Microchip Technology

ATSAMD21E15B-AU - 32KB Flash ARM Cortex-M0+ MCU | Microchip

MPN: ATSAMD21E15B-AU ✓ Active
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1.62 V to 3.6 V (3.3 V nominal) Vdss 32-pin TQFP Package 48 MHz Speed 32 KB Memory
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Price updated: 2026-09-21
Volume Pricing
Qty Unit Price Extended
1 $2.85 $2.85
10 $2.56 $25.60
100 $2.21 $221.00
500 $1.94 $970.00
1,000 $1.72 $1,720.00
3,000 $1.45 $4,350.00
ℹ️ All prices are in USD

ATSAMD21E15B-AU Overview

The Microchip Technology ATSAMD21E15B-AU is a 32-bit ARM Cortex-M0+ microcontroller from the SAM D21 family, integrating 32KB Flash and 4KB SRAM in a 32-pin TQFP package. It operates at up to 48 MHz and is powered from a 3.3V nominal supply (1.62V-3.6V range). The device targets general-purpose embedded applications requiring low power consumption and rich peripherals.

A microcontroller (MCU) is a single-chip computer that integrates a CPU core, memory, and programmable I/O peripherals. Within the broader semiconductor hierarchy, the ATSAMD21E15B-AU belongs to the ARM Cortex-M0+ class of microcontrollers, which are designed for energy-efficient 32-bit computing in cost-sensitive applications. The SAM D21 series extends Cortex-M0+ with Microchip's Event System, SERCOM peripherals, and full-speed USB support on selected variants.

Key differentiating features include a 12-channel 350 µs minimum sample time 12-bit ADC, up to 26 GPIO lines, and six SERCOM interfaces that can each be configured as UART, I²C, or SPI. The integrated Event System allows peripherals to communicate without CPU intervention, reducing active time and current draw. SleepWalking peripherals continue to monitor external events while the CPU sleeps, achieving standby currents measured in microamperes.

Architecturally, the ATSAMD21E15B-AU uses a single-cycle hardware multiplier and a Nested Vector Interrupt Controller (NVIC) to deliver deterministic interrupt response. The advanced analog peripherals, including a 10-bit DAC and two analog comparators, make it suitable for sensor signal conditioning. The on-chip Full-Speed USB 2.0 device interface (selected variants) simplifies connectivity for hardware peripherals.

Typical applications include IoT sensor nodes, home automation controllers, wearable fitness bands, USB human-interface devices, and industrial control subsystems. The combination of low power, USB connectivity, and capacitive touch support makes it popular in consumer electronics and connected home products.

When designing with this MCU, allocate sufficient decoupling capacitance near each VDD pin and route the SWD signals (SWDIO/SWDCLK) as short as possible for reliable debug. The on-chip 32.768 kHz oscillator should be configured for low-power RTC modes. Verify the specific variant's peripheral count against your BOM requirements.

Drop-in alternatives for ATSAMD21E15B-AU — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with ATSAMD21E15B-AU (same form factor and footprint) — differing in ADC, Package, Operating Temperature, Timer/Counters, RoHS Status.

Microchip Technology
ADC: 12-bit, up to 350 ksps, up to 10 channels
Package: 32-pin TQFP (7x7 mm)
Operating Temperature: -40C to +85C (Industrial)
Compare with ATSAMD21E15B-AU →
Microchip Technology
ADC: 12-bit, up to 14 channels
Package: 32-pin TQFP (7x7 mm)
Timer/Counters: TC: 3 x 16-bit, TCC: 2 x 16-bit
Compare with ATSAMD21E15B-AU →
Microchip Technology
ADC: 12-bit, up to 20 channels, 350 ksps
Package: 32-pin TQFP (7x7 mm)
RoHS Status: Compliant (Pb-free)
Compare with ATSAMD21E15B-AU →
Microchip Technology
ADC: 12-bit, up to 350 ksps
Package: 32-TQFP (7x7 mm)
Operating Temperature: -40C to +85C
Compare with ATSAMD21E15B-AU →
Microchip Technology
ADC: 12-bit, up to 20 channels
Package: 35-WLCSP (2.82 x 2.53 mm)
Operating Temperature: -40 C to +85 C (Industrial)
Compare with ATSAMD21E15B-AU →
Microchip Technology
ADC: 12-bit, up to 350 ksps, up to 20 channels
Package: 32-pin TQFP (7x7 mm), 0.8 mm pitch
Timer/Counters: Three 16-bit TC, one 32-bit TCC, one 24-bit RTC
Compare with ATSAMD21E15B-AU →
Microchip Technology
ADC: 12-bit, up to 350 ksps, 14 channels
Package: 32-pin TQFP (7x7 mm)
Operating Temperature: -40C to +125C (extended / automotive)
Compare with ATSAMD21E15B-AU →

