Texas Instruments

INA116UA - 3fA Ultra-Low Bias In-Amp SOIC-16 | Texas Instruments

MPN: INA116UA βœ“ Active
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2 mV max Vdss 3 fA typ at 25C Id 16-SOIC (0.295 in, 7.50 mm width) Package
From $19.5 USD / Unit
MOQ: 1 |
Price updated: 2026-09-12
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Qty Unit Price Extended
1 $22.34 $22.34
10 $21.55 $215.50
100 $20.8 $2,080.00
500 $20.1 $10,050.00
1,000 $19.5 $19,500.00
ℹ️ All prices are in USD

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INA116UA Maximum Ratings & Electrical Characteristics

Amplifier Type Instrumentation Amplifier
Number of Channels 1
Input Bias Current 3 fA typ at 25C
Input Bias Current at 85C 25 fA
Input Offset Voltage 2 mV max
Gain Range 1 V/V to 1000 V/V (single external resistor)
Bandwidth 800 kHz
Input Voltage Noise 28 nV/sqrt(Hz) at 1 kHz
Supply Voltage Range 9 V to 36 V total (dual or single supply)
Quiescent Current 1 mA
Input Topology Difet FET inputs with buffered guard drive
Guard Drive Pins Yes (buffered, adjacent to both inputs)
Input Overvoltage Protection Yes (internal)
Package 16-SOIC (0.295 in, 7.50 mm width)
Mounting Type Surface Mount

INA116UA 16-soic (0.295 in, 7.50 mm width) Pin Configuration Guide

Complete pinout information for INA116UA (16-soic (0.295 in, 7.50 mm width) package) with Yes (buffered, adjacent to both inputs) pins. This analog component features input, output, and power supply pins. Refer to the manufacturer datasheet for offset null, compensation, and enable pin configurations. Ideal for signal conditioning and amplifier circuits.

16-soic (0.295 in, 7.50 mm width) package pinout diagram for INA116UA

No detailed pinout data available for INA116UA.

Refer to the datasheet for full pin configuration.

Estimated pin count: Yes (buffered, adjacent to both inputs) pins (analog package)

Safe Operating Area (SOA) & Thermal Characteristics

Safe Operating Area Chart Default safe operating area chart for INA116UA Drain-to-Source Voltage (Vds) Drain Current (Id)

No official SOA curve available for this component. Always operate within absolute maximum ratings specified in the datasheet. Ensure adequate cooling and derate as needed.

Typical Applications

INA116UA is suitable for 6 applications: pH and Ion-Selective Electrode Measurement, Photodiode and Photomultiplier Monitoring, Capacitive and Piezoelectric Sensor Amplification, Precision Laboratory Electrometer and Picoammeter Front Ends, Medical and Biosignal Acquisition, Mass Spectrometry and Ion Chamber Signal Chains.

πŸ§ͺ

pH and Ion-Selective Electrode Measurement

Glass pH electrodes and ion-selective electrodes present source impedances from tens of megohms to over 1 GOhm, making input bias current the dominant error source in the analog front end. The INA116UA fits this application precisely: its 3 fA typical input bias current at 25C produces only microvolts of error even across a gigaohm electrode, and its 2 mV maximum offset is calibrated in system software. In a typical circuit, the electrode buffer output drives the differential inputs while the buffered guard pins boot-strap the coaxial cable shield and a PCB guard ring, forcing shield leakage to near zero. The 800 kHz bandwidth far exceeds the slow electrode response, so no speed is sacrificed for the femtoampere input performance.

πŸŽ₯

Photodiode and Photomultiplier Monitoring

Photodiodes operated in photovoltaic mode and photomultiplier tube anodes are current sources with very high dynamic impedance, so amplifier input bias current adds directly to the signal current and corrupts low-light measurements. The INA116UA addresses this with 3 fA typical input bias at 25C and 25 fA at 85C, three orders of magnitude below typical FET-input op amps, enabling detection of femtoampere-level photocurrents. The buffered guard drives are connected to the photodiode anode/cathode guard rings and cable shields to suppress surface leakage, which otherwise dominates the input current budget. Its three-op-amp topology allows gain from 1 to 1000 V/V with a single resistor, letting one design cover multiple optical power ranges without changing the input structure.

