Microchip Technology

ATMEGA645A-MU - 8-Bit AVR MCU 16MHz 64KB Flash | Microchip

MPN: ATMEGA645A-MU ✓ Active
In Stock Ships in 1-3 business days
1.8 V to 5.5 V Vdss 64-QFN (9x9 mm) Exposed Pad (64-VFQFN) Package 16 MHz Speed 64 KB (32K x 16) Memory
From $3.7 USD / Unit
MOQ: 1 |
Price updated: 2026-09-18
Volume Pricing
Qty Unit Price Extended
1 $5.77 $5.77
10 $5.19 $51.90
100 $4.62 $462.00
500 $4.16 $2,080.00
1,000 $3.7 $3,700.00
ℹ️ All prices are in USD

ATMEGA645A-MU Overview

The Microchip Technology ATMEGA645A-MU is an 8-bit AVR RISC microcontroller with 64 KB of In-System Programmable Flash, 4 KB SRAM, 2 KB EEPROM, and a 16 MHz maximum clock frequency, housed in a 64-pin QFN (9x9 mm) package with exposed pad.

An 8-bit AVR ATmega microcontroller is a Harvard-architecture RISC processor that executes most instructions in a single clock cycle, positioning it in the embedded hierarchy as: ATMEGA645A -> ATmega family -> AVR 8-bit MCU -> microcontroller unit (MCU). These devices integrate program memory, data memory, peripherals, and a CPU core on a single die, making them a complete embedded control solution.

Key features include single-cycle RISC execution through 32 general-purpose working registers, read-while-write Flash for self-programming, JTAG boundary-scan and on-chip debugging, and a rich analog and timer peripheral set. The device operates from 1.8V to 5.5V, supporting both battery-powered and 5V industrial designs.

The AVR core combines a fast ALU with the 32-register file, which is directly connected to the ALU, allowing two independent registers to be accessed in one instruction executed in one clock cycle. This architecture achieves throughputs up to 16 MIPS at 16 MHz, roughly ten times faster than conventional CISC microcontrollers. Peripherals include an 8-channel 10-bit ADC, USART, SPI, two-wire interface (TWI/I2C), timers with PWM, and an on-chip temperature sensor.

Typical applications include industrial control panels, HVAC and building automation, consumer appliances, metering systems, and LCD-equipped instruments, where the ATMEGA645A's large 64 KB Flash accommodates C-based firmware with graphics or communication stacks.

When designing, plan the clock source early: at 5V the device supports up to 16 MHz, and an external crystal plus decoupling on AVCC is required for full ADC accuracy.

This page synthesizes verified distributor pricing, same-family drop-in alternatives, and practical AVR design guidance not found in the manufacturer datasheet.

Drop-in alternatives for ATMEGA645A-MU — same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Variants in this series

Same-series models that are drop-in compatible with ATMEGA645A-MU (same form factor and footprint) — differing in Package, Flash Memory, Core Processor, ADC Resolution, EEPROM.

Microchip Technology
Package: 64-QFN (9x9 mm) Exposed Pad
Flash Memory: 32 KB (16K x 16)
EEPROM: 1 KB
Compare with ATMEGA645A-MU →
Microchip Technology
Package: 64-QFN (9 x 9 mm)
ADC Resolution: 10 bit
Compare with ATMEGA645A-MU →
Microchip Technology
Package: 64-QFN (9x9 mm) MLF, surface mount
Flash Memory: 64 KB (32K x 16) ISP
Core Processor: AVR 8-bit RISC
Compare with ATMEGA645A-MU →
Microchip Technology
Package: 64-VFQFN Exposed Pad (9x9 mm)
EEPROM: 2 KB
Compare with ATMEGA645A-MU →

Quick Comparison Tool — Select alternative parts for side-by-side comparison:

ATMEGA645-16MUR

✅ Drop-In
Microchip Technology
📦 64-QFN (9x9)
8-bit AVR RISC · 8-Bit · 16 MHz · 64 KB (32K x 16) Flash · 2 KB · 4 KB · 4.5 V to 5.5 V · 53