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

ATSAMD21E15B-AUT

✅ Drop-In
Microchip Technology
📦 32-pin TQFP
ARM Cortex-M0+ (32-bit) · 48 MHz · 32 KB · 4 KB · 1.62 V to 3.63 V · 3.3 V typical · 32-pin TQFP (7x7 mm) · Tape & Reel (AUT suffix)

✓ In Stock

$1.4 / Unit

View Datasheet →

ATSAMD21E15A-AU

✅ Drop-In
📦 32-pin TQFP
A silicon revision, same memory (32KB/4KB), same 32-pin TQFP footprint, drop-in compatible

📋 Reference alternative (not in catalog)

ATSAMD21E15B-MU

✅ Drop-In ⚠️ 参数待验证
📦 32-pin QFN
same die, 32-pin QFN package (vs TQFP), +USB Full-Speed peripheral added

📋 Reference alternative (not in catalog)

ATSAMD21E16B-AU

✅ Drop-In ⚠️ 参数待验证
Microchip Technology
📦 32-pin TQFP
ARM Cortex-M0+ · 32-Bit Single-Core · 48 MHz · 2.46 CoreMark/MHz · 64 KB (32K x 16) · 8 KB · 1.62 V to 3.63 V · Up to 26

✓ In Stock

$2.1 / Unit

View Datasheet →

ATSAMD20E15B-AUT

✅ Drop-In
Microchip Technology
📦 32-pin TQFP
ARM Cortex-M0+ (32-bit) · 48 MHz · 32 KB (32K x 8) · 4 KB · 1.62 V to 3.63 V · -40C to +85C (Industrial) · 12-bit, up to 350 ksps, up to 10 channels · 10-bit, 350 ksps

✓ In Stock

$2.52 / Unit

View Datasheet →

ATSAMD21E15B-AFT

✅ Drop-In
Microchip Technology
📦 32-pin TQFP
ARM Cortex-M0+ · 32-bit · 48 MHz · 32 KB (32K x 8) · 4 KB · 1.62 V to 3.63 V · 26 (max) · 32-pin TQFP (7x7 mm)

✓ In Stock

$1.96 / Unit

View Datasheet →

ATSAMD21E15B-AU Maximum Ratings & Electrical Characteristics

Core ARM Cortex-M0+ (32-bit)
Maximum Clock Frequency 48 MHz
Flash Memory 32 KB
SRAM 4 KB
Supply Voltage 1.62 V to 3.6 V (3.3 V nominal)
Operating Temperature -40 °C to +85 °C (industrial)
Package 32-pin TQFP
GPIO Count Up to 26
ADC 12-bit, 20 channels
DAC 10-bit, 1 channel
SERCOM 6 configurable (UART/SPI/I²C)
Timers/Counters TC x6, TCC x2
Analog Comparators 2
RTC Yes (32.768 kHz)
Programming Interface Serial Wire Debug (SWD)
RoHS Status Compliant

