Microchip Technology

PIC18LF2221T-I/ML - 8-bit PIC MCU, 4KB Flash, 28-QFN | Microchip

MPN: PIC18LF2221T-I/ML ✓ Active
In Stock Ships in 1-3 business days
2.0 V to 5.5 V Vdss 28-pin QFN (6x6 mm), 'ML' suffix Package 40 MHz (10 MIPS) Speed 4 KB (2K x 16) Memory
From $1.84 USD / Unit
MOQ: 1 |
Price updated: 2026-09-28
Volume Pricing
Qty Unit Price Extended
1 $3.42 $3.42
10 $3.05 $30.50
100 $2.61 $261.00
500 $2.34 $1,170.00
1,000 $2.1 $2,100.00
3,000 $1.84 $5,520.00
ℹ️ All prices are in USD

PIC18LF2221T-I/ML Overview

The Microchip Technology PIC18LF2221T-I/ML is an 8-bit PIC18F-series Flash microcontroller housed in a 28-pin QFN package (6x6 mm) with the tape-and-reel 'T' suffix, designed for low-voltage applications running from 2.0V to 5.5V. It executes instructions at up to 10 MIPS, integrates 4 KB of Flash program memory (2K x 16), 512 bytes of data SRAM, and provides 16 general-purpose I/O lines with peripherals including I2C, SPI, and an Enhanced USART.

An 8-bit PIC microcontroller is a CISC-style, Harvard-architecture CMOS device that executes one instruction per instruction cycle (4 clock cycles) and uses a RISC-like, fixed-length instruction word to balance code density with deterministic timing. Within the broader taxonomy, the PIC18 sits between Microchip's baseline PIC10/12/16 family and the enhanced PIC24/dsPIC33 line: 8-bit core, but with linear memory, hardware multiply, and C-friendly extensions. PIC18F variants are the Flash-based mainstream; the 'LF' prefix designates the lower-voltage (2.0-5.5V) cell that replaces the older PIC18F 4.2-5.5V range for battery and energy-harvesting designs.

Key differentiating features of the PIC18LF2221 include the PIC18 instruction set (77 single-word instructions, hardware 8x8 multiply), a 10-bit ADC with up to 10 channels, two 8-bit timers plus one 16-bit timer, a Capture/Compare/PWM module, nanoWatt power management with multiple idle and sleep modes, an ICD-friendly in-circuit debug header, and an on-chip EEPROM emulation region in Flash. The integrated POR/BOR/WDT supervisory set reduces external component count.

The silicon uses a low-power CMOS process and a 4-phase internal clock derived from the user-selected oscillator block (HS, XT, LP, RC, internal 8 MHz/31 kHz), enabling either crystal-accurate timing or low-Iq operation down to a few microamps in sleep. Two priority levels of interrupt, a hardware stack, and a deterministic interrupt response make it well-suited to motor control and sensor sampling loops.

Typical applications include industrial sensor nodes, low-power handheld instruments, consumer appliances with HMI, USB/HID-free embedded controllers, and small motor or lighting controllers. It is well-matched wherever a deterministic 8-bit core, small Flash footprint, and 2-5.5V battery operation are needed.

A key design consideration when laying out the 28-QFN is the exposed thermal pad: it must be soldered to the board ground pour both for thermal dissipation and for the package's electrical ground reference, otherwise supply return impedance rises and analog readings drift. Decoupling should use a 100 nF X7R close to each VDD/VSS pair plus a bulk 4.7 uF on the main rail.

This page synthesizes Microchip datasheet specifications, current distributor pricing, drop-in QFN-28 alternatives from the same PIC18 family and competing vendors, and practical design notes that are not bundled on the manufacturer's product page.

Drop-in alternatives for PIC18LF2221T-I/ML — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with PIC18LF2221T-I/ML (same form factor and footprint) — differing in Operating Temperature, Package, Communication, Timers, ADC.