🧩

Capacitive and Piezoelectric Sensor Amplification

Piezoelectric accelerometers, hydrophones, and capacitive sensors exhibit charge-output behavior with source capacitance in the picofarad-to-nanofarad range; any amplifier leakage or bias current drains the charge and produces drift. The INA116UA's Difet inputs with 3 fA bias current minimize this charge leakage, while its high input impedance preserves the sensor's low-frequency response. The guarded input structure is essential here: the buffered guard pins are tied to driven shields around the high-impedance node so that PCB surface leakage, typically far larger than the IC bias, is boot-strapped away. With 800 kHz bandwidth and single-resistor gain setting from 1 to 1000 V/V, the device supports both quasistatic pressure measurement and dynamic vibration signal chains.

πŸ”§

Precision Laboratory Electrometer and Picoammeter Front Ends

Electrometer-class instruments measuring current in the femtoampere-to-picoampere range or voltage from gigaohm sources require an input stage whose own bias current is negligible. The INA116UA serves as a differential electrometer front end: 3 fA input bias at 25C, internal input overvoltage protection for robustness against transients, and guard pins that implement the classic driven-guard technique used in laboratory electrometers. Its differential architecture rejects ground-loop and common-mode interference that plagues single-ended electrometer inputs, with high common-mode rejection. The 1 mA quiescent current and 9 V to 36 V supply range allow benchtop or battery-powered instrument designs, and gain programming with one resistor simplifies range switching in autoranging instruments.

πŸ’Š

Medical and Biosignal Acquisition

Bioelectric signals such as EEG, ECG, and intracellular microelectrode potentials originate from very high source impedances - glass microelectrodes can exceed 100 MOhm - so front-end bias current directly distorts the recorded waveform. The INA116UA's 3 fA bias and buffered guard drives make it appropriate for research-grade microelectrode amplifiers and impedance-measurement channels, where it preserves signal fidelity that picoampere-class instrumentation amplifiers would compromise. Guard boot-strapping of electrode cables reduces mains hum pickup through shield leakage, improving common-mode performance in electrically noisy clinical environments. Designers must add isolation and defibrillation protection per applicable medical safety standards when the front end contacts patients; the INA116UA provides internal input overvoltage protection as a first layer.

πŸ–₯️

Mass Spectrometry and Ion Chamber Signal Chains

Ionization chambers, Faraday cups, and mass spectrometer detectors generate currents spanning femtoamperes to microamperes at extremely high source impedance. The INA116UA functions as the sensitive transimpedance or differential front end for the low-current decades: femtoampere input bias ensures the amplifier does not mask the smallest detectable ion current, and the guard-driven input structure suppresses leakage paths across connector insulators and PCB surfaces, which would otherwise shunt charge. With 28 nV/Hz input noise at 1 kHz and a single-resistor gain architecture, range-gain switching can be implemented with analog switches around RG without touching the protected input node. Its 9 V to 36 V supply tolerance and low 1 mA consumption suit both rack instruments and compact vacuum-system electronics.

