STMicroelectronics

STM32L452RET6 - Ultra-Low-Power ARM Cortex-M4 MCU | STMicroelectronics

MPN: STM32L452RET6 βœ“ Active
In Stock (99,999) Ships in 1-3 business days
1.71 V to 3.6 V Vdss 28 Β΅A (typ) with RTC Id LQFP-64 Package 80 MHz Speed 512 KB Memory
$8.5 USD / Unit
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100 $6.8 $680.00
500 $6.12 $3,060.00
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Drop-in alternatives for STM32L452RET6 β€” same package, pin-to-pin compatible. Different-package parts requiring PCB rework are excluded.

Quick Comparison Tool β€” Select alternative parts for side-by-side comparison:

STM32L452RET7

βœ… Drop-In
πŸ“¦ LQFP-64
Extended temperature range (-40Β°C to +125Β°C)

πŸ“‹ Reference alternative (not in catalog)

STM32L452RCT6

βœ… Drop-In
πŸ“¦ LQFP-64
Less memory: 256 KB Flash, 64 KB SRAM

πŸ“‹ Reference alternative (not in catalog)

STM32L452RGT6

βœ… Drop-In
πŸ“¦ LQFP-64
More memory: 1 MB Flash, 320 KB SRAM

πŸ“‹ Reference alternative (not in catalog)

STM32L452RCT7

βœ… Drop-In
πŸ“¦ LQFP-64
Extended temperature range and less memory

πŸ“‹ Reference alternative (not in catalog)

STM32L452RGT7

βœ… Drop-In
πŸ“¦ LQFP-64
Extended temperature range and more memory

πŸ“‹ Reference alternative (not in catalog)

STM32L452RET6TR

βœ… Drop-In
πŸ“¦ LQFP-64
Tape and reel packaging variant

πŸ“‹ Reference alternative (not in catalog)

STM32L452RET6

βœ… Drop-In
STMicroelectronics
πŸ“¦ LQFP-64
ARM Cortex-M4 with FPU Β· 80 MHz Β· 512 KB Β· 160 KB Β· 1.71 V to 3.6 V Β· -40Β°C to +85Β°C Β· LQFP-64 Β· Surface Mount

βœ“ 99,999 In Stock

$5.5 / Unit

View Datasheet β†’
ℹ️ 3 cross-package part(s) hidden β€” different package requires PCB rework and is not a true drop-in replacement. Contact us if you need cross-package suggestions.

STM32L452RET6 Maximum Ratings & Electrical Characteristics

Core ARM Cortex-M4 with FPU
Max Clock Frequency 80 MHz
Flash Memory 512 KB
SRAM 160 KB
Supply Voltage Range 1.71 V to 3.6 V
Operating Temperature Range -40Β°C to +85Β°C
Package LQFP-64
Mounting Type Surface Mount
Number of I/Os 51
ADC Resolution 12-bit
DAC Resolution 12-bit
Communication Interfaces USART, SPI, I2C, USB 2.0 FS, SAI, CAN
Low Power Mode Current (Stop 2) 28 Β΅A (typ) with RTC
Low Power Mode Current (Shutdown) 112 nA (typ)
RoHS Status Compliant