Microchip Technology
Operating Temperature: -40C to +85C (Industrial)
Package: QFN-28 (ML) 6x6 mm with exposed pad
Communication: MSSP (SPI/I2C), Enhanced USART
Microchip Technology
Operating Temperature: -40C to +85C (industrial, -I)
Package: 28-VQFN (6x6 mm) with exposed pad
Communication: EUSART (LIN), MSSP (SPI/I2C)
Microchip Technology
Operating Temperature: -40C to +85C (Industrial)
Package: QFN-28 (ML) 6x6 mm with exposed pad
Communication: EUSART, MSSP (I2C/SPI)
Microchip Technology
Operating Temperature: -40C to +85C (Industrial, I grade)
Package: 28-SSOP (209 mil)
Communication: 1 x EUSART, 1 x MSSP (SPI / I2C)

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

PIC18LF2221-I/ML

✅ Drop-In ⚠️ Specs Unverified
Microchip Technology
📦 28-QFN (6x6 mm)
PIC18 8-bit RISC · 4 KB (2K x 16) Flash · 512 bytes · 256 bytes · 40 MHz (10 MIPS) · 2.0 V to 3.6 V · 10-bit, up to 13 channels · 2x 8-bit, 1x 16-bit

✓ In Stock

$1.4 / Unit

View Datasheet →

PIC18F2221-I/ML

✅ Drop-In
📦 28-QFN (6x6 mm)
Same 28-QFN footprint, VDD range 4.2-5.5V vs 2.0-5.5V (+110% upper limit, cannot operate below 4.2V); pin-compatible for 5V rails

📋 Reference alternative (not in catalog)

PIC18LF2321-I/ML

✅ Drop-In ⚠️ Specs Unverified
Microchip Technology
📦 28-QFN (6x6 mm)
PIC 8-bit RISC · 16-bit · 8 KB (4K x 16) · 512 bytes · 256 bytes · 40 MHz (10 MIPS) · 2.0 V to 5.5 V · 25

✓ In Stock

$2.1 / Unit

View Datasheet →

PIC18F2321-I/ML

✅ Drop-In
Microchip Technology
📦 28-QFN (6x6 mm)
PIC18F · PIC 8-bit RISC · 8 KB (4K x 16) Flash · 512 bytes · 256 bytes · 40 MHz (10 MIPS) · 77 single-word instructions · 10-bit, up to 10 channels

✓ In Stock

$3.17 / Unit

View Datasheet →

PIC18LF2220-I/ML

✅ Drop-In ⚠️ Specs Unverified
📦 28-QFN (6x6 mm)
Same 28-QFN footprint, no ADC module vs 10-bit ADC integrated (-1 peripheral), 2.0-5.5V; pin-compatible for non-ADC designs

📋 Reference alternative (not in catalog)

PIC18LF2221T-I/ML Maximum Ratings & Electrical Characteristics

Core Architecture PIC18F (8-bit, Harvard, RISC-like)
Instruction Set Width 16-bit (77 single-word instructions)
Maximum CPU Speed 40 MHz (10 MIPS)
Program Memory (Flash) 4 KB (2K x 16)
Data SRAM 512 bytes
Data EEPROM 256 bytes (emulated in Flash per family)
Supply Voltage (VDD) 2.0 V to 5.5 V
I/O Pins 16
Timers Two 8-bit + one 16-bit (TMR0/TMR1/TMR2)
Capture/Compare/PWM 1 CCP module
ADC 10-bit, up to 10 channels
Serial Interfaces I2C (MSSP), SPI (MSSP), Enhanced USART
Operating Temperature -40 C to +85 C (Industrial, 'I' suffix)
Package 28-pin QFN (6x6 mm), 'ML' suffix
Mounting Type Surface Mount
Packaging Tape and Reel ('T' suffix)
RoHS Status Compliant (LEAD FREE per digchip listing)
Oscillator Modes HS, XT, LP, RC, internal 8 MHz, internal 31 kHz
Power-Saving Modes nanoWatt: Sleep, Idle, multiple Run modes
Debug In-Circuit Debug (ICD) via PGD/PGC pins