ATSAMD21E15B-AU Pin Configuration

TQFP-32 (7x7mm) Package Pinout Diagram TQFP-32 7x7mm, P0.8mm, JEDEC MS-026. Pin 1 by dot. TQFP-32 (7x7mm) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32
Pin 1 PA00 — General-purpose I/O, ADC input
Pin 2 PA01 — General-purpose I/O, ADC input
Pin 3 PA02 — General-purpose I/O, ADC input, DAC output
Pin 4 PA03 — General-purpose I/O, ADC input, analog comparator
Pin 5 PA04 — General-purpose I/O, ADC input, VREFA
Pin 6 PA05 — General-purpose I/O, ADC input, VREFB
Pin 7 PA06 — General-purpose I/O, ADC input
Pin 8 PA07 — General-purpose I/O, ADC input
Pin 9 VDD — Digital supply voltage
Pin 10 GND — Ground
Pin 11 PA08 — General-purpose I/O, NMI
Pin 12 PA09 — General-purpose I/O
Pin 13 PA10 — General-purpose I/O
Pin 14 PA11 — General-purpose I/O
Pin 15 PA14 — General-purpose I/O, SWDIO
Pin 16 PA15 — General-purpose I/O
Pin 17 PA16 — General-purpose I/O
Pin 18 PA17 — General-purpose I/O
Pin 19 PA18 — General-purpose I/O
Pin 20 PA19 — General-purpose I/O
Pin 21 PA20 — General-purpose I/O
Pin 22 PA21 — General-purpose I/O, SERCOM
Pin 23 PA22 — General-purpose I/O, SERCOM
Pin 24 PA23 — General-purpose I/O, SERCOM
Pin 25 PA24 — General-purpose I/O
Pin 26 PA25 — General-purpose I/O, SWDCLK
Pin 27 PA27 — General-purpose I/O
Pin 28 PA28 — General-purpose I/O, RESET
Pin 29 PB00 — General-purpose I/O
Pin 30 PB01 — General-purpose I/O
Pin 31 PB02 — General-purpose I/O, ADC input
Pin 32 PB03 — General-purpose I/O, ADC input

Typical Applications

ATSAMD21E15B-AU is suitable for 7 applications: IoT Sensor Nodes, USB Human Interface Devices, Home Automation Controllers, Wearable Fitness Bands, Industrial Control Subsystems, Capacitive Touch User Interfaces, Educational and Maker Boards.

🧩

IoT Sensor Nodes

The ATSAMD21E15B-AU fits IoT sensor node designs through its 48 MHz Cortex-M0+ core and 4KB SRAM that comfortably run wireless stacks and sensor-fusion tasks. The 12-bit ADC with 20 channels interfaces directly with analog temperature, humidity, and gas sensors without external converters. SleepWalking peripherals allow the MCU to wake only when a meaningful sensor event occurs, extending coin-cell battery life to years. Compared to discrete 8-bit MCU designs, the integrated SERCOM blocks reduce PCB footprint by eliminating external UART/I²C expanders, making it ideal for sub-1GHz wireless sensor motes.

🎥

USB Human Interface Devices

For USB HID peripherals such as keyboards, mice, and game controllers, the ATSAMD21E15B-AU (in the USB-capable -MU/-CU suffix variants) integrates a Full-Speed USB 2.0 device controller with on-chip transceivers. The 48 MHz Cortex-M0+ executes HID report generation with negligible latency, while six SERCOM blocks handle additional I/O for mechanical switches, encoders, or RGB lighting. Compared to external USB controller chips, the integrated peripheral saves BOM cost and PCB area, ideal for low-cost consumer peripherals.

🏭

Home Automation Controllers

The ATSAMD21E15B-AU is well-suited for home automation hubs where multiple communication protocols must coexist. Six SERCOM interfaces can simultaneously drive RS-485 for Modbus, SPI for an external display controller, I²C for sensors, and UART for debug logging without CPU overhead. The 12-bit ADC monitors battery or supply voltage rails for predictive maintenance, while the Event System routes peripheral-to-peripheral signals at hardware speed. With 32KB Flash, designers can implement Zigbee or Matter protocol stacks with room for application-layer customization.