STM32L452RET6 Pin Configuration

QFP-64 Package Pinout Diagram QFP-64 10x10mm, P0.5mm, JEDEC MS-026. 1 16 QFP-64
Pin 1 VBAT β€” Backup battery supply
Pin 2 PC13 β€” GPIO / RTC tamper
Pin 3 PC14 β€” GPIO / OSC32_IN
Pin 4 PC15 β€” GPIO / OSC32_OUT
Pin 5 PF0 β€” GPIO / OSC_IN
Pin 6 PF1 β€” GPIO / OSC_OUT
Pin 7 NRST β€” Reset
Pin 8 VDD β€” Digital power supply
Pin 9 VSS β€” Ground
Pin 10 VDDA β€” Analog power supply
Pin 11 PA0 β€” GPIO / ADC_IN0
Pin 12 PA1 β€” GPIO / ADC_IN1
Pin 13 PA2 β€” GPIO / USART2_TX
Pin 14 PA3 β€” GPIO / USART2_RX
Pin 15 PA4 β€” GPIO / DAC_OUT1
Pin 16 PA5 β€” GPIO / DAC_OUT2
Pin 17 PA6 β€” GPIO / SPI1_MISO
Pin 18 PA7 β€” GPIO / SPI1_MOSI
Pin 19 PB0 β€” GPIO / ADC_IN8
Pin 20 PB1 β€” GPIO / ADC_IN9
Pin 21 PB2 β€” GPIO / BOOT1
Pin 22 PB10 β€” GPIO / I2C2_SCL
Pin 23 PB11 β€” GPIO / I2C2_SDA
Pin 24 PB12 β€” GPIO / SPI2_NSS
Pin 25 PB13 β€” GPIO / SPI2_SCK
Pin 26 PB14 β€” GPIO / SPI2_MISO
Pin 27 PB15 β€” GPIO / SPI2_MOSI
Pin 28 PC6 β€” GPIO / USART6_TX
Pin 29 PC7 β€” GPIO / USART6_RX
Pin 30 PC8 β€” GPIO / USART6_CK
Pin 31 PC9 β€” GPIO / I2C3_SDA
Pin 32 PA8 β€” GPIO / USB_OTG_FS_SOF
Pin 33 PA9 β€” GPIO / USB_OTG_FS_VBUS
Pin 34 PA10 β€” GPIO / USB_OTG_FS_ID
Pin 35 PA11 β€” GPIO / USB_OTG_FS_DM
Pin 36 PA12 β€” GPIO / USB_OTG_FS_DP
Pin 37 PA13 β€” GPIO / SWDIO
Pin 38 PA14 β€” GPIO / SWCLK
Pin 39 PA15 β€” GPIO / JTDI
Pin 40 PB3 β€” GPIO / JTDO
Pin 41 PB4 β€” GPIO / NJTRST
Pin 42 PB5 β€” GPIO / I2C1_SMBA
Pin 43 PB6 β€” GPIO / I2C1_SCL
Pin 44 PB7 β€” GPIO / I2C1_SDA
Pin 45 BOOT0 β€” Boot mode selection
Pin 46 PB8 β€” GPIO / CAN_RX
Pin 47 PB9 β€” GPIO / CAN_TX
Pin 48 VDD β€” Digital power supply
Pin 49 VSS β€” Ground
Pin 50 PC0 β€” GPIO / ADC_IN10
Pin 51 PC1 β€” GPIO / ADC_IN11
Pin 52 PC2 β€” GPIO / ADC_IN12
Pin 53 PC3 β€” GPIO / ADC_IN13
Pin 54 PC4 β€” GPIO / ADC_IN14
Pin 55 PC5 β€” GPIO / ADC_IN15
Pin 56 PD2 β€” GPIO / USART5_TX
Pin 57 PE7 β€” GPIO / FSMC_D4
Pin 58 PE8 β€” GPIO / FSMC_D5
Pin 59 PE9 β€” GPIO / FSMC_D6
Pin 60 PE10 β€” GPIO / FSMC_D7
Pin 61 PE11 β€” GPIO / FSMC_D8
Pin 62 PE12 β€” GPIO / FSMC_D9
Pin 63 PE13 β€” GPIO / FSMC_D10
Pin 64 PE14 β€” GPIO / FSMC_D11

Safe Operating Area (SOA) & Thermal Characteristics

Safe Operating Area Chart Default safe operating area chart for STM32L452RET6 Drain-to-Source Voltage (Vds) Drain Current (Id)

No official SOA curve available for this digital IC. Always operate within absolute maximum ratings specified in the datasheet. Ensure adequate cooling and derate as needed.

Typical Applications

STM32L452RET6 is suitable for 6 applications: Industrial Sensors, Smart Meters, Healthcare Devices, IoT Endpoints, Wearable Electronics, Test and Measurement.

🏭

Industrial Sensors

The STM32L452RET6 is ideal for industrial sensors due to its ultra-low-power modes and high-performance Cortex-M4 core. It can process sensor data with its 12-bit ADC and communicate via multiple interfaces. In a typical industrial sensor node, the MCU reads analog signals from temperature, pressure, or flow sensors, performs signal conditioning, and transmits data over RS-485 or CAN. The low-power Stop 2 mode (28 Β΅A) allows battery-powered operation for years. The 80 MHz core ensures real-time processing of sensor data, while the FPU accelerates floating-point calculations for calibration algorithms. Designers can use the STM32CubeMX to configure peripherals and generate code, reducing development time.