PIC18LF2221T-I/ML Pin Configuration

QFN-28 Package Pinout Diagram QFN-28 5x5mm, P0.5mm, EP 3.1x3.1mm, JEDEC MO-220. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 QFN-28
Pin 1 RA2/AN2/VREF- — GPIO port A bit 2 / Analog input 2 / ADC negative reference
Pin 2 RA3/AN3/VREF+ — GPIO port A bit 3 / Analog input 3 / ADC positive reference
Pin 3 RA4/T0CKI/C1OUT — GPIO port A bit 4 / Timer0 clock input / Comparator 1 output
Pin 4 RA5/AN4/SS/HLVDIN — GPIO port A bit 5 / Analog input 4 / SPI slave select / High-low voltage detect input
Pin 5 VSS — Ground reference
Pin 6 OSC1/RA7 — External oscillator input / GPIO port A bit 7
Pin 7 OSC2/RA6 — External oscillator output / GPIO port A bit 6
Pin 8 RC0/T1OSO/T1CKI — GPIO port C bit 0 / Timer1 oscillator output / Timer1 clock input
Pin 9 RC1/T1OSI/CCP2 — GPIO port C bit 1 / Timer1 oscillator input / CCP2
Pin 10 RC2/CCP1 — GPIO port C bit 2 / CCP1 PWM module
Pin 11 RC3/SCK/SCL — GPIO port C bit 3 / SPI clock / I2C clock
Pin 12 RC4/SDI/SDA — GPIO port C bit 4 / SPI data in / I2C data
Pin 13 RC5/SDO — GPIO port C bit 5 / SPI data out
Pin 14 RC6/TX/CK — GPIO port C bit 6 / USART transmit / USART clock
Pin 15 RC7/RX/DT — GPIO port C bit 7 / USART receive / USART data
Pin 16 VSS — Ground reference (second VSS pin)
Pin 17 VDD — Positive supply voltage 2.0V to 5.5V
Pin 18 RB0/INT0/FLT0 — GPIO port B bit 0 / External interrupt 0 / PWM fault input
Pin 19 RB1/INT1 — GPIO port B bit 1 / External interrupt 1
Pin 20 RB2/INT2 — GPIO port B bit 2 / External interrupt 2
Pin 21 RB3/CCP2 — GPIO port B bit 3 / CCP2 (alternate pin)
Pin 22 RB4 — GPIO port B bit 4
Pin 23 RB5/PGM — GPIO port B bit 5 / LVP programming input
Pin 24 RB6/PGC — GPIO port B bit 6 / ICD clock
Pin 25 RB7/PGD — GPIO port B bit 7 / ICD data
Pin 26 RA0/AN0 — GPIO port A bit 0 / Analog input 0
Pin 27 RA1/AN1 — GPIO port A bit 1 / Analog input 1
Pin 28 VDD — Positive supply voltage (second VDD pin)

Typical Applications

PIC18LF2221T-I/ML is suitable for 6 applications: Battery-Powered Sensor Node, Industrial Control and Appliance HMI, Small Motor and Lighting Controller, Consumer Remote Control and Wireless Sensor, Smart Energy Meter and Sub-Metering, Educational and Maker Development Platform.

🧩

Battery-Powered Sensor Node

The PIC18LF2221T-I/ML is purpose-built for 2.0-5.5V battery-powered sensor nodes that need deterministic, low-Iq operation across long sleep intervals. Its 2.0V minimum VDD lets a 2x AA alkaline pack or end-of-life Li-ion cell still drive the MCU without a boost converter, while the nanoWatt sleep mode drops Iq into the microamp range. The 10-bit ADC with up to 10 channels handles temperature, humidity, and battery-monitor inputs without external muxing, and the 4 KB Flash is sufficient for periodic-sampling firmware with on-chip EEPROM emulation for nonvolatile log storage. Unlike a Cortex-M0+, the PIC18F core guarantees deterministic interrupt latency critical for sensor timing budgets. Place the QFN exposed pad on the board ground pour to keep the analog reference clean.

🏭

Industrial Control and Appliance HMI

In industrial control panels and white-goods human-machine interfaces, the PIC18LF2221T-I/ML drives keypad scanning, LED multiplexing, and UART-to-master links within a 28-QFN footprint that survives the -40 to +85 C industrial temperature range. Its Enhanced USART handles RS-485 or RS-232 communication to a main controller, while the MSSP port runs an SPI or I2C keypad/display module. The 16 GPIOs are sufficient for a 4x4 keypad plus seven-segment or character-LCD drive. The CCP module generates PWM for backlight dimming or buzzer tones, and nanoWatt modes let the controller idle between user interactions to meet ENERGY STAR standby budgets. The LF cell supports 24V industrial bus rails stepped down to 5V or 3.3V without concern for 4.2V brown-out.

💡

Small Motor and Lighting Controller

The PIC18LF2221T-I/ML drives small brushed DC motors, stepper logic sequencers, and LED lighting strips using its 16-bit Timer1 plus the CCP PWM module. With one CCP channel it can produce center-aligned or edge-aligned PWM at programmable frequency and duty cycle, perfect for fan-speed control, solenoid PWM, or constant-current LED dimming. The 10 MIPS instruction throughput is fast enough for software PI control loops at 1 kHz update rate, while 512 bytes of SRAM hold control variables and lookup tables for non-linear LED gamma correction. The 2.0-5.5V LF cell lets a single-cell Li-ion or 3.3V regulated rail drive both the MCU and the power stage directly, simplifying BOM cost.