📱

Wearable Fitness Bands

For wearable fitness trackers, the ATSAMD21E15B-AU delivers the energy efficiency required for multi-day battery life. SleepWalking peripherals monitor accelerometer interrupts while the CPU stays in standby, drawing only single-digit microamps. The Cortex-M0+ core wakes in microseconds to update OLED displays and BLE radio modules. Compared to larger Cortex-M4 alternatives, the ATSAMD21E15B-AU's compact 32-pin TQFP enables ultra-thin wearable form factors without sacrificing analog performance for heart-rate sensing.

🏭

Industrial Control Subsystems

In industrial control systems, the ATSAMD21E15B-AU provides deterministic interrupt response through its NVIC and SERCOM peripherals that handle multi-protocol field-bus communication. The industrial -40 °C to +85 °C temperature range covers most factory-floor environments, and the 12-bit ADC reads 4-20 mA loop signals directly. The integrated Event System enables safety-critical interlocks without CPU latency, satisfying real-time control requirements. Compared to discrete PLC logic, this MCU reduces cost while maintaining deterministic behaviour for motor-control and process-control subsystems.

💡

Capacitive Touch User Interfaces

The ATSAMD21E15B-AU supports capacitive touch buttons, sliders, and wheels through its built-in Peripheral Touch Controller (PTC). The PTC handles electrode scanning in hardware, freeing the Cortex-M0+ to manage communication tasks. With up to 26 GPIO-capable pins, designers can implement 10+ touch zones in a single MCU. Compared to dedicated touch ICs, integrating the PTC reduces BOM and PCB complexity for kitchen appliances, IoT switches, and consumer electronics that benefit from sealed, glass-fronted interfaces.

🖥️

Educational and Maker Boards

The ATSAMD21E15B-AU is widely deployed on Arduino-compatible boards and SparkFun development kits because of its accessible Cortex-M0+ core and rich peripherals. With 32KB Flash and 4KB SRAM, it handles beginner-level sketches, real-time operating systems, and Bluetooth Low Energy stacks. The integrated Serial Wire Debug interface supports plug-and-play programming through Atmel Studio, PlatformIO, and Arduino IDE. Compared to legacy 8-bit AVR MCUs, this MCU brings 32-bit performance and modern peripherals to maker and educational applications.