✓ In Stock

$3.35 / Unit

View Datasheet →

ATMEGA6450A-MU

✅ Drop-In ⚠️ 参数待验证
📦 64-QFN (9x9)
same 64-QFN (9x9) package, same 64KB Flash / 4KB SRAM / 16MHz, part of the same ATmega645A/6450A datasheet family

📋 Reference alternative (not in catalog)

ATMEGA645P-MU

✅ Drop-In ⚠️ 参数待验证
Microchip Technology
📦 64-QFN (9x9)
AVR 8-bit RISC · 8-bit · 16 MHz · 64 KB (32K x 16) ISP · 2 KB · 4 KB · 54 · 2.7 V to 5.5 V

✓ In Stock

$4.21 / Unit

View Datasheet →

ATMEGA325A-MU

✅ Drop-In ⚠️ 参数待验证
Microchip Technology
📦 64-QFN (9x9)
AVR · 8-Bit · 20 MHz · 32 KB (16K x 16) · 2 KB · 1 KB · 54 · 64-QFN (9x9 mm) Exposed Pad

✓ In Stock

$3.49 / Unit

View Datasheet →

ATMEGA645A-MU Maximum Ratings & Electrical Characteristics

Core Processor AVR
Core Size 8-Bit
Speed 16 MHz
Flash Memory 64 KB (32K x 16)
EEPROM Size 2 KB
RAM Size 4 KB
Supply Voltage (Vcc/Vdd) 1.8 V to 5.5 V
Number of I/O 54 / 69 general purpose I/O lines
Package 64-QFN (9x9 mm) Exposed Pad (64-VFQFN)
Mounting Type Surface Mount
ADC Resolution 10-bit
Oscillator Type Internal + External
Programming Interface ISP, JTAG, ICSP
Series AVR ATmega
RoHS Status Compliant

ATMEGA645A-MU 64-qfn (9x9 mm) exposed pad (64-vfqfn) Pin Configuration Guide

Pin configuration for ATMEGA645A-MU (64-qfn (9x9 mm) exposed pad (64-vfqfn) package). This digital IC includes GPIO, communication interfaces (UART, SPI, I2C), and power pins. Refer to the manufacturer datasheet for alternate pin functions and configuration options. Essential for embedded system design and PCB layout.

64-qfn (9x9 mm) exposed pad (64-vfqfn) package pinout diagram for ATMEGA645A-MU

No detailed pinout data available for ATMEGA645A-MU.

Refer to the datasheet for full pin configuration.

Typical Applications

ATMEGA645A-MU is suitable for 6 applications: Industrial Control Panels, HVAC and Building Automation, Metering and Instrumentation, Consumer Appliances, Battery-Powered Portable Devices, Embedded Development and Prototyping.

🏭

Industrial Control Panels

The ATMEGA645A-MU fits industrial control panels because its 5V-tolerant 1.8V to 5.5V supply range aligns with legacy factory logic levels, its 54 general-purpose I/O lines drive relays, contactors, and indicator banks directly, and its 8-channel 10-bit ADC samples analog sensor inputs such as potentiometers and current-sense outputs. The 64 KB Flash is large enough to hold state machines, MODBUS-style serial routines on the USART, and configuration data in the 2 KB EEPROM. In a typical panel, the MCU runs at 16 MHz from a crystal, polls discrete inputs each scan, and uses timer PWM outputs for actuator control; unlike 32-bit alternatives it requires no external memory and draws low static power, simplifying enclosed thermal design.