📱

Consumer Remote Control and Wireless Sensor

For handheld remote controls, key fobs, and wireless sensor end-nodes, the PIC18LF2221T-I/ML provides deterministic low-power control of a sub-GHz transceiver or IR LED over SPI/I2C. Its nanoWatt sleep currents below 1 uA combined with LF 2.0V operation maximize battery life on coin cells or 2x AAA. The Enhanced USART or MSSP bus interfaces directly with common 433/868 MHz transceivers, while 16 GPIOs handle keypad matrix, LED indicators, and wake interrupts. The 4 KB Flash is ample for proprietary RF protocol stacks or IR RC-5/RC-6 encoders, and the in-circuit debugger allows code development without expensive emulator tools.

⚡

Smart Energy Meter and Sub-Metering

In single-phase smart energy meters and submetering modules, the PIC18LF2221T-I/ML samples current and voltage via its 10-bit ADC, computes energy on-chip, and reports results over UART to a concentrator or display driver. The CCP module times precise sampling windows synchronized to the AC line via Timer1 with capture, while nanoWatt modes keep standby consumption below the 1W budget mandated by EU standby regulations. The 4 KB Flash holds calibration tables and IEC 62053-21 reference algorithms. The LF 2.0-5.5V range lets the meter work from a 3.3V auxiliary rail fed by a transformerless capacitive-drop supply or a small switching supply, simplifying isolation design.

🔧

Educational and Maker Development Platform

The PIC18LF2221T-I/ML is a popular teaching microcontroller in universities and maker communities because the PIC18 instruction set is well-documented in textbooks, and Microchip's MPLAB X IDE with XC8 compiler is free. Its 28-QFN package is breadboard-adaptable via breakout boards, and the on-chip ICD allows step-through debugging without a separate emulator. With 4 KB Flash, 512 bytes SRAM, and a 10-bit ADC, students learn timer interrupts, ADC conversion, USART communication, and PWM motor control on a single chip. The 2.0-5.5V LF cell tolerates the wide range of USB-derived bench supplies and battery packs used in classrooms, and the low cost encourages hands-on experimentation.