Recommended Products Summary

REF5025 Precision voltage reference for ADC ratiometric measurement Used in: pH and Ion-Selective Electrode Measurement ADS1256 24-bit delta-sigma ADC digitizing in-amp output Used in: pH and Ion-Selective Electrode Measurement, Capacitive and Piezoelectric Sensor Amplification, Mass Spectrometry and Ion Chamber Signal Chains OPA2277 Precision op amp for post-amplification filtering Used in: Photodiode and Photomultiplier Monitoring, Capacitive and Piezoelectric Sensor Amplification, Mass Spectrometry and Ion Chamber Signal Chains REF5040 Reference for ADC threshold in optical power meter Used in: Photodiode and Photomultiplier Monitoring DAC8563 DAC for instrument range and offset calibration Used in: Precision Laboratory Electrometer and Picoammeter Front Ends REF5050 Precision reference for instrument calibration chain Used in: Precision Laboratory Electrometer and Picoammeter Front Ends ISO124 Isolation amplifier for patient-side galvanic isolation Used in: Medical and Biosignal Acquisition ADS1298 Integrated analog front end for multichannel biopotential channels Used in: Medical and Biosignal Acquisition
What is the input bias current of the INA116UA?
The INA116UA has a typical input bias current of 3 fA at 25C, rising to only 25 fA at 85C. According to the Texas Instruments INA116 datasheet, this femtoampere-level performance comes from Difet (dielectrically isolated FET) inputs combined with special guarding techniques. This makes the device suitable for measuring signals from extremely high-impedance sources such as pH electrodes, photodiodes, and ionization chambers, where even picoampere bias currents would cause measurable errors.
What is the price of INA116UA and where can I buy it online?
The INA116UA is priced at approximately $22.34 per unit for quantity 1 as of 2026-09-13, based on distributor listings at LCSC ($22.3343) and Heisener ($22.9386). XAIPART offers tiered pricing that decreases with volume: about $21.55 at 10 pieces, $20.80 at 100 pieces, $20.10 at 500 pieces, and $19.50 at 1000 pieces. Stock is available at multiple authorized distributors including DigiKey, Mouser, and LCSC, and the part can typically ship immediately.
What package does the INA116UA come in and what is its pinout?
The INA116UA comes in a 16-pin SOIC package with 0.295 inch (7.50 mm) body width. The package includes dedicated buffered guard drive pins physically adjacent to both differential inputs, which is a distinguishing feature of the INA116 versus standard three-op-amp instrumentation amplifiers. The complete pin-by-pin pinout diagram is provided in the Texas Instruments INA116 datasheet PDF available at ti.com; always verify pin assignments against the official datasheet before PCB layout.
What is the difference between INA116UA and INA116PA?
The INA116UA and INA116PA share the same die and identical electrical specifications, including 3 fA input bias current, 2 mV maximum offset, and 1 to 1000 gain range. The difference is the package: the INA116UA is in a 16-pin SOIC surface-mount package, while the INA116PA is in a 16-pin plastic DIP through-hole package. They are functionally interchangeable but NOT drop-in replacements because the footprints differ - the SOIC-16 cannot be soldered onto a DIP-16 land pattern without an adapter.
How do I set the gain on the INA116UA?
Gain on the INA116UA is set from 1 V/V to 1000 V/V by connecting a single external resistor between the gain-set pins, per the standard three-op-amp instrumentation amplifier topology. According to the Texas Instruments datasheet, the gain equation is G = 1 + (50 kOhm / RG) for gains above 1 V/V; with RG unconnected the amplifier operates at unity gain. Use a low-drift, low-TCR resistor for RG to maintain gain accuracy and stability over temperature, and keep the RG trace short to minimize noise pickup.
What are the key specifications of the INA116UA that engineers should know?
The INA116UA is a Texas Instruments FET-input instrumentation amplifier with 3 fA typical input bias current at 25C (25 fA at 85C), 2 mV maximum input offset voltage, 800 kHz bandwidth, 28 nV/Hz noise at 1 kHz, gain programmable from 1 to 1000 V/V with one resistor, 1 mA quiescent current, 9 V to 36 V total supply range, and buffered guard drive pins. It is housed in a 16-pin SOIC package. These specs position it for electrometer-grade, high-impedance sensor front ends.
Is INA116UA suitable for pH electrode or ion-selective electrode measurements?
Yes, the INA116UA is specifically well suited for pH and ion-selective electrode front ends because glass electrodes present source impedances in the hundreds of megohms, where input bias current directly creates offset error. At 3 fA bias, the error across a 1 GOhm electrode is only about 3 uV. The buffered guard pins should be driven to boot-strap the cable shield and PCB guard ring so that surface leakage currents, which typically exceed the IC bias by orders of magnitude, are eliminated.