🧩

HVAC and Building Automation

Building automation nodes benefit from the ATMEGA645A-MU's combination of a two-wire interface (TWI/I2C) for temperature and humidity sensors, a USART for RS-485 trunk communication via external transceivers, and timer PWM outputs for damper and fan control. The 1.8V to 5.5V rail flexibility lets designers run the logic from a single 3.3V or 5V wall-adapter supply, while the 64 KB Flash accommodates scheduling tables, PID loops, and firmware-update bootloaders without external storage. The 4 KB SRAM holds network buffers comfortably, and the 2 KB EEPROM retains setpoints through power loss. Because the QFN's exposed pad improves board-level heat spreading, thermostat enclosures with no airflow remain within safe junction limits at typical mA-level loads.

🖥️

Metering and Instrumentation

Energy and utility metering designs use the ATMEGA645A-MU's 8-channel 10-bit ADC for multi-channel voltage and current sampling, its 16 MHz RISC core for real-time RMS computation, and its EEPROM for tamper and consumption logs that must survive power interruption. The 64 KB Flash stores calibration tables plus LCD-driving firmware, and JTAG boundary scan supports production test of dense meter PCBs. With the device running at 5V, ADC noise margin improves over 3V designs, an advantage when measuring small shunt signals. The read-while-write Flash enables field firmware updates over the meter's communication port without halting measurement routines, an important regulatory convenience for deployed meter fleets.

📺

Consumer Appliances

White goods and small appliances employ the ATMEGA645A-MU to run user interfaces (keys, encoders, and segment LCDs), motor PWM control, and safety interlocks in one chip. The wide 1.8V to 5.5V supply range tolerates unregulated auxiliaries derived from mains supplies, and the internal oscillator option allows cost-down designs that skip the crystal on non-timing-critical products. Its 64 KB Flash provides headroom for localized UI strings, diagnostic code, and OTA-style serial bootloaders, while the 2 KB EEPROM stores cycle counters and error logs. The 64-QFN's small 9x9 mm footprint fits crowded appliance control PCBs, and the exposed pad anchors the part against vibration and thermal cycling typical of kitchen environments.

📱

Battery-Powered Portable Devices

Portable instruments leverage the ATMEGA645A-MU's low-power AVR core and multiple sleep modes to stretch battery life while retaining 64 KB of code space for feature-rich firmware. Operating down to 1.8V means the device runs directly from two alkaline cells or a single lithium coin cell through most of the discharge curve, avoiding a boost converter. Designers typically clock at 1-8 MHz via the internal RC oscillator in active mode, drop to power-save sleep between measurements, and use timer or TWI wakeups from the real-time peripherals. The 4 KB SRAM buffers data-logger samples, and the 10-bit ADC digitizes sensor channels without an external converter, minimizing bill-of-materials cost in handheld enclosures.

🔧

Embedded Development and Prototyping

The ATMEGA645A-MU is a strong prototyping vehicle because Microchip supports it with the MPLAB SNAP and AVR ISP programmers through ICSP and JTAG, per the official product page, enabling on-chip debugging on the target board rather than guess-and-reflash cycles. The ATmega645A family is documented in the consolidated ATmega165A/325A/645A datasheet together with migration note AVR500, so engineers moving between 32 KB and 64 KB family members share one reference. The large 64 KB Flash removes early size constraints for C code, and the DIP-free QFN suits final-form-factor prototype PCBs. Open-source avr-gcc toolchains and Arduino-style bootloaders run on the AVR core, letting teams iterate firmware quickly before production freeze.

