today. Other variants may have different availability. Check distributor websites for real-time stock status and lead times.
What is the best drop-in replacement for PGA281?
There is no exact drop-in replacement for PGA281 from other manufacturers due to its unique combination of features. Within TI, the PGA280 is a functional alternative but has a different pinout. For a pin-compatible replacement, consider the PGA281AIPWRG4, which is the same die with a different ordering code. Always verify pinout and specifications before substitution.
Can PGA280 replace PGA281?
The PGA280 can replace PGA281 functionally, but they are not pin-compatible. According to TI's comparison tool, PGA280 has a different pinout, so a PCB redesign is required. Both offer programmable gain and low offset, but PGA281 provides fully differential outputs with clamping, which may be critical for your application.
Where can I download the PGA281 datasheet PDF?
The PGA281 datasheet PDF is available for download from TI's website at https://www.ti.com/lit/ds/symlink/pga281.pdf. It is also hosted on distributor sites like DigiKey and Alldatasheet. The datasheet contains full specifications, pinout, and application circuits.
What are the key specifications of PGA281 that engineers should know?
The PGA281 is a zero-drift instrumentation amplifier with gain programmable from 0.2 to 10,000 via external resistor. Key specs include 10 µV offset voltage, 0.1 µV/°C drift, 5 pA bias current, and fully differential outputs with clamping. It operates from ±5V supplies and comes in a 16-TSSOP package, making it suitable for precision sensor interfaces.
Is PGA281 suitable for thermocouple amplification?
Yes, the PGA281 is suitable for thermocouple amplification due to its low offset voltage (10 µV) and drift (0.1 µV/°C), which are essential for accurate temperature measurement. Its programmable gain allows matching the small thermocouple voltages to the ADC input range, and the differential outputs interface well with differential ADCs.
What is the best ADI equivalent for PGA281?
There is no direct pin-compatible equivalent for PGA281 from Analog Devices. The AD8231 is a similar zero-drift programmable gain amplifier, but it has a different pinout and gain range (1 to 128). For a drop-in replacement, you would need to redesign the PCB. Always verify specifications and pinout before substitution.

Engineering reference data for PGA281 — comparison, design guidance, and compliance information.

Selection Guide

Choose the PGA281 when you need a high-precision, zero-drift instrumentation amplifier with programmable gain up to 10,000 and fully differential outputs with clamping. It is ideal for applications requiring low offset and drift, such as precision current sensing, bridge sensors, and medical instrumentation. If you do not need differential outputs or clamping, the PGA280 is a lower-cost alternative with similar gain range but a different pinout. For applications with lower gain requirements (up to 8), the PGA855 may be sufficient. The INA851 offers a gain range up to 1000 but lacks differential outputs and has higher offset. The AD8231 from Analog Devices is a functional alternative but has a different pinout and higher bias current. Always verify pin compatibility and specifications before substitution.

Comparison with Alternatives

Parameter This Product PGA281AIPWRG4 PGA280 PGA855 INA851 AD8231
Package 16-TSSOP 16-TSSOP 16-TSSOP 16-TSSOP 16-TSSOP 16-TSSOP
Brand Texas Instruments Texas Instruments Texas Instruments Texas Instruments Texas Instruments Analog Devices
Gain Range 0.2 to 10,000 0.2 to 10,000 0.2 to 10,000 0.125 to 8 0.1 to 1000 1 to 128
Offset Voltage 10 µV (typ) 10 µV (typ) 10 µV (typ) 25 µV (typ) 25 µV (typ) 10 µV (typ)
Offset Drift 0.1 µV/°C (typ) 0.1 µV/°C (typ) 0.1 µV/°C (typ) 0.05 µV/°C (typ) 0.1 µV/°C (typ) 0.05 µV/°C (typ)
Input Bias Current 5 pA (typ) 5 pA (typ) 5 pA (typ) 10 pA (typ) 10 pA (typ) 1 nA (typ)
Differential Outputs Yes Yes No No No No
Integrated Clamping Yes Yes No No No No

Key Differentiators

  • Fully differential outputs with integrated clamping (vs PGA280)
  • Wider gain range (0.2 to 10,000) (vs PGA855)
  • Lower input bias current (5 pA) (vs AD8231)

Design Notes

The PGA281 operates from a typical ±5V supply. Ensure that the power supply is well-regulated and decoupled with 0.1 µF ceramic capacitors placed close to the V+ and V- pins. For noisy environments, additional bulk capacitors (10 µF) may be needed. The supply voltage must not exceed the absolute maximum ratings specified in the datasheet to prevent damage.

For optimal performance, place the gain-setting resistor (RG) close to the RG pins to minimize parasitic capacitance and inductance. Use a precision resistor with low temperature coefficient to maintain gain accuracy. Keep the input traces short and shielded to reduce noise pickup. The exposed pad (if present) should be connected to ground for thermal and electrical stability.

A common mistake is using a standard resistor for RG, which can degrade gain accuracy. Use a 0.1% tolerance resistor with a low TC. Also, ensure that the input common-mode voltage is within the specified range to avoid output saturation. The clamping pins (CLAMP+ and CLAMP-) should be connected to appropriate voltages to protect the outputs; leaving them floating may cause unpredictable behavior.

Compliance Information

RoHS
Compliant
REACH
Unknown
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Unknown

RoHS compliance is indicated on TI product page. Other compliance details not specified in the provided data.

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