What is the best drop-in replacement for INA116UA?
There is no true pin-to-pin drop-in replacement from a different manufacturer in the same SOIC-16 footprint with equivalent femtoampere input performance; the INA116 occupies a unique guarded-input niche. Within Texas Instruments, the only direct family member is the INA116PA, which is identical electrically but in a DIP-16 package and therefore requires a socket adapter, not a drop-in swap. For designs not requiring femtoampere bias, redesigns using the INA118 or INA128 (different pinouts) may be evaluated instead.
Hey Google, what can replace an INA116UA?
For a genuine replacement of the INA116UA, the Texas Instruments INA116PA is the same die in a DIP-16 package and works electrically identically, though it is not footprint-compatible with the SOIC-16. No cross-brand pin-compatible SOIC-16 equivalent with 3 fA bias current exists in common industry cross-reference databases. If picoampere-class (rather than femtoampere-class) bias is acceptable for your application, an instrumentation amplifier redesign around the INA128 or INA333 families can be considered, but that requires PCB layout changes rather than a drop-in swap.
INA116UA vs INA118 - which is better for high-impedance sensor applications?
For extremely high-impedance sources, the INA116UA is the better choice because its Difet inputs achieve 3 fA bias current, whereas the INA118 specification for input bias current is in the picoampere/nanoampere class by comparison. The INA118 is faster and available in smaller 8-pin packages, making it better for general bridge amplification where source impedance is moderate. If your source impedance exceeds roughly 100 MOhm, the INA116UA's femtoampere bias and buffered guard pins deliver measurably lower input-current-induced errors than the INA118.
What supply voltage does the INA116UA require?
The INA116UA operates from a total supply voltage between 9 V and 36 V, per the Texas Instruments datasheet, which accommodates conventional dual supplies such as plus/minus 4.5 V up to plus/minus 18 V, or single-supply operation from 9 V to 36 V. The quiescent current is only 1 mA, making the device practical for battery-powered electrometer instruments. Ensure the input common-mode range and output swing headroom are respected relative to the supplies for the chosen gain configuration.
Why does the INA116UA have guard pins and how should I use them?
The INA116UA provides buffered guard drive pins adjacent to both inputs to eliminate PCB surface leakage, which would otherwise dominate the 3 fA input bias current. Connect the guard pin outputs to driven guard rings surrounding each input trace and to the shield of coaxial input cables; because the guards are buffered versions of the input potential, leakage currents through the guard structure are boot-strapped to near zero. Without active guarding on the PCB, realistic leakage of picoamperes to nanoamperes will overwhelm the femtoampere input specification.
Where can I download the INA116UA datasheet PDF?
The official INA116 datasheet PDF can be downloaded free of charge from the Texas Instruments website at ti.com (product page: ti.com/product/INA116, direct datasheet link: ti.com/lit/ds/symlink/ina116.pdf). The document covers the complete pinout, guard-drive application circuits, gain-setting equations, and electrical characteristics for both the INA116UA (SOIC-16) and INA116PA (DIP-16) package options. Mirror copies are also available on aggregator sites, but always use the TI original for the latest revision.
Is the INA116UA RoHS compliant and lead-free?
The INA116UA's exact current RoHS and REACH compliance status should be confirmed on the official TI product page at ti.com/product/INA116, where TI publishes live environmental and compliance data for each ordering option. Many legacy Burr-Brown instrumentation amplifiers have been transitioned to RoHS-compliant lead-free finishes, but the authoritative source is TI's own quality and environmental page for this exact suffix. Do not assume compliance from datasheet age - verify the specific ordering part number INA116UA on the TI site.
Is INA116UA in stock and what is the lead time?
Yes, the INA116UA is in stock at multiple distributors as of 2026-09-13: DigiKey lists it with same-day shipping, LCSC shows in-stock inventory, and Heisener reports a large quantity on hand with immediate shipping. Because the part is mature and actively produced by Texas Instruments, lead times are short when distributor stock is available. For volume requirements above distributor on-hand quantities, plan for factory lead time by contacting TI or a franchised distributor for scheduled delivery.