What are the key specifications of ATMEGA645A-MU?
The ATMEGA645A-MU is an 8-bit AVR ATmega microcontroller with 64 KB ISP Flash, 4 KB SRAM, 2 KB EEPROM, a 16 MHz maximum clock, and 54/69 general-purpose I/O lines in a 64-QFN (9x9 mm) exposed-pad package. It operates from 1.8V to 5.5V and includes JTAG and ISP programming support. According to the Microchip ATmega645A product page, the RISC core executes most instructions in a single cycle, delivering up to 16 MIPS throughput at 16 MHz.
What is the price of ATMEGA645A-MU?
As of 2026-09-18, distributor pricing for the ATMEGA645A-MU starts at approximately $5.77 per unit at quantity 1, with volume breaks reducing the unit cost to roughly $3.70 at 1,000 pieces. Heisener lists 15,036 pieces in stock with a unit price of $5.7695 and immediate shipment. Actual pricing varies by distributor, quantity, and stock location, so compare DigiKey, Mouser, and Octopart listings before purchasing.
Is ATMEGA645A-MU in stock and what is the lead time?
Yes, the ATMEGA645A-MU is broadly in stock across major distributors as of 2026-09-18. DigiKey states 'buy now, ships today,' Heisener shows 15,036 pieces in stock that can ship immediately, and Octopart aggregates pricing from 7 distributors. Lead time at authorized distributors is effectively same-day to a few days for stocked quantities; broker lead times are typically 3-5 days for delivery depending on shipping choice.
Where to buy ATMEGA645A-MU online?
The ATMEGA645A-MU can be purchased online from DigiKey (product page 2270999), Mouser, Octopart-linked distributors, and specialty distributors such as Heisener, Ampheo, and Xecor. For guaranteed-authentic parts, buy from authorized distributors like DigiKey or Mouser, which ship the same day for in-stock items. Always verify the '64-QFN (9x9)' package suffix -MU matches your PCB footprint before ordering, since the -AU variant comes in a TQFP package instead.
What is the difference between ATMEGA645A-MU and ATMEGA645A-MUR?
The only difference between the ATMEGA645A-MU and ATMEGA645A-MUR is the packaging method: the -MU suffix denotes Tape & Reel quantities in the 64-QFN (9x9) package, while the suffix denotes the same die in a different reel configuration for high-volume assembly. Electrically, both are identical 8-bit AVR MCUs with 64 KB Flash, 4 KB SRAM, and a 16 MHz clock. According to FindIC and Utmel comparison pages, they are treated as the same functional part for design purposes.
What is the difference between ATMEGA645A-MU and ATMEGA645A-AU?
The ATMEGA645A-MU and ATMEGA645A-AU contain the same 8-bit AVR die with 64 KB Flash and 16 MHz operation, but they differ in package: the -MU variant is a 64-QFN (9x9 mm) with exposed pad for surface-mount assembly, while the -AU variant is a 64-TQFP (14x14 mm) with gull-wing leads. They are NOT drop-in replacements for each other because the footprints differ. Choose -MU for compact, thermally enhanced layouts and -AU for hand soldering or prototyping.
What is the best drop-in replacement for ATMEGA645A-MU?
The best same-brand drop-in replacement for the ATMEGA645A-MU is the ATMEGA645-16MUR, which uses the same 64-QFN (9x9 mm) footprint and offers identical 64 KB Flash, 4 KB SRAM, and 16 MHz performance. Family members ATMEGA6450A-MU (identical ratings, part of the same datasheet family) and ATMEGA645P-MU (picoPower variant with lower sleep current) are also pin-compatible in the same package. Verify exact ordering data in the Microchip ATmega165A/325A/645A datasheet before qualifying any substitute.
Can ATMEGA325A-MU replace ATMEGA645A-MU?
Physically yes, functionally it depends: the ATMEGA325A-MU shares the 64-QFN package and pinout with the ATMEGA645A-MU, but it has only 32 KB Flash instead of 64 KB (a 50% reduction). If your compiled firmware image fits in 32 KB and you do not need the extra program space, the ATMEGA325A-MU is a pin-to-pin drop-in option at lower cost. For code bases near or above 32 KB, stay with the 64 KB ATMEGA645A or ATMEGA6450A family.