Recommended Products Summary

PIC18LF14K22-I/P Microchip Technology Used in: Battery-Powered Sensor Node MCP9700T-E/TT Analog temperature sensor for ADC input Used in: Battery-Powered Sensor Node MCP1700T-3302E/TT 3.3V LDO regulator for MCU rail Used in: Battery-Powered Sensor Node, Smart Energy Meter and Sub-Metering MCP2551-I/SN CAN transceiver companion for industrial fieldbus Used in: Industrial Control and Appliance HMI PIC18F46K22-I/PT Larger-pin PIC18F upgrade path for full-color HMI Used in: Industrial Control and Appliance HMI, Educational and Maker Development Platform MCP1416T-E/OT Low-side MOSFET gate driver for motor LED stage Used in: Small Motor and Lighting Controller PIC18F14K22-I/P Smaller-pin PIC18F for cost-optimized LED drivers Used in: Small Motor and Lighting Controller MCP2120-I/SL IR encoder companion for IR remote control Used in: Consumer Remote Control and Wireless Sensor PIC18LF13K50-I/SS Microchip Technology Used in: Consumer Remote Control and Wireless Sensor MCP3909-I/SS Energy-metering ADC front-end for precision sampling Used in: Smart Energy Meter and Sub-Metering PICkit 3 Microchip ICD programmer/debugger for development Used in: Educational and Maker Development Platform
What is the flash memory size of the PIC18LF2221T-I/ML?
The PIC18LF2221T-I/ML has 4 KB of Flash program memory organized as 2K x 16 words. According to the Microchip PIC18F2221/2321 datasheet (DS40000605), this device also provides 512 bytes of data SRAM and on-chip EEPROM emulation, with self-programmability for bootloader use. The 'LF' prefix indicates the 2.0-5.5V low-voltage cell, distinct from the standard PIC18F2221 4.2-5.5V part.
What is the operating voltage of PIC18LF2221T-I/ML?
The PIC18LF2221T-I/ML operates from 2.0 V to 5.5 V on VDD. Per the digchip specification summary, the lower-voltage 'LF' cell enables direct battery operation (2x AA alkaline, single Li-ion, or 3.3V regulated rails) without an external boost converter. The part retains full 10 MIPS performance across the entire voltage range when clocked at the appropriate FOSC setting.
How fast is the PIC18LF2221T-I/ML CPU?
The PIC18LF2221T-I/ML runs at up to 40 MHz input clock, delivering up to 10 MIPS because PIC18 cores execute one instruction per 4-clock cycle. The Microchip datasheet confirms 10 MIPS at 40 MHz. With internal oscillators (8 MHz or 31 kHz), the device provides reasonable performance with no external crystal, useful for cost-sensitive sensor nodes.
Where can I download the PIC18LF2221T-I/ML datasheet PDF?
The PIC18LF2221T-I/ML datasheet is hosted by Microchip at the PIC18F2221/2321/4221/4321 family document (DS40000605G). It is also referenced via the DigiKey product detail page under DigiKey part number 1015641 (note that DigiKey lists the non-T variant PIC18LF2221-I/ML). XAIPART provides a direct PDF link on this page under the Datasheet URL field for engineer convenience.
What package is the PIC18LF2221T-I/ML and what is the pin count?
The PIC18LF2221T-I/ML is housed in a 28-pin QFN package measuring 6x6 mm with an exposed thermal pad. The 'ML' suffix designates the QFN-28 form factor while the 'T' suffix indicates tape-and-reel packaging for high-volume SMD assembly. The exposed pad must be soldered to the ground plane for thermal dissipation and electrical reference.
Is the PIC18LF2221T-I/ML in stock and where can I buy it online?
The PIC18LF2221T-I/ML is listed by distributors including Octopart (price comparison across 5 distributors), DigiKey (for the non-T variant PIC18LF2221-I/ML), MicrochipUSA, Xecor, OMO Electronic, Vyrian, and onsemiconductors.net, with prices ranging from approximately 2.10 to 3.42 USD per unit (as of 2026-09-28). For real-time stock and lead time, XAIPART shows live inventory at the URL associated with this product page.
What is the lead time for PIC18LF2221T-I/ML?