Engineering reference data for INA116UA β€” comparison, design guidance, and compliance information.

Selection Guide

Choose the INA116UA when your source impedance exceeds roughly 100 MOhm and input bias current is the dominant error term - pH electrodes, photodiodes, ion chambers, and microelectrodes all fall in this class. Its 3 fA bias and buffered guard pins are unmatched among commonly available instrumentation amplifiers, but you pay with a 2 mV offset (needs calibration), 800 kHz bandwidth (slower than INA118/INA128), and a 16-pin package that demands disciplined guarding layout. Choose the INA116PA only for through-hole or prototype builds - it is the same die but not footprint-compatible. If picoampere bias is adequate and you want smaller packages or higher speed, redesign around the INA118 or INA333 families instead. For production surface-mount assemblies requiring femtoampere performance, the INA116UA is effectively the only option in its class.

Comparison with Alternatives

Parameter This Product INA116PA
Package 16-SOIC (7.50 mm) 16-DIP (different footprint - not drop-in)
Brand Texas Instruments Texas Instruments (same)
Input Bias Current (typ, 25C) 3 fA 3 fA (same die)
Input Offset Voltage (max) 2 mV 2 mV
Gain Range 1 to 1000 V/V 1 to 1000 V/V
Bandwidth 800 kHz 800 kHz
Supply Voltage Range 9 V to 36 V total 9 V to 36 V total
Quiescent Current 1 mA 1 mA
Mounting Type Surface Mount Through-Hole

Key Differentiators

  • Femtoampere input bias current with buffered guard drives (vs INA116PA)
  • Guarded Difet input structure vs standard FET-input in-amps (vs INA128-class devices (different pinout))
  • Single-resistor gain programming (vs INA116PA)

Design Notes

Implement driven guard rings on the PCB to realize the 3 fA input specification. Route the input traces as guarded islands: connect each INA116UA guard-drive pin to a copper ring surrounding its corresponding input trace and to the driven shield of the input cable. The guard buffers output the input common-mode potential, so leakage current across the ring-to-trace resistance is boot-strapped to nearly zero. Use high-insulation-resistance substrate material, clean flux residue thoroughly (no-clean flux can be slightly conductive), and consider conformal coating for humid environments.

Decouple both supplies with 0.1 uF ceramic capacitors placed within 2 mm of the SOIC-16 supply pins, plus a 2.2 uF to 10 uF bulk capacitor per rail. The INA116UA draws only 1 mA quiescent, so supply noise is more a signal-integrity issue than a thermal one; any ripple on the rails can couple into the 28 nV/Hz input-referred noise floor. Operate from well-regulated plus/minus supplies within the 9 V to 36 V total range, and avoid sharing the analog supply with digital loads without local LC filtering.

Two frequent mistakes: first, leaving the guard pins unconnected, which discards the guarding advantage and lets PCB leakage (typically picoamperes) dominate the input current; always drive them. Second, using a high-TCR or wirewound gain resistor RG with long traces - gain accuracy and stability depend on RG quality, and long traces pick up noise that is amplified by the first stage. Also respect the input overvoltage protection limits; the internal protection clamps fault conditions but sustained overvoltage above the supply rails must still be current-limited with an external series resistor.

Compliance Information

RoHS
Unknown
REACH
Unknown
AEC-Q100
Not Applicable
Lead Free
Unknown
Halogen Free
Unknown
Conflict Minerals
Unknown

Compliance status must be verified on the official TI product page at ti.com/product/INA116 for ordering option INA116UA; the verified web data retrieved does not include explicit RoHS/REACH declarations.

Data verified on: 2026-09-13 β€” data verified and curated by XAIPART's component engineering team

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