Is ATMEGA645A-MU suitable for industrial control applications?
Yes, the ATMEGA645A-MU is well suited for industrial control thanks to its 1.8V to 5.5V operating range, which tolerates the 5V logic levels common on factory floors, plus an 8-channel 10-bit ADC for sensor inputs and 54 general-purpose I/O lines for relays and indicators. The 64 KB Flash accommodates larger C programs with communication stacks, and JTAG enables on-chip debugging during development. Its industrial heritage within the AVR ATmega family makes it a proven choice for control panels and metering.
When should I choose ATMEGA645A-MU over ATMEGA325A-MU?
Choose the ATMEGA645A-MU when your firmware requires more than 32 KB of program memory, such as graphics libraries, communication stacks, or extended feature sets, since it provides 64 KB Flash versus 32 KB in the ATMEGA325A-MU. Both share the same 16 MHz clock, 4 KB SRAM, and identical 64-QFN footprint, so migration is purely a memory decision. If your code comfortably fits below 30 KB with margin for updates, the ATMEGA325A-MU saves cost; otherwise the 645A is the safer long-term choice.
What is the best Microchip (Atmel) equivalent for ATMEGA645A-MU?
The best same-manufacturer equivalents for the ATMEGA645A-MU are its own family members: ATMEGA645-16MUR (same die and 64-QFN package), ATMEGA6450A-MU (identical specifications within the same datasheet family), and ATMEGA645P-MU (picoPower version with reduced sleep-mode consumption in the same 64-QFN package). All operate at 1.8V to 5.5V and 16 MHz with 64 KB Flash. Cross-brand equivalents were not confirmed in verified cross-reference data, so no third-party part is recommended here.
Where can I download the ATMEGA645A-MU datasheet PDF?
The ATMEGA645A-MU datasheet is available as a PDF from Microchip Technology's official site (the device appears in the ATmega165A/PA/325A/PA/3250A/PA/645A/P/6450A/P datasheet, document Atmel-8285) and from mirror sites such as AllDataSheet and DatasheetQ. For the authoritative and current revision, always download from ww1.microchip.com or the ATmega645A product page, which also links application notes like AVR500 covering migration between ATmega64 and ATmega645.
What is the supply voltage range of ATMEGA645A-MU?
The ATMEGA645A-MU operates from 1.8V to 5.5V according to verified distributor specification data (Atmel-Micro listing: Voltage - Supply 1.8V ~ 5.5V). This wide range supports a single lithium cell (3.0-3.6V), two AA batteries (about 3V), and 5V industrial rails in one design. Note that maximum clock frequency is voltage-dependent: full 16 MHz operation requires higher supply voltage, so derate the clock if running near 1.8V per the AVR datasheet frequency-versus-voltage curve.
How do I program the ATMEGA645A-MU?
The ATMEGA645A-MU supports In-Circuit Serial Programming (ICSP/ISP) via the SPI pins and JTAG programming and debugging via the four-pin JTAG port. According to the Microchip product page, the MPLAB SNAP programmer connects through a High-Speed USB 2.0 interface and uses two device I/O pins plus the reset line for in-circuit debugging and ICSP. The 64 KB Flash supports read-while-write self-programming, enabling bootloader-based firmware updates over UART or other interfaces in the field.
Is ATMEGA645A-MU the same as ATMEGA64?
No, the ATMEGA645A-MU is not identical to the ATmega64, although they are closely related. According to Microchip application note AVR500 (doc2576), ATmega64 and ATmega645 are coexisting devices, not designed as replacements for each other; they are pin compatible for all but a few pins and share a very similar feature set. Differences include peripheral mapping and package options. If migrating an ATmega64 design to the ATMEGA645A, follow AVR500 for the exact pin and register changes required.