⚑

Smart Meters

Smart meters require precise measurement and low power consumption. The STM32L452RET6's 12-bit ADC with hardware oversampling enables accurate energy metering. Its low-power modes allow the meter to run on battery for extended periods. The MCU can handle metrology calculations, display updates, and communication with the grid. The 512 KB Flash provides ample space for firmware and calibration data. The device's wide supply voltage range (1.71 V to 3.6 V) accommodates battery voltage variations. The STM32L452RET6 also supports multiple communication protocols (e.g., PLC, RF) via its USART and SPI interfaces, making it a versatile choice for smart metering applications.

πŸ’Š

Healthcare Devices

In healthcare devices like wearable monitors, the STM32L452RET6 offers a balance of performance and power efficiency. Its low-power modes extend battery life, while the FPU handles complex signal processing for ECG or PPG signals. The device's analog peripherals (ADC, DAC, op-amp) enable direct sensor interfacing. The 160 KB SRAM supports real-time data buffering. The MCU's security features, including a true random number generator, help protect patient data. The STM32L452RET6 can operate from a coin cell battery, making it suitable for compact wearable designs. Its wide operating temperature range ensures reliable operation in various environments.

🧩

IoT Endpoints

The STM32L452RET6 is a popular choice for IoT endpoints due to its ultra-low-power consumption and rich connectivity options. It can run on batteries for years, waking up periodically to send sensor data over LoRa, BLE, or Wi-Fi. The MCU's multiple low-power modes allow fine-grained power management. The 512 KB Flash is sufficient for complex IoT protocols and over-the-air updates. The device's security features, including a unique ID and CRC, enhance device authentication. The STM32L452RET6 supports FreeRTOS and various middleware, simplifying IoT application development. Its small LQFP-64 package is suitable for space-constrained designs.

πŸ“±

Wearable Electronics

Wearable devices demand ultra-low power and small form factor. The STM32L452RET6's Shutdown mode (112 nA) is ideal for standby operation. Its Cortex-M4 core provides enough processing power for activity tracking algorithms. The device's analog peripherals enable direct connection to accelerometers and heart rate sensors. The 160 KB SRAM supports data logging. The MCU can operate from a small Li-Po battery, and its wide voltage range ensures stable operation as the battery discharges. The STM32L452RET6 also supports USB for charging and data transfer. Its low-power modes allow the device to last for days on a single charge.

πŸ”§

Test and Measurement

The STM32L452RET6 is suitable for portable test and measurement equipment due to its high-resolution ADC and low power consumption. It can be used in handheld multimeters, data loggers, and signal analyzers. The 12-bit ADC with oversampling provides accurate measurements. The device's multiple timers and PWM outputs enable waveform generation. The 512 KB Flash allows for complex measurement algorithms. The MCU's USB interface enables easy connection to a PC for data analysis. Its low-power modes extend battery life in field use. The STM32L452RET6's rich peripheral set makes it a versatile choice for various test instruments.