Recommended Products Summary

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What is the core architecture of the ATSAMD21E15B-AU?
The ATSAMD21E15B-AU uses an ARM Cortex-M0+ 32-bit core running up to 48 MHz. According to the Microchip SAM D21 datasheet, it integrates 32KB Flash and 4KB SRAM with hardware single-cycle multiply and an NVIC for deterministic interrupt response. This makes it ideal for low-power, cost-sensitive embedded applications.
How much Flash and RAM does the ATSAMD21E15B-AU have?
The ATSAMD21E15B-AU has 32KB of in-system programmable Flash and 4KB of SRAM. This memory footprint targets general-purpose embedded firmware and small RTOS applications. Developers can extend code storage via external SPI Flash if additional non-volatile memory is required.
What is the operating voltage range of the ATSAMD21E15B-AU?
The ATSAMD21E15B-AU operates from 1.62 V to 3.6 V with 3.3 V as the nominal supply. According to Microchip, this wide range enables single-cell Li-ion or 2xAA battery operation. Core peripherals and analog blocks share the same rail, simplifying power tree design.
How many GPIO pins does the ATSAMD21E15B-AU provide?
The ATSAMD21E15B-AU exposes up to 26 GPIO pins in the 32-pin TQFP package. These pins are multiplexed with SERCOM, ADC, DAC, and event system functions. Designers should consult the pinout table for alternate-function assignments before committing to a PCB layout.
Does the ATSAMD21E15B-AU support USB?
The base ATSAMD21E15B-AU variant does not include the on-chip Full-Speed USB 2.0 peripheral. According to the Microchip SAM D21 ordering code table, the 'U' suffix indicates USB support. Engineers needing USB should select the ATSAMD21E15B-MU or ATSAMD21E15CU variants instead.
What is the operating temperature range of the ATSAMD21E15B-AU?
The ATSAMD21E15B-AU operates from -40 °C to +85 °C industrial grade. The 'B-AU' ordering suffix 'AU' confirms TQFP-32 industrial temperature grade. For AEC-Q100 automotive-grade applications, Microchip offers -AN/-AUT variants of the same family.
Where can I buy the ATSAMD21E15B-AU and what is its price?
The ATSAMD21E15B-AU is available from authorized distributors including Mouser, DigiKey, Octopart-listed suppliers, and Arrow, as of 2026-09-21. The unit price starts at approximately $2.85 for qty-1 and decreases to $1.45 per unit at 3000-piece reel quantity. Lead time for in-stock reels is typically 2-6 weeks.
Is the ATSAMD21E15B-AU in stock at major distributors?
The ATSAMD21E15B-AU shows active stock at Mouser and is widely available on distributors at Octopart as of 2026-09-21. Production status is active per Microchip. For high-quantity orders above 10,000 units, requesting a factory direct quote via Microchip's sales channel is recommended for shortest lead time.
What is the lead time for ATSAMD21E15B-AU?
Standard lead time for the ATSAMD21E15B-AU in stock at franchised distributors is 4-8 weeks as of 2026-09-21. Production orders through Microchip typically follow 12-16 week lead times. For prototyping, distributors maintain reel and tray stock that can ship within 48 hours.
ATSAMD21E15B-AU vs ATSAMD20E15A-AU - which is better for low-power applications?
The ATSAMD21E15B-AU is generally better for new low-power designs because the SAM D21 family adds SleepWalking peripherals, an Event System, and a 12-bit ADC versus the D20's 10-bit ADC. The D20 is suitable for cost-driven upgrades from legacy Atmel designs. Pin compatibility between the two families enables drop-in replacement on existing PCBs.
What is the best drop-in replacement for the ATSAMD21E15B-AU?
The best same-brand drop-in replacement is the ATSAMD21E15B-AUT (tape-and-reel packaging variant, identical die) or ATSAMD21E15A-AU (A silicon revision, same 32-pin TQFP footprint). Both source from the same SAM D21 family and share pin compatibility. Engineers needing more Flash should select the ATSAMD21E16B-AU footprint pin-compatible variant.
When should I choose the ATSAMD21E15B-AU over the ATSAMD21G18A-AU?
Choose the ATSAMD21E15B-AU when you need a smaller 32-pin TQFP footprint, 32KB Flash and 4KB RAM are sufficient, and you do not require USB. Choose the ATSAMD21G18A-AU when you need 64-pin QFP with more I/O, USB support, and 256KB Flash. Both share the Cortex-M0+ core and SERCOM peripheral architecture.
Where can I download the ATSAMD21E15B-AU datasheet PDF?
The official ATSAMD21E15B-AU datasheet PDF can be accessed at https://ww1.microchip.com/downloads/en/DeviceDoc/SAM-D21-Family-Silicon-Datasheet-DS40001882.pdf or via Microchip's product page at https://www.microchip.com/en-us/product/ATSAMD21E15. The datasheet document number is DS40001882, covering the complete SAM D21 family including E, G, J variants.
Where can I find the ATSAMD21E15B-AU pinout diagram?
The pinout diagram for the ATSAMD21E15B-AU 32-pin TQFP package is published in Section 7 of the SAM D21 family datasheet, also accessible from the Microchip product page. Per the datasheet, the pinout follows the standard TQFP-32 layout with pin 1 marked by the dot indicator at the top-left of the package.
What are the key specifications of the ATSAMD21E15B-AU that engineers should know?
The ATSAMD21E15B-AU integrates a 48 MHz ARM Cortex-M0+ core, 32KB Flash, 4KB SRAM, 26 multiplexed I/O, a 12-bit 20-channel ADC, 10-bit DAC, six SERCOM blocks, two analog comparators, and full RTC with 32.768 kHz oscillator support. Per Microchip, the supply range is 1.62V-3.6V across -40 °C to +85 °C industrial grade in TQFP-32. It is pin-compatible with other SAM D21 family variants.

Engineering reference data for ATSAMD21E15B-AU — comparison, design guidance, and compliance information.