Engineering reference data for ATMEGA645A-MU — comparison, design guidance, and compliance information.

Selection Guide

Choose the ATMEGA645A-MU when you need maximum code space (64 KB Flash) and full SRAM (4 KB) in a compact 9x9 mm QFN for space-constrained industrial, appliance, or metering designs at 5V or 3V. Select the ATMEGA645P-MU instead for battery-powered products, since its picoPower technology cuts sleep current substantially while remaining pin-identical. Pick ATMEGA325A-MU when firmware fits in 32 KB and you want lower cost without a PCB change. Choose ATMEGA645A-AU (64-TQFP) for hand-assembled prototypes or boards requiring easier inspection. If migrating from ATmega64, consult Microchip application note AVR500 first: the parts are pin compatible except for a few pins and are coexisting devices, not direct replacements. All listed alternatives share the AVR toolchain, ISP/JTAG programming flow, and 1.8V-5.5V supply range, so firmware and programmer investments carry over with minor register-level changes.

Comparison with Alternatives

Parameter This Product ATMEGA645-16MUR ATMEGA6450A-MU ATMEGA645P-MU ATMEGA325A-MU
Package 64-QFN (9x9) 64-QFN (9x9) - same 64-QFN (9x9) - same 64-QFN (9x9) - same 64-QFN (9x9) - same
Brand Microchip Technology Microchip Technology Microchip Technology Microchip Technology Microchip Technology
Flash Memory 64 KB 64 KB 64 KB 64 KB 32 KB
SRAM 4 KB 4 KB 4 KB 4 KB 2 KB
Max Clock 16 MHz 16 MHz 16 MHz 16 MHz 16 MHz
Supply Voltage 1.8 V to 5.5 V 1.8 V to 5.5 V 1.8 V to 5.5 V 1.8 V to 5.5 V 1.8 V to 5.5 V
Low-Power Feature Standard ATmega sleep modes Standard Standard picoPower (lower sleep current) Standard
Programming / Debug ISP, JTAG, ICSP ISP, JTAG ISP, JTAG ISP, JTAG ISP, JTAG

Key Differentiators

  • Double the program memory for feature-rich firmware (vs ATMEGA325A-MU)
  • picoPower variant available for battery designs (vs ATMEGA645P-MU)
  • Compact thermally enhanced QFN over TQFP (vs ATMEGA645A-AU)

Design Notes

Decouple VCC and AVCC independently: place a 100 nF ceramic capacitor within 2 mm of each VCC pin and a separate 100 nF plus 10 uF pair on AVCC, connected to analog ground through an LC or RC filter. AVCC must not differ from VCC by more than 0.3V, per AVR family supply requirements. For ADC accuracy, keep the digital return path away from the analog ground region under the exposed pad; the 64-QFN exposed pad should be soldered to a grounded copper pour for both electrical grounding and heat spreading.

Clock frequency depends on supply voltage: 16 MHz operation is only valid at the upper end of the 1.8V-5.5V range, so check the frequency-versus-voltage curve in the ATmega645A datasheet before selecting a crystal. Also confirm that any replacement from the family (e.g., ATmega325A) matches fuse settings and JTAG enable state - JTAG is enabled by default on this family and the four JTAG pins are not available as GPIO unless the JTAGEN fuse is disabled, a frequent source of 'missing I/O pins' issues on port designs migrated from non-JTAG ATmegas.

For the 64-QFN (9x9) land pattern, design thermal vias under the exposed pad (roughly a 4x4 or 5x5 via array filled or tented per assembly capability) tied to the ground plane to improve both thermal performance and signal grounding. Trace lengths to the crystal should be kept under 10 mm with guard ground rings. Route the RESET line with a 10 kOhm pull-up and keep it short to support reliable ISP programming; on dense boards, bring RESET and the SPI ISP pins to a 6-pin programming header for in-circuit updates with MPLAB SNAP or equivalent AVR programmers.

Compliance Information

RoHS
Compliant
REACH
Unknown
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Unknown
Conflict Minerals
Unknown

RoHS compliant per distributor listings (DigiKey/Mouser). REACH and halogen-free status not stated in the provided verified data.

Data verified on: 2026-09-18 — data verified and curated by XAIPART's component engineering team

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Related Components & Terms

Microchip Technology Atmel ATMEGA645A-MU ATMEGA645-16MUR ATMEGA6450A-MU ATMEGA645P-MU ATMEGA325A-MU ATmega64 AVR 8-bit RISC microcontroller MCU Flash memory EEPROM 64-QFN (9x9) TQFP ISP JTAG ICSP RoHS AVR500 application note picoPower MPLAB SNAP 10-bit ADC industrial control metering
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