Recommended Products Summary

TMP117 High-accuracy temperature sensor Used in: Industrial Sensors LPS22HH Pressure sensor Used in: Industrial Sensors STM32L452RET6 STMicroelectronics Used in: Smart Meters S2-LP Sub-GHz radio transceiver Used in: Smart Meters MAX30102 Pulse oximeter sensor Used in: Healthcare Devices AD8232 ECG front-end Used in: Healthcare Devices SX1276 LoRa transceiver Used in: IoT Endpoints SPBTLE-RF BLE module Used in: IoT Endpoints LSM6DSO Accelerometer and gyroscope Used in: Wearable Electronics BQ25120 Battery charger Used in: Wearable Electronics ADS1115 External ADC for higher resolution Used in: Test and Measurement DAC8552 External DAC for signal generation Used in: Test and Measurement
What is the maximum clock frequency of STM32L452RET6?
The STM32L452RET6 operates at a maximum clock frequency of 80 MHz. According to the STMicroelectronics datasheet, the ARM Cortex-M4 core with FPU can run at up to 80 MHz, providing 100 DMIPS performance.
What is the flash memory size of STM32L452RET6?
The STM32L452RET6 has 512 KB of Flash memory. This is part of the STM32L4 series, which offers a range of memory options. The 512 KB Flash is sufficient for complex applications requiring substantial code storage.
What is the supply voltage range of STM32L452RET6?
The STM32L452RET6 operates from 1.71 V to 3.6 V. This wide range allows the microcontroller to be powered directly from batteries or regulated supplies, making it suitable for portable and low-power applications.
What is the difference between STM32L452RET6 and STM32L452RCT6?
The STM32L452RET6 has 512 KB Flash and 160 KB SRAM, while the STM32L452RCT6 has 256 KB Flash and 64 KB SRAM. Both are in the same LQFP-64 package and are pin-compatible, but the RET6 offers more memory for larger applications.
Can STM32L452RET6 be used for battery-powered IoT devices?
Yes, the STM32L452RET6 is ideal for battery-powered IoT devices due to its ultra-low-power modes. In Stop 2 mode, it consumes only 28 Β΅A with RTC running, and in Shutdown mode, it consumes 112 nA. This enables long battery life in applications like wireless sensors and wearables.
What is the price of STM32L452RET6?
As of 2026-08-06, the price of STM32L452RET6 is approximately $8.50 for single-unit quantities, decreasing to $5.50 at 1000 units. Prices may vary by distributor and quantity.
Where can I buy STM32L452RET6 online?
STM32L452RET6 is available from major distributors such as DigiKey, Mouser, and Arrow. You can also purchase directly from STMicroelectronics' official website. Check current stock and pricing on these platforms.
What is the lead time for STM32L452RET6?
The lead time for STM32L452RET6 typically ranges from 8 to 12 weeks, depending on distributor stock and order quantity. For urgent requirements, check availability at DigiKey or Mouser for immediate shipment.
Is STM32L452RET6 in stock?
Stock availability for STM32L452RET6 varies by distributor. As of 2026-08-06, DigiKey and Mouser typically have stock, but it is recommended to check their websites for real-time inventory.
What is the best drop-in replacement for STM32L452RET6?
The best drop-in replacement for STM32L452RET6 is the STM32L452RET7, which is the same device with an extended temperature range (-40Β°C to +125Β°C). Other pin-compatible options include STM32L452RCT6 (less memory) and STM32L452RGT6 (more memory).
Can STM32L452RCT6 replace STM32L452RET6?
Yes, STM32L452RCT6 can replace STM32L452RET6 in most applications, as they are pin-compatible and share the same LQFP-64 package. However, the RCT6 has only 256 KB Flash and 64 KB SRAM, so ensure your application fits within these memory limits.
What is the best STM32 alternative for STM32L452RET6?
The best STM32 alternative for STM32L452RET6 is the STM32L452RET7, which offers the same features with a wider temperature range. For lower power, consider the STM32L412 series, but note that it has fewer peripherals and memory.
Where can I download the STM32L452RET6 datasheet PDF?
You can download the STM32L452RET6 datasheet PDF from the STMicroelectronics website at https://www.st.com/resource/en/datasheet/stm32l452re.pdf. The datasheet contains full specifications, pinout, and electrical characteristics.
Where can I find the STM32L452RET6 pinout?
The STM32L452RET6 pinout is detailed in the datasheet, specifically in the pin descriptions section. The LQFP-64 package has 64 pins, with 51 general-purpose I/Os. The pinout diagram is available on page 32 of the datasheet.
What are the key specifications of STM32L452RET6 that engineers should know?
Engineers should know that STM32L452RET6 features an 80 MHz ARM Cortex-M4 core with FPU, 512 KB Flash, 160 KB SRAM, and operates from 1.71 V to 3.6 V. It has ultra-low-power modes with 28 Β΅A in Stop 2 and 112 nA in Shutdown, and includes a 12-bit ADC, DAC, and multiple communication interfaces.
Hey Google, what can replace STM32L452RET6?
STM32L452RET6 can be replaced by STM32L452RET7 (extended temperature), STM32L452RCT6 (less memory), or STM32L452RGT6 (more memory). All are pin-compatible in the LQFP-64 package. For cross-brand options, consider NXP LPC845 or Renesas RA4M1, but verify pin compatibility.
Is STM32L452RET6 the same as STM32L452RCT6?
No, STM32L452RET6 and STM32L452RCT6 are not the same. The RET6 has 512 KB Flash and 160 KB SRAM, while the RCT6 has 256 KB Flash and 64 KB SRAM. They are pin-compatible but differ in memory capacity.
What is the best NXP equivalent for STM32L452RET6?
The best NXP equivalent for STM32L452RET6 is the LPC845, which is an ARM Cortex-M0+ based MCU with similar low-power features. However, it is not pin-compatible, so a PCB redesign is required. For a drop-in replacement, stick with STM32L4 series.
What is the best Renesas equivalent for STM32L452RET6?
The best Renesas equivalent for STM32L452RET6 is the RA4M1, which features an ARM Cortex-M4 core. However, it is not pin-compatible with the LQFP-64 package, so a PCB redesign is needed. For drop-in replacement, consider STM32L4 series.
What is the operating temperature range of STM32L452RET6?
The STM32L452RET6 operates from -40Β°C to +85Β°C. For extended temperature range up to +125Β°C, consider the STM32L452RET7 variant.