Selection Guide

Choose the ATSAMD21E15B-AU when you need a 32-pin TQFP Cortex-M0+ MCU with 32KB Flash, 4KB SRAM, 26 GPIO, and 12-bit ADC for general-purpose low-power embedded applications. It targets cost-sensitive designs that benefit from rich SERCOM peripherals and SleepWalking energy efficiency. Choose ATSAMD21E15B-AUT if you need tape-and-reel packaging for high-volume production. Choose ATSAMD21E15A-AU when sourcing legacy A-silicon revision inventory. For higher temperature grades, ATSAMD21E15B-AFT (-40°C to +125°C) is pin-compatible. Choose ATSAMD20E15B-AU only when migrating from existing D20 PCB designs; otherwise prefer the D21 family for its enhanced peripherals.

Comparison with Alternatives

Parameter This Product ATSAMD21E15B-AUT ATSAMD21E15A-AU ATSAMD20E15B-AU
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Package 32-pin TQFP 32-pin TQFP - same 32-pin TQFP - same 32-pin TQFP - same
Flash 32 KB 32 KB 32 KB 32 KB
SRAM 4 KB 4 KB 4 KB 4 KB
Maximum Clock 48 MHz 48 MHz 48 MHz 48 MHz
ADC Resolution 12-bit 12-bit 12-bit 10-bit
USB Support No (base variant) No No No
Event System Yes Yes Yes No
Operating Temperature -40 °C to +85 °C -40 °C to +85 °C -40 °C to +85 °C -40 °C to +85 °C

Key Differentiators

  • Integrated Event System hardware routing (vs ATSAMD20E15B-AU)
  • Higher-resolution 12-bit ADC vs 10-bit on D20 family (vs ATSAMD20E15B-AU)
  • Lower active current with SleepWalking peripherals (vs ATSAMD21E15B-AU vs larger Cortex-M4 MCUs)

Design Notes

Place 100 nF decoupling capacitors as close as possible to every VDD pin and a bulk 10 µF capacitor near the package supply entry. The ATSAMD21E15B-AU supports separate VDDANA and VDDIO supply rails; tying them together via ferrite beads improves noise isolation for the analog ADC reference. According to the SAM D21 datasheet, configuring the on-chip voltage regulator's low-dropout mode reduces quiescent current to single-digit microamps in standby.

Route the SWDIO and SWDCLK traces with ground shielding and avoid crossing noisy signal paths. The 32-pin TQFP package supports 0.8 mm pitch routing on a 4-layer PCB with continuous ground plane beneath the device. Per Microchip layout guidelines, keep crystal traces short and symmetric to the GND plane to minimize oscillator start-up jitter and EMI.

Do not program the NMI pin (PA08) without considering its alternate function - leaving it floating can cause unexpected wake events. The 32.768 kHz external crystal requires proper load capacitor selection per the crystal vendor's CL specification; typical values are 12 pF. Ensure NVMCTRL locked regions are unlocked before any flash erase operation to prevent silent programming failures during firmware updates.

When using the SERCOM blocks for high-speed SPI above 12 MHz, add series source termination resistors near the MCU output pins to dampen reflections on long PCB traces. For I²C buses, use external 4.7 kΩ pull-ups rather than relying on weak internal pull-ups, especially when multiple slaves are connected. The 12-bit ADC's input impedance requires careful source-impedance budgeting; a 1 kΩ external series resistor with 10 nF input capacitance forms a suitable anti-alias filter.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Qualified
Lead Free
Yes
Halogen Free
Yes
Conflict Minerals
Compliant

RoHS and REACH compliance per product page. Not AEC-Q100 qualified in this suffix; automotive variants (-AN/-AUT) are AEC-Q100 Grade 1 qualified.

Data verified on: 2026-09-21 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

Microchip Technology ATSAMD21E15B-AU ATSAMD21E15B-AUT ATSAMD21E15A-AU ATSAMD21E16B-AU ATSAMD20E15B-AU ARM Cortex-M0+ microcontroller 32-bit MCU TQFP-32 RoHS REACH SERCOM ADC DAC SleepWalking Event System IoT sensor node USB HID capacitive touch industrial grade
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