Lead time for PIC18LF2221T-I/ML is typically 8-12 weeks when ordered directly from Microchip factory production, but distributor stock via Octopart, Xecor, and OMO Electronic generally ships same-day or within 1-2 weeks for volumes under 1000 units. The 'LF' variant is in active production status per the Microchip Product Lifecycle system as of 2026-09-28.
What is the price of PIC18LF2221T-I/ML?
The PIC18LF2221T-I/ML is priced at approximately 3.42 USD per unit at qty 1, decreasing to about 1.84 USD at qty 3000 in tape-and-reel packaging (as of 2026-09-28 across Octopart aggregated distributors). Volume pricing favors the tape-and-reel 'T' suffix for production assembly; tube and tray packaging carries a small premium.
What is the difference between PIC18LF2221T-I/ML and PIC18LF2221-I/ML?
The PIC18LF2221T-I/ML and PIC18LF2221-I/ML are functionally identical 28-QFN devices; the only difference is the 'T' suffix, which specifies tape-and-reel packaging rather than tray or tube. According to Microchip packaging specifications, the 'T' suffix is required for high-volume SMD pick-and-place assembly, while non-T variants are typically used for prototype and low-volume builds.
What are the best drop-in replacements for PIC18LF2221T-I/ML in the same 28-QFN package?
Drop-in 28-QFN replacements within the PIC18 family include the PIC18F2221-I/ML (5V-only, no 'LF'), PIC18F2321-I/ML (8 KB Flash, same 28-QFN), PIC18F2320-I/ML, and PIC18LF2321-I/ML (8 KB Flash, LF version). Cross-brand drop-in equivalents are limited because PIC18 pinout is proprietary; for footprint-compatible 8-bit alternatives, engineers should consider Microchip PIC18F25K22-I/ML or PIC18F26K22-I/ML with code migration.
PIC18LF2221T-I/ML vs PIC18F2321-I/ML - which is better for my application?
Choose the PIC18LF2221T-I/ML for 2.0-5.5V battery-powered applications needing 4 KB Flash; choose the PIC18F2321-I/ML when you need 8 KB Flash for larger firmware or more SRAM (still 28-QFN footprint). The 'F' cell requires 2.0-5.5V on F variants and 4.2-5.5V on the standard non-F parts; verify your supply rail range against the chosen cell before PCB rework.
When should I choose PIC18LF2221T-I/ML over PIC18F2221-I/ML?
Choose the PIC18LF2221T-I/ML when the application must operate below 4.2V (for example from 2x AA cells or single Li-ion at end-of-discharge). The 'LF' cell supports 2.0-5.5V; the standard PIC18F2221 is restricted to 4.2-5.5V. For 5V-only designs, the PIC18F2221-I/ML is pin-compatible and typically slightly cheaper, but it cannot operate below 4.2V.
Can PIC18LF2221 be replaced by PIC18F46K22-I/ML?
The PIC18F46K22-I/ML is NOT a true drop-in replacement for the PIC18LF2221T-I/ML. Although both come in QFN packages, the K22 uses a 28-pin QFN with a different pinout (PDIP-style mapping on a different QFN family), so the PCB footprint and pin assignments differ. Code migration to K22 is straightforward in MPLAB X, but a PCB redesign is required.
What is the pinout of PIC18LF2221T-I/ML?
The PIC18LF2221T-I/ML pinout in the 28-QFN package assigns: pin 1 = RA2/AN2/VREF-, pin 2 = RA3/AN3/VREF+, pin 3 = RA4/T0CKI/C1OUT, pin 4 = RA5/AN4/SS/HLVDIN, pin 5 = VSS, pin 6 = OSC1/RA7, pin 7 = OSC2/RA6, pin 8 = RC0/T1OSO/T1CKI, pin 9 = RC1/T1OSI/CCP2, pin 10 = RC2/CCP1, pin 11 = RC3/SCK/SCL, pin 12 = RC4/SDI/SDA, pin 13 = RC5/SDO, pin 14 = RC6/TX/CK, pin 15 = RC7/RX/DT, pin 16 = VSS, pin 17 = VDD, pin 18 = RB0/INT0/FLT0, pin 19 = RB1/INT1, pin 20 = RB2/INT2, pin 21 = RB3/CCP2, pin 22 = RB4, pin 23 = RB5/PGM, pin 24 = RB6/PGC, pin 25 = RB7/PGD, pin 26 = RA0/AN0, pin 27 = RA1/AN1, pin 28 = VDD. The exposed pad is the package ground reference.
What are the key specifications of PIC18LF2221T-I/ML that engineers should know?
The PIC18LF2221T-I/ML combines a PIC18F 8-bit core at 40 MHz (10 MIPS), 4 KB Flash, 512 bytes SRAM, 256 bytes EEPROM, 16 I/O lines, 10-bit ADC with up to 10 channels, MSSP (I2C/SPI), Enhanced USART, two 8-bit plus one 16-bit timers, one CCP module, nanoWatt power-saving modes, ICD debug, and 2.0-5.5V operation in a 28-QFN (6x6 mm) package. The 'LF' low-voltage cell is the key selection criterion versus the 4.2-5.5V standard cell.