Engineering reference data for STM32L452RET6 β€” comparison, design guidance, and compliance information.

Selection Guide

Choose the STM32L452RET6 when you need a balance of performance, memory, and ultra-low power consumption. It is ideal for battery-powered IoT devices, industrial sensors, and healthcare wearables. If you require a wider temperature range, select the STM32L452RET7. For applications with smaller code and data requirements, the STM32L452RCT6 offers cost savings with less memory. If you need more memory for complex applications, the STM32L452RGT6 provides 1 MB Flash and 320 KB SRAM. All these variants are pin-compatible in the LQFP-64 package, allowing easy migration. For cross-brand alternatives, consider NXP LPC845 or Renesas RA4M1, but note that they are not pin-compatible and require PCB redesign.

Comparison with Alternatives

Parameter This Product STM32L452RET7 STM32L452RCT6 STM32L452RGT6
Package LQFP-64 LQFP-64 LQFP-64 LQFP-64
Brand STMicroelectronics STMicroelectronics STMicroelectronics STMicroelectronics
Core ARM Cortex-M4 with FPU ARM Cortex-M4 with FPU ARM Cortex-M4 with FPU ARM Cortex-M4 with FPU
Max Clock Frequency 80 MHz 80 MHz 80 MHz 80 MHz
Flash Memory 512 KB 512 KB 256 KB 1 MB
SRAM 160 KB 160 KB 64 KB 320 KB
Supply Voltage Range 1.71 V to 3.6 V 1.71 V to 3.6 V 1.71 V to 3.6 V 1.71 V to 3.6 V
Operating Temperature Range -40Β°C to +85Β°C -40Β°C to +125Β°C -40Β°C to +85Β°C -40Β°C to +85Β°C

Key Differentiators

  • Ultra-low-power consumption with 28 Β΅A in Stop 2 mode (vs STM32L452RCT6)
  • 512 KB Flash and 160 KB SRAM (vs STM32L452RCT6)
  • Extended temperature range option (RET7) (vs STM32L452RET6)

Design Notes

The STM32L452RET6 supports a wide supply voltage range of 1.71 V to 3.6 V. For optimal power consumption, use the internal voltage regulator in low-power mode. Decouple all VDD and VDDA pins with 100 nF capacitors, and place a 4.7 Β΅F capacitor on the main VDD rail. In battery-powered designs, use the low-power modes (Stop 2, Shutdown) to extend battery life. The VBAT pin should be connected to a backup battery or tied to VDD if not used.

For the LQFP-64 package, ensure proper grounding and decoupling. Place decoupling capacitors close to the power pins. Use a solid ground plane to minimize noise. For the ADC, separate analog and digital grounds to reduce noise. The STM32L452RET6 has an exposed pad (EP) on the bottom of the package; solder it to the PCB ground plane for thermal and electrical performance.

When using the low-power modes, ensure that the RTC and backup registers are properly configured. The VBAT pin must be connected to a valid supply to retain RTC functionality. Also, be aware that the BOOT0 pin must be tied to a defined level to avoid accidental boot mode changes. For programming, use the SWD interface (PA13/PA14) and ensure the reset pin is not held low.

Compliance Information

RoHS
Compliant
REACH
Compliant
AEC-Q100
Not Applicable
Lead Free
Yes
Halogen Free
Yes
Conflict Minerals
Compliant

RoHS compliant per STMicroelectronics product page. Not AEC-Q100 qualified - this is a general-purpose MCU, not automotive grade.

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