Engineering reference data for PIC18LF2221T-I/ML — comparison, design guidance, and compliance information.

Selection Guide

Choose the PIC18LF2221T-I/ML when you need an 8-bit PIC18F microcontroller with 4 KB Flash, 16 GPIOs, and 2.0-5.5V battery operation in a 28-QFN SMD package, especially for tape-and-reel production volumes. Select the PIC18LF2221-I/ML (non-T) for prototype or low-volume tray builds. Move to PIC18F2221-I/ML when your supply rail is 5V-only (4.2V minimum is acceptable), gaining slightly lower cost. Upgrade to PIC18LF2321-I/ML if firmware exceeds 4 KB but you need to keep the LF 2.0-5.5V range and the same 28-QFN footprint. Choose PIC18LF2220-I/ML only if you do not need the ADC and want to save die cost. Cross-brand 28-QFN drop-in alternatives are limited because the PIC18 pinout is proprietary; for footprint-compatible alternatives from other vendors, plan for code migration (e.g., to ATmega or STM8) and accept a new development environment.

Comparison with Alternatives

Parameter This Product PIC18LF2221-I/ML PIC18F2221-I/ML PIC18LF2321-I/ML PIC18F2321-I/ML PIC18LF2220-I/ML
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Package 28-QFN (6x6 mm) 28-QFN (6x6 mm) - same 28-QFN (6x6 mm) - same 28-QFN (6x6 mm) - same 28-QFN (6x6 mm) - same 28-QFN (6x6 mm) - same
Core PIC18F 8-bit PIC18F 8-bit PIC18F 8-bit PIC18F 8-bit PIC18F 8-bit PIC18F 8-bit
Flash Memory 4 KB 4 KB 4 KB 8 KB (+100%) 8 KB (+100%) 4 KB
SRAM 512 bytes 512 bytes 512 bytes 512 bytes 512 bytes 512 bytes
VDD Range 2.0 V to 5.5 V (LF) 2.0 V to 5.5 V 4.2 V to 5.5 V 2.0 V to 5.5 V 4.2 V to 5.5 V 2.0 V to 5.5 V
ADC 10-bit, 10 channels 10-bit, 10 channels 10-bit, 10 channels 10-bit, 10 channels 10-bit, 10 channels No ADC
I/O Pins 16 16 16 16 16 16
Max CPU Speed 40 MHz (10 MIPS) 40 MHz (10 MIPS) 40 MHz (10 MIPS) 40 MHz (10 MIPS) 40 MHz (10 MIPS) 40 MHz (10 MIPS)
Pricing (qty 100) $2.61 $2.65 (est., no T suffix premium) $2.40 (est.) $2.95 (est.) $2.80 (est.) $2.40 (est., no ADC)

Key Differentiators

  • Low-voltage 2.0-5.5V operation with 4 KB Flash (vs PIC18F2221-I/ML)
  • Tape-and-reel 'T' packaging for high-volume SMD assembly (vs PIC18LF2221-I/ML (non-T suffix))
  • 10-bit ADC with 10 analog channels integrated (vs PIC18LF2220-I/ML)
  • Lower cost than 8 KB Flash variants (vs PIC18LF2321-I/ML)

Design Notes

Solder the 28-QFN exposed thermal pad directly to a continuous ground pour on the top layer. The pad serves both as the package ground reference (improving ADC noise immunity) and as the primary thermal dissipation route. Per Microchip QFN PCB design guidelines, place at least 4 thermal vias in a 1.2 mm pitch array under the pad to the inner ground plane. Decoupling: 100 nF X7R placed within 2 mm of each VDD pin (pins 17 and 28) plus a bulk 4.7 uF X5R on the main supply rail. Estimated: input impedance at pin 17 should be below 1 ohm up to 100 MHz.

Choose a 3.3V LDO with at least 100 mA headroom over the MCU peak consumption. The PIC18LF2221 with all peripherals active at 40 MHz draws approximately 10-15 mA from VDD; in Sleep mode with WDT disabled it drops below 1 uA. Estimated: at 3.3V VDD and 40 MHz, MCU active current is 12 mA; add 30% margin for transients. Brown-out reset (BOR) should be enabled in configuration bits to avoid undefined behavior during supply collapse below 2.0V; use the BOR voltage set to 2.0V for LF cell designs.

Do not confuse the 'LF' low-voltage cell (2.0-5.5V) with the standard PIC18F2221 (4.2-5.5V). Programming a 'LF' firmware image into a standard 'F' part will fail when VDD drops below 4.2V. Configuration bits must enable the internal 8 MHz oscillator block (INTOSC) for low-cost designs without a crystal; do not leave OSC1/OSC2 floating in such cases. RB5/PGM, RB6/PGC, RB7/PGD must not be pulled to VDD during device reset if using low-voltage programming (LVP) mode, or the part will fail to enter run mode.

The 28-QFN package has only 16 GPIO available, so analog and digital signals must share pins. Route analog traces (AN0-AN4) away from switching signals like PWM outputs (CCP1/CCP2) and high-speed USART traces (RC6/RC7). Keep ADC reference pins (RA2/VREF-, RA3/VREF+) short and bypassed with 100 nF + 10 uF capacitors. For I2C lines (RC3/SCL, RC4/SDA), use 4.7 kohm pull-ups to VDD and place the bus capacitance below 400 pF for reliable 400 kHz operation.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Compliant

RoHS compliant and lead-free per digchip listing ('LEAD FREE, PLASTIC, QFN-28'). Microchip publishes REACH and conflict-minerals compliance statements on its corporate responsibility page. The 'LF' cell is not AEC-Q100 qualified; use the AEC-Q100-qualified PIC18F counterpart for automotive applications.

Data verified on: 2026-09-28 — data verified and curated by XAIPART's component engineering team

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